Regulation of headache response and transcriptomic network by the trigeminal ganglion clock
CONCLUSION: Our study unveiled robust circadian rhythms in the trigeminal ganglion at the behavioral, transcriptomic, and pharmacogenetic levels. These results support a fundamental role of the clock in pain pathophysiology.PLAIN LANGUAGE SUMMARY: Several headache diseases, such as migraine and cluster headache, have headaches that occur at the same time each day. We learned that the trigeminal ganglion, an important pain structure in several headache diseases, has a 24-hour cycle that might be related to this daily cycle of headaches. Our genetic analysis suggests that some medications may be more effective in treating mi...
Source: Headache - January 30, 2024 Category: Neurology Authors: Chorong Han Ji Ye Lim Nobuya Koike Sun Young Kim Kaori Ono Celia K Tran Elizaveta Mangutov Eunju Kim Yanping Zhang Lingyong Li Amynah A Pradhan Kazuhiro Yagita Zheng Chen Seung-Hee Yoo Mark J Burish Source Type: research
Retraction Note: Rhynchophylline attenuates migraine in trigeminal nucleus caudalis in nitroglycerin-induced rat model by inhibiting MAPK/NF- кB signaling
Mol Cell Biochem. 2024 Jan 29. doi: 10.1007/s11010-024-04941-1. Online ahead of print.NO ABSTRACTPMID:38285381 | DOI:10.1007/s11010-024-04941-1 (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - January 29, 2024 Category: Biochemistry Authors: Tianbao Lai Liangyi Chen Xingyu Chen Jianquan He Peiyu Lv Hua Ge Source Type: research
Bronchial carcinoid: a neuroendocrine manifestation —presented as bronchospasm and hypertension during resection
AbstractBronchopulmonary carcinoid tumors are rare, slow-growing malignant neuroendocrine tumors. Early diagnosis is pivotal as surgical resection is the main stay of treatment. A 40-year-old female with typical bronchial carcinoid presented with complaints of breathlessness on mild to moderate exertion, intermittent productive cough, low-grade fever, and loss of appetite since 1 year. Right lobectomy was performed with regional lymph node resection; during resection of the tumor, manipulation led to a massive surge and fluctuations in blood pressure which were managed with deepening of the plane of anesthesia and admini...
Source: Indian Journal of Thoracic and Cardiovascular Surgery - January 27, 2024 Category: Cardiovascular & Thoracic Surgery Source Type: research
