Serostatus of Coxsackie B in a sample of women with miscarriage in Baghdad, Iraq
CONCLUSION: This investigation posits Coxsackie B virus (CBV) as a possible etiology for miscarriage in the Iraqi female population. Further studies employing larger cohorts and robust methodologies, beyond the current detection technique, are warranted to corroborate these observations and elucidate the potential mechanisms by which CBV might induce miscarriage.PMID:38669524 | DOI:10.3233/HAB-240005 (Source: Human Antibodies)
Source: Human Antibodies - April 26, 2024 Category: Biochemistry Authors: Mervet B Jasim Asmaa B Al-Obaidi Enas Adnan Abdulrasul Haider Faisal Ghazi Source Type: research
Prenatal Diagnosis by Trio Clinical Exome Sequencing: Single Center Experience
This study aims to identify the genetic cause of ultrasound anomalies through clinical exome sequencing (CES) analysis. The focus is on utilizing CES analysis in a trio setting, involving the fetuses and both parents. To achieve this objective, prenatal trio clinical exome sequencing was conducted in 51 fetuseses exhibiting ultrasound anomalies with previously negative results from chromosomal microarray (CMA) analysis. The study revealed pathogenic variants in 24% of the analyzed cases (12 out of 51). It is worth noting that the findings include de novo variants in 50% of cases and the transmission of causative variants f...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Katia Margiotti Marco Fabiani Antonella Cima Francesco Libotte Alvaro Mesoraca Claudio Giorlandino Source Type: research
The chromosomal characteristics of spontaneous abortion and its potential associated copy number variants and genes
ConclusionWe found variability in chromosomal abnormalities across clinical features, identifying eight crucial copy number variations (CNVs) and multiple key genes that may be linked to spontaneous abortion. This research enhances the comprehension of genetic factors contributing to spontaneous abortion. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - April 26, 2024 Category: Reproduction Medicine Source Type: research
The Association between Histidine-Rich Glycoprotein rs10770 Genotype and Recurrent Miscarriage in Iranian Women
CONCLUSION: The study highlights the importance of HRG rs10770 in understanding RM, shedding light on its implications for reproductive health. Furthermore, it became evident that women carrying the homozygous C/C genotype exhibited increased susceptibility to the risk of RM.PMID:38659607 | PMC:PMC11042909 | DOI:10.1155/2024/2501086 (Source: Biomed Res)
Source: Biomed Res - April 25, 2024 Category: Research Authors: Mahbobeh Latifimehr Leila Nazari Ali Asghar Rastegari Zahra Zamani Pezhman Fard-Esfahani Source Type: research
The Association between Histidine-Rich Glycoprotein rs10770 Genotype and Recurrent Miscarriage in Iranian Women
CONCLUSION: The study highlights the importance of HRG rs10770 in understanding RM, shedding light on its implications for reproductive health. Furthermore, it became evident that women carrying the homozygous C/C genotype exhibited increased susceptibility to the risk of RM.PMID:38659607 | PMC:PMC11042909 | DOI:10.1155/2024/2501086 (Source: Biomed Res)
Source: Biomed Res - April 25, 2024 Category: Research Authors: Mahbobeh Latifimehr Leila Nazari Ali Asghar Rastegari Zahra Zamani Pezhman Fard-Esfahani Source Type: research
Recent advances in mechanisms ensuring the pairing, synapsis and segregation of XY chromosomes in mice and humans
Cell Mol Life Sci. 2024 Apr 23;81(1):194. doi: 10.1007/s00018-024-05216-0.ABSTRACTSex chromosome aneuploidies are among the most common variations in human whole chromosome copy numbers, with an estimated prevalence in the general population of 1:400 to 1:1400 live births. Unlike whole-chromosome aneuploidies of autosomes, those of sex chromosomes, such as the 47, XXY aneuploidy that causes Klinefelter Syndrome (KS), often originate from the paternal side, caused by a lack of crossover (CO) formation between the X and Y chromosomes. COs must form between all chromosome pairs to pass meiotic checkpoints and are the product ...
Source: Cellular and Molecular Life Sciences : CMLS - April 23, 2024 Category: Cytology Authors: Matteo Lampitto Marco Barchi Source Type: research
Recent advances in mechanisms ensuring the pairing, synapsis and segregation of XY chromosomes in mice and humans
Cell Mol Life Sci. 2024 Apr 23;81(1):194. doi: 10.1007/s00018-024-05216-0.ABSTRACTSex chromosome aneuploidies are among the most common variations in human whole chromosome copy numbers, with an estimated prevalence in the general population of 1:400 to 1:1400 live births. Unlike whole-chromosome aneuploidies of autosomes, those of sex chromosomes, such as the 47, XXY aneuploidy that causes Klinefelter Syndrome (KS), often originate from the paternal side, caused by a lack of crossover (CO) formation between the X and Y chromosomes. COs must form between all chromosome pairs to pass meiotic checkpoints and are the product ...
Source: Cellular and Molecular Life Sciences : CMLS - April 23, 2024 Category: Cytology Authors: Matteo Lampitto Marco Barchi Source Type: research
Yishen Huatan Huoxue decoction and quercetin ameliorate decidualization dysfunction in polycystic ovary syndrome: A comprehensive investigation combining clinical trial and experimental studies
This study provides valuable molecular insights of YHHD and highlight the therapeutic potential of quercetin in treating decidualization dysfunction in PCOS.PMID:38644207 | DOI:10.5582/ddt.2024.01003 (Source: Drug Discoveries and Therapeutics)
Source: Drug Discoveries and Therapeutics - April 21, 2024 Category: Drugs & Pharmacology Authors: Jing Wang Lisha Li Jing Zhou Xinyao Pan Qing Qi Hongmei Sun Ling Wang Source Type: research
Association of fetal growth restriction and stillbirth in twin compared with singleton pregnancies
CONCLUSIONS: Our study demonstrates a significant association between SGA, particularly for FGR, with increased odds of stillbirths in singleton pregnancies across all gestational ages. For twin pregnancies, when twin-specific charts were used, SGA and in particular FGR were associated with a significantly increased risk of stillbirth, across all gestational ages at delivery. This article is protected by copyright. All rights reserved.PMID:38642338 | DOI:10.1002/uog.27661 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - April 20, 2024 Category: Radiology Authors: A Mart ínez-Varea S Prasad J Domenech E Kalafat J Morales-Rosell ó A Khalil Source Type: research
Association of fetal growth restriction and stillbirth in twin compared with singleton pregnancies
CONCLUSIONS: Our study demonstrates a significant association between SGA, particularly for FGR, with increased odds of stillbirths in singleton pregnancies across all gestational ages. For twin pregnancies, when twin-specific charts were used, SGA and in particular FGR were associated with a significantly increased risk of stillbirth, across all gestational ages at delivery. This article is protected by copyright. All rights reserved.PMID:38642338 | DOI:10.1002/uog.27661 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - April 20, 2024 Category: Radiology Authors: A Mart ínez-Varea S Prasad J Domenech E Kalafat J Morales-Rosell ó A Khalil Source Type: research
Association of fetal growth restriction and stillbirth in twin compared with singleton pregnancies
CONCLUSIONS: Our study demonstrates a significant association between SGA, particularly for FGR, with increased odds of stillbirths in singleton pregnancies across all gestational ages. For twin pregnancies, when twin-specific charts were used, SGA and in particular FGR were associated with a significantly increased risk of stillbirth, across all gestational ages at delivery. This article is protected by copyright. All rights reserved.PMID:38642338 | DOI:10.1002/uog.27661 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - April 20, 2024 Category: Radiology Authors: A Mart ínez-Varea S Prasad J Domenech E Kalafat J Morales-Rosell ó A Khalil Source Type: research
Aneuploidy detection in pooled polar bodies using rapid nanopore sequencing
ConclusionThe automated detection of the ploidy classification per chromosome and shorter duplications or deletions depending on the sequencing depth demonstrates an advantage of the ONT method over standard, commercial aCGH methods, which do not consider the presence of three chromatids in pooled polar bodies. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - April 20, 2024 Category: Reproduction Medicine Source Type: research
Effect of time post warming to embryo transfer on human blastocyst metabolism and pregnancy outcome
ConclusionOverall, our results show that differences in the time of post warming culture have no significant impact on miscarriage or live birth rate for frozen embryo transfers. This information can be beneficial for clinical practices with either minimal staffing or a high number of patient cases. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - April 20, 2024 Category: Reproduction Medicine Source Type: research
