New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
World J Gastroenterol. 2023 Oct 7;29(37):5292-5304. doi: 10.3748/wjg.v29.i37.5292.ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults. Damage to cholangiocytes triggers the development of intrahepatic cholestasis, which progresses to cirrhosis in the terminal stage of the disease. Accumulating data indicate that damage to biliary epithelial cells [(BECs), cholangiocytes] is most likely associated with the intracellular accumulation of bile acids, which have potent detergent properties and damaging effects on cell m...
Source: World Journal of Gastroenterology - October 30, 2023 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev Source Type: research
New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
World J Gastroenterol. 2023 Oct 7;29(37):5292-5304. doi: 10.3748/wjg.v29.i37.5292.ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults. Damage to cholangiocytes triggers the development of intrahepatic cholestasis, which progresses to cirrhosis in the terminal stage of the disease. Accumulating data indicate that damage to biliary epithelial cells [(BECs), cholangiocytes] is most likely associated with the intracellular accumulation of bile acids, which have potent detergent properties and damaging effects on cell m...
Source: World Journal of Gastroenterology : WJG - October 30, 2023 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev Source Type: research
New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
World J Gastroenterol. 2023 Oct 7;29(37):5292-5304. doi: 10.3748/wjg.v29.i37.5292.ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults. Damage to cholangiocytes triggers the development of intrahepatic cholestasis, which progresses to cirrhosis in the terminal stage of the disease. Accumulating data indicate that damage to biliary epithelial cells [(BECs), cholangiocytes] is most likely associated with the intracellular accumulation of bile acids, which have potent detergent properties and damaging effects on cell m...
Source: World Journal of Gastroenterology - October 30, 2023 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev Source Type: research
New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
World J Gastroenterol. 2023 Oct 7;29(37):5292-5304. doi: 10.3748/wjg.v29.i37.5292.ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults. Damage to cholangiocytes triggers the development of intrahepatic cholestasis, which progresses to cirrhosis in the terminal stage of the disease. Accumulating data indicate that damage to biliary epithelial cells [(BECs), cholangiocytes] is most likely associated with the intracellular accumulation of bile acids, which have potent detergent properties and damaging effects on cell m...
Source: World Journal of Gastroenterology : WJG - October 30, 2023 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev Source Type: research
New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
World J Gastroenterol. 2023 Oct 7;29(37):5292-5304. doi: 10.3748/wjg.v29.i37.5292.ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults. Damage to cholangiocytes triggers the development of intrahepatic cholestasis, which progresses to cirrhosis in the terminal stage of the disease. Accumulating data indicate that damage to biliary epithelial cells [(BECs), cholangiocytes] is most likely associated with the intracellular accumulation of bile acids, which have potent detergent properties and damaging effects on cell m...
Source: World Journal of Gastroenterology - October 30, 2023 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev Source Type: research
New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
World J Gastroenterol. 2023 Oct 7;29(37):5292-5304. doi: 10.3748/wjg.v29.i37.5292.ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults. Damage to cholangiocytes triggers the development of intrahepatic cholestasis, which progresses to cirrhosis in the terminal stage of the disease. Accumulating data indicate that damage to biliary epithelial cells [(BECs), cholangiocytes] is most likely associated with the intracellular accumulation of bile acids, which have potent detergent properties and damaging effects on cell m...
Source: World Journal of Gastroenterology : WJG - October 30, 2023 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev Source Type: research
New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
World J Gastroenterol. 2023 Oct 7;29(37):5292-5304. doi: 10.3748/wjg.v29.i37.5292.ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults. Damage to cholangiocytes triggers the development of intrahepatic cholestasis, which progresses to cirrhosis in the terminal stage of the disease. Accumulating data indicate that damage to biliary epithelial cells [(BECs), cholangiocytes] is most likely associated with the intracellular accumulation of bile acids, which have potent detergent properties and damaging effects on cell m...
Source: World Journal of Gastroenterology - October 30, 2023 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev Source Type: research
New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
World J Gastroenterol. 2023 Oct 7;29(37):5292-5304. doi: 10.3748/wjg.v29.i37.5292.ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults. Damage to cholangiocytes triggers the development of intrahepatic cholestasis, which progresses to cirrhosis in the terminal stage of the disease. Accumulating data indicate that damage to biliary epithelial cells [(BECs), cholangiocytes] is most likely associated with the intracellular accumulation of bile acids, which have potent detergent properties and damaging effects on cell m...
Source: World Journal of Gastroenterology : WJG - October 30, 2023 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev Source Type: research
New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
World J Gastroenterol. 2023 Oct 7;29(37):5292-5304. doi: 10.3748/wjg.v29.i37.5292.ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults. Damage to cholangiocytes triggers the development of intrahepatic cholestasis, which progresses to cirrhosis in the terminal stage of the disease. Accumulating data indicate that damage to biliary epithelial cells [(BECs), cholangiocytes] is most likely associated with the intracellular accumulation of bile acids, which have potent detergent properties and damaging effects on cell m...
Source: World Journal of Gastroenterology - October 30, 2023 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev Source Type: research
New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
World J Gastroenterol. 2023 Oct 7;29(37):5292-5304. doi: 10.3748/wjg.v29.i37.5292.ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults. Damage to cholangiocytes triggers the development of intrahepatic cholestasis, which progresses to cirrhosis in the terminal stage of the disease. Accumulating data indicate that damage to biliary epithelial cells [(BECs), cholangiocytes] is most likely associated with the intracellular accumulation of bile acids, which have potent detergent properties and damaging effects on cell m...
Source: World Journal of Gastroenterology : WJG - October 30, 2023 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev Source Type: research
New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
World J Gastroenterol. 2023 Oct 7;29(37):5292-5304. doi: 10.3748/wjg.v29.i37.5292.ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults. Damage to cholangiocytes triggers the development of intrahepatic cholestasis, which progresses to cirrhosis in the terminal stage of the disease. Accumulating data indicate that damage to biliary epithelial cells [(BECs), cholangiocytes] is most likely associated with the intracellular accumulation of bile acids, which have potent detergent properties and damaging effects on cell m...
Source: World Journal of Gastroenterology - October 30, 2023 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev Source Type: research
New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
World J Gastroenterol. 2023 Oct 7;29(37):5292-5304. doi: 10.3748/wjg.v29.i37.5292.ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults. Damage to cholangiocytes triggers the development of intrahepatic cholestasis, which progresses to cirrhosis in the terminal stage of the disease. Accumulating data indicate that damage to biliary epithelial cells [(BECs), cholangiocytes] is most likely associated with the intracellular accumulation of bile acids, which have potent detergent properties and damaging effects on cell m...
Source: World Journal of Gastroenterology : WJG - October 30, 2023 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev Source Type: research
New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
World J Gastroenterol. 2023 Oct 7;29(37):5292-5304. doi: 10.3748/wjg.v29.i37.5292.ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults. Damage to cholangiocytes triggers the development of intrahepatic cholestasis, which progresses to cirrhosis in the terminal stage of the disease. Accumulating data indicate that damage to biliary epithelial cells [(BECs), cholangiocytes] is most likely associated with the intracellular accumulation of bile acids, which have potent detergent properties and damaging effects on cell m...
Source: World Journal of Gastroenterology - October 30, 2023 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev Source Type: research
New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
World J Gastroenterol. 2023 Oct 7;29(37):5292-5304. doi: 10.3748/wjg.v29.i37.5292.ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults. Damage to cholangiocytes triggers the development of intrahepatic cholestasis, which progresses to cirrhosis in the terminal stage of the disease. Accumulating data indicate that damage to biliary epithelial cells [(BECs), cholangiocytes] is most likely associated with the intracellular accumulation of bile acids, which have potent detergent properties and damaging effects on cell m...
Source: World Journal of Gastroenterology : WJG - October 30, 2023 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev Source Type: research
New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
World J Gastroenterol. 2023 Oct 7;29(37):5292-5304. doi: 10.3748/wjg.v29.i37.5292.ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults. Damage to cholangiocytes triggers the development of intrahepatic cholestasis, which progresses to cirrhosis in the terminal stage of the disease. Accumulating data indicate that damage to biliary epithelial cells [(BECs), cholangiocytes] is most likely associated with the intracellular accumulation of bile acids, which have potent detergent properties and damaging effects on cell m...
Source: World Journal of Gastroenterology - October 30, 2023 Category: Gastroenterology Authors: Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev Source Type: research
