Impact of unilateral dual-brachial arteries on endothelial-dependent and endothelial-independent vasodilation: a case study
Applied Physiology, Nutrition, and Metabolism, Ahead of Print. Brachial artery bifurcation has been documented in ∼5%–10% of cadaver models, but our understanding of arterial function in these rare cases is unknown. This case study examined vasodilatory responses between a right bifurcated (right superficial brachial artery, right deep brachial artery) versus a left nonbifurcated brachial artery in a 28-yea r-old healthy female. Vasodilatory functions were assessed via flow-mediated dilation and nitroglycerin-mediated dilation (0.4 mg sublingual spray) techniques. Bifurcation of the brachial artery promotes lower endo...
Source: Applied Physiology, Nutrition, and Metabolism - August 16, 2023 Category: Physiology Authors: Molly K. Courish Madeline E. Shivgulam Jessica R. MacLeod Derek S. Kimmerly Myles W. O'Brien Source Type: research
Neuroimaging in the pre-ictal or premonitory phase of migraine: a narrative review
ConclusionAdvances in human migraine research, including the use of functional imaging techniques lacking radiation or radio-isotope exposure, have led to an exciting opportunity to study the premonitory phase using repeated measures imaging designs. These studies have provided novel insights into attack initiation, migraine neurochemistry and therapeutic targets. Emerging migraine-specific therapies, such as those targeting calcitonin gene-related peptide (CGRP), are showing promise acutely when taken during premonitory phase to reduce symptoms and prevent subsequent headache. Therapeutic research in this area using PS fo...
Source: The Journal of Headache and Pain - August 11, 2023 Category: Neurology Source Type: research
Rutaecarpine alleviates migraine in nitroglycerin-induced mice by regulating PTEN/PGK1 signaling pathway to activate NRF2 antioxidant system
Biomed Pharmacother. 2023 Aug 7;166:115300. doi: 10.1016/j.biopha.2023.115300. Online ahead of print.ABSTRACTBACKGROUND: Due to its widespread prevalence, migraine is a common neurovascular condition that has a major impact on people's health and quality of life. Rutaecarpine (RUT) is one of the main effective components of Evodia rutaecarpa, which has a wide range of biological activities. However, the exact mechanism by which RUT improves migraine remain unknown.PURPOSE: The purpose of this study was to investigate whether RUT improves migraine by inhibiting oxidative stress via activating the Nrf2 antioxidant system thr...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 9, 2023 Category: Drugs & Pharmacology Authors: Min Xu Zhenhua Shi Ziyang He Xiaoyang Ling Wenhua Wang Hua Liu Mingjie Gong Source Type: research
A new experimental rat model of nocebo-related nausea involving double mechanisms of observational learning and conditioning
CONCLUSION: The present study provides a useful experimental model of nocebo nausea that might be used to develop potential molecular pathways and therapeutic strategies for nocebo.PMID:37545429 | DOI:10.1111/cns.14389 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 7, 2023 Category: Neuroscience Authors: Yu Zhang Wanbin Huang Zhengming Shan Yanjie Zhou Tao Qiu Luyu Hu Liu Yang Yue Wang Zheman Xiao Source Type: research
A new experimental rat model of nocebo-related nausea involving double mechanisms of observational learning and conditioning
CONCLUSION: The present study provides a useful experimental model of nocebo nausea that might be used to develop potential molecular pathways and therapeutic strategies for nocebo.PMID:37545429 | DOI:10.1111/cns.14389 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - August 7, 2023 Category: Neuroscience Authors: Yu Zhang Wanbin Huang Zhengming Shan Yanjie Zhou Tao Qiu Luyu Hu Liu Yang Yue Wang Zheman Xiao Source Type: research
Aryl hydrocarbon receptors improve migraine-like pain behaviors in rats through the regulation of regulatory T cell/T-helper 17 cell-related homeostasis
CONCLUSIONS: The AHR participates in the development of CM by regulating Treg/Th17-related homeostasis. Therefore, treatments targeting the AHR/Treg/Th17 signaling pathway could be new effective interventions for CM treatment.PMID:37539825 | DOI:10.1111/head.14599 (Source: Headache)
Source: Headache - August 4, 2023 Category: Neurology Authors: Liu Yang Yanjie Zhou Lily Zhang Yue Wang Yu Zhang Zheman Xiao Source Type: research
Aryl hydrocarbon receptors improve migraine-like pain behaviors in rats through the regulation of regulatory T cell/T-helper 17 cell-related homeostasis
CONCLUSIONS: The AHR participates in the development of CM by regulating Treg/Th17-related homeostasis. Therefore, treatments targeting the AHR/Treg/Th17 signaling pathway could be new effective interventions for CM treatment.PMID:37539825 | DOI:10.1111/head.14599 (Source: Headache)
Source: Headache - August 4, 2023 Category: Neurology Authors: Liu Yang Yanjie Zhou Lily Zhang Yue Wang Yu Zhang Zheman Xiao Source Type: research
Aryl hydrocarbon receptors improve migraine-like pain behaviors in rats through the regulation of regulatory T cell/T-helper 17 cell-related homeostasis
CONCLUSIONS: The AHR participates in the development of CM by regulating Treg/Th17-related homeostasis. Therefore, treatments targeting the AHR/Treg/Th17 signaling pathway could be new effective interventions for CM treatment.PMID:37539825 | DOI:10.1111/head.14599 (Source: Headache)
Source: Headache - August 4, 2023 Category: Neurology Authors: Liu Yang Yanjie Zhou Lily Zhang Yue Wang Yu Zhang Zheman Xiao Source Type: research
Distal Radial Approach in Coronary Angiography Using a Transdermal Nitroglycerin Patch: Double-Blinded Randomized Trial
Nitroglycerin dilates the radial artery and prevents spasm, which increases the success rate of sheath cannulation through the conventional transradial approach. However, the effects of nitroglycerin on distal radial approach (DRA) procedures are not known. The aim of this study is to elucidate whether a transdermal nitroglycerin patch improves the rate of successful DRA cannulation. A total of 92 patients scheduled for coronary angiography by means of DRA randomly received (1:1) a transdermal nitroglycerin patch preintegrated with the covering material or only the covering material on their upper arm on the side of the pu...
Source: The American Journal of Cardiology - July 28, 2023 Category: Cardiology Authors: Kota Murai, Masashi Fujino, Takamasa Iwai, Kenichiro Sawada, Hideo Matama, Hiroyuki Miura, Satoshi Honda, Shuichi Yoneda, Kensuke Takagi, Fumiyuki Otsuka, Yu Kataoka, Yasuhide Asaumi, Yoshio Tahara, Teruo Noguchi Source Type: research
Levcromakalim provokes an acute rapid-onset migraine-like phenotype without inducing cortical spreading depolarization
ConclusionsSingle LVC administration induced the fastest manifestation and recovery of acute migraine-like phenotype which was not mediated by CSD waves in the cerebral cortex. We suppose LVC triggered rapid-onset migraine-like symptoms are probably related to functional alterations in the trigeminal nociceptive system and K+ channel opening properties of LVC. Understanding the neurobiological mechanisms of this nociceptive window, may provide a novel target in migraine treatment. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 24, 2023 Category: Neurology Source Type: research
Pill or pump? Nitroglycerin 0.5 mg tablet vs 0.8 mg spray: Effect on proximal vessel diameters at Coronary CT Angiography (CCTA)
The administration of sublingual Nitroglycerin (NTG) prior to CT coronary angiography (CCTA) can be perfomed using pump spray or tablets. Choice of method seems to be based on local preference, rather than published guidelines. This retrospective analysis tested whether proximal coronary diameters differed dependent on the sublingual administration of 0.5 mg Nitroglycerin (NTG) tablets or 0.8 mg NTG spray. (Source: Radiography)
Source: Radiography - July 19, 2023 Category: Radiology Authors: M.W. Kusk, C.S. Bromark, M. Hestbek-M øller, L.Ø. Davidsen, H. Precht, K. Brage Source Type: research
