β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multi-resolution characterization of cancer cell subgroups to identify pathways and cell states that are heteroge...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multi-resolution characterization of cancer cell subgroups to identify pathways and cell states that are heteroge...
Source: Cell Research - June 23, 2023 Category: Cytology Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multi-resolution characterization of cancer cell subgroups to identify pathways and cell states that are heteroge...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multi-resolution characterization of cancer cell subgroups to identify pathways and cell states that are heteroge...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multi-resolution characterization of cancer cell subgroups to identify pathways and cell states that are heteroge...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multi-resolution characterization of cancer cell subgroups to identify pathways and cell states that are heteroge...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multi-resolution characterization of cancer cell subgroups to identify pathways and cell states that are heteroge...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multiresolution characterization of cancer cell subgroups to identify pathways and cell states that are heterogen...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multiresolution characterization of cancer cell subgroups to identify pathways and cell states that are heterogen...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multiresolution characterization of cancer cell subgroups to identify pathways and cell states that are heterogen...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Head and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multi-resolution characterization of cancer cell subgroups to identify pathways and cell states that are heterogeneously represented, followed by casual inference analysis to elucidate activating and inhibitory relationship...
Source: Translational Research - June 21, 2023 Category: Research Authors: Eric R. Reed, Stacy A. Jankowski, Anthony J. Spinella, Vikki Noonan, Robert Haddad, Kenichi Nomoto, Junji Matsui, Manish V. Bais, Xaralabos Varelas, Maria A. Kukuruzinska, Stefano Monti Source Type: research
Worry and Mindfulness Differentially Impact Symptom Burden Following Treatment Among Breast Cancer Survivors: Findings From a Randomized Crossover Trial
CONCLUSION: Results from this study highlight the benefits of adaptive emotion regulation in helping mitigate symptoms associated with breast cancer survivorship.PMID:37335884 | DOI:10.1093/abm/kaad032 (Source: Annals of Behavioral Medicine)
Source: Annals of Behavioral Medicine - June 19, 2023 Category: Psychiatry & Psychology Authors: Megan E Renna Annelise A Madison Juan Peng Marcella Rosie Shrout Maryam Lustberg Bhuvaneswari Ramaswamy Robert Wesolowski Jeffrey B VanDeusen Nicole O Williams Sagar D Sardesai Anne M Noonan Raquel E Reinbolt Daniel G Stover Mathew Cherian William B Malar Source Type: research
Worry and Mindfulness Differentially Impact Symptom Burden Following Treatment Among Breast Cancer Survivors: Findings From a Randomized Crossover Trial
CONCLUSION: Results from this study highlight the benefits of adaptive emotion regulation in helping mitigate symptoms associated with breast cancer survivorship.PMID:37335884 | DOI:10.1093/abm/kaad032 (Source: Annals of Behavioral Medicine)
Source: Annals of Behavioral Medicine - June 19, 2023 Category: Psychiatry & Psychology Authors: Megan E Renna Annelise A Madison Juan Peng Marcella Rosie Shrout Maryam Lustberg Bhuvaneswari Ramaswamy Robert Wesolowski Jeffrey B VanDeusen Nicole O Williams Sagar D Sardesai Anne M Noonan Raquel E Reinbolt Daniel G Stover Mathew Cherian William B Malar Source Type: research
Worry and Mindfulness Differentially Impact Symptom Burden Following Treatment Among Breast Cancer Survivors: Findings From a Randomized Crossover Trial
CONCLUSION: Results from this study highlight the benefits of adaptive emotion regulation in helping mitigate symptoms associated with breast cancer survivorship.PMID:37335884 | DOI:10.1093/abm/kaad032 (Source: Annals of Behavioral Medicine)
Source: Annals of Behavioral Medicine - June 19, 2023 Category: Psychiatry & Psychology Authors: Megan E Renna Annelise A Madison Juan Peng Marcella Rosie Shrout Maryam Lustberg Bhuvaneswari Ramaswamy Robert Wesolowski Jeffrey B VanDeusen Nicole O Williams Sagar D Sardesai Anne M Noonan Raquel E Reinbolt Daniel G Stover Mathew Cherian William B Malar Source Type: research
Worry and Mindfulness Differentially Impact Symptom Burden Following Treatment Among Breast Cancer Survivors: Findings From a Randomized Crossover Trial
CONCLUSION: Results from this study highlight the benefits of adaptive emotion regulation in helping mitigate symptoms associated with breast cancer survivorship.PMID:37335884 | DOI:10.1093/abm/kaad032 (Source: Annals of Behavioral Medicine)
Source: Annals of Behavioral Medicine - June 19, 2023 Category: Psychiatry & Psychology Authors: Megan E Renna Annelise A Madison Juan Peng Marcella Rosie Shrout Maryam Lustberg Bhuvaneswari Ramaswamy Robert Wesolowski Jeffrey B VanDeusen Nicole O Williams Sagar D Sardesai Anne M Noonan Raquel E Reinbolt Daniel G Stover Mathew Cherian William B Malar Source Type: research
