Emergence of Poultry-Associated Human Salmonella enterica Serovar Abortusovis Infections, New South Wales, Australia
Emerg Infect Dis. 2024 Apr;30(4):691-700. doi: 10.3201/eid3004.230958.ABSTRACTSalmonella enterica serovar Abortusovis is a ovine-adapted pathogen that causes spontaneous abortion. Salmonella Abortusovis was reported in poultry in 2009 and has since been reported in human infections in New South Wales, Australia. Phylogenomic analysis revealed a clade of 51 closely related isolates from Australia originating in 2004. That clade was genetically distinct from ovine-associated isolates. The clade was widespread in New South Wales poultry production facilities but was only responsible for sporadic human infections. Some known v...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Michael Payne Sarah Williamson Qinning Wang Xiaomei Zhang Vitali Sintchenko Anthony Pavic Ruiting Lan Source Type: research
Emergence of Poultry-Associated Human Salmonella enterica Serovar Abortusovis Infections, New South Wales, Australia
Emerg Infect Dis. 2024 Apr;30(4):691-700. doi: 10.3201/eid3004.230958.ABSTRACTSalmonella enterica serovar Abortusovis is a ovine-adapted pathogen that causes spontaneous abortion. Salmonella Abortusovis was reported in poultry in 2009 and has since been reported in human infections in New South Wales, Australia. Phylogenomic analysis revealed a clade of 51 closely related isolates from Australia originating in 2004. That clade was genetically distinct from ovine-associated isolates. The clade was widespread in New South Wales poultry production facilities but was only responsible for sporadic human infections. Some known v...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Michael Payne Sarah Williamson Qinning Wang Xiaomei Zhang Vitali Sintchenko Anthony Pavic Ruiting Lan Source Type: research
Cryptochrome 2 suppresses epithelial-mesenchymal transition by promoting trophoblastic ferroptosis in unexplained recurrent spontaneous abortion
This study aims to investigate the regulatory relationship between circadian rhythm gene cryptochrome 2 (CRY2) and ferroptosis on the migratory ability of trophoblast cells. (Source: American Journal of Pathology)
Source: American Journal of Pathology - March 25, 2024 Category: Pathology Authors: Faminzi Li, Liantao Guo, Mengqi Zhou, Lu Han, Shujuan Wu, Lianzhi Wu, Jing Yang Tags: Regular Article Source Type: research
Effectiveness of metformin to pregnant women with PCOS to reduce spontaneous abortion and gestational diabetes mellitus: a protocol for an overview of reviews
Introduction
Polycystic ovary syndrome (PCOS) is a globally prevalent endocrinological disorder and has been associated with poor pregnancy outcomes, including a higher rate of gestational diabetes and miscarriage. Metformin is among the drugs investigated to improve the prognosis of pregnant women with PCOS.
Objective
To conduct an overview of systematic reviews examining the effects of metformin versus placebo or no intervention throughout pregnancy among pregnant women with a preconception PCOS diagnosis to reduce the incidence of miscarriage and gestational diabetes.
Methods and analysis
We will perform an overview o...
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Nassif, D. S., Januario, B. L., Sousa, B. A., Thabane, L., Abbade, J. F. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
Copy number variation sequencing for the products of conception: What is the optimal testing strategy
CONCLUSIONS: We propose an initial CNV-seq followed by QF-PCR if needed-an efficient and cost-effective strategy for the genetic analysis of POCs.PMID:38522821 | DOI:10.1016/j.cca.2024.117884 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - March 24, 2024 Category: Chemistry Authors: Yiyao Chen Xu Han Renyi Hua Niu Li Lanlan Zhang Wenjing Hu Yanlin Wang Zhida Qian Shuyuan Li Source Type: research
Copy number variation sequencing for the products of conception: What is the optimal testing strategy
CONCLUSIONS: We propose an initial CNV-seq followed by QF-PCR if needed-an efficient and cost-effective strategy for the genetic analysis of POCs.PMID:38522821 | DOI:10.1016/j.cca.2024.117884 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - March 24, 2024 Category: Chemistry Authors: Yiyao Chen Xu Han Renyi Hua Niu Li Lanlan Zhang Wenjing Hu Yanlin Wang Zhida Qian Shuyuan Li Source Type: research
Effect of bromodomain PHD-finger transcription factor (BPTF) on trophoblast epithelial-to-mesenchymal transition
In conclusion, BPTF participates in the regulation of trophoblast EMT by activating Slug expression, suggesting that BPTF defects are an important factor in RM pathogenesis.PMID:38521110 | DOI:10.1016/j.gene.2024.148405 (Source: Gene)
Source: Gene - March 23, 2024 Category: Genetics & Stem Cells Authors: Linqing Pan Fuquan Zhu Aochen Yu Chao Jia Huaiyun Tang Minglian Zhou Mingrui Li Shiwen Jiang Juan Li Yugui Cui Lisha Tang Source Type: research
Effect of bromodomain PHD-finger transcription factor (BPTF) on trophoblast epithelial-to-mesenchymal transition
In conclusion, BPTF participates in the regulation of trophoblast EMT by activating Slug expression, suggesting that BPTF defects are an important factor in RM pathogenesis.PMID:38521110 | DOI:10.1016/j.gene.2024.148405 (Source: Gene)
Source: Gene - March 23, 2024 Category: Genetics & Stem Cells Authors: Linqing Pan Fuquan Zhu Aochen Yu Chao Jia Huaiyun Tang Minglian Zhou Mingrui Li Shiwen Jiang Juan Li Yugui Cui Lisha Tang Source Type: research
Effect of bromodomain PHD-finger transcription factor (BPTF) on trophoblast epithelial-to-mesenchymal transition
In conclusion, BPTF participates in the regulation of trophoblast EMT by activating Slug expression, suggesting that BPTF defects are an important factor in RM pathogenesis.PMID:38521110 | DOI:10.1016/j.gene.2024.148405 (Source: Gene)
Source: Gene - March 23, 2024 Category: Genetics & Stem Cells Authors: Linqing Pan Fuquan Zhu Aochen Yu Chao Jia Huaiyun Tang Minglian Zhou Mingrui Li Shiwen Jiang Juan Li Yugui Cui Lisha Tang Source Type: research
The Role of Cytokines in Early Pregnancy: Fertilization, Implantation, and Maintenance
This article examines the responsible cytokines and their roles, and how their interplay predicts continued pregnancy or spontaneous miscarriage. It also explores the conflicting theories on their contribution to pregnancy outcomes.Recent FindingsRecent studies have furthered the hypothesis that the maternal immune response is responsible for outcomes across the pregnancy spectrum, from early pregnancy loss to preeclampsia. They dispute, however, previous notions that successful pregnancy is exclusively a phenomenon of immune suppression. Reproductive failure cannot easily be explained by simple imbalances of the Th1- and ...
Source: Current Obstetrics and Gynecology Reports - March 23, 2024 Category: OBGYN Source Type: research
Immunological parameters of maternal peripheral blood as predictors of future pregnancy outcomes in patients with unexplained recurrent pregnancy loss
ConclusionsOur findings suggest that the implementation of such prediction models could serve as valuable tools for providing comprehensive information and facilitating clinicians in their decision-making processes. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - March 22, 2024 Category: OBGYN Authors: Yingrong Li,
Irene X. Y. Wu,
Xuan Wang,
Jinlu Song,
Quan Chen,
Weiru Zhang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Vitamin D deficiency in black women with uterine fibroids
Uterine leiomyomas are benign tumors of the uterus that are composed of smooth muscle cells and fibroblasts and are rich in extracellular matrix. Leiomyomas are often associated with pelvic pain or pressure, menorrhagia, dysmenorrhea, dyspareunia, miscarriage and infertility, and are one of the leading indications for hysterectomy. Vitamin D is a hormone with anti-proliferative and anti-fibrotic effects that have been found to inhibit the growth of human uterine leiomyoma cells. In vitro studies have shown that myometrial tissue are sensitive target organs for vitamin D, and that their cell growth is effectively inhibited ...
Source: American Journal of Obstetrics and Gynecology - March 21, 2024 Category: OBGYN Authors: J Williams, K Forlenza, H Swede, D Luciano, A Ulrich Source Type: research
Hysteroscopic resection of complete uterine septum with intraoperative fluoroscopic guidance
The prevalence of Mullerian duct anomalies is 1-3% with the most common being complete or partial septate uterus. Pregnancy consequences of anomaly include spontaneous abortion, preterm birth, breech, and abruption. Some physicians have argued for prophylactic hysteroscopic metroplasty in women with septate uterus at the time of diagnosis to prevent miscarriages and pregnancy complications. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - March 21, 2024 Category: OBGYN Authors: M Chai, R Jalloul, M Abdallah Source Type: research
GSE169269 Single cell transcriptome analysis of decidua macrophages in normal and recurrent spontaneous abortion patients
Contributors : Qingliang Zheng ; Liping JinSeries Type : Expression profiling by high throughput sequencingOrganism :We isolated CD14+CD45+ dM Φ from the normal or RSA decidua by flow cytometry, followed by single cell RNA sequencing (scRNA-seq). In total, 23,062 single-cell transcriptomes of macrophage were profiled (12,470 Normal and 10,592 RSA), which were divided into 13 major clusters via T-distributed stochastic neighbor embedding ( t-SNE) visualization. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
Author Response On: Impact of Dobbs v. Jackson Women ’s Health Organization on Professional Decision Making among Urology Applicants
We engage in research for many reasons, but this manuscript held significant personal interest for me. Amid the rigors of residency training, I experienced the loss of a very desired pregnancy. When the Dobbs ’ decision leaked in May 2022, I was an attending. One of my first thoughts was how differently my miscarriage experience could have been as a resident. In 2019, I had the financial resources to travel out-of-state if needed, but I was allowed to recover in my own home. I was able to receive the n ecessary medical care with speed and dignity. (Source: Urology)
Source: Urology - March 21, 2024 Category: Urology & Nephrology Authors: Danielle Velez, Casey A. Seideman Source Type: research
