Study on the transport and internalization mechanism of dietary supplement nattokinase in the small intestine using animal and Caco-2 cell monolayer models
This study first evaluated the preventive effect of supplementing low dose (4000 FU (Fibrin Unit)/kg, n = 6), medium dose (8000 FU/kg, n = 6), and high dose (12000 FU/kg, n = 6) of nattokinase on carrageenan induced thrombosis in mice. Subsequently, we used the rat gut sac model, ligated intestinal loop model, and Caco-2 cell uptake model to study the intestinal transport mechanism of NK.4. Results indicate that NK is a moderately absorbed biomolecule whose transport through enterocytes is energy- and time-dependent. Chlorpromazine, nystatin and EIPA all inhibited the endocytosis of NK to varying degrees, indicating that t...
Source: Xenobiotica - November 16, 2023 Category: Research Authors: Huawei Feng Chang Liu Qingqing Liu Jie Wang Yingyue Zeng Yue Sun Man Zhang Hui Zhang Zhikui Liu Jian Zhao Hongsheng Liu Source Type: research
Study on the transport and internalization mechanism of dietary supplement nattokinase in the small intestine using animal and Caco-2 cell monolayer models
This study first evaluated the preventive effect of supplementing low dose (4000 FU (Fibrin Unit)/kg, n = 6), medium dose (8000 FU/kg, n = 6), and high dose (12000 FU/kg, n = 6) of nattokinase on carrageenan induced thrombosis in mice. Subsequently, we used the rat gut sac model, ligated intestinal loop model, and Caco-2 cell uptake model to study the intestinal transport mechanism of NK.4. Results indicate that NK is a moderately absorbed biomolecule whose transport through enterocytes is energy- and time-dependent. Chlorpromazine, nystatin and EIPA all inhibited the endocytosis of NK to varying degrees, indicating that t...
Source: Xenobiotica - November 16, 2023 Category: Research Authors: Huawei Feng Chang Liu Qingqing Liu Jie Wang Yingyue Zeng Yue Sun Man Zhang Hui Zhang Zhikui Liu Jian Zhao Hongsheng Liu Source Type: research
Candida palmioleophila candidemia and bacterial co-infection in a 3-month-old infant with biliary atresia
Candidemia caused by rare and uncommon Candida species is becoming more prevalent in pediatric healthcare settings, resulting in significant morbidity and mortality. One such species, Candida palmioleophila, is resistant to fluconazole but highly susceptible to echinocandins. Here, we report the first documented case of C. palmioleophila candidemia in Iran that occurred in a male infant with biliary atresia who had been hospitalized for 2 months. The patient’s blood and urine cultures were positive for both yeast and bacterial species. Through DNA sequence analysis, the yeast isolate was identified as C. palmioleophila. ...
Source: Frontiers in cellular and infection microbiology - November 2, 2023 Category: Microbiology Source Type: research
Species identification, antifungal susceptibility patterns, and vitamin D3 level in women with vaginal candidiasis: a case-control study in Iran
In conclusion, our study revealed a potential link between vitamin D3 deficiency and VVC in women. Although our findings showed significantly lower vitamin D3 levels in women with VVC, further research is needed to establish a definitive causative relationship between vitamin D3 deficiency and VVC. Nonetheless, our study highlights the potential importance of maintaining adequate levels of vitamin D3 and the need for further exploration in this area.PMID:37771196 | DOI:10.1080/03630242.2023.2262623 (Source: Women and Health)
Source: Women and Health - September 29, 2023 Category: Primary Care Authors: Rahil Maani-Shirazi Somayeh Yazdanpanah Maryam Yazdani Kamiar Zomorodian Amin Ayatollah-Mosavi Source Type: research
Species identification, antifungal susceptibility patterns, and vitamin D3 level in women with vaginal candidiasis: a case-control study in Iran
In conclusion, our study revealed a potential link between vitamin D3 deficiency and VVC in women. Although our findings showed significantly lower vitamin D3 levels in women with VVC, further research is needed to establish a definitive causative relationship between vitamin D3 deficiency and VVC. Nonetheless, our study highlights the potential importance of maintaining adequate levels of vitamin D3 and the need for further exploration in this area.PMID:37771196 | DOI:10.1080/03630242.2023.2262623 (Source: Women and Health)
Source: Women and Health - September 29, 2023 Category: Primary Care Authors: Rahil Maani-Shirazi Somayeh Yazdanpanah Maryam Yazdani Kamiar Zomorodian Amin Ayatollah-Mosavi Source Type: research
Species identification, antifungal susceptibility patterns, and vitamin D3 level in women with vaginal candidiasis: a case-control study in Iran
In conclusion, our study revealed a potential link between vitamin D3 deficiency and VVC in women. Although our findings showed significantly lower vitamin D3 levels in women with VVC, further research is needed to establish a definitive causative relationship between vitamin D3 deficiency and VVC. Nonetheless, our study highlights the potential importance of maintaining adequate levels of vitamin D3 and the need for further exploration in this area.PMID:37771196 | DOI:10.1080/03630242.2023.2262623 (Source: Women and Health)
Source: Women and Health - September 29, 2023 Category: Primary Care Authors: Rahil Maani-Shirazi Somayeh Yazdanpanah Maryam Yazdani Kamiar Zomorodian Amin Ayatollah-Mosavi Source Type: research
Antimicrobial photodynamic therapy in the treatment of oral erythematous candidiasis: a controlled and randomized clinical trial
ConclusionsaPDT proved to be a clinically and microbiologically effective therapy for treating EC.Trial registrationRegistered at ClinicalTrials.gov; Set 12th, 2019; No. RBR-8w8599.Clinical relevanceaPDT is a promising alternative treatment since it presents satisfactory results and does not cause damage to oral tissues or develop resistance to the treatment. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - September 18, 2023 Category: Dentistry Source Type: research
Using chitosan, hyaluronic acid, alginate, and gelatin-based smart biological hydrogels for drug delivery in oral mucosal lesions: A review
CONCLUSION: Smart biological hydrogels show great promise as topical drug delivery systems for oral mucosal lesions, offering sustained drug release, increased therapeutic efficacy, and minimized systemic complications. Technological advancement is expected to lead to the development of more effective and safer drug delivery systems. The potential benefits of biological polymer-based hydrogels make them an exciting area of research for oral mucosal lesion treatment.PMID:37648126 | DOI:10.1016/j.ijbiomac.2023.126573 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - August 30, 2023 Category: Biochemistry Authors: Nazafarin Samiraninezhad Khatereh Asadi Hojat Rezazadeh Ahmad Gholami Source Type: research
Evaluation and comparison of antifungal effect of voriconazole with nystatin on candida species derived from neoplastic patients undergoing maxillofacial radiotherapy
Conclusion: The results of the present study showed that before radiotherapy, all species were sensitive to nystatin, while a percentage of albicans and nonalbicans were resistant to voriconazole. In the 2nd week of radiotherapy similar to prior to radiotherapy, all species isolated from patients were sensitive to nystatin, while a percentage of albicans and nonalbicans were resistant to voriconazole. Key Words: Neoplastic patients, nystatin, oral candidiasis, radiotherapy, voriconazole (Source: Dental Research Journal)
Source: Dental Research Journal - July 23, 2023 Category: Dentistry Source Type: research
< em > In vitro < /em > antifungal potency of the moronecidin-like peptide against < em > Candida albicans, Candida glabrata, < /em > and < em > Candida tropicalis < /em >
CONCLUSION: According to the results of the present study, the moronecidin-like peptide could be a new strategy in the treatment of infections caused by Candida strains. The discovery of the exact mechanism of which requires extensive clinical studies in this field.PMID:37448671 | PMC:PMC10336287 | DOI:10.18502/ijm.v15i3.12907 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - July 14, 2023 Category: Microbiology Authors: Nasrin Amirrajab Seyed Amin Ayatollahi Mousavi Behrooz Taheri Samira Salari Noor Ali Ahmadi Sarsahra Source Type: research
