How can Warfarin be safe “ even in ” first trimester of pregnancy ? The story behind the 5 mg cut-off !
The well known pro-coagulant state of pregnancy is an evolutionary protective process to make blood clot quicker, to save fetal loss in early pregnancy and mitigate postpartum bleeding. Still, in many women, this natural adaptive process confers an enhanced thrombotic risk. The molecular mechanisms for this pro-coagulant state are, there is increased factor VII, fibrinogen, reduced protein S. It is interesting to note, while plasminogen levels are elevated, D-dimer is also increased, indicating an ongoing fight between pro & anticoagulant forces, converting the physiological maternal- placental bed a mini harmless DIC ...
Source: Dr.S.Venkatesan MD - March 20, 2024 Category: Cardiology Authors: dr s venkatesan Tags: cardiology -pregnancy Pregnancy and heart pregnancy and heart disease Uncategorized carpreg registry zahara esc acc guidelines on pregnancy and heart disease first trmestr use of oac warfarin heparin switch over lmwh bridge in pregnancy Source Type: blogs
Comprehension of Miranda Warnings In Adults with Chronic, Moderate-Severe Traumatic Brain Injury
Jade Mitchell (Vanderbilt University), Malcolm Edwards (College of William& Mary), Kimberly Walsh (Vanderbilt University), Sarah Brown-Schmidt (Vanderbilt University), et al., Comprehension of Miranda Warnings In Adults with Chronic, Moderate-Severe Traumatic Brain Injury (2024): Introduction: To compare comprehension of Miranda... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - March 20, 2024 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Mitochondrial Dysfunction in the Aging of the Brain
Mitochondria are the power plants of the cell, primarily responsible for packaging adenosine triphosphate (ATP) molecules as chemical energy stores for use throughout the cell. Hundreds of mitochondria swarm inside every cell, the descendants of ancient symbiotic bacteria. These organelles retain many features characteristic of bacteria. For example, mitochondria contain a small circular genome, depleted of genes that have moved into the cell nucleus over evolutionary time. Mitochondria also constantly divide, fuse together, and swap component parts. Mitochondrial quality is controlled by the processes of mitophagy that re...
Source: Fight Aging! - March 19, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Cognitive Decline Is A Myth: The Real Reason Names Are Harder To Recall With Age
A steady decline? Experts question whether the human brain really slows down with age. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 19, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Source Type: blogs
Microplastics, Major Problem
By KIM BELLARD
It’s been almost four years since I first wrote about microplastics; long story short, they’re everywhere. In the ground, in the oceans (even at the very bottom), in the atmosphere. More to the point, they’re in the air you breathe and in the food you eat. They’re in you, and no one thinks that is a good thing. But we’re only starting to understand the harm they cause.
The Washington Post recently reported:
Scientists have found microplastics — or their tinier cousins, nanoplastics — embedded in the human placenta, in blood, in the heart and in the liver and bowels. In one re...
Source: The Health Care Blog - March 19, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Kim Bellard Microplastics Source Type: blogs
Towards a Better Understanding of the Role of the Gut Microbiome in Alzheimer's Disease
This article summarizes research presented at the virtual symposium and workshop, "New Approaches for Understanding the Potential Role of Microbes in Alzheimer's Disease." The objective of these events was to review the evidence base and catalyze research to address knowledge gaps in the hypothesis that infections or microbes play some causative role in the development or progression of Alzheimer's disease. Alzheimer's disease is a complex disease; this symposium was rooted in an understanding that its pathogenesis could be triggered by both microbe-dependent and microbe-independent pathways and the two are not mutually ex...
Source: Fight Aging! - March 15, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Efforts to Produce Drugs to Slow or Reverse Sarcopenia Benefit from the Semaglutide Hype
This popular science article is a reminder that all too little in this world happens for entirely rational reasons. Drugs aimed at slowing or reversing the age-related loss of muscle mass leading to sarcopenia are presently under development by a number of companies, though none of the candidates discussed are producing effect sizes that look very favorable in comparison to the effects of resistance exercise. These efforts will likely benefit from the present manufactured hype that attends the use of antidiabetic GLP1 receptor agonists for weight loss, as one of the side-effects of this drug is modest loss of muscle mass. ...
Source: Fight Aging! - March 15, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
This Fun Activity Does More For Your Brain Than Simple Exercise (M)
The activity has a surprising cognitive edge over other types of workout. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 14, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Exercise subscribers-only Source Type: blogs
Is the Aging Hippocampus Particularly Vulnerable to Blood-Brain Barrier Dysfunction?
The hippocampus in the brain is vital to cognitive functions involving learning and memory. In today's open access paper, researchers review the evidence for the hippocampus to be particularly vulnerable to damaging mechanisms, including those involved in aging. It is tentatively suggested that physiological and biochemical differences in the hippocampus point to a greater fragility of the hippocampal blood-brain barrier as a common thread underlying pathological changes observed in aging and Alzheimer's disease. The blood-brain barrier is a specialized layer of cells that wrap blood vessels passing through the central ner...
Source: Fight Aging! - March 13, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Metformin and Galantamine Combination Modestly Improves Sarcopenia Symptoms
Therapies that reuse existing drugs with sizable bodies of human data tend to move more rapidly to the clinic than is the case for better, more ambitious approaches that break new ground. Greater speed in reaching the clinic means a lower cost of development, and this economic incentive is why so much of clinical development consists of drug reuse and only modestly effective therapies. In the case of sarcopenia, the age-related loss of muscle mass and strength, sizable funding is presently devoted to the development of small molecule therapies that do not produce greater gains than resistance exercise. A good deal of what ...
Source: Fight Aging! - March 13, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Unlock Your Brain ’ s Hidden Potential With This Simple Nature Hack (M)
The wisdom of naturalists like Thoreau validated by science as researchers unveil the mental benefits of nature immersion. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 10, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Attention subscribers-only Source Type: blogs
Bonus Features – March 10, 2024 – Only 36% of CEOs have assessed how to govern the risks of AI, Emory Healthcare is deploying Epic on MacBook Air, plus 27 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News
The Biden Cancer Moonshot is advancing a recommended minimum set of key cancer-related data elements under USCDI+ Cancer, a subset of United States Core Data for Interoperability.
Atlanta’s Emory Healthcare is deploy...
Source: EMR and HIPAA - March 10, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Alayacare Amwell Apple Vision Pro Cancer Moonshot CCS CHG Healthcare ClearDATA Dr. Geeta Nayyar Emory Healthcare Epic Hyperspace Ernst & Young eXeX Experis FDB FertilAI Google Cloud Healthcare IT Today Bonus Source Type: blogs
Fight Aging! Newsletter, March 11th 2024
In conclusion, this Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process.
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Considering the Mechanisms of Vascular Calcification
https://www.fightaging.org/archives/2024/03/considering-the-mechanisms-of-vascular-calcification/
Harmful calcification of structures in the cardiovascular system proceeds alongside the development of the fatty lesions of atherosclerosis. Both disease processes are accelerated by chronic inflammation, but d...
Source: Fight Aging! - March 10, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Elon Musk ’ s Neuralink aims to empower disabled with brain implants
As of January 29th, the Elon Musk startup Neuralink delivered its first brain implant to a human. As described in initial reports, the patient seems to be doing well and is already benefiting from increased interneuronal communication. The goal of this application is to empower those with disabilities, specifically those with sensory and motor deficits,
Read more…
Elon Musk’s Neuralink aims to empower disabled with brain implants originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 9, 2024 Category: General Medicine Authors: Shalini Yagnik and Tejas Sekhar Tags: Tech Health IT Source Type: blogs
Integrating Ambient Clinical Voice Technology – The Impacts, Challenges, and Benefits
In a time where burnout is at an all-time high, any solution that can help lessen the workload burden of our clinicians is worth looking into. One such solution is ambient clinical voice. Integrating this solution into your organization can save your clinicians a lot of time through documentation automation. However, integrating a new technology will affect all areas of your organization, and with all new technologies, there are always pros and cons to be aware of before jumping.
So in order to help you get a deeper look at what integrating ambient clinical voice into your organization will look like – what it will i...
Source: EMR and HIPAA - March 9, 2024 Category: Information Technology Authors: Grayson Miller Tags: AI/Machine Learning Ambulatory Clinical Communication and Patient Experience EMR-EHR Health IT Company Healthcare IT Hospital - Health System LTPAC 3M Health Information Systems ACI ACV Ambient Clinical Intelligence Ambient Clini Source Type: blogs
