114 Stimulating Nrf2 and Heme-Oxygenase 1 pathways to help the skin fighting against daily environmental insults

The skin is routinely exposed to stresses from the environment: pollution, sun … These repeated and regular exposures can profoundly affect skin physiology, and may lead to irreversible consequences. We studied the potential of a maracuja seeds extract, particularly enriched in polyphenols, to enhance skin defense mechanisms involved in environmental stress response. One of the main pathways involved in skin defense and detoxification against environmental stress, involves heme oxygenase 1 (HO1) induction, which is controlled by the Nrf2 transcription factor.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidermal Structure and Function Source Type: research