Levcromakalim provokes an acute rapid-onset migraine-like phenotype without inducing cortical spreading depolarization

ConclusionsSingle LVC administration induced the fastest manifestation and recovery of acute migraine-like phenotype which was not mediated by CSD waves in the cerebral cortex. We suppose LVC triggered rapid-onset migraine-like symptoms are probably related to functional alterations in the trigeminal nociceptive system and K+ channel opening properties of LVC. Understanding the neurobiological mechanisms of this nociceptive window, may provide a novel target in migraine treatment.
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research