Accelerating cryoprotectant delivery using vacuum infiltration
Cryobiology. 2023 Jul 12:104558. doi: 10.1016/j.cryobiol.2023.104558. Online ahead of print.ABSTRACTThe ability to cryopreserve bone marrow within the vertebral body (VB) would offer significant clinical and research benefits. However, cryopreservation of large structures, such as VBs, is challenging due to mass transport limitations that prevent the effective delivery of cryoprotectants into the tissue. To overcome this challenge, we examined the potential of vacuum infiltration, along with carbonation, to increase the penetration of cryoprotectants. In particular, we hypothesized that initial exposure to high-pressure ca...
Source: Cryobiology - July 14, 2023 Category: Biology Authors: Ryan J Forcier Robert T Heussner Lauren Newsom Morgan B Giers Wa'el Al Rawashdeh Kimberly A Buchanan Erik J Woods Brian H Johnstone Adam Z Higgins Source Type: research

Accelerating cryoprotectant delivery using vacuum infiltration
Cryobiology. 2023 Jul 12:104558. doi: 10.1016/j.cryobiol.2023.104558. Online ahead of print.ABSTRACTThe ability to cryopreserve bone marrow within the vertebral body (VB) would offer significant clinical and research benefits. However, cryopreservation of large structures, such as VBs, is challenging due to mass transport limitations that prevent the effective delivery of cryoprotectants into the tissue. To overcome this challenge, we examined the potential of vacuum infiltration, along with carbonation, to increase the penetration of cryoprotectants. In particular, we hypothesized that initial exposure to high-pressure ca...
Source: Cryobiology - July 14, 2023 Category: Biology Authors: Ryan J Forcier Robert T Heussner Lauren Newsom Morgan B Giers Wa'el Al Rawashdeh Kimberly A Buchanan Erik J Woods Brian H Johnstone Adam Z Higgins Source Type: research

Accelerating cryoprotectant delivery using vacuum infiltration
Cryobiology. 2023 Jul 12:104558. doi: 10.1016/j.cryobiol.2023.104558. Online ahead of print.ABSTRACTThe ability to cryopreserve bone marrow within the vertebral body (VB) would offer significant clinical and research benefits. However, cryopreservation of large structures, such as VBs, is challenging due to mass transport limitations that prevent the effective delivery of cryoprotectants into the tissue. To overcome this challenge, we examined the potential of vacuum infiltration, along with carbonation, to increase the penetration of cryoprotectants. In particular, we hypothesized that initial exposure to high-pressure ca...
Source: Cryobiology - July 14, 2023 Category: Biology Authors: Ryan J Forcier Robert T Heussner Lauren Newsom Morgan B Giers Wa'el Al Rawashdeh Kimberly A Buchanan Erik J Woods Brian H Johnstone Adam Z Higgins Source Type: research

Accelerating cryoprotectant delivery using vacuum infiltration
Cryobiology. 2023 Jul 12:104558. doi: 10.1016/j.cryobiol.2023.104558. Online ahead of print.ABSTRACTThe ability to cryopreserve bone marrow within the vertebral body (VB) would offer significant clinical and research benefits. However, cryopreservation of large structures, such as VBs, is challenging due to mass transport limitations that prevent the effective delivery of cryoprotectants into the tissue. To overcome this challenge, we examined the potential of vacuum infiltration, along with carbonation, to increase the penetration of cryoprotectants. In particular, we hypothesized that initial exposure to high-pressure ca...
Source: Cryobiology - July 14, 2023 Category: Biology Authors: Ryan J Forcier Robert T Heussner Lauren Newsom Morgan B Giers Wa'el Al Rawashdeh Kimberly A Buchanan Erik J Woods Brian H Johnstone Adam Z Higgins Source Type: research

Accelerating cryoprotectant delivery using vacuum infiltration
Cryobiology. 2023 Jul 12:104558. doi: 10.1016/j.cryobiol.2023.104558. Online ahead of print.ABSTRACTThe ability to cryopreserve bone marrow within the vertebral body (VB) would offer significant clinical and research benefits. However, cryopreservation of large structures, such as VBs, is challenging due to mass transport limitations that prevent the effective delivery of cryoprotectants into the tissue. To overcome this challenge, we examined the potential of vacuum infiltration, along with carbonation, to increase the penetration of cryoprotectants. In particular, we hypothesized that initial exposure to high-pressure ca...
Source: Cryobiology - July 14, 2023 Category: Biology Authors: Ryan J Forcier Robert T Heussner Lauren Newsom Morgan B Giers Wa'el Al Rawashdeh Kimberly A Buchanan Erik J Woods Brian H Johnstone Adam Z Higgins Source Type: research

Accelerating cryoprotectant delivery using vacuum infiltration
Cryobiology. 2023 Jul 12:104558. doi: 10.1016/j.cryobiol.2023.104558. Online ahead of print.ABSTRACTThe ability to cryopreserve bone marrow within the vertebral body (VB) would offer significant clinical and research benefits. However, cryopreservation of large structures, such as VBs, is challenging due to mass transport limitations that prevent the effective delivery of cryoprotectants into the tissue. To overcome this challenge, we examined the potential of vacuum infiltration, along with carbonation, to increase the penetration of cryoprotectants. In particular, we hypothesized that initial exposure to high-pressure ca...
Source: Cryobiology - July 14, 2023 Category: Biology Authors: Ryan J Forcier Robert T Heussner Lauren Newsom Morgan B Giers Wa'el Al Rawashdeh Kimberly A Buchanan Erik J Woods Brian H Johnstone Adam Z Higgins Source Type: research

Accelerating cryoprotectant delivery using vacuum infiltration
Cryobiology. 2023 Jul 13;112:104558. doi: 10.1016/j.cryobiol.2023.104558. Online ahead of print.ABSTRACTThe ability to cryopreserve bone marrow within the vertebral body (VB) would offer significant clinical and research benefits. However, cryopreservation of large structures, such as VBs, is challenging due to mass transport limitations that prevent the effective delivery of cryoprotectants into the tissue. To overcome this challenge, we examined the potential of vacuum infiltration, along with carbonation, to increase the penetration of cryoprotectants. In particular, we hypothesized that initial exposure to high-pressur...
Source: Cryobiology - July 14, 2023 Category: Biology Authors: Ryan J Forcier Robert T Heussner Lauren Newsom Morgan B Giers Wa'el Al Rawashdeh Kimberly A Buchanan Erik J Woods Brian H Johnstone Adam Z Higgins Source Type: research

Accelerating cryoprotectant delivery using vacuum infiltration
Cryobiology. 2023 Jul 13;112:104558. doi: 10.1016/j.cryobiol.2023.104558. Online ahead of print.ABSTRACTThe ability to cryopreserve bone marrow within the vertebral body (VB) would offer significant clinical and research benefits. However, cryopreservation of large structures, such as VBs, is challenging due to mass transport limitations that prevent the effective delivery of cryoprotectants into the tissue. To overcome this challenge, we examined the potential of vacuum infiltration, along with carbonation, to increase the penetration of cryoprotectants. In particular, we hypothesized that initial exposure to high-pressur...
Source: Cryobiology - July 14, 2023 Category: Biology Authors: Ryan J Forcier Robert T Heussner Lauren Newsom Morgan B Giers Wa'el Al Rawashdeh Kimberly A Buchanan Erik J Woods Brian H Johnstone Adam Z Higgins Source Type: research

Fast soft-tissue deformations coupled with mixed reality toward the next-generation childbirth training simulator
AbstractHigh-quality gynecologist and midwife training is particularly relevant to limit medical complications and reduce maternal and fetal morbimortalities. Physical and virtual training simulators have been developed. However, physical simulators offer a simplified model and limited visualization of the childbirth process, while virtual simulators still lack a realistic interactive system and are generally limited to imposed predefined gestures. Objective performance assessment based on the simulation numerical outcomes is still not at hand. In the present work, we developed  a virtual childbirth simulator based on the...
Source: Medical and Biological Engineering and Computing - July 13, 2023 Category: Biomedical Engineering Source Type: research

Re-evaluation of modifiable risk factors for obstetric anal sphincter injury in a real-world setting
ConclusionsMediolateral episiotomy was protective against OASI in both spontaneous and instrumental deliveries of primiparae. Increased fetal weight and large fetal head circumference, particularly in short women, were significant risk factors. These findings support the performance of ultrasound to acquire updated fetal measures before admission to the labor ward. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - July 12, 2023 Category: OBGYN Source Type: research

A prospective study on neonatal ophthalmic injuries associated with forceps delivery
Assisted delivery by forceps is needed to expedite vaginal delivery in certain maternal and fetal conditions. The aim of this study was to evaluate the incidence and the extent of ophthalmological injuries in neonates after forceps delivery. (Source: Journal of AAPOS)
Source: Journal of AAPOS - July 12, 2023 Category: Opthalmology Authors: Choi Wah Kong, William Wing Kee To, Tracy Hiu Ting Lai, Emily Wai Ho Tang, Yok Chiu Ho, Kenneth Kai Wang Li Tags: Major Article Source Type: research

Re-evaluation of modifiable risk factors for obstetric anal sphincter injury in a real-world setting
ConclusionsMediolateral episiotomy was protective against OASI in both spontaneous and instrumental deliveries of primiparae. Increased fetal weight and large fetal head circumference, particularly in short women, were significant risk factors. These findings support the performance of ultrasound to acquire updated fetal measures before admission to the labor ward. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - July 12, 2023 Category: OBGYN Source Type: research

Solidification and Oral Delivery of Biologics to the Colon- A Review
Eur J Pharm Sci. 2023 Jul 8:106523. doi: 10.1016/j.ejps.2023.106523. Online ahead of print.ABSTRACTThe oral delivery of biologics such as therapeutic proteins, peptides and oligonucleotides for the treatment of colon related diseases has been the focus of increasing attention over the last years. However, the major disadvantage of these macromolecules is their degradation propensity in liquid state which can lead to the undesirable and complete loss of function. Therefore, to increase the stability of the biologic and reduce their degradation propensity, formulation techniques such as solidification can be performed to obt...
Source: European Journal of Pharmaceutical Sciences - July 10, 2023 Category: Drugs & Pharmacology Authors: Katharina Tatjana Kopp Lien Saerens Jody Voorspoels Guy Van den Mooter Source Type: research

Solidification and Oral Delivery of Biologics to the Colon- A Review
Eur J Pharm Sci. 2023 Jul 8:106523. doi: 10.1016/j.ejps.2023.106523. Online ahead of print.ABSTRACTThe oral delivery of biologics such as therapeutic proteins, peptides and oligonucleotides for the treatment of colon related diseases has been the focus of increasing attention over the last years. However, the major disadvantage of these macromolecules is their degradation propensity in liquid state which can lead to the undesirable and complete loss of function. Therefore, to increase the stability of the biologic and reduce their degradation propensity, formulation techniques such as solidification can be performed to obt...
Source: European Journal of Pharmaceutical Sciences - July 10, 2023 Category: Drugs & Pharmacology Authors: Katharina Tatjana Kopp Lien Saerens Jody Voorspoels Guy Van den Mooter Source Type: research

Maternal and fetal outcomes of pregnancies associated with single versus double abnormal values in 100 gr glucose tolerance test
ConclusionWe found no significant differences between pregnant women with single and double abnormal values in 100 gr OGTT regarding maternal and neonatal outcomes, except for macrosomia and need for pharmaceutical treatment. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - July 7, 2023 Category: Endocrinology Source Type: research