Current understanding of essential trace elements in intrahepatic cholestasis of pregnancy
Biometals. 2024 Feb 17. doi: 10.1007/s10534-024-00586-1. Online ahead of print.ABSTRACTTrace elements are important components in the body and have fundamental roles in maintaining a healthy and balanced pregnancy process. Either deficiency or excess of trace elements, including selenium, iron, zinc, copper, and magnesium can lead to pregnancy complications. As a rare disorder during pregnancy of unknown aetiology, intrahepatic cholestasis of pregnancy (ICP) poses a significant risk to the fetus of perinatal mortality. ICP is a multifactorial complication of which the pathogenesis is still an enigma. Epidemiological studie...
Source: Biometals - February 17, 2024 Category: Biochemistry Authors: Dan Shan Qian Chen Yupei Xie Siyu Dai Yayi Hu Source Type: research
Current understanding of essential trace elements in intrahepatic cholestasis of pregnancy
Biometals. 2024 Feb 17. doi: 10.1007/s10534-024-00586-1. Online ahead of print.ABSTRACTTrace elements are important components in the body and have fundamental roles in maintaining a healthy and balanced pregnancy process. Either deficiency or excess of trace elements, including selenium, iron, zinc, copper, and magnesium can lead to pregnancy complications. As a rare disorder during pregnancy of unknown aetiology, intrahepatic cholestasis of pregnancy (ICP) poses a significant risk to the fetus of perinatal mortality. ICP is a multifactorial complication of which the pathogenesis is still an enigma. Epidemiological studie...
Source: Biometals - February 17, 2024 Category: Biochemistry Authors: Dan Shan Qian Chen Yupei Xie Siyu Dai Yayi Hu Source Type: research
Current understanding of essential trace elements in intrahepatic cholestasis of pregnancy
Biometals. 2024 Feb 17. doi: 10.1007/s10534-024-00586-1. Online ahead of print.ABSTRACTTrace elements are important components in the body and have fundamental roles in maintaining a healthy and balanced pregnancy process. Either deficiency or excess of trace elements, including selenium, iron, zinc, copper, and magnesium can lead to pregnancy complications. As a rare disorder during pregnancy of unknown aetiology, intrahepatic cholestasis of pregnancy (ICP) poses a significant risk to the fetus of perinatal mortality. ICP is a multifactorial complication of which the pathogenesis is still an enigma. Epidemiological studie...
Source: Biometals - February 17, 2024 Category: Biochemistry Authors: Dan Shan Qian Chen Yupei Xie Siyu Dai Yayi Hu Source Type: research
Current understanding of essential trace elements in intrahepatic cholestasis of pregnancy
Biometals. 2024 Feb 17. doi: 10.1007/s10534-024-00586-1. Online ahead of print.ABSTRACTTrace elements are important components in the body and have fundamental roles in maintaining a healthy and balanced pregnancy process. Either deficiency or excess of trace elements, including selenium, iron, zinc, copper, and magnesium can lead to pregnancy complications. As a rare disorder during pregnancy of unknown aetiology, intrahepatic cholestasis of pregnancy (ICP) poses a significant risk to the fetus of perinatal mortality. ICP is a multifactorial complication of which the pathogenesis is still an enigma. Epidemiological studie...
Source: Biometals - February 17, 2024 Category: Biochemistry Authors: Dan Shan Qian Chen Yupei Xie Siyu Dai Yayi Hu Source Type: research
Current understanding of essential trace elements in intrahepatic cholestasis of pregnancy
Biometals. 2024 Feb 17. doi: 10.1007/s10534-024-00586-1. Online ahead of print.ABSTRACTTrace elements are important components in the body and have fundamental roles in maintaining a healthy and balanced pregnancy process. Either deficiency or excess of trace elements, including selenium, iron, zinc, copper, and magnesium can lead to pregnancy complications. As a rare disorder during pregnancy of unknown aetiology, intrahepatic cholestasis of pregnancy (ICP) poses a significant risk to the fetus of perinatal mortality. ICP is a multifactorial complication of which the pathogenesis is still an enigma. Epidemiological studie...
Source: Biometals - February 17, 2024 Category: Biochemistry Authors: Dan Shan Qian Chen Yupei Xie Siyu Dai Yayi Hu Source Type: research
Current understanding of essential trace elements in intrahepatic cholestasis of pregnancy
Biometals. 2024 Feb 17. doi: 10.1007/s10534-024-00586-1. Online ahead of print.ABSTRACTTrace elements are important components in the body and have fundamental roles in maintaining a healthy and balanced pregnancy process. Either deficiency or excess of trace elements, including selenium, iron, zinc, copper, and magnesium can lead to pregnancy complications. As a rare disorder during pregnancy of unknown aetiology, intrahepatic cholestasis of pregnancy (ICP) poses a significant risk to the fetus of perinatal mortality. ICP is a multifactorial complication of which the pathogenesis is still an enigma. Epidemiological studie...
Source: Biometals - February 17, 2024 Category: Biochemistry Authors: Dan Shan Qian Chen Yupei Xie Siyu Dai Yayi Hu Source Type: research
Exosomes from Intrahepatic Cholestasis of Pregnancy Induce Cell Apoptosis Through the miRNA-6891-5p/YWHAE Pathway
ConclusionsThis study indicates that serum exosomes from ICP patients can impact the apoptosis of placental trophoblast HTR-8/SVeno cells through the miR-6891-5P/YWHAE pathway and can serve as specific molecular markers for ICP diagnosis.Graphical Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - February 15, 2024 Category: Gastroenterology Source Type: research
Clinical symptoms, biochemistry, and liver histology during the native liver period of progressive familial intrahepatic cholestasis type 2
This study aimed to understand the course of PFIC2 during the native liver period. (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - February 10, 2024 Category: Internal Medicine Authors: Hiroki Kondou, Satoshi Nakano, Tadahaya Mizuno, Kazuhiko Bessho, Yasuhiro Hasegawa, Atsuko Nakazawa, Ken Tanikawa, Yoshihiro Azuma, Tatsuya Okamoto, Ayano Inui, Kazuo Imagawa, Mureo Kasahara, Yoh Zen, Mitsuyoshi Suzuki and Hisamitsu Hayashi Tags: Research Source Type: research
Molecular basis of progressive familial intrahepatic cholestasis 3. A proteomics study
Proteomics analysis provides a detailed molecular landscape of PFIC3, pointing to several drivers of the progression of the disease that might prove useful for the management of patients. AbstractProgressive familial intrahepatic cholestasis type 3 (PFIC3) is a severe rare liver disease that affects between 1/50,000 and 1/100,000 children. In physiological conditions, bile is produced by the liver and stored in the gallbladder, and then it flows to the small intestine to play its role in fat digestion. To prevent tissue damage, bile acids (BAs) are kept in phospholipid micelles. Mutations in phosphatidyl choline transporte...
Source: BioFactors - January 30, 2024 Category: Biochemistry Authors: Laura Guerrero,
Lorena Carmona ‐Rodríguez,
Fátima Milhano Santos,
Sergio Ciordia,
Luiz Stark,
Loreto Hierro,
Pablo Pérez‐Montero,
David Vicent,
Fernando J. Corrales Tags: RESEARCH ARTICLE Source Type: research
Genetic cholestasis in children and adults
Bile is produced in hepatocytes and flows to the duodenum. Cholestasis can ensue when there is either a reduction in bile flow or obstruction at any level. Proteins, including nuclear receptors, hepatobiliary transporters and structural proteins, are vital for the transport of biliary constituents and maintenance of the stability of the canalicular membrane and tight junctions. Variants in genes encoding these proteins have been implicated in the pathogenesis of cholestasis, predominantly intrahepatic cholestasis with retention of bile acids within the liver. (Source: Journal of Hepatology)
Source: Journal of Hepatology - January 30, 2024 Category: Gastroenterology Authors: Jeremy S. Nayagam, Rosa Miquel, Richard J. Thompson, Deepak Joshi Tags: Hepatology Snapshot Source Type: research
Molecular basis of progressive familial intrahepatic cholestasis 3. A proteomics study
Proteomics analysis provides a detailed molecular landscape of PFIC3, pointing to several drivers of the progression of the disease that might prove useful for the management of patients. AbstractProgressive familial intrahepatic cholestasis type 3 (PFIC3) is a severe rare liver disease that affects between 1/50,000 and 1/100,000 children. In physiological conditions, bile is produced by the liver and stored in the gallbladder, and then it flows to the small intestine to play its role in fat digestion. To prevent tissue damage, bile acids (BAs) are kept in phospholipid micelles. Mutations in phosphatidyl choline transporte...
Source: BioFactors - January 29, 2024 Category: Biochemistry Authors: Laura Guerrero,
Lorena Carmona ‐Rodríguez,
Fátima Milhano Santos,
Sergio Ciordia,
Luiz Stark,
Loreto Hierro,
Pablo Pérez‐Montero,
David Vicent,
Fernando J. Corrales Tags: RESEARCH ARTICLE Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
