Implications of high homocysteine levels in migraine pain: An experimental study of the excitability of peripheral meningeal afferents in rats with hyperhomocysteinemia
CONCLUSIONS: Our results demonstrated higher excitability of the trigeminal system of rats with hyperhomocysteinemia. Together with our previous finding about the lower threshold of generation of cortical spreading depression in rats with hyperhomocysteinemia, the present data provide evidence of homocysteine as a factor that increases the sensitivity of the peripheral migraine mechanisms, and the control of homocysteine level may be an important strategy for reducing the risk and/or severity of migraine headache attacks.PMID:38650105 | DOI:10.1111/head.14710 (Source: Headache)
Source: Headache - April 23, 2024 Category: Neurology Authors: Elizaveta Ermakova Kseniia Shaidullova Oleg Gafurov Alsu Kabirova Dinara Nurmieva Guzel Sitdikova Source Type: research
Implications of high homocysteine levels in migraine pain: An experimental study of the excitability of peripheral meningeal afferents in rats with hyperhomocysteinemia
CONCLUSIONS: Our results demonstrated higher excitability of the trigeminal system of rats with hyperhomocysteinemia. Together with our previous finding about the lower threshold of generation of cortical spreading depression in rats with hyperhomocysteinemia, the present data provide evidence of homocysteine as a factor that increases the sensitivity of the peripheral migraine mechanisms, and the control of homocysteine level may be an important strategy for reducing the risk and/or severity of migraine headache attacks.PMID:38650105 | DOI:10.1111/head.14710 (Source: Headache)
Source: Headache - April 23, 2024 Category: Neurology Authors: Elizaveta Ermakova Kseniia Shaidullova Oleg Gafurov Alsu Kabirova Dinara Nurmieva Guzel Sitdikova Source Type: research
Combination Administration of Heparin and Nitroglycerin for the Treatment of Polycaprolactone-Induced Intravascular Embolism: A Preclinical Investigation
ConclusionsThe combination of heparin and nitroglycerin effectively restores blood flow reperfusion in the intravascular embolization caused by PCL filler injection, alleviates local tissue edema and flap necrosis. These findings offer a novel approach for future clinical management of intravascular embolization with PCL-containing filler injection.No Level AssignedThis journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, a...
Source: Aesthetic Plastic Surgery - April 9, 2024 Category: Cosmetic Surgery Source Type: research
Unveiling the therapeutic potential of Dl-3-n-butylphthalide in NTG-induced migraine mouse: activating the Nrf2 pathway to alleviate oxidative stress and neuroinflammation
ConclusionsOur data suggest that NBP may alleviate migraine by activating the Nrf2 pathway to reduce oxidative stress and inflammation in migraine mouse models, confirming that it may be a potential drug for the treatment of migraine.Graphical Abstract (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - April 2, 2024 Category: Neurology Source Type: research
Evaluation Of Sex as A Biological Variable in A Preclinical Migraine Model
Chronic migraine is a prevalent disabling condition. Migraine pathophysiology is poorly understood although there may be interplay between neurogenic inflammation, sex hormones, and migraine-induced pain behaviors. We hypothesized that there is a sex-linked difference in migraine-like behaviors and proinflammatory cytokine expression. To test this hypothesis, we used male and female 8-week-old C57BL/6J mice that received intraperitoneal injections of either nitroglycerin (10mg/kg) or saline on five alternating days. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Kofi Frimpong-Manson, Jenny L. Wilkerson Source Type: research
Enhanced External Counterpulsation Outcomes Study: Retrospective Analyses of Data Obtained from Patients at a Single Medical Center in United States
Int J Angiol DOI: 10.1055/s-0044-1782657The aim was to explore the effectiveness of enhanced external counterpulsation (EECP) therapy in patients with severe angina pectoris/ chronic heart failure symptoms, who were not suitable candidates for invasive treatment. This retrospective study employed a comprehensive methodology that includes individualized treatment, continuous monitoring, and thorough pre- and postprogram evaluations to assess the efficacy of EECP therapy. The standard protocol involved 35 one-hour treatments, with flexibility for extensions based on therapeutic progress. When pre- and posttreatment results w...
Source: International Journal of Angiology - March 30, 2024 Category: Cardiology Authors: Akula, Ashok Grafft, Heidi R. Tak, Nadia Haberman, Douglas A. Tak, Tahir Tags: Original Article Source Type: research
Managing Patients With Sympathetic Crashing Acute Pulmonary Edema (SCAPE) Using the SCAPE Treatment Protocol: A Case Series
Perm J. 2023 Mar 29:1-5. doi: 10.7812/TPP/23.149. Online ahead of print.ABSTRACTPulmonary edema refers to the accumulation of excessive fluid in the alveolar walls and alveolar spaces of the lungs. It is a life-threatening condition with a high mortality rate and requires immediate assessment and management. Use of intravenous nitroglycerin has been advocated for such cases. The authors present a case series of 3 patients who presented to the emergency department with sympathetic crashing acute pulmonary edema (SCAPE) and were managed with high-dose intravenous nitroglycerin and bilevel positive airway pressure support usi...
Source: The Permanente journal - March 29, 2024 Category: General Medicine Authors: Ankur Verma Sanjay Jaiswal Anubhooti Mahawar Maheshwar Lal Saumya Gupta Ruhima Begum Source Type: research
