Fight Aging! Newsletter, December 25th 2023
This study generates a comprehensive single-cell transcriptomic atlas of human atherosclerosis including 118,578 high-quality cells from atherosclerotic coronary and carotid arteries. By performing systematic benchmarking of integration methods, we mitigated data overcorrection while separating major cell lineages. Notably, we define cell subtypes that have not been previously identified from individual human atherosclerosis scRNA-seq studies. Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome...
Source: Fight Aging! - December 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Mineralocorticoid Receptors: MCQ
Mineralocorticoid Receptors are found in all of the following, Except? [1] A. Liver B. Colon C. Hippocampus D. Kidney Correct answer : A. Liver Mineralocorticoid receptors are found in sodium transporting epithelia like that in kidney and colon as well as in nonepithelial tissues like heart and brain [2]. They also have high affinity for glucocorticoids [3]. Aldosterone promotes myocardial fibroblast proliferation and has a role in myocardial fibrosis. This accounts for the beneficial antifibrotic effect of mineralocorticoid receptor antagonists when used in the management of heart failure [4]. References https://pgblaze...
Source: Cardiophile MD - December 24, 2023 Category: Cardiology Authors: Johnson Francis Tags: Medicine MCQ - CVS Source Type: blogs

Concerted Effort to Define Responsible Use of AI in Healthcare is Sorely Needed
The following is a guest article by Amy Hester, PhD, RN, BC, FAAN, Chairwoman and CEO at HD Nursing The growing use of artificial intelligence (AI) across a number of industries, particularly in healthcare, has shown both great promise as well as cause for alarm.  A perfect example of not only misusing AI, but also continuing to use a model to make decisions affecting individual care that can be error-prone involves a recent class-action lawsuit filed against one of the nation’s largest health plans and its subsidiary.  Both companies stand accused of illegally using an algorithm to deny rehabilitation care to seriousl...
Source: EMR and HIPAA - December 22, 2023 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Regulations Artificial Intelligence Dr. Amy Hester Ethical AI HD Nursing Healthcare AI Healthcare Automation responsible AI Source Type: blogs

Sizes of Immune Cell Subsets Correlate with Human Mortality
In this study, we found that T cells and natural killer (NK) cells with low expression of CD56 were inversely associated with mortality while neutrophils were positively associated with mortality. In addition, we found myeloid dendritic cells to be nominally associated with a reduced odds of mortality, and CD4+ effector memory T cells and IgD- memory B cells to be nominally associated with increased mortality odds. Several previous studies have shown a positive association between neutrophils and mortality and our study confirmed these previous findings. The number of neutrophils are preserved in older adults though...
Source: Fight Aging! - December 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Nectandrin B Extends Life in Flies
In this study, we present evidence that Nectandrin B (NecB), a bioactive lignan compound isolated from nutmeg, significantly extended the lifespan of the fruit fly Drosophila melanogaster by as much as 42.6% compared to the control group. NecB also improved age-related symptoms including locomotive deterioration, body weight gain, eye degeneration, and neurodegeneration in aging D. melanogaster. This result represents the most substantial improvement in lifespan observed in animal experiments to date, suggesting that NecB may hold promise as a potential therapeutic agent for promoting longevity and addressing age-related d...
Source: Fight Aging! - December 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Lifelong learning: a game-changer in diagnosing dizziness
The eyes can’t see what the mind doesn’t yet know – an axiom to remind us not just of the value of lifelong learning, but that the answers are often in the exam room with us. Though bright and committed clinical people we may be, we’re dragged by the tendrils of a lumbering behemoth. American Read more… Lifelong learning: a game-changer in diagnosing dizziness originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 21, 2023 Category: General Medicine Authors: Tags: Conditions Neurology Source Type: blogs

The Brain Can Adapt To Injury — But Not By ‘ Rewiring ’ Itself (M)
Adapting to brain injury requires a lot of hard work, repetition and training. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - December 21, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Neuroscience subscribers-only Source Type: blogs

Please help us shape SharpBrains books, activities and services
Dear SharpBrains reader and friend, please take a few minutes to provide your feedback as we’re preparing a substantial update of The SharpBrains Guide to Brain Fitness and our overall activities.   Take Survey HERE   Happy Holidays and Let’s Have a Great 2024! The post Please help us shape SharpBrains books, activities and services appeared first on SharpBrains. (Source: SharpBrains)
Source: SharpBrains - December 21, 2023 Category: Neuroscience Authors: Alvaro Fernandez Tags: Uncategorized Source Type: blogs

Please help us shape SharpBrains books, activities and services
Dear SharpBrains reader and friend, please take a few minutes to provide your feedback as we’re preparing a substantial update of The SharpBrains Guide to Brain Fitness and our overall activities.   Take Survey Here The post Please help us shape SharpBrains books, activities and services appeared first on SharpBrains. (Source: SharpBrains)
Source: SharpBrains - December 21, 2023 Category: Neuroscience Authors: Alvaro Fernandez Tags: Brain/ Mental Health Education & Lifelong Learning Source Type: blogs

Inflammaging in the Inner Ear, a Path to Hearing Loss
Inflammaging is a blanket term for the inappropriate inflammatory reaction of the immune system to the accumulation of molecular damage and other changes that take place with age. Constant, low-grade, unresolved inflammatory activation of the immune system is a feature of aging. It alters cell behavior for the worse and is disruptive to tissue structure and function. A number of different mechanisms contribute to forming and maintaining the state of inflammaging, such as pro-inflammatory signaling produced by ever-larger numbers of senescent cells, and innate immune recognition of mislocalized mitochondrial DNA that result...
Source: Fight Aging! - December 20, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Seeking Success in Science Through NIH-Funded Training
Credit: Courtesy of Hasset Nurelegne. “What’s great about a career in research is that there are so many paths you can take. I get so excited for the future when I think about all the open doors ahead of me,” says Hasset Nurelegne, a senior at Emory University in Atlanta, Georgia. Hasset is majoring in neuroscience and behavioral biology (NBB) as well as English. Since her first year on campus, Hasset has been an active participant in an NIGMS-funded program at Emory that aims to develop a diverse pool of scientists, the Initiative for Maximizing Student Development (IMSD) (which is now just for graduate student...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 20, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Training Source Type: blogs

Targeting siRNA to Microglia to Suppress PU.1 Expression and Reduce Neuroinflammation
Researchers here report on their development of a means to target microglia in the brain with small interfering RNA (siRNA) to reduce PU.1 protein expression. PU.1 is implicated in the regulation of inflammation in microglia, and a number of groups are attempting to produce a basis for therapies. Chronic inflammation driven by microglia is a feature of aging and neurodegenerative conditions. Unresolved, constant inflammation is disruptive of tissue structure and function, and the brain is no exception. Inflammation is thought to be an important factor in the onset and progression of the most common forms of neurodegenerati...
Source: Fight Aging! - December 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The harsh reality of dementia
Dementia is a general term for diseases affecting memory, thinking, or decision-making, impacting daily activities. Someone in the world develops dementia, on average, every 3 seconds. That’s 10 million new cases of dementia each year worldwide. In 2020, over 55 million individuals worldwide were living with this disease. This figure is expected to double every Read more… The harsh reality of dementia originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 19, 2023 Category: General Medicine Authors: Tags: Conditions Neurology Source Type: blogs

Reviewing the Contributions of Circadian Rhythm Dysfunction and Dysbiosis to Blood-Brain Barrier Leakage
The blood-brain barrier is a layer of specialized cells wrapping blood vessels that pass through the brain. Only certain molecules and cells are admitted. The metabolism of the brain is thus isolated from that of the rest of the body. In particular, the immune system of the brain is quite different from that of the rest of the body. Unfortunately, this isolation is a vulnerability when, like all biological systems, the blood-brain barrier begins to break down and leak. The leakage of inappropriate molecules and cells into the brain provokes inflammation and dysfunction, and this is likely a contributing factor in the devel...
Source: Fight Aging! - December 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Further Consideration of Subtypes of Alzheimer's Disease
There has been some thought given to whether Alzheimer's disease is a collection of fairly distinct subtypes, with different origins and different dominant processes of pathology. The evidence for subtypes of Alzheimer's disease is suggestive, as noted in this article. It remains to be seen as to what the research community will do with all of this data, but it is possible that some therapies are not as bad as originally thought, if analysis were restricted to only one subtype of Alzheimer's disease. Proteins floating in the cerebrospinal fluid (CSF) might do more than diagnose Alzheimer's disease (AD) - they may ...
Source: Fight Aging! - December 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs