Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
