Assessing nystatin cream treatment efficacy against Leishmania (L.) amazonensis infection in BALB/c model
Exp Parasitol. 2023 May 15:108547. doi: 10.1016/j.exppara.2023.108547. Online ahead of print.ABSTRACTThe current scenario for cutaneous leishmaniasis treatment includes the use of first and second-choice drugs, both therapeutic strategies presenting several adverse effects and being related to an increment of treatment-refractory parasite strains. These facts encourage the search for new treatment approaches, including repositioning drugs, such as nystatin. Although some in vitro assays show that this polyene macrolide compound has leishmanicidal activity, no in vivo evidence for a similar activity has been shown so far fo...
Source: Experimental Parasitology - May 17, 2023 Category: Parasitology Authors: Luiz Filipe Gon çalves-Oliveira Juliana Figueiredo Peixoto Geovane Dias-Lopes Franklin Souza da Silva Luzia Monteiro de Castro C ôrtes Helv écio Vinícius Antunes Rocha Carlos Roberto Alves Source Type: research
Assessing nystatin cream treatment efficacy against Leishmania (L.) amazonensis infection in BALB/c model
Exp Parasitol. 2023 May 15:108547. doi: 10.1016/j.exppara.2023.108547. Online ahead of print.ABSTRACTThe current scenario for cutaneous leishmaniasis treatment includes the use of first and second-choice drugs, both therapeutic strategies presenting several adverse effects and being related to an increment of treatment-refractory parasite strains. These facts encourage the search for new treatment approaches, including repositioning drugs, such as nystatin. Although some in vitro assays show that this polyene macrolide compound has leishmanicidal activity, no in vivo evidence for a similar activity has been shown so far fo...
Source: Experimental Parasitology - May 17, 2023 Category: Parasitology Authors: Luiz Filipe Gon çalves-Oliveira Juliana Figueiredo Peixoto Geovane Dias-Lopes Franklin Souza da Silva Luzia Monteiro de Castro C ôrtes Helv écio Vinícius Antunes Rocha Carlos Roberto Alves Source Type: research
Assessing nystatin cream treatment efficacy against Leishmania (L.) amazonensis infection in BALB/c model
Exp Parasitol. 2023 May 15;250:108547. doi: 10.1016/j.exppara.2023.108547. Online ahead of print.ABSTRACTThe current scenario for cutaneous leishmaniasis treatment includes the use of first and second-choice drugs, both therapeutic strategies presenting several adverse effects and being related to an increment of treatment-refractory parasite strains. These facts encourage the search for new treatment approaches, including repositioning drugs, such as nystatin. Although in vitro assays show that this polyene macrolide compound has leishmanicidal activity, no in vivo evidence for a similar activity has been shown so far for...
Source: Experimental Parasitology - May 17, 2023 Category: Parasitology Authors: Luiz Filipe Gon çalves-Oliveira Juliana Figueiredo Peixoto Geovane Dias-Lopes Franklin Souza-Silva Luzia Monteiro de Castro C ôrtes Helv écio Vinícius Antunes Rocha Carlos Roberto Alves Source Type: research
Assessing nystatin cream treatment efficacy against Leishmania (L.) amazonensis infection in BALB/c model
Exp Parasitol. 2023 May 15;250:108547. doi: 10.1016/j.exppara.2023.108547. Online ahead of print.ABSTRACTThe current scenario for cutaneous leishmaniasis treatment includes the use of first and second-choice drugs, both therapeutic strategies presenting several adverse effects and being related to an increment of treatment-refractory parasite strains. These facts encourage the search for new treatment approaches, including repositioning drugs, such as nystatin. Although in vitro assays show that this polyene macrolide compound has leishmanicidal activity, no in vivo evidence for a similar activity has been shown so far for...
Source: Experimental Parasitology - May 17, 2023 Category: Parasitology Authors: Luiz Filipe Gon çalves-Oliveira Juliana Figueiredo Peixoto Geovane Dias-Lopes Franklin Souza-Silva Luzia Monteiro de Castro C ôrtes Helv écio Vinícius Antunes Rocha Carlos Roberto Alves Source Type: research
Assessing nystatin cream treatment efficacy against Leishmania (L.) amazonensis infection in BALB/c model
Exp Parasitol. 2023 May 15;250:108547. doi: 10.1016/j.exppara.2023.108547. Online ahead of print.ABSTRACTThe current scenario for cutaneous leishmaniasis treatment includes the use of first and second-choice drugs, both therapeutic strategies presenting several adverse effects and being related to an increment of treatment-refractory parasite strains. These facts encourage the search for new treatment approaches, including repositioning drugs, such as nystatin. Although in vitro assays show that this polyene macrolide compound has leishmanicidal activity, no in vivo evidence for a similar activity has been shown so far for...
Source: Experimental Parasitology - May 17, 2023 Category: Parasitology Authors: Luiz Filipe Gon çalves-Oliveira Juliana Figueiredo Peixoto Geovane Dias-Lopes Franklin Souza-Silva Luzia Monteiro de Castro C ôrtes Helv écio Vinícius Antunes Rocha Carlos Roberto Alves Source Type: research
Assessing nystatin cream treatment efficacy against Leishmania (L.) amazonensis infection in BALB/c model
Exp Parasitol. 2023 May 15;250:108547. doi: 10.1016/j.exppara.2023.108547. Online ahead of print.ABSTRACTThe current scenario for cutaneous leishmaniasis treatment includes the use of first and second-choice drugs, both therapeutic strategies presenting several adverse effects and being related to an increment of treatment-refractory parasite strains. These facts encourage the search for new treatment approaches, including repositioning drugs, such as nystatin. Although in vitro assays show that this polyene macrolide compound has leishmanicidal activity, no in vivo evidence for a similar activity has been shown so far for...
Source: Experimental Parasitology - May 17, 2023 Category: Parasitology Authors: Luiz Filipe Gon çalves-Oliveira Juliana Figueiredo Peixoto Geovane Dias-Lopes Franklin Souza-Silva Luzia Monteiro de Castro C ôrtes Helv écio Vinícius Antunes Rocha Carlos Roberto Alves Source Type: research
Investigation of the antifungal effects of curcumin against nystatin ‑resistant Candida albicans
Conclusion: According to this research, it was shown that curcumin with MIC value of7.8 –32.25 μg/mL has inhibitory effects on nystatin‑resistant C. albicans strains.Key Words: Candida albicans, curcumin, nystatin, nystatin ‑resistant Candida albicans (Source: Dental Research Journal)
Source: Dental Research Journal - April 30, 2023 Category: Dentistry Source Type: research
Miconazole for the treatment of vulvovaginal candidiasis. < em > In vitro < /em > , < em > in vivo < /em > and clinical results. Review of the literature
J Obstet Gynaecol. 2023 Dec;43(1):2195001. doi: 10.1080/01443615.2023.2195001.ABSTRACTAt concentrations achieved following systemic administration, the primary effect of imidazoles and triazoles on fungi is inhibition of 14-α-sterol demethylase, a microsomal cytochrome P450 (CYP) enzyme. Imidazoles and triazoles impair the biosynthesis of ergosterol for the cytoplasmic membrane and lead to the accumulation of 14-α-methyl sterols. The synthetic imidazole miconazole is additionally able to increase intracellular reactive oxygen species, at least in part through inhibition of fungal catalase and peroxidase. This unique feat...
Source: Journal of Obstetrics and Gynaecology - April 8, 2023 Category: OBGYN Authors: Pedro Antonio Regidor Manopchai Thamkhantho Chenchit Chayachinda Santiago Palacios Source Type: research
Comparison of tea tree oil 5%, tea tree oil 10%, and nystatin inhibition zones against vaginal Candida isolates in pregnancy
Conclusions:Tea Tree Oil displayed antifungal activity againstCandida species causing VVC in pregnancy. Further studies are required to investigate optimal TTO concentrations as a VVC treatment in pregnancy. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - March 30, 2023 Category: Infectious Diseases Authors: Evy Ervianti, Damayanti, Indah Purnamasari, Linda Astari, Budi Prasetyo, Pepy D Endraswari, Budi Utomo, Endang Wahyu Fitriani, Diah Mira Indramaya, M Yulianto Listiawan, Cita Rosita Sigit Prakoeswa Source Type: research
Effects of Nystatin oral rinse on oral Candida species and Streptococcus mutans among healthy adults
ConclusionsThe study results indicate that oral antifungal treatment had an effect onS. mutans salivary carriage. Future clinical trials are warranted to comprehensively assess the impact of antifungal treatment on the oral flora other thanS. mutans andCandida.Clinical relevanceDue to the potential cariogenic role of oralCandida species, antifungal approaches shed new light on the prevention and management of dental caries from a fungal perspective. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - March 24, 2023 Category: Dentistry Source Type: research
Curcumin nanoparticles: the topical antimycotic suspension treating oral candidiasis
In conclusion, nanocurcumin has a good antifungal effect as nystatin, however, its therapeutic efficacy takes a longer time to appear than nystatin. The enhanced bioavailability of curcumin at the nanoscale qualifies this nano-herb as a promising alternative therapy for o ral candidiasis, evading nystatin-associated morbidity. (Source: Odontology)
Source: Odontology - March 17, 2023 Category: Dentistry Source Type: research
