The hippocampal Salt-Inducible Kinase 2-CREB-Regulated Transcription Co-activator 1 system mediates the antidepressant actions of paroxetine in mice
Behav Brain Res. 2024 Mar 27:114972. doi: 10.1016/j.bbr.2024.114972. Online ahead of print.ABSTRACTThe hippocampal salt-inducible kinase 2 (SIK2)-CREB-regulated transcription co-activator 1 (CRTC1) system has been demonstrated to participate in not only the pathogenesis of depression but also the antidepressant mechanisms of several antidepressant medications including fluoxetine, paroxetine, and mirtazapine. Like fluoxetine, paroxetine is also a widely used selective serotonin (5-HT) reuptake inhibitor (SSRI). Recent studies have indicated that paroxetine also modulates several pharmacological targets other than the 5-HT ...
Source: Behavioural Brain Research - March 29, 2024 Category: Neurology Authors: Xiang-Ming Cai Xiao-Yu Sun Rui Li Pei-Juan Wang Jian-Cheng Qi Yu-Xin Ge Lei Yang Source Type: research
The hippocampal Salt-Inducible Kinase 2-CREB-Regulated Transcription Co-activator 1 system mediates the antidepressant actions of paroxetine in mice
Behav Brain Res. 2024 Mar 27:114972. doi: 10.1016/j.bbr.2024.114972. Online ahead of print.ABSTRACTThe hippocampal salt-inducible kinase 2 (SIK2)-CREB-regulated transcription co-activator 1 (CRTC1) system has been demonstrated to participate in not only the pathogenesis of depression but also the antidepressant mechanisms of several antidepressant medications including fluoxetine, paroxetine, and mirtazapine. Like fluoxetine, paroxetine is also a widely used selective serotonin (5-HT) reuptake inhibitor (SSRI). Recent studies have indicated that paroxetine also modulates several pharmacological targets other than the 5-HT ...
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Xiang-Ming Cai Xiao-Yu Sun Rui Li Pei-Juan Wang Jian-Cheng Qi Yu-Xin Ge Lei Yang Source Type: research
The hippocampal Salt-Inducible Kinase 2-CREB-Regulated Transcription Co-activator 1 system mediates the antidepressant actions of paroxetine in mice
Behav Brain Res. 2024 Mar 27:114972. doi: 10.1016/j.bbr.2024.114972. Online ahead of print.ABSTRACTThe hippocampal salt-inducible kinase 2 (SIK2)-CREB-regulated transcription co-activator 1 (CRTC1) system has been demonstrated to participate in not only the pathogenesis of depression but also the antidepressant mechanisms of several antidepressant medications including fluoxetine, paroxetine, and mirtazapine. Like fluoxetine, paroxetine is also a widely used selective serotonin (5-HT) reuptake inhibitor (SSRI). Recent studies have indicated that paroxetine also modulates several pharmacological targets other than the 5-HT ...
Source: Behavioural Brain Research - March 29, 2024 Category: Neurology Authors: Xiang-Ming Cai Xiao-Yu Sun Rui Li Pei-Juan Wang Jian-Cheng Qi Yu-Xin Ge Lei Yang Source Type: research
The hippocampal Salt-Inducible Kinase 2-CREB-Regulated Transcription Co-activator 1 system mediates the antidepressant actions of paroxetine in mice
Behav Brain Res. 2024 Mar 27:114972. doi: 10.1016/j.bbr.2024.114972. Online ahead of print.ABSTRACTThe hippocampal salt-inducible kinase 2 (SIK2)-CREB-regulated transcription co-activator 1 (CRTC1) system has been demonstrated to participate in not only the pathogenesis of depression but also the antidepressant mechanisms of several antidepressant medications including fluoxetine, paroxetine, and mirtazapine. Like fluoxetine, paroxetine is also a widely used selective serotonin (5-HT) reuptake inhibitor (SSRI). Recent studies have indicated that paroxetine also modulates several pharmacological targets other than the 5-HT ...
Source: Brain Research - March 29, 2024 Category: Neurology Authors: Xiang-Ming Cai Xiao-Yu Sun Rui Li Pei-Juan Wang Jian-Cheng Qi Yu-Xin Ge Lei Yang Source Type: research
Erratum: Pharmacokinetics of a Single Transdermal Dose of Mirtazapine in Rhesus Macaques ( < em > Macaca mulatta < /em > )
Comp Med. 2024 Feb 1;74(1):26. doi: 10.30802/AALAS-CM-24-000010.NO ABSTRACTPMID:38532261 | DOI:10.30802/AALAS-CM-24-000010 (Source: Comparative Medicine)
Source: Comparative Medicine - March 27, 2024 Category: Zoology Source Type: research
Erratum: Pharmacokinetics of a Single Transdermal Dose of Mirtazapine in Rhesus Macaques ( < em > Macaca mulatta < /em > )
Comp Med. 2024 Feb 1;74(1):26. doi: 10.30802/AALAS-CM-24-000010.NO ABSTRACTPMID:38532261 | PMC:PMC10938562 | DOI:10.30802/AALAS-CM-24-000010 (Source: Comparative Medicine)
Source: Comparative Medicine - March 27, 2024 Category: Zoology Source Type: research
Erratum: Pharmacokinetics of a Single Transdermal Dose of Mirtazapine in Rhesus Macaques ( < em > Macaca mulatta < /em > )
Comp Med. 2024 Feb 1;74(1):26. doi: 10.30802/AALAS-CM-24-000010.NO ABSTRACTPMID:38532261 | PMC:PMC10938562 | DOI:10.30802/AALAS-CM-24-000010 (Source: Comparative Medicine)
Source: Comparative Medicine - March 27, 2024 Category: Zoology Source Type: research
Erratum: Pharmacokinetics of a Single Transdermal Dose of Mirtazapine in Rhesus Macaques ( < em > Macaca mulatta < /em > )
Comp Med. 2024 Feb 1;74(1):26. doi: 10.30802/AALAS-CM-24-000010.NO ABSTRACTPMID:38532261 | PMC:PMC10938562 | DOI:10.30802/AALAS-CM-24-000010 (Source: Comparative Medicine)
Source: Comparative Medicine - March 27, 2024 Category: Zoology Source Type: research
Mirtazapine and Vitamin B6 May Be Best Options for Antipsychotic-Induced Akathisia
APA ’s Good Faith Estimates Survey: Please Respond TodayThe No Surprises Actrequires clinicians to provide patients who are uninsured or are insured but choose not to submit claims through their health plan with a Good Faith Estimate of the cost of care. The Centers for Medicare and Medicaid Services has asked APA for your feedback on efforts to comply with these requirements and any educational support you may need from CMS. The deadline istoday, March 8.TAKE SURVEYAkathisia —a feeling of restlessness that is often accompanied by movements like rocking or pacing—is a common side effect of antipsychotic medications. ...
Source: Psychiatr News - March 8, 2024 Category: Psychiatry Tags: akathisia antipsychotic JAMA Network Open meta-analysis mirtazapine restlessness trazodone vitamin B6 Source Type: research
Treatment resistance in anxiety disorders-Definition and treatment options
Nervenarzt. 2024 Mar 4. doi: 10.1007/s00115-024-01627-3. Online ahead of print.ABSTRACTTreatment resistance in anxiety disorders represents a clinical challenge, contributes to the chronicity of the diseases as well as sequential comorbidities, and is associated with a significant individual and socioeconomic burden. This narrative review presents the operational definition of treatment resistance in anxiety disorders according to international consensus criteria (< 50% reduction in the Hamilton Anxiety Scale, HAM‑A, score or < 50% reduction in the Beck Anxiety Inventory, BAI, score or a clinical global impression-...
Source: Der Nervenarzt - March 4, 2024 Category: Neurology Authors: Katharina Domschke Andreas Str öhle Peter Zwanzger Source Type: research
Treatment resistance in anxiety disorders-Definition and treatment options
Nervenarzt. 2024 Mar 4. doi: 10.1007/s00115-024-01627-3. Online ahead of print.ABSTRACTTreatment resistance in anxiety disorders represents a clinical challenge, contributes to the chronicity of the diseases as well as sequential comorbidities, and is associated with a significant individual and socioeconomic burden. This narrative review presents the operational definition of treatment resistance in anxiety disorders according to international consensus criteria (< 50% reduction in the Hamilton Anxiety Scale, HAM‑A, score or < 50% reduction in the Beck Anxiety Inventory, BAI, score or a clinical global impression-...
Source: Der Nervenarzt - March 4, 2024 Category: Neurology Authors: Katharina Domschke Andreas Str öhle Peter Zwanzger Source Type: research
The Relevance of Integrating CYP2C19 Phenoconversion Effects into
Clinical Pharmacogenetics
Discussion PC of CYP2C19 changes phenotypes but does not improve
correlations with serum concentrations. However, only a limited number of
patients received perturbators of CYP2C19. Studies with large numbers of
patients are still lacking, and thus, it cannot be decided if there are minor
differences and which method of correction to use. For the time being, PC is
relevant in individual patients treated with CYP2C19-affecting drugs, for
example, esomeprazole. To ensure adequate serum concentrations in these
patients, this study suggests the use of therap...
Source: Pharmacopsychiatry - February 14, 2024 Category: Psychiatry Authors: Scherf-Clavel, Maike Weber, Heike Unterecker, Stefan Frantz, Amelie Eckert, Andreas Reif, Andreas Deckert, J ürgen Hahn, Martina Tags: Original Paper Source Type: research
Formulation, Optimization and Full Characterization of Mirtazapine Loaded Aquasomes: A new technique to boost antidepressant effects
ConclusionThese results confirmed that the antidepressant effect of MRT was significantly boosted in formulated aquasomes, and thereby they provide a promising carrier nano vesicular system for effective delivery of MRT.PMID:38334395 | DOI:10.1080/03639045.2024.2313538 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - February 9, 2024 Category: Drugs & Pharmacology Authors: Lamiaa Mohamed Hussein Ali Aya Mohamed Dawaba Shereen Ahmed El-Adawy Source Type: research
