Diabetic Peripheral Neuropathy: Prevention and Treatment
Am Fam Physician. 2024 Mar;109(3):226-232.ABSTRACTDiabetic peripheral neuropathy occurs in up to 50% of patients with diabetes mellitus and increases the risk of diabetic foot ulcers and infections. Consistent screening and clear communication are essential to decrease disparities in assessment of neuropathic symptoms and diagnosis. Physicians should address underlying risk factors such as poor glycemic control, vitamin B12 deficiency, elevated blood pressure, and obesity to reduce the likelihood of developing neuropathy. First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, am...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Scott Bragg Sarah Tucker Marrison Sean Haley Source Type: research
Antinociceptive effect of LMH-2, a new sigma-1 receptor antagonist analog of haloperidol, on the neuropathic pain of diabetic mice
This study evaluates the antiallodynic and antihyperalgesic effects of LMH-2, a new haloperidol (HAL) analog that acts as sigma-1 receptor (σ1 R) antagonist, in diabetic mice using a model of neuropathic pain induced by chronic hyperglycemia. Additionally, we compared its effects with those of HAL. Hyperglycemia was induced in mice by nicotinamide-streptozotocin administration (NA-STZ, 50-130 mg/kg). Four weeks later, mechanical allodynia was assessed using the up-down method, and hyperalgesia was evoked with formalin 0.5%. We evaluated antiallodynic and antihyperalgesic effects of LMH-2 (5.6-56.2 mg/kg), HAL (0.018-0.18 ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 4, 2024 Category: Drugs & Pharmacology Authors: Rosa Ventura-Mart ínez Guadalupe Esther Ángeles-López Diana Gonz ález-Ugalde Tania Dom ínguez-Páez Gabriel Navarrete-V ázquez Ruth Jaimez Myrna D éciga-Campos Source Type: research
Diabetic Peripheral Neuropathy: Prevention and Treatment
Am Fam Physician. 2024 Mar;109(3):226-232.ABSTRACTDiabetic peripheral neuropathy occurs in up to 50% of patients with diabetes mellitus and increases the risk of diabetic foot ulcers and infections. Consistent screening and clear communication are essential to decrease disparities in assessment of neuropathic symptoms and diagnosis. Physicians should address underlying risk factors such as poor glycemic control, vitamin B12 deficiency, elevated blood pressure, and obesity to reduce the likelihood of developing neuropathy. First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, am...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Scott Bragg Sarah Tucker Marrison Sean Haley Source Type: research
Diabetic Peripheral Neuropathy: Prevention and Treatment
Am Fam Physician. 2024 Mar;109(3):226-232.ABSTRACTDiabetic peripheral neuropathy occurs in up to 50% of patients with diabetes mellitus and increases the risk of diabetic foot ulcers and infections. Consistent screening and clear communication are essential to decrease disparities in assessment of neuropathic symptoms and diagnosis. Physicians should address underlying risk factors such as poor glycemic control, vitamin B12 deficiency, elevated blood pressure, and obesity to reduce the likelihood of developing neuropathy. First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, am...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Scott Bragg Sarah Tucker Marrison Sean Haley Source Type: research
Diabetic Peripheral Neuropathy: Prevention and Treatment
Am Fam Physician. 2024 Mar;109(3):226-232.ABSTRACTDiabetic peripheral neuropathy occurs in up to 50% of patients with diabetes mellitus and increases the risk of diabetic foot ulcers and infections. Consistent screening and clear communication are essential to decrease disparities in assessment of neuropathic symptoms and diagnosis. Physicians should address underlying risk factors such as poor glycemic control, vitamin B12 deficiency, elevated blood pressure, and obesity to reduce the likelihood of developing neuropathy. First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, am...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Scott Bragg Sarah Tucker Marrison Sean Haley Source Type: research
Diabetic Peripheral Neuropathy: Prevention and Treatment
Am Fam Physician. 2024 Mar;109(3):226-232.ABSTRACTDiabetic peripheral neuropathy occurs in up to 50% of patients with diabetes mellitus and increases the risk of diabetic foot ulcers and infections. Consistent screening and clear communication are essential to decrease disparities in assessment of neuropathic symptoms and diagnosis. Physicians should address underlying risk factors such as poor glycemic control, vitamin B12 deficiency, elevated blood pressure, and obesity to reduce the likelihood of developing neuropathy. First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, am...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Scott Bragg Sarah Tucker Marrison Sean Haley Source Type: research
Diabetic Peripheral Neuropathy: Prevention and Treatment
Am Fam Physician. 2024 Mar;109(3):226-232.ABSTRACTDiabetic peripheral neuropathy occurs in up to 50% of patients with diabetes mellitus and increases the risk of diabetic foot ulcers and infections. Consistent screening and clear communication are essential to decrease disparities in assessment of neuropathic symptoms and diagnosis. Physicians should address underlying risk factors such as poor glycemic control, vitamin B12 deficiency, elevated blood pressure, and obesity to reduce the likelihood of developing neuropathy. First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, am...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Scott Bragg Sarah Tucker Marrison Sean Haley Source Type: research
Diabetic Peripheral Neuropathy: Prevention and Treatment
Am Fam Physician. 2024 Mar;109(3):226-232.ABSTRACTDiabetic peripheral neuropathy occurs in up to 50% of patients with diabetes mellitus and increases the risk of diabetic foot ulcers and infections. Consistent screening and clear communication are essential to decrease disparities in assessment of neuropathic symptoms and diagnosis. Physicians should address underlying risk factors such as poor glycemic control, vitamin B12 deficiency, elevated blood pressure, and obesity to reduce the likelihood of developing neuropathy. First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, am...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Scott Bragg Sarah Tucker Marrison Sean Haley Source Type: research
Diabetic Peripheral Neuropathy: Prevention and Treatment
Am Fam Physician. 2024 Mar;109(3):226-232.ABSTRACTDiabetic peripheral neuropathy occurs in up to 50% of patients with diabetes mellitus and increases the risk of diabetic foot ulcers and infections. Consistent screening and clear communication are essential to decrease disparities in assessment of neuropathic symptoms and diagnosis. Physicians should address underlying risk factors such as poor glycemic control, vitamin B12 deficiency, elevated blood pressure, and obesity to reduce the likelihood of developing neuropathy. First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, am...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Scott Bragg Sarah Tucker Marrison Sean Haley Source Type: research
Diabetic Peripheral Neuropathy: Prevention and Treatment
Am Fam Physician. 2024 Mar;109(3):226-232.ABSTRACTDiabetic peripheral neuropathy occurs in up to 50% of patients with diabetes mellitus and increases the risk of diabetic foot ulcers and infections. Consistent screening and clear communication are essential to decrease disparities in assessment of neuropathic symptoms and diagnosis. Physicians should address underlying risk factors such as poor glycemic control, vitamin B12 deficiency, elevated blood pressure, and obesity to reduce the likelihood of developing neuropathy. First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, am...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Scott Bragg Sarah Tucker Marrison Sean Haley Source Type: research
Diabetic Peripheral Neuropathy: Prevention and Treatment
Am Fam Physician. 2024 Mar;109(3):226-232.ABSTRACTDiabetic peripheral neuropathy occurs in up to 50% of patients with diabetes mellitus and increases the risk of diabetic foot ulcers and infections. Consistent screening and clear communication are essential to decrease disparities in assessment of neuropathic symptoms and diagnosis. Physicians should address underlying risk factors such as poor glycemic control, vitamin B12 deficiency, elevated blood pressure, and obesity to reduce the likelihood of developing neuropathy. First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, am...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Scott Bragg Sarah Tucker Marrison Sean Haley Source Type: research
Peripheral Nerve Stimulation for a Refractory Case of Postherpetic Neuralgia in the Upper Limb: A Case Report
This report presents a patient with upper limb PHN who responded to peripheral nerve stimulation (PNS) after he failed to obtain sufficient pain relief with conservative management.PMID:38558725 | PMC:PMC10979704 | DOI:10.7759/cureus.55168 (Source: Herpes)
Source: Herpes - April 1, 2024 Category: Infectious Diseases Authors: Arun Kalava Simeon V Mihaylov Harriet Kaye Austin Saru Acharya Source Type: research
Application of non-lethal bioSPME-LC-MS/MS for the detection of human pharmaceuticals in soft corals: A survey at the North Nilandhe atoll (Maldives)
Chemosphere. 2024 Mar 28:141781. doi: 10.1016/j.chemosphere.2024.141781. Online ahead of print.ABSTRACTAt present the information regarding the occurrence of human pharmaceuticals (PhaCs) in coral reefs and their potential impacts on the associated fauna is limited. To optimize the collection of data in these delicate environments, we employed a solid-phase microextraction (bioSPME) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) procedure that enabled in vivo determinations in soft corals. Specifically, we researched the antibiotics Ofloxacin Sulfamethoxazole and Clarithromycin, the anti-inflammat...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Alessandro Becchi Marco Mantovani Marina Lasagni Elena Collina Simone Montano Paolo Galli Francesco Saliu Source Type: research
Application of non-lethal bioSPME-LC-MS/MS for the detection of human pharmaceuticals in soft corals: A survey at the North Nilandhe atoll (Maldives)
Chemosphere. 2024 Mar 28:141781. doi: 10.1016/j.chemosphere.2024.141781. Online ahead of print.ABSTRACTAt present the information regarding the occurrence of human pharmaceuticals (PhaCs) in coral reefs and their potential impacts on the associated fauna is limited. To optimize the collection of data in these delicate environments, we employed a solid-phase microextraction (bioSPME) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) procedure that enabled in vivo determinations in soft corals. Specifically, we researched the antibiotics Ofloxacin Sulfamethoxazole and Clarithromycin, the anti-inflammat...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Alessandro Becchi Marco Mantovani Marina Lasagni Elena Collina Simone Montano Paolo Galli Francesco Saliu Source Type: research
Application of non-lethal bioSPME-LC-MS/MS for the detection of human pharmaceuticals in soft corals: A survey at the North Nilandhe atoll (Maldives)
Chemosphere. 2024 Mar 28:141781. doi: 10.1016/j.chemosphere.2024.141781. Online ahead of print.ABSTRACTAt present the information regarding the occurrence of human pharmaceuticals (PhaCs) in coral reefs and their potential impacts on the associated fauna is limited. To optimize the collection of data in these delicate environments, we employed a solid-phase microextraction (bioSPME) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) procedure that enabled in vivo determinations in soft corals. Specifically, we researched the antibiotics Ofloxacin Sulfamethoxazole and Clarithromycin, the anti-inflammat...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Alessandro Becchi Marco Mantovani Marina Lasagni Elena Collina Simone Montano Paolo Galli Francesco Saliu Source Type: research
