Regulatory T Cells Contribute to Reduced Myelination in the Aging Brain
Myelin surrounds the axons that connect neurons to one another, and is required for the transmission of electrical impulses. This myelin sheath is maintained by oligodendrocytes. These cells do not carry out their work in isolation; a great many factors are involved in determining the size and capabilities of the oligodendrocyte population. Aging is disruptive to the myelination carried out by oligodendrocytes. The consequences are not as bad as the profound loss of myelin that takes place in demyelinating diseases such as multiple sclerosis, but age-related loss of myelination does appear to degrade cognitive function. Re...
Source: Fight Aging! - March 29, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Inhibiting P16 in Microglia Reduces Amyloid Plaques in Mice
Researchers here show that targeting microglia in a mouse model of Alzheimer's disease to suppress p16 expression can reduce amyloid-β plaques. This appears to be a way to interfere in a maladaptive reaction to amyloid-β on the part of microglia, innate immune cells responsible for clearing molecular debris from brain tissue. P16 is a marker of cellular senescence, though may also be characteristic of non-senescent but still problematic, pro-inflammatory microglia. There is a good amount of evidence to suggest that both senescent and overly active microglia are important to the progression of neurodegenerative conditions...
Source: Fight Aging! - March 28, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Loss of Anti-Microbial Peptides as a Mechanism for Age-Related Changes in Gut Microbiome Composition
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression promotes increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes. (Source: Fight Aging!)
Source: Fight Aging! - March 27, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Surprising Way Your Brain Processes Both Music And Speech (M)
When listening to music or speech, our brains do much more than just track what people are currently saying or the notes being played right now. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 27, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Music subscribers-only Source Type: blogs
How To Boost Your Cognitive Reserves To Limit Decline In Later Life
The five factors linked to healthier brain aging. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 27, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Source Type: blogs
Investigating the Primary Cilium: Q & A With Xuecai Ge
Credit: Courtesy of Dr. Xuecai Ge.
The brain is a large and complex organ, but some very small structures guide its development. Xuecai Ge, Ph.D., an associate professor of molecular and cell biology at the University of California, Merced (UC Merced), has devoted her career to understanding one of these structures called the primary cilium. In an interview, Dr. Ge shared how her childhood experience inspired her to study science and what makes the primary cilium fascinating.
Q: How did you first become interested in science?
A: When I was a little kid, my mom was a primary care doctor, and I saw her treat patients...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 27, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Cellular Processes Profiles Source Type: blogs
Can you predict Alzheimer ’ s? New research on early detection.
You can’t treat something until you know it’s there. Currently, there’s no cure for Alzheimer’s disease (AD) but earlier diagnosis may lead to better understanding of how the disease inexorably progresses, which in turn may lead to prevention of AD and ultimately eradication of this horrific scourge. The latest breakthroughs in earlier diagnosis and even
Read more…
Can you predict Alzheimer’s? New research on early detection. originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 27, 2024 Category: General Medicine Authors: Marc Arginteanu, MD Tags: Conditions Neurology Source Type: blogs
Lipid Droplets in Microglia Involved in Alzheimer's Pathology
Microglia are innate immune cells resident in the central nervous system. Microglial dysfunction is clearly a contributing factor in the onset and progression of age-related neurodegenerative conditions, including Alzheimer's disease, as well as the accompanying chronic inflammation of brain tissue. As to why microglia become problematic and inflammatory, there are any number of possible contributing mechanisms to consider. Cellular senescence, mitochondrial dysfunction, reactions to cell debris or the presence of persistent viral infections, and more. In this vein, researchers here discuss excessive lipid accumulation in ...
Source: Fight Aging! - March 27, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
More Commentary on the Role of PF4 in Reducing Brain Inflammation
Platelets in the blood are not just involved in clotting. Near every aspect of our biology has evolved many different functions, and the complexity of our biochemistry is still far from fully explored. Increased platelet factor 4 (PF4) shows up as a feature in a number of different interventions known to reduce inflammation in the aging brain. Researchers are now moving in the direction of developing therapies for neurodegenerative conditions based on the upregulation of PF4 or the delivery of recombinant PF4.
Platelets are a component of blood best known for their role in clotting, but research in recent years ha...
Source: Fight Aging! - March 27, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Scientists Unlock Mystery Of Why Long COVID Causes Brain Fog (M)
Up to 10 percent of people get long COVID after being infected with the SARS-CoV2 virus. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 26, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: COVID19 subscribers-only Source Type: blogs
Important Complications of Eisenmenger Syndrome
Transcript of the video: Eisenmenger syndrome is an important complication of large left to right shunts which develop later due to development of pulmonary vascular obstructive disease and severe pulmonary hypertension. The first report of Eisenmenger was by Victor Eisenmenger in 1897 and that was in a thirty year old person who later succumbed to massive hemoptysis. This highlights one of the most important complications of Eisenmenger syndrome, that is airway hemorrhage. Airway hemorrhage can occur in those who ascend to high altitude and during air travel. But it commonly occurs at low level itself. It is one of the mo...
Source: Cardiophile MD - March 26, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Apigenin, Sleep, and Aging
For those following research into efforts to upregulate NAD+ levels to improve mitochondrial function, this paper is an interesting sidebar. Some degree of loss of NAD+ emerges from increased activity of CD38. Apigenin is a dietary supplement that can modestly influence both sleep and pace of aging, the latter in short-lived laboratory species at least. Apigenin can increase NAD+ levels by inhibiting CD38 activity. Like much of metabolism, this is all very interesting, but the effect sizes are nothing to write home about. If upregulating NAD+ levels is the goal, you'll do better by exercising. The fundamental flaw in so mu...
Source: Fight Aging! - March 26, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
CIO Podcast – Episode 71: Data, Analytics, and AI with Richard Clark, PhD
For the 71st episode of the CIO podcast hosted by Healthcare IT Today, we are joined by Richard Clark, PhD, Senior Vice President and Chief Analytics Officer at Highmark Health to discuss data, analytics, and AI! To kick off this episode, we discuss Clark’s double role working for a payer and provider and how that has allowed him to do things that would otherwise be difficult if he wasn’t. Then we take a look at the use of AI and GenAI and talk about where it is making the most impact in healthcare today and where we think it will make the most impact 3 years from now. Next, Clark shares some tips for what peop...
Source: EMR and HIPAA - March 25, 2024 Category: Information Technology Authors: John Lynn Tags: AI/Machine Learning Analytics/Big Data C-Suite Leadership Healthcare CIO Podcasts Healthcare IT Hospital - Health System IT Infrastructure and Dev Ops AI Solutions CIO Leadership GenAI Google Cloud Healthcare Analytics Healthcare D Source Type: blogs
The Center for Neuroscience and Behavior at American University Presents The Therapeutic Use of Psychedelic Drugs: Legal, Policy and Neuroscientific Perspectives
; 8:00AM – 6:00PM on Friday, April 12th, 2024. The symposium, hosted by the American University Washington College of Law,... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - March 25, 2024 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
