Noonan Syndrome Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Multifunctional cytokine production marks influenza A virus specific CD4 T cells with high expression of survival molecules
This article is protected by copyright. All rights reserved.PMID:37490492 | DOI:10.1002/eji.202350559 (Source: European Journal of Immunology)
Source: European Journal of Immunology - July 25, 2023 Category: Allergy & Immunology Authors: Lotus M Westerhof Jonathan Noonan Kerrie E Hargrave Elizabeth T Chimbayo Zhiling Cheng Thomas Purnell Mark R Jackson Nicholas Borcherding Megan Kl MacLeod Source Type: research

Preparing nurse scientists for health services and policy research: Five-year outcomes of interprofessional postdoctoral training in the National Clinician Scholars Program
The National Clinician Scholars Program (NCSP) is an interprofessional postdoctoral fellowship for physicians and nurses with a PhD. or DNP focused on health services research, policy, and leadership. (Source: Nursing Outlook)
Source: Nursing Outlook - July 22, 2023 Category: Nursing Authors: Kristen R. Choi, Barbara L. Brush, Susan A. Chapman, Deena Kelly Costa, Shelli L. Feder, Jos é I. Gutierrez, MarySue V. Heilemann, Milisa Manojlovich, Devon Noonan, Linda G. Park, Kathleen Potempa, Julie Sochalski Source Type: research

Feasibility evaluation of novel AI-based deep-learning contouring algorithm for radiotherapy
CONCLUSIONS: The highest agreement registered between OARs generated by Organs-RT and their respective references was for the bladder, heart, lungs, and femoral heads, with an overall DSC≥0.92. The poorest agreement was for the rectum, esophagus, and lips, with an overall DSC⩽0.81. Nonetheless, Organs-RT serves as a reliable auto-contouring tool by minimizing overall contouring time and increasing time-saving efficiency in radiotherapy treatment planning.PMID:37464581 | DOI:10.1002/acm2.14090 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - July 19, 2023 Category: Cancer & Oncology Authors: Luis A Maduro Bustos Abhirup Sarkar Laura A Doyle Kelly Andreou Jodie Noonan Diana Nurbagandova SunJay A Shah Omoruyi Credit Irabor Firas Mourtada Source Type: research

Feasibility evaluation of novel AI-based deep-learning contouring algorithm for radiotherapy
CONCLUSIONS: The highest agreement registered between OARs generated by Organs-RT and their respective references was for the bladder, heart, lungs, and femoral heads, with an overall DSC≥0.92. The poorest agreement was for the rectum, esophagus, and lips, with an overall DSC⩽0.81. Nonetheless, Organs-RT serves as a reliable auto-contouring tool by minimizing overall contouring time and increasing time-saving efficiency in radiotherapy treatment planning.PMID:37464581 | DOI:10.1002/acm2.14090 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - July 19, 2023 Category: Physics Authors: Luis A Maduro Bustos Abhirup Sarkar Laura A Doyle Kelly Andreou Jodie Noonan Diana Nurbagandova SunJay A Shah Omoruyi Credit Irabor Firas Mourtada Source Type: research

RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy
Sci Adv. 2023 Jul 14;9(28):eadf4766. doi: 10.1126/sciadv.adf4766. Epub 2023 Jul 14.ABSTRACTRIT1 is a RAS guanosine triphosphatase (GTPase) that regulates different aspects of signal transduction and is mutated in lung cancer, leukemia, and in the germline of individuals with Noonan syndrome. Pathogenic RIT1 proteins promote mitogen-activated protein kinase (MAPK) hyperactivation; however, this mechanism remains poorly understood. Here, we show that RAF kinases are direct effectors of membrane-bound mutant RIT1 necessary for MAPK activation. We identify critical residues in RIT1 that facilitate interaction with membrane lip...
Source: Adv Data - July 14, 2023 Category: Epidemiology Authors: Antonio Cuevas-Navarro Morgan Wagner Richard Van Monalisa Swain Stephanie Mo John Columbus Madeline R Allison Alice Cheng Simon Messing Thomas J Turbyville Dhirendra K Simanshu Matthew J Sale Frank McCormick Andrew G Stephen Pau Castel Source Type: research

My assistive technology outcomes framework: rights-based outcome tools for consumers to 'measure what matters'
Assist Technol. 2023 Jul 12:1-9. doi: 10.1080/10400435.2023.2229891. Online ahead of print.ABSTRACTAT outcomes research is the systematic investigation of changes produced by AT in the lives of AT users and their environments. In contrast to focal outcome measures, My Assistive Technology Outcomes Framework (MyATOF) envisions an alternative starting point, co-designing a holistic and evidence-based set of outcome dimensions enabling AT users to quantify their own outcomes. International classification systems, research evidence, regulatory and service delivery frameworks underpin six optional tools: supports, outcomes, cos...
Source: Assistive Technology - July 12, 2023 Category: Rehabilitation Authors: Natasha Layton L Callaway E Wilson D Bell M Prain M Noonan A Volkert E Doyle Source Type: research

Self ‐efficacy in the context of nursing education and transition to practice as a registered practitioner: A systematic review
AbstractAimThe aim of this systematic review is to identify, describe and synthesize evidence from experimental studies conducted to measure and conceptualize self-efficacy within the context of nursing education and the transition of nursing students to practice as a registered practitioners.DesignSystematic review.MethodsPapers were screened by four independent reviewers, and data were extracted using a standardized data extraction tool. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance and checklists were used to guide this review.ResultsThe review included 47 studies, using a quas...
Source: Nursing Open - July 9, 2023 Category: Nursing Authors: Mousa Abusubhiah, Nuala Walshe, Rena Creedon, Brendan Noonan, Josephine Hegarty Tags: SYSTEMATIC REVIEW Source Type: research

Two residues determine nicotinic acetylcholine receptor requirement for RIC ‐3
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - July 7, 2023 Category: Biochemistry Authors: Jennifer D. Noonan, Robin N. Beech Tags: RESEARCH ARTICLE Source Type: research

Developing online simulated practice placements: a case study
This article offers an overview of that work, addressing challenges, operational issues, and insight into some of the activities developed to support students' learning.PMID:37410679 | DOI:10.12968/bjon.2023.32.13.636 (Source: British Journal of Nursing)
Source: British Journal of Nursing - July 6, 2023 Category: Nursing Authors: Linda Sanderson Lisa Choma Tim Cappelli Sally Arrey Ian Noonan Stephen Prescott Christopher Essen Carolyn McCrorie Andrew Bland Source Type: research