Application of non-lethal bioSPME-LC-MS/MS for the detection of human pharmaceuticals in soft corals: A survey at the North Nilandhe atoll (Maldives)
Chemosphere. 2024 Mar 28:141781. doi: 10.1016/j.chemosphere.2024.141781. Online ahead of print.ABSTRACTAt present the information regarding the occurrence of human pharmaceuticals (PhaCs) in coral reefs and their potential impacts on the associated fauna is limited. To optimize the collection of data in these delicate environments, we employed a solid-phase microextraction (bioSPME) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) procedure that enabled in vivo determinations in soft corals. Specifically, we researched the antibiotics Ofloxacin Sulfamethoxazole and Clarithromycin, the anti-inflammat...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Alessandro Becchi Marco Mantovani Marina Lasagni Elena Collina Simone Montano Paolo Galli Francesco Saliu Source Type: research
Molecules, Vol. 29, Pages 1480: Monitoring Pharmaceuticals and Personal Care Products in Healthcare Effluent Wastewater Samples and the Effectiveness of Drug Removal in Wastewater Treatment Plants Using the UHPLC-MS/MS Method
This study reveals the prevalence of several different drugs; mean concentrations of 702 μg L−1 of iomeprol, 48.8 μg L−1 of iopromide, 29.9 μg L−1 of gabapentin, 42.0 μg L−1 of caffeine and 82.5 μg L−1 of paracetamol were present. An analysis of 20 samples from ten WWTPs revealed different removal efficiencies for different analytes. Paracetamol was present in the inflow samples of all ten WWTPs and its removal efficiency was 100%. Analytes such as caffeine, ketoprofen, naproxen or atenolol showed hi...
Source: Molecules - March 27, 2024 Category: Chemistry Authors: Lucia Molnarova Tatana Halesova Daniela Tomesova Marta Vaclavikova Zuzana Bosakova Tags: Article Source Type: research
A next generation peripherally restricted Cav α2δ-1 ligand with inhibitory action on Cav2.2 channels and utility in neuropathic pain
Biomed Pharmacother. 2024 Mar 25;174:116472. doi: 10.1016/j.biopha.2024.116472. Online ahead of print.ABSTRACTThe Voltage-Gated Calcium Channel (VGCC) auxiliary subunit Cavα2δ-1 (CACNA2D1) is the target/receptor of gabapentinoids which are known therapeutics in epilepsy and neuropathic pain. Following damage to the peripheral sensory nervous system, Cavα2δ-1 is upregulated in dorsal root ganglion (DRG) neurons in several animal models of chronic neuropathic pain. Gabapentinoids, such as gabapentin and pregabalin, engage with Cavα2δ-1 via binding an arginine residue (R241) within an RRR motif located at the N-terminus...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 26, 2024 Category: Drugs & Pharmacology Authors: Franz Kricek Christine Ruf Premji Meghani Ivana A Souza Maria A Gandini Gerald W Zamponi George Skouteris Source Type: research
A next generation peripherally restricted Cav α2δ-1 ligand with inhibitory action on Cav2.2 channels and utility in neuropathic pain
Biomed Pharmacother. 2024 Mar 25;174:116472. doi: 10.1016/j.biopha.2024.116472. Online ahead of print.ABSTRACTThe Voltage-Gated Calcium Channel (VGCC) auxiliary subunit Cavα2δ-1 (CACNA2D1) is the target/receptor of gabapentinoids which are known therapeutics in epilepsy and neuropathic pain. Following damage to the peripheral sensory nervous system, Cavα2δ-1 is upregulated in dorsal root ganglion (DRG) neurons in several animal models of chronic neuropathic pain. Gabapentinoids, such as gabapentin and pregabalin, engage with Cavα2δ-1 via binding an arginine residue (R241) within an RRR motif located at the N-terminus...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 26, 2024 Category: Drugs & Pharmacology Authors: Franz Kricek Christine Ruf Premji Meghani Ivana A Souza Maria A Gandini Gerald W Zamponi George Skouteris Source Type: research
Incidence and Risk Factors for ICU-Associated Delirium in the Alert Geriatric Trauma Population
This study analyzed the overall incidence of delirium, comorbid conditions, injury patterns, and pharmacological risk factors for the development of delirium in an alert, geriatric trauma population.METHODS: IRB-approved, prospective, consecutive cohort series at two Southeastern Level 1 trauma centers from June 11 to August 15, 2023. Delirium was assessed using the Confusion Assessment Method (CAM) score. Comorbidities and medications were detailed from electronic medical records. Inclusion criteria: age ≥55, GCS ≥14, and ICU admission for trauma. Patients on a ventilator were excluded. Data was analyzed using SPSS ve...
Source: The American Surgeon - March 23, 2024 Category: Surgery Authors: Sarah C Ulderich Williams Ansam I Qaddoumi John T Meghreblian Mary E McBride Sarah A King Muhammad A Elahi Debbie Tuggle R Eric Heidel Lou M Smith Source Type: research
Incidence and Risk Factors for ICU-Associated Delirium in the Alert Geriatric Trauma Population
This study analyzed the overall incidence of delirium, comorbid conditions, injury patterns, and pharmacological risk factors for the development of delirium in an alert, geriatric trauma population.METHODS: IRB-approved, prospective, consecutive cohort series at two Southeastern Level 1 trauma centers from June 11 to August 15, 2023. Delirium was assessed using the Confusion Assessment Method (CAM) score. Comorbidities and medications were detailed from electronic medical records. Inclusion criteria: age ≥55, GCS ≥14, and ICU admission for trauma. Patients on a ventilator were excluded. Data was analyzed using SPSS ve...
Source: The American Surgeon - March 23, 2024 Category: Surgery Authors: Sarah C Ulderich Williams Ansam I Qaddoumi John T Meghreblian Mary E McBride Sarah A King Muhammad A Elahi Debbie Tuggle R Eric Heidel Lou M Smith Source Type: research
Development of lactic acid based chain extender and soybean oil-derived polyurethanes for ecofriendly sustained drug delivery systems
Int J Biol Macromol. 2024 Mar 11:130717. doi: 10.1016/j.ijbiomac.2024.130717. Online ahead of print.ABSTRACTIn the present study, a range of sustainable, biocompatible and biodegradable polyurethanes (PU-1 to PU-4) were synthesized using different combinations of biobased polyol (obtained through the epoxidation of soybean oil, followed by ring opening with ethanol) and polyethylene glycol (PEG) and isophorone diisocyanate. The sustainable chain extender used in this study was synthesized by the esterification of lactic acid with ethylene glycol (EG). The synthesized PU samples were characterized through scanning electron ...
Source: International Journal of Biological Macromolecules - March 13, 2024 Category: Biochemistry Authors: Amer Iqbal Muhammad Asif Javaid Muhammad Tahir Hussain Zulfiqar Ali Raza Source Type: research
Development of lactic acid based chain extender and soybean oil-derived polyurethanes for ecofriendly sustained drug delivery systems
Int J Biol Macromol. 2024 Mar 11:130717. doi: 10.1016/j.ijbiomac.2024.130717. Online ahead of print.ABSTRACTIn the present study, a range of sustainable, biocompatible and biodegradable polyurethanes (PU-1 to PU-4) were synthesized using different combinations of biobased polyol (obtained through the epoxidation of soybean oil, followed by ring opening with ethanol) and polyethylene glycol (PEG) and isophorone diisocyanate. The sustainable chain extender used in this study was synthesized by the esterification of lactic acid with ethylene glycol (EG). The synthesized PU samples were characterized through scanning electron ...
Source: International Journal of Biological Macromolecules - March 13, 2024 Category: Biochemistry Authors: Amer Iqbal Muhammad Asif Javaid Muhammad Tahir Hussain Zulfiqar Ali Raza Source Type: research
Retigabine and gabapentin restore channel function and neuronal firing in a cellular model of an epilepsy-associated dominant-negative KCNQ5 variant
Neuropharmacology. 2024 Feb 28:109892. doi: 10.1016/j.neuropharm.2024.109892. Online ahead of print.ABSTRACTKCNQ5 encodes the voltage-gated potassium channel KV7.5, a member of the KV7 channel family, which conducts the M-current. This current is a potent regulator of neuronal excitability by regulating membrane potential in the subthreshold range of action potentials and mediating the medium and slow afterhyperpolarization. Recently, we have identified five loss-of-function variants in KCNQ5 in patients with genetic generalized epilepsy. Using the most severe dominant-negative variant (R359C), we set out to investigate ph...
Source: Neuropharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Johanna Kr üger Holger Lerche Source Type: research
Retigabine and gabapentin restore channel function and neuronal firing in a cellular model of an epilepsy-associated dominant-negative KCNQ5 variant
Neuropharmacology. 2024 Feb 28:109892. doi: 10.1016/j.neuropharm.2024.109892. Online ahead of print.ABSTRACTKCNQ5 encodes the voltage-gated potassium channel KV7.5, a member of the KV7 channel family, which conducts the M-current. This current is a potent regulator of neuronal excitability by regulating membrane potential in the subthreshold range of action potentials and mediating the medium and slow afterhyperpolarization. Recently, we have identified five loss-of-function variants in KCNQ5 in patients with genetic generalized epilepsy. Using the most severe dominant-negative variant (R359C), we set out to investigate ph...
Source: Neuropharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Johanna Kr üger Holger Lerche Source Type: research
Pharmacological and Non-pharmacological Approaches for the Management of Neuropathic Pain in Multiple Sclerosis
The objective of this ar ticle is to provide an overview of literature on pharmacological and non-pharmacological strategies employed in the management of neuropathic pain in multiple sclerosis. Pharmacological options include cannabinoids, muscle relaxants (tizanidine, baclofen, dantrolene), anticonvulsants (benzodiazepine s, gabapentin, phenytoin, carbamazepine, lamotrigine), antidepressants (duloxetine, venlafaxine, tricyclic antidepressants), opioids (naltrexone), and botulinum toxin variants, which have evidence from various clinical trials. Non-pharmacological approaches for trigeminal neuralgia may include neuro sur...
Source: CNS Drugs - February 29, 2024 Category: Neurology Source Type: research
Gabapentin in drugged driving investigations
J Forensic Sci. 2024 Feb 25. doi: 10.1111/1556-4029.15500. Online ahead of print.ABSTRACTThe increasing use and misuse of gabapentin pose a major risk to public health and traffic safety. Gabapentin has been approved by the Food and Drug Administration (FDA) since 1993 for adjunctive therapy in the treatment of epilepsy and neuralgia but is increasingly being prescribed for numerous off-label uses including insomnia, anxiety, depression, and migraine. Reported side effects include blurred vision, drowsiness, and loss of coordination. Driving behaviors such as exiting the lane of travel and crashes have been reported in con...
Source: Journal of Forensic Sciences - February 25, 2024 Category: Forensic Medicine Authors: Jolene J Bierly Ayako Chan-Hosokawa Source Type: research
Quantification of stimulus-evoked tactile allodynia in free moving mice by the chainmail sensitivity test
Chronic pain occurs at epidemic levels throughout the population. Hypersensitivity to touch, is a cardinal symptom of chronic pain. Despite dedicated research for over a century, quantifying this hypersensitivity has remained impossible at scale. To address these issues, we developed the Chainmail Sensitivity Test (CST). Our results show that control mice spend significantly more time on the chainmail portion of the device than mice subject to neuropathy. Treatment with gabapentin abolishes this difference. CST-derived data correlate well with von Frey measurements and quantify hypersensitivity due to inflammation. Our stu...
Source: Frontiers in Pharmacology - February 23, 2024 Category: Drugs & Pharmacology Source Type: research
Vesicovaginal and vesicorectal fistula in a patient with systemic sclerosis: A case report
Key Clinical MessageThis case highlights the need for further research to explore a potential link between systemic sclerosis and fistula development, and the importance of raising awareness among clinicians about this possibility for timely appropriate management.AbstractThe primary diagnosis in this case is systemic sclerosis (scleroderma) in a 47-year-old female patient with various clinical manifestations, including vesicovaginal and vesicorectal fistulas. The medical interventions and diagnostic workup involved an electrocardiogram, cardiac echocardiogram, pulmonary function tests, beta blockers, aspirin, inhaled cort...
Source: Clinical Case Reports - February 22, 2024 Category: General Medicine Authors: Mohammad Quteineh,
Sajedah N. Obeid,
Khayry Al ‐Shami,
Hamdah Hanifa Tags: CASE REPORT Source Type: research
Phenibut —an Illegal Food Supplement With Psychotropic Effects and Health Risks
CONCLUSION: Phenibut causes symptoms resembling those of gabapentinoid and benzodiazepine use. There have been reports of phenibut use in combination with other psychotropic drugs; in particular, its use together with opiates could increase the risk of coma and respiratory depression. No deaths due to phenibut intoxication have been published in Germany or elsewhere in Western Europe, although such cases may have been overlooked, as this drug is still largely unknown to Western medicine.PMID:38377332 | DOI:10.3238/arztebl.m2024.0003 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - February 20, 2024 Category: General Medicine Authors: Udo Bonnet Norbert Scherbaum Andreas Schaper Michael Soyka Source Type: research
