Atomic Scale Structure of Self-assembled Lipidated Peptide Nanomaterials
This article is protected by copyright. All rights reserved.PMID:38489817 | DOI:10.1002/adma.202311103 (Source: Adv Data)
Source: Adv Data - March 15, 2024 Category: Epidemiology Authors: Billy J Williams-Noonan Ketav Kulkarni Nevena Todorova Matteo Franceschi Christopher Wilde Mark P Del Borgo Louise C Serpell Marie-Isabel Aguilar Irene Yarovsky Source Type: research
Microwave Ablation of the Pig Growth Plate: Proof of Concept for Minimally Invasive Epiphysiodesis
CONCLUSION: A microwave antenna placed into a pig's proximal tibia growth plate can slow the growth of the tibia without apparent pain and alteration of gait and function.CLINICAL RELEVANCE: Further investigation and refinement of our animal model is ongoing and includes shorter ablation times and comparison of dynamic ablation (moving the antennae during the ablation) as well as static ablation of the tibia from a medial and lateral portal. These refinements and planned comparison with standard mechanical growth arrest in our pig model may lead to a similar approach to ablate growth plates in children with LLD.PMID:384710...
Source: Clinical Orthopaedics and Related Research - March 12, 2024 Category: Orthopaedics Authors: Samuel O Noonan Kyle J Miller Stephanie Goldstein Ellen Leiferman James White Chris Brace Kenneth J Noonan Source Type: research
Microwave Ablation of the Pig Growth Plate: Proof of Concept for Minimally Invasive Epiphysiodesis
CONCLUSION: A microwave antenna placed into a pig's proximal tibia growth plate can slow the growth of the tibia without apparent pain and alteration of gait and function.CLINICAL RELEVANCE: Further investigation and refinement of our animal model is ongoing and includes shorter ablation times and comparison of dynamic ablation (moving the antennae during the ablation) as well as static ablation of the tibia from a medial and lateral portal. These refinements and planned comparison with standard mechanical growth arrest in our pig model may lead to a similar approach to ablate growth plates in children with LLD.PMID:384710...
Source: Clinical Orthopaedics and Related Research - March 12, 2024 Category: Orthopaedics Authors: Samuel O Noonan Kyle J Miller Stephanie Goldstein Ellen Leiferman James White Chris Brace Kenneth J Noonan Source Type: research
Microwave Ablation of the Pig Growth Plate: Proof of Concept for Minimally Invasive Epiphysiodesis
CONCLUSION: A microwave antenna placed into a pig's proximal tibia growth plate can slow the growth of the tibia without apparent pain and alteration of gait and function.CLINICAL RELEVANCE: Further investigation and refinement of our animal model is ongoing and includes shorter ablation times and comparison of dynamic ablation (moving the antennae during the ablation) as well as static ablation of the tibia from a medial and lateral portal. These refinements and planned comparison with standard mechanical growth arrest in our pig model may lead to a similar approach to ablate growth plates in children with LLD.PMID:384710...
Source: Clinical Orthopaedics and Related Research - March 12, 2024 Category: Orthopaedics Authors: Samuel O Noonan Kyle J Miller Stephanie Goldstein Ellen Leiferman James White Chris Brace Kenneth J Noonan Source Type: research
Genes, Vol. 15, Pages 345: Spectrum of Mutations in PTPN11 in Russian Cohort
Ryzhkova
Noonan syndrome is a group of diseases with a similar clinical picture, consisting of 16 diseases caused by mutations in 15 genes. According to the literature, approximately half of all cases are attributed to Noonan syndrome type 1, NSML, caused by mutations in the PTPN11 gene. We analyzed 456 unrelated probands using a gene panel NGS, and in 206 cases, the cause of the disease was identified. Approximately half of the cases (107) were caused by variants in the PTPN11 gene, including three previously undescribed variants, one of which was classified as VOUS, and the other two as LP causative complex alleles....
Source: Genes - March 7, 2024 Category: Genetics & Stem Cells Authors: Anna Orlova Daria Guseva Nina Demina Aleksander Polyakov Oksana Ryzhkova Tags: Article Source Type: research
Tactile localization promotes infant self-recognition in the mirror-mark test
Curr Biol. 2024 Feb 27:S0960-9822(24)00170-2. doi: 10.1016/j.cub.2024.02.028. Online ahead of print.ABSTRACTMirror self-recognition has been hailed by many as a milestone in the acquisition of self-awareness with respect to phylogenesis and human ontogenesis.1,2,3,4,5,6 Yet there has been considerable controversy over the extent to which species other than humans and their closest primate relatives are capable of mirror self-recognition, and to the mechanisms that give rise to this ability.1,7 One influential view is that mirror self-recognition in humans and their closest primate relatives is a cognitive advance that is a...
Source: Current Biology - March 5, 2024 Category: Biology Authors: Lisa K Chinn Claire F Noonan Katarina S Patton Jeffrey J Lockman Source Type: research
Anti-M üllerian hormone, testicular descent and cryptorchidism
Anti-Müllerian hormone (AMH) is a Sertoli cell-secreted glycoprotein involved in male fetal sex differentiation: it provokes the regression of Müllerian ducts, which otherwise give rise to the Fallopian tubes, the uterus and the upper part of the vagina. In the first trimester of fetal life, AMH is expressed independently of gonadotropins, whereas from the second trimester onwards AMH testicular production is stimulated by FSH and oestrogens; at puberty, AMH expression is inhibited by androgens. AMH has also been suggested to participate in testicular descent during fetal life, but its role remains unclear. Serum AMH is ...
Source: Frontiers in Endocrinology - March 4, 2024 Category: Endocrinology Source Type: research
Classifying clinical phenotypes of functional recovery for acute traumatic spinal cord injury. An observational cohort study
CONCLUSION: Acknowledging the presence of four characteristic subgroups of patients with distinct phenotypes of functional recovery based on PPSS, LEMS, and UEMS could be used by clinicians early after tSCI to plan rehabilitation and establish realistic goals. An improved sensory function could be key for potentiating motor gains, as a PPSS ≥ 27 was a predictor of a good function.PMID:38390856 | DOI:10.1080/09638288.2024.2320267 (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - February 23, 2024 Category: Rehabilitation Authors: Pascal Mputu Mputu Marie Beaus éjour Andr éane Richard-Denis Nader Fallah Vanessa K Noonan Jean-Marc Mac-Thiong Source Type: research
Classifying clinical phenotypes of functional recovery for acute traumatic spinal cord injury. An observational cohort study
CONCLUSION: Acknowledging the presence of four characteristic subgroups of patients with distinct phenotypes of functional recovery based on PPSS, LEMS, and UEMS could be used by clinicians early after tSCI to plan rehabilitation and establish realistic goals. An improved sensory function could be key for potentiating motor gains, as a PPSS ≥ 27 was a predictor of a good function.PMID:38390856 | DOI:10.1080/09638288.2024.2320267 (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - February 23, 2024 Category: Rehabilitation Authors: Pascal Mputu Mputu Marie Beaus éjour Andr éane Richard-Denis Nader Fallah Vanessa K Noonan Jean-Marc Mac-Thiong Source Type: research
Addressing controversial areas in the management of advanced prostate cancer in Canada: Areas of consensus and controversy from the third Canadian consensus forum
CONCLUSIONS: CCF3 identified consensus agreement and provides guidance on >30 practice scenarios related to management of PCa and nine areas of controversy, which represent opportunities for research and education to improve patient care. Consensus initiatives provide valuable guidance on areas of controversy as clinicians await high-level evidence.PMID:38381937 | DOI:10.5489/cuaj.8537 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - February 21, 2024 Category: Urology & Nephrology Authors: Fred Saad Sebastien J Hotte Krista Noonan Shawn Malone Christopher Morash Tamim Niazi Ricardo A Rendon Bobby Shayegan Naveen S Basappa Ilias Cagiannos Brita Danielson Guila Delouya Ricardo Fernandes Cristiano Ferrario Antonio Finelli Geoffrey T Gotto Robe Source Type: research
Addressing controversial areas in the management of advanced prostate cancer in Canada: Areas of consensus and controversy from the third Canadian consensus forum
CONCLUSIONS: CCF3 identified consensus agreement and provides guidance on >30 practice scenarios related to management of PCa and nine areas of controversy, which represent opportunities for research and education to improve patient care. Consensus initiatives provide valuable guidance on areas of controversy as clinicians await high-level evidence.PMID:38381937 | DOI:10.5489/cuaj.8537 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - February 21, 2024 Category: Urology & Nephrology Authors: Fred Saad Sebastien J Hotte Krista Noonan Shawn Malone Christopher Morash Tamim Niazi Ricardo A Rendon Bobby Shayegan Naveen S Basappa Ilias Cagiannos Brita Danielson Guila Delouya Ricardo Fernandes Cristiano Ferrario Antonio Finelli Geoffrey T Gotto Robe Source Type: research
Addressing controversial areas in the management of advanced prostate cancer in Canada: Areas of consensus and controversy from the third Canadian consensus forum
CONCLUSIONS: CCF3 identified consensus agreement and provides guidance on >30 practice scenarios related to management of PCa and nine areas of controversy, which represent opportunities for research and education to improve patient care. Consensus initiatives provide valuable guidance on areas of controversy as clinicians await high-level evidence.PMID:38381937 | DOI:10.5489/cuaj.8537 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - February 21, 2024 Category: Urology & Nephrology Authors: Fred Saad Sebastien J Hotte Krista Noonan Shawn Malone Christopher Morash Tamim Niazi Ricardo A Rendon Bobby Shayegan Naveen S Basappa Ilias Cagiannos Brita Danielson Guila Delouya Ricardo Fernandes Cristiano Ferrario Antonio Finelli Geoffrey T Gotto Robe Source Type: research
Addressing controversial areas in the management of advanced prostate cancer in Canada: Areas of consensus and controversy from the third Canadian consensus forum
CONCLUSIONS: CCF3 identified consensus agreement and provides guidance on >30 practice scenarios related to management of PCa and nine areas of controversy, which represent opportunities for research and education to improve patient care. Consensus initiatives provide valuable guidance on areas of controversy as clinicians await high-level evidence.PMID:38381937 | DOI:10.5489/cuaj.8537 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - February 21, 2024 Category: Urology & Nephrology Authors: Fred Saad Sebastien J Hotte Krista Noonan Shawn Malone Christopher Morash Tamim Niazi Ricardo A Rendon Bobby Shayegan Naveen S Basappa Ilias Cagiannos Brita Danielson Guila Delouya Ricardo Fernandes Cristiano Ferrario Antonio Finelli Geoffrey T Gotto Robe Source Type: research
Addressing controversial areas in the management of advanced prostate cancer in Canada: Areas of consensus and controversy from the third Canadian consensus forum
CONCLUSIONS: CCF3 identified consensus agreement and provides guidance on >30 practice scenarios related to management of PCa and nine areas of controversy, which represent opportunities for research and education to improve patient care. Consensus initiatives provide valuable guidance on areas of controversy as clinicians await high-level evidence.PMID:38381937 | DOI:10.5489/cuaj.8537 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - February 21, 2024 Category: Urology & Nephrology Authors: Fred Saad Sebastien J Hotte Krista Noonan Shawn Malone Christopher Morash Tamim Niazi Ricardo A Rendon Bobby Shayegan Naveen S Basappa Ilias Cagiannos Brita Danielson Guila Delouya Ricardo Fernandes Cristiano Ferrario Antonio Finelli Geoffrey T Gotto Robe Source Type: research
Addressing controversial areas in the management of advanced prostate cancer in Canada: Areas of consensus and controversy from the third Canadian consensus forum
CONCLUSIONS: CCF3 identified consensus agreement and provides guidance on >30 practice scenarios related to management of PCa and nine areas of controversy, which represent opportunities for research and education to improve patient care. Consensus initiatives provide valuable guidance on areas of controversy as clinicians await high-level evidence.PMID:38381937 | DOI:10.5489/cuaj.8537 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - February 21, 2024 Category: Urology & Nephrology Authors: Fred Saad Sebastien J Hotte Krista Noonan Shawn Malone Christopher Morash Tamim Niazi Ricardo A Rendon Bobby Shayegan Naveen S Basappa Ilias Cagiannos Brita Danielson Guila Delouya Ricardo Fernandes Cristiano Ferrario Antonio Finelli Geoffrey T Gotto Robe Source Type: research
