Mirtazapine modulates Glutamate and GABA levels in the animal model of maternal depression. MRI and < sup > 1 < /sup > H MRS study in female rats
The objective of the study was not only to study an animal model of CUS using magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) focused on the hippocampus, but also to use this technique to verify the effectiveness of mirtazapine antidepressant treatment. In the group with CUS, we found a significant decrease in the relative concentration of γ-aminobutyric acid (GABA/tCr) and glutamate+glutamine (Glx/tCr) compared to the control group, while we did not observe any statistically significant change in hippocampal volumes. Moreover, the forced swim test revealed an increase in depression-li...
Source: Behavioural Brain Research - January 14, 2023 Category: Neurology Authors: M Makova S Kasparova T Tvrdik M Vinas Noguera K Belovicova K Csatlosova M Dubovicky Source Type: research
Mirtazapine modulates Glutamate and GABA levels in the animal model of maternal depression. MRI and < sup > 1 < /sup > H MRS study in female rats
The objective of the study was not only to study an animal model of CUS using magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) focused on the hippocampus, but also to use this technique to verify the effectiveness of mirtazapine antidepressant treatment. In the group with CUS, we found a significant decrease in the relative concentration of γ-aminobutyric acid (GABA/tCr) and glutamate+glutamine (Glx/tCr) compared to the control group, while we did not observe any statistically significant change in hippocampal volumes. Moreover, the forced swim test revealed an increase in depression-li...
Source: Brain Research - January 14, 2023 Category: Neurology Authors: M Makova S Kasparova T Tvrdik M Vinas Noguera K Belovicova K Csatlosova M Dubovicky Source Type: research
Mirtazapine modulates Glutamate and GABA levels in the animal model of maternal depression. MRI and < sup > 1 < /sup > H MRS study in female rats
The objective of the study was not only to study an animal model of CUS using magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) focused on the hippocampus, but also to use this technique to verify the effectiveness of mirtazapine antidepressant treatment. In the group with CUS, we found a significant decrease in the relative concentration of γ-aminobutyric acid (GABA/tCr) and glutamate+glutamine (Glx/tCr) compared to the control group, while we did not observe any statistically significant change in hippocampal volumes. Moreover, the forced swim test revealed an increase in depression-li...
Source: Behavioural Brain Research - January 14, 2023 Category: Neurology Authors: M Makova S Kasparova T Tvrdik M Vinas Noguera K Belovicova K Csatlosova M Dubovicky Source Type: research
Mirtazapine modulates Glutamate and GABA levels in the animal model of maternal depression. MRI and < sup > 1 < /sup > H MRS study in female rats
The objective of the study was not only to study an animal model of CUS using magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) focused on the hippocampus, but also to use this technique to verify the effectiveness of mirtazapine antidepressant treatment. In the group with CUS, we found a significant decrease in the relative concentration of γ-aminobutyric acid (GABA/tCr) and glutamate+glutamine (Glx/tCr) compared to the control group, while we did not observe any statistically significant change in hippocampal volumes. Moreover, the forced swim test revealed an increase in depression-li...
Source: Brain Research - January 14, 2023 Category: Neurology Authors: M Makova S Kasparova T Tvrdik M Vinas Noguera K Belovicova K Csatlosova M Dubovicky Source Type: research
Akathisia after chronic usage of synthetic cathinones: A case study
ConclusionThe current case suggests that besides cocaine, amphetamines and methamphetamines, synthetic cathinones can also increase the risk for development of extrapyramidal symptoms such as akathisia. Especially a-PVP-analogs as used by the current patient and Pyrovalerone-analogs such as Methylenedioxypyrovalerone (MDPV) are very powerful dopamine reuptake-inhibitors which might lead to strong locomotor activation. Up to this day it remains very difficult to establish a guideline concerning the treatment of intoxication with synthetic cathinones or dependence thereof. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - December 23, 2022 Category: Psychiatry Source Type: research
Sedative drug-use in Denmark, 2000 to 2019: a nationwide drug utilization study
ConclusionIn Denmark different central regulations have influenced prescription practice toward more restrictive use of Z-drugs and benzodiazepines, except for hypnotic benzodiazepine prescriptions increased after the introduction of special palliative care. An increase in use of newer sedative drugs, however, indicates that the regulations do not remove the need for sedative drugs in the population. (Source: Social Psychiatry and Psychiatric Epidemiology)
Source: Social Psychiatry and Psychiatric Epidemiology - December 23, 2022 Category: Psychiatry Source Type: research
