Sintocalmy, a Passiflora incarnata Based Herbal, Attenuates Morphine Withdrawal in Mice.
This study shows anti-addiction effects for a commercial standardized extract of P. incarnata and suggests the relevance of proper clinical assessment. PMID: 33544325 [PubMed - as supplied by publisher] (Source: Neurochemical Research)
Source: Neurochemical Research - February 5, 2021 Category: Neuroscience Authors: Dos Reis Izolan L, da Silva DM, Oliveira HBL, de Oliveira Salomon JL, Peruzzi CP, Garcia SC, Dallegrave E, Zanotto C, Elisabetsky E, Gonçalves CA, Arbo MD, Konrath EL, Leal MB Tags: Neurochem Res Source Type: research

Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2
Planta Med DOI: 10.1055/a-1305-3936Herbal medication used in the treatment of sleep disorders and anxiety often contain extracts of Valeriana officinalis or Passiflora incarnata. Valerenic acid in V. officinalis and apigenin, orientin, and vitexin in P. incarnata are thought to contribute to their therapeutic effect. It was the aim of this study to test whether these constituents of herbal extracts are interacting with the uptake of estrone 3-sulfate, pregnenolone sulfate, and dehydroepiandrosterone sulfate mediated by the uptake transporters organic anion transporting polypeptide 2B1 (OATP2B1) or organic anion transporti...
Source: Planta Medica - January 28, 2021 Category: Drugs & Pharmacology Authors: Sch äfer, Anima M. Gilgen, Pierrine M. Spirgi, Clara Potterat, Olivier Meyer zu Schwabedissen, Henriette E. Tags: Original Papers Source Type: research

Anti-anxiety properties of selected medicinal plants.
The objective of this review is to provide information about the healing outcomes of anxiety treatment with natural products. Valeriana officinalis, Citrus aurantium, Commelina benghalensis, Achyranthes aspera, Mimosa pudica, Achillea millefolium, Nymphaea alba, Leonurus cardiac, Camellia sinensis, Turnera aphrodisiaca, Crataegus oxyacantha and Piper methysticum showed promising effects on anxiety in animal models. In clinical studies, passion flower, kava, valerian, St John's wort, and ashwagandha showed the most positive results. More studies are needed for the exploration of the anti-anxiety of medicinal plants. In drug...
Source: Current Pharmaceutical Biotechnology - January 22, 2021 Category: Biotechnology Authors: Khan A, Akram M, Thiruvengadam M, Daniyal M, Zakki SA, Munir N, Zainab R, Heydari M, Mosavat SH, Rebezov M, Shariati MA Tags: Curr Pharm Biotechnol Source Type: research

Herbal Medicinal Products from Passiflora for Anxiety: An Unexploited Potential.
Authors: da Fonseca LR, Rodrigues RA, Ramos AS, da Cruz JD, Ferreira JLP, Silva JRA, Amaral ACF Abstract Herbal medicines containing Passiflora species have been widely used to treat anxiety since ancient times. The species Passiflora incarnata L. is included in many Pharmacopoeias, and it is the most used species in food, cosmetic, and pharmaceutical industries. However, there are around 600 species of the genus Passiflora and probably other species that can be used safely. Thus, this article was based on a search into the uses of the main species of the genus Passiflora with anxiolytic activity and its m...
Source: The Scientific World Journal - August 13, 2020 Category: Science Tags: ScientificWorldJournal Source Type: research

Endophytic fungi from Passiflora incarnata: an antioxidant compound source.
In this study, from 315 endophytic fungi isolated from P. incarnata leaves, 60 were selected to determinate presence of chemical constituents related with antioxidant activity, based on their production of soluble pigments. The promising fungi were evaluated specifically on their potential to produce phenolic compounds, flavonoids and for antioxidant activity. Five isolates significantly produced flavonoids and phenolic compounds in the ethyl acetate and n-Butanol extracts, also saponins and high antioxidant activity against the DPPH (2.2-diphenyl-1-picrylhydrazyl) free radical. A strain of Aspergillus nidulans var. dentat...
Source: Archives of Microbiology - August 1, 2020 Category: Microbiology Authors: da Silva MHR, Cueva-Yesquén LG, Júnior SB, Garcia VL, Sartoratto A, de Angelis DF, de Angelis DA Tags: Arch Microbiol Source Type: research

Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study
The purpose of the present double-blind randomized placebo-controlled clinical study was to investigate the effects of Passionflower on polysomnographic sleep parameters in subjects with insomnia disorder. A total number 110 adult participants (mean age = 40.47 ± 11.68, Female = 53.6%) met the inclusion criteria of insomnia disorder according to the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders). After randomization, patients received either the Passionflower extract or the placebo for 2 weeks. Patients underwent an overnight polysomnography and completed sleep diaries, Insomnia Severity Index...
Source: International Clinical Psychopharmacology - December 3, 2019 Category: Psychiatry Tags: Original Articles Source Type: research

Comparison of specific endophytic bacterial communities in different developmental stages of Passiflora incarnata using culture ‐dependent and culture‐independent analysis
This study aimed to compare and determine the structure and composition of cultivable and uncultivable bacterial endophytic communities in vegetative and reproductive stages (RS) ofPassiflora incarnata. To that end, the endophytic communities were assessed by plating and Illumina ‐based 16S rRNA gene amplicon sequencing. Two hundred and four cultivable bacterial strains were successfully isolated. From the plant’s RS, the isolated strains were identified mainly as belonging to the generaSphingomonas,Curtobacterium, andMethylobacterium, whereasBacillus was the dominant genus isolated from the vegetative stage (VS). From...
Source: MicrobiologyOpen - August 26, 2019 Category: Microbiology Authors: Marcela C. Goulart, Luis G. Cueva ‐Yesquén, Kelly J. Hidalgo Martinez, Derlene Attili‐Angelis, Fabiana Fantinatti‐Garboggini Tags: ORIGINAL ARTICLE Source Type: research

A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study.
CONCLUSIONS: This pilot study suggests that the combination of melatonin, vitamin B6, and medicinal plants may be beneficial in mild-to-moderate insomnia. PMID: 31331545 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - July 25, 2019 Category: Complementary Medicine Authors: Lemoine P, Bablon JC, Da Silva C Tags: Complement Ther Med Source Type: research

Improvement in neurogenesis and memory function by administration of Passiflora incarnata L. extract applied to sleep disorder in rodent models
In conclusion, our results suggest that PF lead high hippocampal neurogenesis in the animals even in inherited sleep-disturbed animals. The increased hippocampal neurogenesis functionally enhanced memory and learning functions by repeated PF oral administration. These results identify PF as a potential therapy for enhancing memory functions and prevention of Alzheimer's disease through actions on the hippocampus. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - April 7, 2019 Category: Neuroscience Source Type: research

Metabolomics And Proteomics Profiles Of Some Medicinal Plants And Correlation With Bdnf Activity
ConclusionThe multivariate data analysis revealed a similar metabolomics profile of H. perforatum and P. incarnata, which also had a similar activity profile. Remarkably, all the primary metabolites belonging to the Krebs Cycle (citric acid, fumaric acid, succinic acid, pyruvic acid, malic acid and citramalic acid, an analog of malic acid) were positively correlated with BDNF activity. Secondary metabolites with a high BDNF expression belonged to flavonoids, xanthone, coumarines, tannin, naphtalenes, terpenoids and carotenoid skeleton. Two proteins from the cytochrome P450 family (P450 71B11 and P450 94B3) were positively ...
Source: Phytomedicine - April 6, 2019 Category: Drugs & Pharmacology Source Type: research

Improvement in neurogenesis and memory function by administration of Passiflora incarnate L. extract applied to sleep disorder in rodent models
In conclusion, our results suggest that PF lead high hippocampal neurogenesis in the animals even in inherited sleep-disturbed animals. The increased hippocampal neurogenesis functionally enhanced memory and learning functions by repeated PF oral administration. These results identify PF as a potential therapy for enhancing memory functions and prevention of Alzheimer's disease through actions on the hippocampus. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - April 4, 2019 Category: Neuroscience Source Type: research

Do recent research studies validate the medicinal plants used in British Columbia, Canada for pet diseases and wild animals taken into temporary care?
Publication date: 23 May 2019Source: Journal of Ethnopharmacology, Volume 236Author(s): Cheryl LansAbstractEthnopharmacological relevanceThere are insufficient safe and effective treatments for chronic pain in pets. In cases such as osteoarthritis there is no commercially available cure and veterinarians use NSAIDs to manage pain. Pet owners may have to plan for a lifetime of plant-based treatment for the conditions that lead to chronic pain in pets. Phytopharmacotherapies have the advantage of being less toxic, cheap or free, readily available, are more likely to be safe for long-term use and have the potential to reset t...
Source: Journal of Ethnopharmacology - March 20, 2019 Category: Drugs & Pharmacology Source Type: research

Do recent research studies validate the medicinal plants used in British Columbia, Canada for immune-mediated and other problems in pets?
ConclusionThe injuries treated in pets in British Columbia included abscesses, sprains and abrasions. Dogs were also treated with medicinal plants for rheumatoid arthritis, joint pain and articular cartilage injuries. More than 40 plants were used. Anal gland problems were treated with Allium sativum L., Aloe vera L., Calendula officinalis L., Plantago major L., Ulmus fulva Michx., Urtica dioica L. and the lichen Usnea longissima Ach. Antioxidants in plants, such as diarctigenin from Arctium lappa, used in ethnoveterinary medicine for rheumatoid arthritis and joint pain in pets are said to be of use in treating pathologica...
Source: Journal of Ethnopharmacology - February 15, 2019 Category: Drugs & Pharmacology Source Type: research