Evaluation of an early twentieth century Afghan herbalist ’s preparations
AbstractMahomet Allum was a flamboyant philanthropist and herbalist who worked in South Australia in the early part of last century, whose herbal therapies generated some controversy at the time. Two of his preparations have survived to the present day, a general tonic and a treatment for liver and kidney dysfunction. Given the frequent use of pharmaceutical drugs in “tonics” at the time, toxicological analysis was undertaken at Forensic Science SA, Adelaide with liquid chromatography/quadrupole-time-of-flight mass-spectrometer (LC-QTOF MS), liquid-chromatography/ diode array detector (LC/UV) and gas chromatography/ ni...
Source: Forensic Science, Medicine, and Pathology - September 27, 2018 Category: Forensic Medicine Source Type: research
Prevalence of drug-herb and drug-supplement interactions in older adults: a cross-sectional survey.
CONCLUSION: GPs should routinely ask questions regarding herbal and supplement use, to identify and manage older adults at potential risk of adverse drug interactions.
PMID: 30249608 [PubMed - as supplied by publisher] (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - September 24, 2018 Category: Primary Care Authors: Agbabiaka TB, Spencer NH, Khanom S, Goodman C Tags: Br J Gen Pract Source Type: research
Comparison of bioactive compounds content in leaf extracts of Passiflora incarnata, P. caerulea and P. alata and in vitro cytotoxic potential on leukemia cell lines
ABSTRACT Passiflora caerulea L., P. alata Curtis and P. incarnata L. (synonym for P. edulis Sims), are the most popular representatives of the Passiflora genus in South America. In recent years, a growing attention is paid to the biological activity and phytochemical profiles of crude extracts from various species of Passiflora in worldwide. The aim of this study was to evaluate and to compare of anti-leukemic activity of the dry crude extracts from leaves of three Passiflora species from greenhouse of Poland in two human acute lymphoblastic leukemia cell lines: CCRF-CEM and its multidrug resistant variant. Two systems of ...
Source: Revista Brasileira de Farmacognosia - June 11, 2018 Category: Drugs & Pharmacology Source Type: research
[Herbal medicines for psychiatric disorders].
CONCLUSION: Due to the promising effects and the low side effect potential within the existing studies, further randomized controlled trials (e. g. for Passiflora incarnata, Rhodiola rosea and Lavendula officinalis) are definitely indicated.
PMID: 29846749 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 30, 2018 Category: Neurology Authors: Anheyer D, Haller H, Klose P, Cramer H, Dobos G Tags: Nervenarzt Source Type: research
1414 A new passion fruit extract promoting skin wound healing process
Wound healing is an essential but complex physiological process that involves the collaboration of various cell types and factors. The kinetic of wound healing is divided into 3 phases which overlap: inflammatory phase, repair phase consisting of cell proliferation and migration, and remodeling phase. We have developed a patented active ingredient from passion fruit, maracuja oil concentrate, rich in unsaponifiable fraction, obtained from one of our sustainable supply chains. Evaluated on 2D in vitro models, the extract induced the proliferation and migration of keratinocytes and fibroblasts, and increased hyaluronic acid....
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: G. Boyer, M. Le roux, S. Bredif, G. Bellemere, S. Leclere bienfait, C. Baudouin Tags: Tissue Regeneration and Wound Healing Source Type: research
An open prospective pilot study of a herbal combination "Relief" as a supportive dietetic measure during alcohol withdrawal.
CONCLUSIONS: Despite the limitations of the present study, the findings showed the potential of Relief for the improvement of the clinical situation of patients with symptoms of alcohol withdrawal and therefore, justify a full-scale well-controlled study design to be implemented.
PMID: 29604618 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - April 3, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
Targeted-Analysis of β-Carboline Alkaloids in Passionfruit (“Maracujá”) by SBSE(PDMS)-LC/Flu and UHPLC-MS
Samples of pulp and seeds of sour (P. edulis) and sweet (P. alata) passionfruit were subjected to targeted analysis to identify β -carboline alkaloids, using combined UHPLC-MS (ultrahigh performance liquid chromatography-mass spectrometry) and SBSE(PDMS) (stir bar sorption extraction using polydimethylsiloxane as stationary phase) for sample preconcentration. All the samples contained harmane and harmine; harmaline was found only in P. alata seeds and in P. edulis pulp, while harmalol was found only in P. alata seeds. An analysis of sweet passionfruit by SBSE(PDMS) combined with LC/Flu (liquid chromatography/fluorescence ...
Source: Journal of the Brazilian Chemical Society - March 15, 2018 Category: Chemistry Source Type: research
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho ‐oncologic relevance
Anxiety and depression are prevalent among cancer patients, with significant negative impact. Many patients prefer herbs for symptom relief to conventional medications which have limited efficacy/side effects. We identified single‐herb medicines that may warrant further study in cancer patients. Our search included PubMed, Allied and Complementary Medicine, Embase, and Cochrane databases, selecting only single‐herb randomized controlled trials between 1996 and 2016 in any population for data extraction, excluding herbs with known potential for interactions with cancer treatments. One hundred articles involving 38 botan...
Source: Phytotherapy Research - February 21, 2018 Category: Biochemistry Authors: K. Simon Yeung, Marisol Hernandez, Jun J. Mao, Ingrid Haviland, Jyothirmai Gubili Tags: REVIEW Source Type: research
Pregnancy outcomes in psychiatric patients treated with passiflora incarnata.
Abstract
Passiflora incarnata is marketed in many countries as anxiolytic herbal supplement. Herbal medicines are natural products, but it doesn't mean they are always safe, especially during pregnancy. Passiflora incarnata extract was not teratogenic in experimental studies. However, there are no data available on possible effects on human pregnancy. Here we report five pregnant women with depression and/or anxiety who used passiflora incarnata in pregnancy. We observed one pregnancy resulting in neonatal death, two pregnancies with premature rupture of membranes, two infants with meconium aspiration synd...
Source: Complementary Therapies in Medicine - February 1, 2018 Category: Complementary Medicine Authors: Ozturk Z, Kalayci CC Tags: Complement Ther Med Source Type: research
Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men – an explorative randomized placebo - controlled double blind study
Conclusion: The results show that Ze 185 significantly attenuated the subjective emotional stress response during an acute stress situation, without affecting biological stress responses. Given that a circumscribed biological stress response is to be considered as an adaptive mechanism, Ze 185 reduces self-reported anxiety response to stress without affecting assumingly adaptive biological stress responses. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - December 12, 2017 Category: Drugs & Pharmacology Source Type: research
GABA ‐modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence
Anxiety disorders are chronic and functionally disabling conditions with high psychological stress, characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia. Gamma‐aminobutyric acid (GABA) is an inhibitory neurotransmitter within the central nervous system and is a key target of pharmacotherapies in the treatment of anxiety. Although current pharmaceutical treatments are often efficacious, they may cause undesirable side effects including cognitive decrements and withdrawal symptoms. Plant‐based “phytomedicines” may provide novel tr...
Source: Phytotherapy Research - November 23, 2017 Category: Biochemistry Authors: Karen Savage, Joseph Firth, Con Stough, Jerome Sarris Tags: REVIEW Source Type: research
Effect of clarified Brazilian native fruit juices on postprandial glycemia in healthy subjects
Publication date: October 2017 Source:Food Research International, Volume 100, Part 2 Author(s): Diully Mata Balisteiro, Renata Luise de Araujo, Luciano Ricardo Giacaglia, Maria Inés Genovese Brazilian native fruits have been shown as excellent sources of polyphenols which are associated with multiple biological activities including inhibition of carbohydrate-hydrolyzing enzymes, α-amylase and α-glucosidase. Postmeal blood glucose elevations and high glycemic index diets can play a major role in the development of type 2 diabetes, therefore alternative approaches to reduce postprandial hyperglycemia are of growing...
Source: Food Research International - September 12, 2017 Category: Food Science Source Type: research
Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease.
This study investigates the effect of the P. cincinnata ethanolic extract (PAS) on mice submitted to a progressive model of Parkinson's disease (PD) induced by reserpine. Male (6-month-old) mice received reserpine (0.1 mg/kg, s.c.), every other day, for 40 days, with or without a concomitant treatment with daily injections of PAS (25 mg/kg, i.p.). Catalepsy, open field, oral movements, and plus-maze discriminative avoidance evaluations were performed across treatment, and immunohistochemistry for tyrosine hydroxylase was conducted at the end. The results showed that PAS treatment delayed the onset of motor impairments ...
Source: Evidence-based Complementary and Alternative Medicine - August 26, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
