Worry and Mindfulness Differentially Impact Symptom Burden Following Treatment Among Breast Cancer Survivors: Findings From a Randomized Crossover Trial
CONCLUSION: Results from this study highlight the benefits of adaptive emotion regulation in helping mitigate symptoms associated with breast cancer survivorship.PMID:37335884 | DOI:10.1093/abm/kaad032 (Source: Annals of Behavioral Medicine)
Source: Annals of Behavioral Medicine - June 19, 2023 Category: Psychiatry & Psychology Authors: Megan E Renna Annelise A Madison Juan Peng Marcella Rosie Shrout Maryam Lustberg Bhuvaneswari Ramaswamy Robert Wesolowski Jeffrey B VanDeusen Nicole O Williams Sagar D Sardesai Anne M Noonan Raquel E Reinbolt Daniel G Stover Mathew Cherian William B Malar Source Type: research
Worry and Mindfulness Differentially Impact Symptom Burden Following Treatment Among Breast Cancer Survivors: Findings From a Randomized Crossover Trial
CONCLUSION: Results from this study highlight the benefits of adaptive emotion regulation in helping mitigate symptoms associated with breast cancer survivorship.PMID:37335884 | DOI:10.1093/abm/kaad032 (Source: Annals of Behavioral Medicine)
Source: Annals of Behavioral Medicine - June 19, 2023 Category: Psychiatry & Psychology Authors: Megan E Renna Annelise A Madison Juan Peng Marcella Rosie Shrout Maryam Lustberg Bhuvaneswari Ramaswamy Robert Wesolowski Jeffrey B VanDeusen Nicole O Williams Sagar D Sardesai Anne M Noonan Raquel E Reinbolt Daniel G Stover Mathew Cherian William B Malar Source Type: research
Neoadjuvant Talazoparib in Patients With Germline BRCA1/2 Mutation-Positive, Early-Stage Triple-Negative Breast Cancer: Results of a Phase II Study
CONCLUSIONS: Neoadjuvant talazoparib monotherapy was active despite pCR rates not meeting the prespecified threshold; these rates were comparable to those observed with combination anthracycline- and taxane-based chemotherapy regimens. Talazoparib was generally well tolerated.CLINICALTRIALS.GOV IDENTIFIER: NCT03499353.PMID:37318349 | DOI:10.1093/oncolo/oyad139 (Source: The Oncologist)
Source: The Oncologist - June 15, 2023 Category: Cancer & Oncology Authors: Jennifer K Litton J Thaddeus Beck Jason M Jones Jay Andersen Joanne L Blum Lida A Mina Raymond Brig Michael Danso Yuan Yuan Antonello Abbattista Kay Noonan Alexander Niyazov Jayeta Chakrabarti Akos Czibere William F Symmans Melinda L Telli Source Type: research
Neoadjuvant Talazoparib in Patients With Germline BRCA1/2 Mutation-Positive, Early-Stage Triple-Negative Breast Cancer: Results of a Phase II Study
CONCLUSIONS: Neoadjuvant talazoparib monotherapy was active despite pCR rates not meeting the prespecified threshold; these rates were comparable to those observed with combination anthracycline- and taxane-based chemotherapy regimens. Talazoparib was generally well tolerated.CLINICALTRIALS.GOV IDENTIFIER: NCT03499353.PMID:37318349 | DOI:10.1093/oncolo/oyad139 (Source: The Oncologist)
Source: The Oncologist - June 15, 2023 Category: Cancer & Oncology Authors: Jennifer K Litton J Thaddeus Beck Jason M Jones Jay Andersen Joanne L Blum Lida A Mina Raymond Brig Michael Danso Yuan Yuan Antonello Abbattista Kay Noonan Alexander Niyazov Jayeta Chakrabarti Akos Czibere William F Symmans Melinda L Telli Source Type: research
Genes, Vol. 14, Pages 1241: Success and Pitfalls of Genetic Testing in Undiagnosed Diseases: Whole Exome Sequencing and Beyond
Banka
Antonio Percesepe
Novel approaches to uncover the molecular etiology of neurodevelopmental disorders (NDD) are highly needed. Even using a powerful tool such as whole exome sequencing (WES), the diagnostic process may still prove long and arduous due to the high clinical and genetic heterogeneity of these conditions. The main strategies to improve the diagnostic rate are based on family segregation, re-evaluation of the clinical features by reverse-phenotyping, re-analysis of unsolved NGS-based cases and epigenetic functional studies. In this article, we described three selected cases from a cohort of patients ...
Source: Genes - June 10, 2023 Category: Genetics & Stem Cells Authors: Valeria Barili Enrico Ambrosini Vera Uliana Melissa Bellini Giulia Vitetta Davide Martorana Ilenia Rita Cannizzaro Antonietta Taiani Erika De Sensi Patrizia Caggiati Sarah Hilton Siddharth Banka Antonio Percesepe Tags: Article Source Type: research
Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis
Front Immunol. 2023 May 24;14:1146704. doi: 10.3389/fimmu.2023.1146704. eCollection 2023.ABSTRACTKnowledge of aging biology needs to be expanded due to the continuously growing number of elderly people worldwide. Aging induces changes that affect all systems of the body. The risk of cardiovascular disease and cancer increases with age. In particular, the age-induced adaptation of the immune system causes a greater susceptibility to infections and contributes to the inability to control pathogen growth and immune-mediated tissue damage. Since the impact of aging on immune function, is still to be fully elucidated, this revi...
Source: Cancer Control - June 9, 2023 Category: Cancer & Oncology Authors: Alba Grifoni Tonino Alonzi Galit Alter Douglas McClain Noonan Alan L Landay Adriana Albini Delia Goletti Source Type: research
Prenatal diagnosis and postnatal outcome of fetal congenital knee dislocation: systematic review of literature
CONCLUSIONS: CKD is a rare fetal anomaly with a prenatal diagnosis achievable from the early second trimester for which favorable outcome can be predicted when no associated anomalies are present. Prenatal diagnosis should include detailed US assessment and amniocentesis for extensive genetic studies, particularly in non-isolated cases. Postnatal early treatment achieves success in most cases without surgical intervention and leads to normal motor outlook. This article is protected by copyright. All rights reserved.PMID:37289939 | DOI:10.1002/uog.26283 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - June 8, 2023 Category: Radiology Authors: P I Cavoretto M Castoldi G Corbella A Forte D Moharamzadeh D Emedoli M Candiani M De Pellegrin Source Type: research
Prenatal diagnosis and postnatal outcome of fetal congenital knee dislocation: systematic review of literature
CONCLUSIONS: CKD is a rare fetal anomaly with a prenatal diagnosis achievable from the early second trimester for which favorable outcome can be predicted when no associated anomalies are present. Prenatal diagnosis should include detailed US assessment and amniocentesis for extensive genetic studies, particularly in non-isolated cases. Postnatal early treatment achieves success in most cases without surgical intervention and leads to normal motor outlook. This article is protected by copyright. All rights reserved.PMID:37289939 | DOI:10.1002/uog.26283 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - June 8, 2023 Category: Radiology Authors: P I Cavoretto M Castoldi G Corbella A Forte D Moharamzadeh D Emedoli M Candiani M De Pellegrin Source Type: research
Prenatal diagnosis and postnatal outcome of fetal congenital knee dislocation: systematic review of literature
CONCLUSIONS: CKD is a rare fetal anomaly with a prenatal diagnosis achievable from the early second trimester for which favorable outcome can be predicted when no associated anomalies are present. Prenatal diagnosis should include detailed US assessment and amniocentesis for extensive genetic studies, particularly in non-isolated cases. Postnatal early treatment achieves success in most cases without surgical intervention and leads to normal motor outlook. This article is protected by copyright. All rights reserved.PMID:37289939 | DOI:10.1002/uog.26283 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - June 8, 2023 Category: Radiology Authors: P I Cavoretto M Castoldi G Corbella A Forte D Moharamzadeh D Emedoli M Candiani M De Pellegrin Source Type: research
Prenatal diagnosis and postnatal outcome of fetal congenital knee dislocation: systematic review of literature
CONCLUSIONS: CKD is a rare fetal anomaly with a prenatal diagnosis achievable from the early second trimester for which favorable outcome can be predicted when no associated anomalies are present. Prenatal diagnosis should include detailed US assessment and amniocentesis for extensive genetic studies, particularly in non-isolated cases. Postnatal early treatment achieves success in most cases without surgical intervention and leads to normal motor outlook. This article is protected by copyright. All rights reserved.PMID:37289939 | DOI:10.1002/uog.26283 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - June 8, 2023 Category: Radiology Authors: P I Cavoretto M Castoldi G Corbella A Forte D Moharamzadeh D Emedoli M Candiani M De Pellegrin Source Type: research
Prenatal diagnosis and postnatal outcome of fetal congenital knee dislocation: systematic review of literature
CONCLUSIONS: CKD is a rare fetal anomaly with a prenatal diagnosis achievable from the early second trimester for which favorable outcome can be predicted when no associated anomalies are present. Prenatal diagnosis should include detailed US assessment and amniocentesis for extensive genetic studies, particularly in non-isolated cases. Postnatal early treatment achieves success in most cases without surgical intervention and leads to normal motor outlook. This article is protected by copyright. All rights reserved.PMID:37289939 | DOI:10.1002/uog.26283 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - June 8, 2023 Category: Radiology Authors: P I Cavoretto M Castoldi G Corbella A Forte D Moharamzadeh D Emedoli M Candiani M De Pellegrin Source Type: research
Prenatal diagnosis and postnatal outcome of fetal congenital knee dislocation: systematic review of literature
CONCLUSIONS: CKD is a rare fetal anomaly with a prenatal diagnosis achievable from the early second trimester for which favorable outcome can be predicted when no associated anomalies are present. Prenatal diagnosis should include detailed US assessment and amniocentesis for extensive genetic studies, particularly in non-isolated cases. Postnatal early treatment achieves success in most cases without surgical intervention and leads to normal motor outlook. This article is protected by copyright. All rights reserved.PMID:37289939 | DOI:10.1002/uog.26283 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - June 8, 2023 Category: Radiology Authors: P I Cavoretto M Castoldi G Corbella A Forte D Moharamzadeh D Emedoli M Candiani M De Pellegrin Source Type: research
Improvement of synaptic plasticity and cognitive function in RASopathies —a monocentre, randomized, double-blind, parallel-group, placebo-controlled, cross-over clinical trial (SynCoRAS)
Cognitive impairment is a common medical issue in rat sarcoma (RAS) pathway disorders, so-called RASopathies, like Neurofibromatosis type 1 (NF1) or Noonan syndrome (NS). It is presumed to be caused by impaire... (Source: Trials)
Source: Trials - June 6, 2023 Category: General Medicine Authors: Nikolai H. Jung, Silvia Egert-Schwender, Beate Schossow, Victoria Kehl, Ute Wahll änder, Louisa Brich, Viktoria Janke, Christiane Blankenstein, Martin Zenker and Volker Mall Tags: Study protocol Source Type: research
Role of SHP2 (PTPN11) in glycoprotein VI-dependent thrombus formation: Improved platelet responsiveness by the allosteric drug SHP099 in Noonan syndrome patients
The protein tyrosine phosphatase SHP2 (PTPN11) is a negative regulator of glycoprotein VI (GPVI)-induced platelet signal under certain conditions. Clinical trials with derivatives of the allosteric drug SHP099, inhibiting SHP2, are ongoing as potential therapy for solid cancers. Gain-of-function mutations of the PTPN11 gene are observed in part of the patients with the Noonan syndrome, associated with a mild bleeding disorder. Assessment of the effects of SHP2 inhibition in platelets from controls and Noonan syndrome patients. (Source: Thrombosis Research)
Source: Thrombosis Research - June 5, 2023 Category: Hematology Authors: Delia I. Fern ández, Marije Diender, Lidia Hermida-Nogueira, Jingnan Huang, Sonia Veiras, Yvonne M.C. Henskens, Maroeska W.M. te Loo, Johan W.M. Heemskerk, Marijke J.E. Kuijpers, Ángel García Source Type: research
Hypertrophic neuropathy: a possible cause of pain in children with Noonan syndrome and related disorders
Conclusion: In the four children included with a NS and related disorders, pain was concomitant with nerve hypertrophy, which suggests an association between these two findings. The use of high-resolution nerve ultrasound and spinal magnetic resonance imaging might result in better understanding of the nature of this pain and the possible association to nerve hypertrophy in patients with NS and related disorders.What is Known:• Children with Noonan syndrome and related disorders may report pain in their legs, which is often interpreted as growing pain.• Some adults with Noonan syndrome and related disorders have hypert...
Source: European Journal of Pediatrics - June 5, 2023 Category: Pediatrics Source Type: research
