Infertility and poor reproductive outcomes as potential predictors of early and premature menopause: lets act before it would be too late!
Commentary on: Liang C, Chung HF, Dobson AJ, Cade JE, Greenwood DC, Hayashi K, Hardy R, Kuh D, Schouw YTV, Sandin S, Weiderpass E, Mishra GD. Is there a link between infertility, miscarriage, stillbirth, and premature or early menopause? Results from pooled analyses of 9 cohort studies. Am J Obstet Gynecol. 2023 Jul;229(1):47.e1-47.e9. doi: 10.1016/j.ajog.2023.04.009. Epub 2023 Apr 13. Implications for practice and research Women with a history of recurrent miscarriages, infertility, or stillbirths should be informed of their increased risk of early or premature or menopause. Future studies should aim to evaluate whether a...
Source: Evidence-Based Nursing - March 28, 2024 Category: Nursing Authors: Etrusco, A., Lagana, A. S. Tags: Women's Health and Midwifery Source Type: research
Cryptochrome 2 suppresses epithelial-mesenchymal transition by promoting trophoblastic ferroptosis in unexplained recurrent spontaneous abortion
This study aims to investigate the regulatory relationship between circadian rhythm gene cryptochrome 2 (CRY2) and ferroptosis on the migratory ability of trophoblast cells. Cell proliferation experiments, wound healing assays, and expression of related markers were conducted to verify the EMT efforts. Trophoblastic ferroptosis was confirmed by the expressions of malondialdehyde, glutathione, mitochondrial membrane potential, divalent iron ions, and expression level of related genes. The results showed significant increased expression of CRY2 and decreased expression of brain and muscle ARNT-like protein 1 (BMAL1) in the U...
Source: The American Journal of Pathology - March 27, 2024 Category: Pathology Authors: Faminzi Li Liantao Guo Mengqi Zhou Lu Han Shujuan Wu Lianzhi Wu Jing Yang Source Type: research
Cryptochrome 2 suppresses epithelial-mesenchymal transition by promoting trophoblastic ferroptosis in unexplained recurrent spontaneous abortion
This study aims to investigate the regulatory relationship between circadian rhythm gene cryptochrome 2 (CRY2) and ferroptosis on the migratory ability of trophoblast cells. Cell proliferation experiments, wound healing assays, and expression of related markers were conducted to verify the EMT efforts. Trophoblastic ferroptosis was confirmed by the expressions of malondialdehyde, glutathione, mitochondrial membrane potential, divalent iron ions, and expression level of related genes. The results showed significant increased expression of CRY2 and decreased expression of brain and muscle ARNT-like protein 1 (BMAL1) in the U...
Source: Am J Pathol - March 27, 2024 Category: Pathology Authors: Faminzi Li Liantao Guo Mengqi Zhou Lu Han Shujuan Wu Lianzhi Wu Jing Yang Source Type: research
Cryptochrome 2 suppresses epithelial-mesenchymal transition by promoting trophoblastic ferroptosis in unexplained recurrent spontaneous abortion
This study aims to investigate the regulatory relationship between circadian rhythm gene cryptochrome 2 (CRY2) and ferroptosis on the migratory ability of trophoblast cells. Cell proliferation experiments, wound healing assays, and expression of related markers were conducted to verify the EMT efforts. Trophoblastic ferroptosis was confirmed by the expressions of malondialdehyde, glutathione, mitochondrial membrane potential, divalent iron ions, and expression level of related genes. The results showed significant increased expression of CRY2 and decreased expression of brain and muscle ARNT-like protein 1 (BMAL1) in the U...
Source: The American Journal of Pathology - March 27, 2024 Category: Pathology Authors: Faminzi Li Liantao Guo Mengqi Zhou Lu Han Shujuan Wu Lianzhi Wu Jing Yang Source Type: research
Cryptochrome 2 suppresses epithelial-mesenchymal transition by promoting trophoblastic ferroptosis in unexplained recurrent spontaneous abortion
This study aims to investigate the regulatory relationship between circadian rhythm gene cryptochrome 2 (CRY2) and ferroptosis on the migratory ability of trophoblast cells. Cell proliferation experiments, wound healing assays, and expression of related markers were conducted to verify the EMT efforts. Trophoblastic ferroptosis was confirmed by the expressions of malondialdehyde, glutathione, mitochondrial membrane potential, divalent iron ions, and expression level of related genes. The results showed significant increased expression of CRY2 and decreased expression of brain and muscle ARNT-like protein 1 (BMAL1) in the U...
Source: Am J Pathol - March 27, 2024 Category: Pathology Authors: Faminzi Li Liantao Guo Mengqi Zhou Lu Han Shujuan Wu Lianzhi Wu Jing Yang Source Type: research
Miscarriage and stillbirth in relation to risk of cardiovascular diseases: A systematic review and meta-analysis
The relationship between pregnancy loss and the risk of cardiovascular diseases (CVDs) remains a matter of debate. Our intention in conducting this meta-analysis was to analyze the relationship between miscarriage and stillbirth and risk of CVDs. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 27, 2024 Category: OBGYN Authors: Mengmeng Wang, Jinli Zhang, Lijun Yuan, Huifang Hu, Tianze Li, Yifei Feng, Yang Zhao, Yuying Wu, Xueru Fu, Yamin Ke, Yajuan Gao, Yaobing Chen, Weifeng Huo, Longkang Wang, Wenkai Zhang, Xi Li, Jiong Liu, Zelin Huang, Fulan Hu, Ming Zhang, Liang Sun, Dongsh Tags: Review article Source Type: research
Recurrent miscarriage and low-titer antiphospholipid antibodies
ConclusionNoteworthy distinctions in laboratory parameters were identified between the low-titer and medium-high titer groups. However, when appropriately treated, the fetal-maternal outcomes were comparable in both groups. Timely intervention by clinicians is imperative to enhance pregnancy outcomes in patients experiencing recurrent miscarriage with low levels of aPL.Key Points•This study challenges the conventional belief that only the higher antiphospholipid antibodies (aPL) titers directly correlated with worse pregnancy outcomes, which emphasized the importance of patients with low titer positive aPL-positive RM.â€...
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research
IJERPH, Vol. 21, Pages 404: Depression Treatment in Pregnancy: Is It Safe, or Is It Not?
Franca Cavaliere
Prenatal depression carries substantial risks for maternal and fetal health and increases susceptibility to postpartum depression. Untreated depression in pregnancy is correlated with adverse outcomes such as an increased risk of suicidal ideation, miscarriage and neonatal growth problems. Notwithstanding concerns about the use of antidepressants, the available treatment options emphasize the importance of specialized medical supervision during gestation. The purpose of this paper is to conduct a brief literature review on the main antidepressant drugs and their effects on pregnancy, assessing their r...
Source: International Journal of Environmental Research and Public Health - March 26, 2024 Category: Environmental Health Authors: Vitalba Gallitelli Rita Franco Sofia Guidi Ludovica Puri Marco Parasiliti Annalisa Vidiri Georgios Eleftheriou Federica Perelli Anna Franca Cavaliere Tags: Review Source Type: research
Emergence of Poultry-Associated Human Salmonella enterica Serovar Abortusovis Infections, New South Wales, Australia
Emerg Infect Dis. 2024 Apr;30(4):691-700. doi: 10.3201/eid3004.230958.ABSTRACTSalmonella enterica serovar Abortusovis is a ovine-adapted pathogen that causes spontaneous abortion. Salmonella Abortusovis was reported in poultry in 2009 and has since been reported in human infections in New South Wales, Australia. Phylogenomic analysis revealed a clade of 51 closely related isolates from Australia originating in 2004. That clade was genetically distinct from ovine-associated isolates. The clade was widespread in New South Wales poultry production facilities but was only responsible for sporadic human infections. Some known v...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Michael Payne Sarah Williamson Qinning Wang Xiaomei Zhang Vitali Sintchenko Anthony Pavic Ruiting Lan Source Type: research
Emergence of Poultry-Associated Human Salmonella enterica Serovar Abortusovis Infections, New South Wales, Australia
Emerg Infect Dis. 2024 Apr;30(4):691-700. doi: 10.3201/eid3004.230958.ABSTRACTSalmonella enterica serovar Abortusovis is a ovine-adapted pathogen that causes spontaneous abortion. Salmonella Abortusovis was reported in poultry in 2009 and has since been reported in human infections in New South Wales, Australia. Phylogenomic analysis revealed a clade of 51 closely related isolates from Australia originating in 2004. That clade was genetically distinct from ovine-associated isolates. The clade was widespread in New South Wales poultry production facilities but was only responsible for sporadic human infections. Some known v...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Michael Payne Sarah Williamson Qinning Wang Xiaomei Zhang Vitali Sintchenko Anthony Pavic Ruiting Lan Source Type: research
Emergence of Poultry-Associated Human Salmonella enterica Serovar Abortusovis Infections, New South Wales, Australia
Emerg Infect Dis. 2024 Apr;30(4):691-700. doi: 10.3201/eid3004.230958.ABSTRACTSalmonella enterica serovar Abortusovis is a ovine-adapted pathogen that causes spontaneous abortion. Salmonella Abortusovis was reported in poultry in 2009 and has since been reported in human infections in New South Wales, Australia. Phylogenomic analysis revealed a clade of 51 closely related isolates from Australia originating in 2004. That clade was genetically distinct from ovine-associated isolates. The clade was widespread in New South Wales poultry production facilities but was only responsible for sporadic human infections. Some known v...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Michael Payne Sarah Williamson Qinning Wang Xiaomei Zhang Vitali Sintchenko Anthony Pavic Ruiting Lan Source Type: research
Emergence of Poultry-Associated Human Salmonella enterica Serovar Abortusovis Infections, New South Wales, Australia
Emerg Infect Dis. 2024 Apr;30(4):691-700. doi: 10.3201/eid3004.230958.ABSTRACTSalmonella enterica serovar Abortusovis is a ovine-adapted pathogen that causes spontaneous abortion. Salmonella Abortusovis was reported in poultry in 2009 and has since been reported in human infections in New South Wales, Australia. Phylogenomic analysis revealed a clade of 51 closely related isolates from Australia originating in 2004. That clade was genetically distinct from ovine-associated isolates. The clade was widespread in New South Wales poultry production facilities but was only responsible for sporadic human infections. Some known v...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Michael Payne Sarah Williamson Qinning Wang Xiaomei Zhang Vitali Sintchenko Anthony Pavic Ruiting Lan Source Type: research
Emergence of Poultry-Associated Human Salmonella enterica Serovar Abortusovis Infections, New South Wales, Australia
Emerg Infect Dis. 2024 Apr;30(4):691-700. doi: 10.3201/eid3004.230958.ABSTRACTSalmonella enterica serovar Abortusovis is a ovine-adapted pathogen that causes spontaneous abortion. Salmonella Abortusovis was reported in poultry in 2009 and has since been reported in human infections in New South Wales, Australia. Phylogenomic analysis revealed a clade of 51 closely related isolates from Australia originating in 2004. That clade was genetically distinct from ovine-associated isolates. The clade was widespread in New South Wales poultry production facilities but was only responsible for sporadic human infections. Some known v...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Michael Payne Sarah Williamson Qinning Wang Xiaomei Zhang Vitali Sintchenko Anthony Pavic Ruiting Lan Source Type: research
