Cellular Senescence in Neurodegenerative Conditions
This open access review paper covers the high points of what is presently known of the contribution of senescent cells to neurodegenerative conditions. Somatic cells become senescent throughout life, largely as they reach the Hayflick limit to replication, but also due to damage or a toxic local environment. Senescent cells halt replication and begin to secrete pro-inflammatory signals to attract the immune system. In youth, senescent cells are rapidly cleared by programmed cell death or by immune cells. With age, the immune system becomes less efficient. As a consequence senescent cells begin to accumulate, and they help ...
Source: Fight Aging! - April 30, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Presence of Cardiometabolic Disease Correlates with Accelerated Brain Aging
It is well known that metabolic dysfunction and cardiovascular disease correlate well with an accelerated onset and progression of neurodegenerative conditions. This is particularly evident when considering these conditions in the context of obesity. Age-related diseases are the late stage consequences of a progressive accumulation of cell and tissue damage, and so a lifestyle that accelerates those underlying damage processes will produce a greater incidence of all of the common age-related diseases. Suffering from one form of age-related disease thus implies greater odds of suffering other forms of age-related disease, a...
Source: Fight Aging! - April 29, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Progressive Failure of Glucose Regulation in the Aging Brain
There has long been a school of thought on Alzheimer's disease that consideres it a form of diabetes, in which dysregulated glucose metabolism features prominently. This dysregulation certainly occurs; the study noted here isn't the only one to show that the aging brain no longer manages glucose adequately. The question is whether this mechanism is important relative to all of the other processes thought to contribute to the pathology of Alzheimer's disease and other neurodegenerative conditions, and where it fits in a chain of cause and consequence. Finding ways to demonstrate the relative importance of different mechanis...
Source: Fight Aging! - April 29, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 29th 2024
In conclusion, we assigned stemness scores to human samples and show evidence of a pan-tissue loss of stemness during human aging, which adds weight to the idea that stem cell deterioration may contribute to human aging.
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The Role of Immune Aging in Neurodegenerative Conditions
https://www.fightaging.org/archives/2024/04/the-role-of-immune-aging-in-neurodegenerative-conditions/
The research community has come to see chronic inflammation and other age-related immune system dysfunctions as an important aspect of neurodegenerative conditions. Inflammation in the short term is n...
Source: Fight Aging! - April 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Alzheimer ’ s agony: a son ’ s vow to never endure
An excerpt from Winter’s End: Dementia and Dying Well. Are there really fates worse than death? Like most people, Dan Winter was uncertain. That is until he visited his father at a memory care unit in Lawrence, Kansas. Dan’s father had been diagnosed with Alzheimer’s disease at the age of 70. Winton “Wint” Allen Winter
Read more…
Alzheimer’s agony: a son’s vow to never endure originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 28, 2024 Category: General Medicine Authors: Lewis Cohen, MD Tags: Conditions Neurology Source Type: blogs
Day Time Sleepiness Triples Risk of Heart Failure!
Daytime sleepiness is not that uncommon. There are many who fall asleep while at work or while reading. Wait before taking it so lightly. It may mean something more sinister.
The Sleep Heart Health Study found that obstructive sleep apnea with excessive daytime sleepiness triples the chance of heart failure and doubles the risk of a heart disease event.
Obstructive sleep apnea known in short as OSA is transient stoppage of breathing while sleeping due to obstruction of the upper air passages. The obstruction is manifest as noisy breathing or snoring. Poor quality of sleep at night leads to daytime sleepiness.
The Sleep Hea...
Source: Cardiophile MD - April 27, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Sick Sinus Syndrome
Sinus node is the natural pacemaker of the heart which gives out regular electrical pulses to produce each heartbeat. When it is diseased, this function is defective and called sick sinus syndrome.
Sinus node, known in short as SA node, is situated in the right upper part of the heart. Normally it gives out 60 to 100 pulses per minute so that heart beats at the same rate. When you exercise or are having a stress, the rate increases gradually.
When the sinus node stops functioning, it can manifest as a long pause in the ECG, the recording of the electrical activity of the heart.
Just as the next senior person takes charge i...
Source: Cardiophile MD - April 26, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Over-diagnosing MI is not* as negligent as missing it!
As the medical literature expands exponentially, the quality and intent of the research questions sound awry. There are only a handful of journals like JAMA that are bold enough to ask some tough and pragmatic questions in this glitzy world of medical extravaganza.
The current issue wants to set the pace for an important debate, on a topic that is rarely discussed.
The question is
Link to the article
Check whether your answers concur with this crucial query from Harvard Medical School and Massachusetts General Hospital. Three questions this article wishes to address.
1.What is the reason it is happening?...
Source: Dr.S.Venkatesan MD - April 25, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized acc aha esc guidlines dilemma in cardiology drsvenkatesan ethics in medicine high senstivity troponins jama network nstemi pci Source Type: blogs
Over-diagnosing MI is not* as negligent as missing it !
As the medical literature expands exponentially, the quality and intent of the research questions sound awry. There are only a handful of journals like JAMA that are bold enough to ask some tough and pragmatic questions in this glitzy world of medical extravaganza.
The current issue wants to set the pace for an important debate, on a topic that is rarely discussed.
The question is
Link to the article
Check whether your answers concur with this crucial query from Harvard Medical School and Massachusetts General Hospital. Three questions this article wishes to address.
1.What is the reason it is happening?...
Source: Dr.S.Venkatesan MD - April 25, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized acc aha esc guidlines dilemma in cardiology drsvenkatesan ethics in medicine high senstivity troponins jama network nstemi pci Source Type: blogs
Reviewing Approaches to Improving Aged Stem Cell Function
A variety of approaches show some promise in improving the function of stem cells in aged tissues. Stem cell populations support their tissue by providing a supply of daughter somatic cells to replace losses. This supply diminishes over time as stem cells reduce their activity for reasons that descend from the known root causes of aging, but which are not fully understood in detail. To the degree that reduced stem cell function is a response to the aged environment rather than a consequence of damage inherent to these cells, then it is useful to find ways to force stem cells to be more active. Whether this is the case may ...
Source: Fight Aging! - April 24, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Leveraging AI to Address the Mental Health Crisis
The following is a guest article by Raj Tumuluri, Founder and CEO at Openstream.ai
As healthcare providers, you are acutely aware of the staggering mental health challenges facing our societies today. Depression, anxiety, PTSD, and suicidal ideation have reached pandemic levels, exacerbated by the relentless pace of modern life. From the general population to students in high-stress environments and frontline workers, a severe shortage of clinical personnel has created harrowing bottlenecks in accessing timely mental health evaluations and care.
The weight of this crisis calls for innovative solutions that can simultaneous...
Source: EMR and HIPAA - April 24, 2024 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Health IT Company Healthcare IT AI Avatars Behaviorial Health AI CAI Conversational AI Conversational Artificial Intelligence Healthcare AI mental health Mental Health AI Mental Health Crisis Openstream.ai Raj Source Type: blogs
The Role of Immune Aging in Neurodegenerative Conditions
The research community has come to see chronic inflammation and other age-related immune system dysfunctions as an important aspect of neurodegenerative conditions. Inflammation in the short term is necessary for defense against pathogens and regeneration following injury. Unresolved, constant inflammation is harmful to tissue structure and function, however, changing cell behavior for the worse. In brain tissue, the effects of inflammatory signaling on the behavior of innate immune cells called microglia appears particularly important. Neurogenerative conditions are characterized by activated microglia. These microglia ar...
Source: Fight Aging! - April 23, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What The Decade Of Your Birth Reveals About Your Brain Size (M)
The decade you were born in may shape not just your life, but your brain size and dementia risk. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 23, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Neuroscience subscribers-only Source Type: blogs
How Significant is First Degree Heart Block?
First degree heart block is an abnormality in the electrical conduction of the heart noted on the ECG, the recording of the electrical activity of the heart. It is not a block in the blood vessels of the heart which we are more familiar with. The waves on an ECG are P, QRS complex and the T wave.
Normal interval between the onset of the P wave and the onset of QRS complex is up to one fifth of a second (0.2 seconds). When this interval is increased, it is called first degree heart block or first degree atrioventricular or AV block to be specific. Atria are the upper chambers of the heart and ventricles the lower chambers.
...
Source: Cardiophile MD - April 23, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Ambitious Goals at Mitrix Bio
Mitrix Bio is one of the companies developing the means to produce large amounts of mitochondria for transplantation. Cells will take up new mitochondria from the surrounding environment, and mitochondria can be harvested from cell cultures. Mitochondrial function declines with age, the result of (a) gene expression changes in the cell nucleus that alter mitochondrial dynamics and the quality control process of mitophagy, and (b) damage to mitochondrial DNA. Evidence from animal studies suggests that replacing mitochondria in aged tissues produces benefits to health and organ function that last for long enough to be intere...
Source: Fight Aging! - April 23, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
