The correlation between serum total bile acid and adverse perinatal outcomes in pregnant women with intrahepatic cholestasis of pregnancy (ICP) and non-ICP hypercholanemia of pregnancy
CONCLUSIONS: If a pregnant woman has moderate-to-severe liver disease and TBA ≥ 100µmol/L, preterm termination of pregnancy (before 34 weeks) may be considered.PMID:38515230 | DOI:10.1080/07853890.2024.2331059 (Source: Molecular Medicine)
Source: Molecular Medicine - March 22, 2024 Category: Molecular Biology Authors: Peizhen Zhang Zhangmin Tan Chuo Li Zhenyan Han Jin Zhou Yuzhu Yin Source Type: research
The correlation between serum total bile acid and adverse perinatal outcomes in pregnant women with intrahepatic cholestasis of pregnancy (ICP) and non-ICP hypercholanemia of pregnancy
CONCLUSIONS: If a pregnant woman has moderate-to-severe liver disease and TBA ≥ 100µmol/L, preterm termination of pregnancy (before 34 weeks) may be considered.PMID:38515230 | DOI:10.1080/07853890.2024.2331059 (Source: Annals of Medicine)
Source: Annals of Medicine - March 22, 2024 Category: Internal Medicine Authors: Peizhen Zhang Zhangmin Tan Chuo Li Zhenyan Han Jin Zhou Yuzhu Yin Source Type: research
The correlation between serum total bile acid and adverse perinatal outcomes in pregnant women with intrahepatic cholestasis of pregnancy (ICP) and non-ICP hypercholanemia of pregnancy
CONCLUSIONS: If a pregnant woman has moderate-to-severe liver disease and TBA ≥ 100µmol/L, preterm termination of pregnancy (before 34 weeks) may be considered.PMID:38515230 | DOI:10.1080/07853890.2024.2331059 (Source: Molecular Medicine)
Source: Molecular Medicine - March 22, 2024 Category: Molecular Biology Authors: Peizhen Zhang Zhangmin Tan Chuo Li Zhenyan Han Jin Zhou Yuzhu Yin Source Type: research
The correlation between serum total bile acid and adverse perinatal outcomes in pregnant women with intrahepatic cholestasis of pregnancy (ICP) and non-ICP hypercholanemia of pregnancy
CONCLUSIONS: If a pregnant woman has moderate-to-severe liver disease and TBA ≥ 100µmol/L, preterm termination of pregnancy (before 34 weeks) may be considered.PMID:38515230 | DOI:10.1080/07853890.2024.2331059 (Source: Annals of Medicine)
Source: Annals of Medicine - March 22, 2024 Category: Internal Medicine Authors: Peizhen Zhang Zhangmin Tan Chuo Li Zhenyan Han Jin Zhou Yuzhu Yin Source Type: research
The correlation between serum total bile acid and adverse perinatal outcomes in pregnant women with intrahepatic cholestasis of pregnancy (ICP) and non-ICP hypercholanemia of pregnancy
CONCLUSIONS: If a pregnant woman has moderate-to-severe liver disease and TBA ≥ 100µmol/L, preterm termination of pregnancy (before 34 weeks) may be considered.PMID:38515230 | PMC:PMC10962286 | DOI:10.1080/07853890.2024.2331059 (Source: Annals of Medicine)
Source: Annals of Medicine - March 22, 2024 Category: Internal Medicine Authors: Peizhen Zhang Zhangmin Tan Chuo Li Zhenyan Han Jin Zhou Yuzhu Yin Source Type: research
Metabolomic Profiling of Serum and Tongue Coating of Pregnant Women with Intrahepatic Cholestasis in Pregnancy
In this study, we performed untargeted metabolomic profiling of the serum, tongue coating, and saliva of 66 pregnant women, including 22 with ICP. The metabolomic profiles of the serum and tongue coatings showed marked differences between the two clinical groups. Forty-six differentially abundant metabolites were identified, and their relative concentrations correlated with total bile acid levels. These differential metabolites included bile acids, lipids, microbiota- and diet-related metabolites, and exposomes. Conventional biochemical markers, including serum aminotransferases and bilirubin, were not significantly increa...
Source: International Journal of Clinical Chemistry - March 21, 2024 Category: Chemistry Authors: Feng Zhang Fang Liu Xiaoyi Xu Weilan Su Yu Rong Fu-Ying Tian Weimin Xiao Yichun Wu Kai P Law Ping Wen Source Type: research
Metabolomic Profiling of Serum and Tongue Coating of Pregnant Women with Intrahepatic Cholestasis in Pregnancy
In this study, we performed untargeted metabolomic profiling of the serum, tongue coating, and saliva of 66 pregnant women, including 22 with ICP. The metabolomic profiles of the serum and tongue coatings showed marked differences between the two clinical groups. Forty-six differentially abundant metabolites were identified, and their relative concentrations correlated with total bile acid levels. These differential metabolites included bile acids, lipids, microbiota- and diet-related metabolites, and exposomes. Conventional biochemical markers, including serum aminotransferases and bilirubin, were not significantly increa...
Source: International Journal of Clinical Chemistry - March 21, 2024 Category: Chemistry Authors: Feng Zhang Fang Liu Xiaoyi Xu Weilan Su Yu Rong Fu-Ying Tian Weimin Xiao Yichun Wu Kai P Law Ping Wen Source Type: research
Molecular Insights of Cholestasis in MDR2 Knockout Murine Liver Organoids
J Proteome Res. 2024 Mar 15. doi: 10.1021/acs.jproteome.3c00900. Online ahead of print.ABSTRACTMDR3 (multidrug resistance 3) deficiency in humans (MDR2 in mice) causes progressive familial intrahepatic cholestasis type 3 (PFIC3). PFIC3 is a lethal disease characterized by an early onset of intrahepatic cholestasis progressing to liver cirrhosis, a preneoplastic condition, putting individuals at risk of hepatocellular carcinoma (HCC). Hepatocyte-like organoids from MDR2-deficient mice (MDR2KO) were used in this work to study the molecular alterations caused by the deficiency of this transporter. Proteomic analysis by mass s...
Source: Cell Research - March 15, 2024 Category: Cytology Authors: Irene Bl ázquez-García Laura Guerrero Cristina Cacho-Navas Nabil Djouder Jaime Millan Alberto Paradela Lorena Carmona-Rodr íguez Fernando J Corrales Source Type: research
Baicalein alleviates intrahepatic cholestasis by regulating bile acid metabolism via an FXR-dependent manner
Biochem Biophys Res Commun. 2024 Feb 17;705:149670. doi: 10.1016/j.bbrc.2024.149670. Online ahead of print.ABSTRACTCholestasis is characterized by impaired bile secretion and flow, leading to the accumulation of toxic bile acids in the liver, further causing inflammatory reaction, fibrosis, and ultimately liver transplantation. Although first-line clinical agents such as Ursodeoxycholic acid (UDCA) and Obeticholic acid (OCA) are available, serious side effects still exist. Therefore, pharmacologic treatment of cholestatic liver disease remains challenging. Here, we used a murine model of cholestasis treated with or without...
Source: Biochemical and Biophysical Research communications - March 5, 2024 Category: Biochemistry Authors: Weifan Huang Yihan Qian Jiacheng Lin Fang Wang Xiaoni Kong Weifeng Tan Source Type: research
Gestational diabetes mellitus aggravates adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy
To evaluate the effect of intrahepatic cholestasis of pregnancy (ICP) with gestational diabetes mellitus (GDM) on perinatal outcomes and establish a prediction model of adverse perinatal outcomes in women with... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - March 1, 2024 Category: Endocrinology Authors: Xia Li, Qin-Yu Cai, Xin Luo, Yong-Heng Wang, Li-Zhen Shao, Shu-Juan Luo, Lan Wang, Ying-Xiong Wang, Xia Lan and Tai-Hang Liu Tags: Research Source Type: research
Liver imaging and pregnancy: what to expect when your patient is expecting
Insights Imaging. 2024 Feb 27;15(1):66. doi: 10.1186/s13244-024-01622-x.ABSTRACTLiver diseases in pregnancy can be specific to gestation or only coincidental. In the latter case, the diagnosis can be difficult. Rapid diagnosis of maternal-fetal emergencies and situations requiring specialized interventions are crucial to preserve the maternal liver and guarantee materno-fetal survival. While detailed questioning of the patient and a clinical examination are highly important, imaging is often essential to reach a diagnosis of these liver diseases and lesions. Three groups of liver diseases may be observed during pregnancy: ...
Source: Herpes - February 27, 2024 Category: Infectious Diseases Authors: Giorgia Porrello Roberto Cannella Jacques Bernuau Antoine Agman Giuseppe Brancatelli Marco Dioguardi Burgio Val érie Vilgrain Source Type: research
Liver imaging and pregnancy: what to expect when your patient is expecting
AbstractLiver diseases in pregnancy can be specific to gestation or only coincidental. In the latter case, the diagnosis can be difficult. Rapid diagnosis of maternal-fetal emergencies and situations requiring specialized interventions are crucial to preserve the maternal liver and guarantee materno-fetal survival. While detailed questioning of the patient and a clinical examination are highly important, imaging is often essential to reach a diagnosis of these liver diseases and lesions. Three groups of liver diseases may be observed during pregnancy: (1) diseases related to pregnancy: intrahepatic cholestasis of pregnancy...
Source: Insights into Imaging - February 27, 2024 Category: Radiology Source Type: research
Gradual dosing of ursodeoxycholic acid in mothers with intrahepatic cholestasis of pregnancy may improve composite neonatal outcome
CONCLUSIONS: Compared to the administration of a full UDCA dose, the administration of a gradually increasing dose of UDCA may be associated with a greater gestational age at delivery and fewer events of unfavorable composite neonatal outcomes. These novel findings should be retested prospectively in a large cohort of patients.PMID:38403070 | DOI:10.1016/j.aohep.2024.101490 (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 25, 2024 Category: Gastroenterology Authors: Amir Hamud Matan J Cohen Drorith Hochner-Celnikier Benjamin Bar-Oz Zvi Ackerman Source Type: research
NR1H4 mutation and rapid progressive intrahepatic cholestasis in infancy: A case report and literature review
AbstractFarnesoid X receptor (FXR) is a nuclear bile acid receptor encoded by theNR1H4 gene, a vital regulator of bile acid homeostasis. Pathogenic mutations ofNR1H4 manifest as low gamma-glutamyl transferase (GGT) cholestasis with rapid progression to liver failure, which is referred to as progressive familial intrahepatic cholestasis 5 (PFIC-5). Herein, we present a case with rapid progressive cholestasis, liver failure in early infancy with theNR1H4 termination mutation. (Source: Clinical Case Reports)
Source: Clinical Case Reports - February 24, 2024 Category: General Medicine Authors: Chiao ‐Yu Yang,
Hung‐Wen Tsai,
Yen‐Yin Chou,
Yao‐Jong Yang Tags: CASE REPORT Source Type: research
