Effects of Gabapentin on Postoperative Pain and Opioid Consumption Following Laparoscopic Cholecystectomy: A Systematic Review and Meta-analysis
CONCLUSIONS: Gabapentin can be added as part of the multimodal pain management for patients undergoing laparoscopic cholecystectomy. Extrapolation of these findings to clinical settings must take into consideration the limitations identified in this review.PMID:37855760 | DOI:10.1016/j.jopan.2023.06.005 (Source: Journal of Perianesthesia Nursing)
Source: Journal of Perianesthesia Nursing - October 19, 2023 Category: Nursing Authors: Katherine A Froehlich Zeus G Deleon Tito D Tubog Source Type: research
Comparative Descriptive Analysis of Physician Versus Patient-Directed Gabapentin Usage In Chronic Pain - A Preliminary Report
CONCLUSIONS: This pilot study suggests that a significant portion of patients choose to administer variable doses of gabapentin and associate this with better efficacy and satisfaction. A larger study is needed to confirm this supposition. Based upon this pilot study, the variable dosing option may be an option for improved therapeutic efficacy or as an alternative to those whose lifestyles do not allow for fixed dosing regimens. Discussion of the risks of gabapentin, including respiratory depression, and clear dosage parameters of use, would need to be outlined when considering a variable dose regimen.PMID:37847922 (Source: Pain Physician)
Source: Pain Physician - October 17, 2023 Category: Anesthesiology Authors: Qing Zhao Ruan Christopher L Robinson Thomas T Simopoulos James C Burns Sravya V Madabhushi Jatinder S Gill Source Type: research
5,7-Dimethoxycoumarin ameliorates vincristine induced neuropathic pain: potential role of 5HT3 receptors and monoamines
This study was designed to investigate the possible analgesic and antiallodynic effects of 5,7-DMC in a murine model of VINP. Vincristine was administered to groups of BALB/c male mice (0.1 mg/kg intraperitoneally) once daily for 14 days to induce VINP. Thermal hyperalgesia and mechanical allodynia were quantified using the tail immersion test and von Frey filament application method. The levels of monoamine neurotransmitters and vitamin C in frontal cortical, striatal and hippocampal tissues, as well as the TNF-α level in plasma, were quantified using high performance liquid chromatography and ELISA respectively. On da...
Source: Frontiers in Pharmacology - October 17, 2023 Category: Drugs & Pharmacology Source Type: research
Effects of Gabapentin on Postoperative Pain and Opioid Consumption Following Laparoscopic Cholecystectomy: A Systematic Review and Meta-analysis
Examine the efficacy of gabapentin on postoperative pain scores and opioid consumption in laparoscopic cholecystectomy. (Source: Journal of PeriAnesthesia Nursing)
Source: Journal of PeriAnesthesia Nursing - October 17, 2023 Category: Nursing Authors: Katherine A. Froehlich, Zeus G. Deleon, Tito D. Tubog Tags: Review Source Type: research
Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial
Peripheral neuropathy is not only the most prevalent consequence of diabetes but also the main reason for foot ulceration, disability, and amputation. Therefore, the current study aims to determine the effecti... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - October 16, 2023 Category: Endocrinology Authors: Sajad Hassanzadeh, Soraya Bagheri, Seyed Majid Ahmadi, Seyed Ahmadreza Ahmadi, Isaac Moradishibany, Hosein Dolatkhah and Sajjad Reisi Tags: Research Source Type: research
Dose rationale for gabapentin and tramadol in pediatric patients with chronic pain
Exposure-guided dose rationale for gabapentin and tramadol in pediatric chronic pain. Upper panels: Simulated concentration versus time profiles of gabapentin (A) and tramadol (B) on the last day of each titration step. Data are shown stratified by weight band for gabapentin. Solid line shows the median, shaded area indicates the 95% confidence interval. Lower panels: Whisker-box plots showing the predicted AUC for gabapentin (C) and predicted AUC for tramadol (D) for each titration step. Gabapentin results are compared to the observed AUC values after doses of 1.2 –3.6 g to adult subjects. Dotted red line shows the pu...
Source: Pharmacology Research and Perspectives - October 10, 2023 Category: Drugs & Pharmacology Authors: Paul Healy,
Luka Verrest,
Mariagrazia Felisi,
Adriana Ceci,
Oscar Della Pasqua,
GAPP Consortium,
Corinne Alberti,
Donato Bonifazi,
Adriana Ceci,
Thomas G. de Leeuw,
Saskia N. de Wildt,
Mariagrazia Felisi,
Florentia Kaguelidou,
Enora Le Roux Tags: ORIGINAL ARTICLE Source Type: research
Using pharmacotherapy to address sleep disturbances in autism spectrum disorders
Expert Rev Neurother. 2023 Oct 9. doi: 10.1080/14737175.2023.2267761. Online ahead of print.ABSTRACTINTRODUCTION: Sleep disorders are the second most common medical comorbidity in autism spectrum disorder (ASD), with effects on daytime behavior and functioning, mood and anxiety, and autism core features. In children with ASD, insomnia has also a negative impact on the whole family quality of life. Therefore, treatment of sleep disturbances should be considered as a primary goal in the management of ASD patients, and it is important to clarify the scientific evidence to inappropriate treatments.AREAS COVERED: The authors re...
Source: Expert Review of Neurotherapeutics - October 9, 2023 Category: Neurology Authors: Valeria Mammarella Silvia Orecchio Noemi Cameli Sara Occhipinti Lavinia Marcucci Giuliano De Meo Alice Innocenti Raffaele Ferri Oliviero Bruni Source Type: research
Using pharmacotherapy to address sleep disturbances in autism spectrum disorders
Expert Rev Neurother. 2023 Oct 9:1-16. doi: 10.1080/14737175.2023.2267761. Online ahead of print.ABSTRACTINTRODUCTION: Sleep disorders are the second most common medical comorbidity in autism spectrum disorder (ASD), with effects on daytime behavior and functioning, mood and anxiety, and autism core features. In children with ASD, insomnia also has a negative impact on the whole family's quality of life. Therefore, treatment of sleep disturbances should be considered as a primary goal in the management of ASD patients, and it is important to clarify the scientific evidence to inappropriate treatments.AREAS COVERED: The aut...
Source: Expert Review of Neurotherapeutics - October 9, 2023 Category: Neurology Authors: Valeria Mammarella Silvia Orecchio Noemi Cameli Sara Occhipinti Lavinia Marcucci Giuliano De Meo Alice Innocenti Raffaele Ferri Oliviero Bruni Source Type: research
