IJERPH, Vol. 19, Pages 15994: Short-End Injection Capillary Electrophoresis and Multivariate Analysis for Simultaneous Determination of Heavy Metals in Passiflora incarnata Tea
Bastos Borges An ultra-fast method for the simultaneous determination of heavy metals in Passiflora incarnata tea by capillary electrophoresis (CE) using a short-end injection combined with multivariate analysis was proposed. Separation was conducted by hydrodynamic injection (5 s at 0.5 psi) using the short-end injection procedure in a fused uncoated silica capillary (50 cm total length, 10.2 cm effective length, 50 µm i.d.) with separation time less than 2 min. An indirect UV detection at 214 nm was employed by using imidazole as a chromophore. The buffer used was 6 mmol/L hydroxybutyric acid (HIBA). Th...
Source: International Journal of Environmental Research and Public Health - November 30, 2022 Category: Environmental Health Authors: Aline Klassen Rafael Ferreira Fernandes D ébora Cristina de Oliveira Maria Patr ícia do Nascimento Marcella Matos Cordeiro Borges Marcone Augusto Leal de Oliveira Leandro Augusto Calixto Keyller Bastos Borges Tags: Article Source Type: research

In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity
In conclusion, this preclinical study shows that the administration of some of these herbal medicines causes in vitro disturbances to key drug metabolism mechanisms. We recommend active pharmacovigilance for Libidibia ferrea (Mart.) L. P. Queiroz, Frangula purshiana Cooper, Schinus terebinthifolia Raddi, and Salix alba L. which were able to alter all targets in our preclinical study. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - October 5, 2022 Category: Drugs & Pharmacology Source Type: research

Nip it in the Bud: Botanicals for Anxiety — a Practical Prescriber’s Guide
AbstractPurpose of ReviewThe goal of this paper is to summarize the evidence for the use of botanical medicines for the treatment of anxiety disorders. We sought to make this review practical for psychiatrists and psychiatric prescribers.Recent FindingsIn 2018, the Natural Medicines database produced a Clinical Management of Anxiety guide that summarized the conventional and natural treatments of anxiety disorders. Based on this guide, four herbal supplements (also referred to as botanicals) were selected for deeper study including kava, lavender, lemon balm and passionflower. All four were considered possibly safe and pos...
Source: Current Psychiatry Reports - September 1, 2022 Category: Psychiatry Source Type: research

Chrysin reduces hypercholesterolemia-mediated atherosclerosis through modulating oxidative stress, microflora, and apoptosis in experimental rats
In this study, we focused on the hypolipidemic proprieties of Chy in hypercholesterolemia-induced atherosclerosis. Male Wistar rats (150-220 g) were divided into four groups as follows: Group I control was fed with standard laboratory chow. Rats in Group II were fed a high-fat diet (HFD) for 60 days. After 60 days of HFD, Group III rats received Chy (100 mg/kg body weight); Group IV rats received Atorvastatin (Atv; 10 mg/kg body weight) for 30 days. Biochemical studies showed Chy, Atv treatment decreased the activities of liver marker enzymes and the levels of Reactive Oxygen Species (ROS) and lipid profile. Gene expressio...
Source: Atherosclerosis - July 27, 2022 Category: Cardiology Authors: Subramani Yuvaraj Sundrasen Sasikumar Shanavas Syed Mohamed Puhari Tharmarajan Ramprasath Nagarethinam Baskaran Varadaraj Vasudevan Govindan Sadasivam Selvam Source Type: research

Molecules, Vol. 27, Pages 3551: Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin
uez Chrysin (5,7-dihydroxyflavone) is a flavonoid isolated from plants, such as Passiflora coerulea, Passiflora incarnata, and Matricaria chamomilla. This natural molecule exerts diverse pharmacological effects, which includes antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and anti-apoptotic effects. Additionally, in brain structures, such as the hippocampus, prefrontal cortex, raphe nucleus, and striatum, involved in the physiopathology of anxiety and depression disorders, several neuropharmacological activities, including the activation of neurotransmitter systems (GABAergic, serotonergic, dopaminergic...
Source: Molecules - May 31, 2022 Category: Chemistry Authors: Juan Francisco Rodr íguez-Landa Le ón Jesús German-Ponciano Abraham Puga-Olgu ín Oscar Jer ónimo Olmos-Vázquez Tags: Review Source Type: research

Molecules, Vol. 26, Pages 6632: In Vitro Liver Metabolism of Six Flavonoid C-Glycosides
mann Several medical plants belonging to the genera Passiflora, Viola, and Crataegus accumulate flavonoid C-glycosides, which likely contribute to their efficacy. Information regarding their phase I and II metabolism in the liver are lacking. Thus, in vitro liver metabolism of orientin, isoorientin, schaftoside, isoschaftoside, vitexin, and isovitexin, all of which accumulated in Passiflora incarnata L., was investigated by incubation in subcellular systems with human liver microsomes and human liver S9 fraction. All metabolite profiles were comprehensively characterized using HPLC-DAD and UHPLC–MS/MS analysis. Mono-...
Source: Molecules - November 1, 2021 Category: Chemistry Authors: Martina Tremmel Christian Paetz J örg Heilmann Tags: Article Source Type: research

Pattern formation in < em > Passiflora incarnata < /em > : An activator-inhibitor model
J Biosci. 2021;46:84.ABSTRACTBased on a careful examination of the onset of violet colored dots along the filaments in the developing floral bud stage and the formation of alternating bands of violet and white color in the matured flowers of Passiflora incarnata (Passion flower), it is concluded that the pattern arises from a competition between the production of violet colored anthocyanin and the colorless flavonols along the filaments. The activator-inhibitor model of Gierer and Meinhardt along with the reaction diffusion theory of Turing is used to explain the formation of concentric rings in the flower.PMID:34423786 (S...
Source: Journal of Biosciences - August 23, 2021 Category: Biomedical Science Authors: Agastya P Bhati S Goyal Ram Yadav Sathyamurthy N Source Type: research

Pattern formation in < em > Passiflora incarnata < /em > : An activator-inhibitor model
J Biosci. 2021;46:84.ABSTRACTBased on a careful examination of the onset of violet colored dots along the filaments in the developing floral bud stage and the formation of alternating bands of violet and white color in the matured flowers of Passiflora incarnata (Passion flower), it is concluded that the pattern arises from a competition between the production of violet colored anthocyanin and the colorless flavonols along the filaments. The activator-inhibitor model of Gierer and Meinhardt along with the reaction diffusion theory of Turing is used to explain the formation of concentric rings in the flower.PMID:34423786 (S...
Source: Journal of Biosciences - August 23, 2021 Category: Biomedical Science Authors: Agastya P Bhati S Goyal Ram Yadav Sathyamurthy N Source Type: research

Pattern formation in < em > Passiflora incarnata < /em > : An activator-inhibitor model
J Biosci. 2021;46:84.ABSTRACTBased on a careful examination of the onset of violet colored dots along the filaments in the developing floral bud stage and the formation of alternating bands of violet and white color in the matured flowers of Passiflora incarnata (Passion flower), it is concluded that the pattern arises from a competition between the production of violet colored anthocyanin and the colorless flavonols along the filaments. The activator-inhibitor model of Gierer and Meinhardt along with the reaction diffusion theory of Turing is used to explain the formation of concentric rings in the flower.PMID:34423786 (S...
Source: Journal of Biosciences - August 23, 2021 Category: Biomedical Science Authors: Agastya P Bhati S Goyal Ram Yadav Sathyamurthy N Source Type: research

Pattern formation in < em > Passiflora incarnata < /em > : An activator-inhibitor model
J Biosci. 2021;46:84.ABSTRACTBased on a careful examination of the onset of violet colored dots along the filaments in the developing floral bud stage and the formation of alternating bands of violet and white color in the matured flowers of Passiflora incarnata (Passion flower), it is concluded that the pattern arises from a competition between the production of violet colored anthocyanin and the colorless flavonols along the filaments. The activator-inhibitor model of Gierer and Meinhardt along with the reaction diffusion theory of Turing is used to explain the formation of concentric rings in the flower.PMID:34423786 (S...
Source: Journal of Biosciences - August 23, 2021 Category: Biomedical Science Authors: Agastya P Bhati S Goyal Ram Yadav Sathyamurthy N Source Type: research

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review
Planta Med DOI: 10.1055/a-1510-9826Sleep disorders are common among the general population and can generate health problems such as insomnia and anxiety. In addition to standard drugs and psychological interventions, there are different complementary plant-based therapies used to treat insomnia and anxiety. This review aimed to find and examine the most recent research on the use of herbal medicines for treating anxiety and insomnia as compiled from clinical trials, as well as to assess the safety and efficacy of these medicines and to elucidate their possible mechanisms of action. The process entailed a search of PubMed, ...
Source: Planta Medica - June 11, 2021 Category: Drugs & Pharmacology Authors: Borr ás, Silvia Mart ínez-Solís, Isabel R íos, José Luis Tags: Reviews Source Type: research

Use of Plant-Derived Natural Products in Sleep Disturbances
Adv Exp Med Biol. 2021;1308:217-224. doi: 10.1007/978-3-030-64872-5_15.ABSTRACTSleep disorders have a high prevalence both in the general population and especially in specific populations such older adults and oncologic patients. Impacting on quality of life, they often translate in drug prescription, with consequent increased risk of drug-drug interactions and adverse drug reactions. In the last years several products derived from plants have been developed with the aim of treating insomnia with lower risk of side effects. Despite several studies have been performed with this aim, the available evidence is inconclusive, a...
Source: Advances in Experimental Medicine and Biology - April 16, 2021 Category: Research Authors: Diana Lelli Livio Cortese Claudio Pedone Source Type: research