Study Compares Clinical Outcomes of Older Adults Prescribed 10 Common Antidepressants
Older adults with depression may be least likely to discontinue or switch treatment when prescribed sertraline for the first time compared with other antidepressants, suggests areport inThe American Journal of Psychiatry. The study compared one-year outcomes in 93,000 Danish residents with depression who for the first time filled a prescription for one of 10 antidepressants. The research was funded in part by the Health Research Foundation of the Central Denmark Region.“Although clinical trials are considered the gold standard in drug effectiveness research, their experimental conditions often do not represent complex, r...
Source: Psychiatr News - October 23, 2023 Category: Psychiatry Tags: antidepressants cardiovascular problems death depression falls older adults sertraline The American Journal of Psychiatry treatment discontinuation Source Type: research
Real-World Evidence on Clinical Outcomes of Commonly Used Antidepressants in Older Adults Initiating Antidepressants for Depression: A Nationwide Cohort Study in Denmark
CONCLUSIONS: This real-world evidence suggests that clinical outcomes may vary among initiators of commonly used antidepressants in older adults, which may inform benefit-risk evaluation at treatment initiation, and highlights the importance of careful selection of antidepressant treatment.PMID:37849303 | DOI:10.1176/appi.ajp.20230356 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - October 18, 2023 Category: Psychiatry Authors: Kazi Ishtiak-Ahmed Katherine L Musliner Kaj Sparle Christensen Erik Lykke Mortensen Andrew A Nierenberg Christiane Gasse Source Type: research
Real-World Evidence on Clinical Outcomes of Commonly Used Antidepressants in Older Adults Initiating Antidepressants for Depression: A Nationwide Cohort Study in Denmark
CONCLUSIONS: This real-world evidence suggests that clinical outcomes may vary among initiators of commonly used antidepressants in older adults, which may inform benefit-risk evaluation at treatment initiation, and highlights the importance of careful selection of antidepressant treatment.PMID:37849303 | DOI:10.1176/appi.ajp.20230356 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - October 18, 2023 Category: Psychiatry Authors: Kazi Ishtiak-Ahmed Katherine L Musliner Kaj Sparle Christensen Erik Lykke Mortensen Andrew A Nierenberg Christiane Gasse Source Type: research
Real-World Evidence on Clinical Outcomes of Commonly Used Antidepressants in Older Adults Initiating Antidepressants for Depression: A Nationwide Cohort Study in Denmark
CONCLUSIONS: This real-world evidence suggests that clinical outcomes may vary among initiators of commonly used antidepressants in older adults, which may inform benefit-risk evaluation at treatment initiation, and highlights the importance of careful selection of antidepressant treatment.PMID:37849303 | DOI:10.1176/appi.ajp.20230356 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - October 18, 2023 Category: Psychiatry Authors: Kazi Ishtiak-Ahmed Katherine L Musliner Kaj Sparle Christensen Erik Lykke Mortensen Andrew A Nierenberg Christiane Gasse Source Type: research
Real-World Evidence on Clinical Outcomes of Commonly Used Antidepressants in Older Adults Initiating Antidepressants for Depression: A Nationwide Cohort Study in Denmark
CONCLUSIONS: This real-world evidence suggests that clinical outcomes may vary among initiators of commonly used antidepressants in older adults, which may inform benefit-risk evaluation at treatment initiation, and highlights the importance of careful selection of antidepressant treatment.PMID:37849303 | DOI:10.1176/appi.ajp.20230356 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - October 18, 2023 Category: Psychiatry Authors: Kazi Ishtiak-Ahmed Katherine L Musliner Kaj Sparle Christensen Erik Lykke Mortensen Andrew A Nierenberg Christiane Gasse Source Type: research
Real-World Evidence on Clinical Outcomes of Commonly Used Antidepressants in Older Adults Initiating Antidepressants for Depression: A Nationwide Cohort Study in Denmark
CONCLUSIONS: This real-world evidence suggests that clinical outcomes may vary among initiators of commonly used antidepressants in older adults, which may inform benefit-risk evaluation at treatment initiation, and highlights the importance of careful selection of antidepressant treatment.PMID:37849303 | DOI:10.1176/appi.ajp.20230356 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - October 18, 2023 Category: Psychiatry Authors: Kazi Ishtiak-Ahmed Katherine L Musliner Kaj Sparle Christensen Erik Lykke Mortensen Andrew A Nierenberg Christiane Gasse Source Type: research
Real-World Evidence on Clinical Outcomes of Commonly Used Antidepressants in Older Adults Initiating Antidepressants for Depression: A Nationwide Cohort Study in Denmark
CONCLUSIONS: This real-world evidence suggests that clinical outcomes may vary among initiators of commonly used antidepressants in older adults, which may inform benefit-risk evaluation at treatment initiation, and highlights the importance of careful selection of antidepressant treatment.PMID:37849303 | DOI:10.1176/appi.ajp.20230356 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - October 18, 2023 Category: Psychiatry Authors: Kazi Ishtiak-Ahmed Katherine L Musliner Kaj Sparle Christensen Erik Lykke Mortensen Andrew A Nierenberg Christiane Gasse Source Type: research
Real-World Evidence on Clinical Outcomes of Commonly Used Antidepressants in Older Adults Initiating Antidepressants for Depression: A Nationwide Cohort Study in Denmark
CONCLUSIONS: This real-world evidence suggests that clinical outcomes may vary among initiators of commonly used antidepressants in older adults, which may inform benefit-risk evaluation at treatment initiation, and highlights the importance of careful selection of antidepressant treatment.PMID:37849303 | DOI:10.1176/appi.ajp.20230356 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - October 18, 2023 Category: Psychiatry Authors: Kazi Ishtiak-Ahmed Katherine L Musliner Kaj Sparle Christensen Erik Lykke Mortensen Andrew A Nierenberg Christiane Gasse Source Type: research
Real-World Evidence on Clinical Outcomes of Commonly Used Antidepressants in Older Adults Initiating Antidepressants for Depression: A Nationwide Cohort Study in Denmark
CONCLUSIONS: This real-world evidence suggests that clinical outcomes may vary among initiators of commonly used antidepressants in older adults, which may inform benefit-risk evaluation at treatment initiation, and highlights the importance of careful selection of antidepressant treatment.PMID:37849303 | DOI:10.1176/appi.ajp.20230356 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - October 18, 2023 Category: Psychiatry Authors: Kazi Ishtiak-Ahmed Katherine L Musliner Kaj Sparle Christensen Erik Lykke Mortensen Andrew A Nierenberg Christiane Gasse Source Type: research
Real-World Evidence on Clinical Outcomes of Commonly Used Antidepressants in Older Adults Initiating Antidepressants for Depression: A Nationwide Cohort Study in Denmark
CONCLUSIONS: This real-world evidence suggests that clinical outcomes may vary among initiators of commonly used antidepressants in older adults, which may inform benefit-risk evaluation at treatment initiation, and highlights the importance of careful selection of antidepressant treatment.PMID:37849303 | DOI:10.1176/appi.ajp.20230356 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - October 18, 2023 Category: Psychiatry Authors: Kazi Ishtiak-Ahmed Katherine L Musliner Kaj Sparle Christensen Erik Lykke Mortensen Andrew A Nierenberg Christiane Gasse Source Type: research
Real-World Evidence on Clinical Outcomes of Commonly Used Antidepressants in Older Adults Initiating Antidepressants for Depression: A Nationwide Cohort Study in Denmark
CONCLUSIONS: This real-world evidence suggests that clinical outcomes may vary among initiators of commonly used antidepressants in older adults, which may inform benefit-risk evaluation at treatment initiation, and highlights the importance of careful selection of antidepressant treatment.PMID:37849303 | DOI:10.1176/appi.ajp.20230356 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - October 18, 2023 Category: Psychiatry Authors: Kazi Ishtiak-Ahmed Katherine L Musliner Kaj Sparle Christensen Erik Lykke Mortensen Andrew A Nierenberg Christiane Gasse Source Type: research
Real-World Evidence on Clinical Outcomes of Commonly Used Antidepressants in Older Adults Initiating Antidepressants for Depression: A Nationwide Cohort Study in Denmark
CONCLUSIONS: This real-world evidence suggests that clinical outcomes may vary among initiators of commonly used antidepressants in older adults, which may inform benefit-risk evaluation at treatment initiation, and highlights the importance of careful selection of antidepressant treatment.PMID:37849303 | DOI:10.1176/appi.ajp.20230356 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - October 18, 2023 Category: Psychiatry Authors: Kazi Ishtiak-Ahmed Katherine L Musliner Kaj Sparle Christensen Erik Lykke Mortensen Andrew A Nierenberg Christiane Gasse Source Type: research
Differential targeting of lysophosphatidic acid LPA < sub > 1 < /sub > , LPA < sub > 2 < /sub > , and LPA < sub > 3 < /sub > receptor signalling by tricyclic and tetracyclic antidepressants
Eur J Pharmacol. 2023 Sep 25:176064. doi: 10.1016/j.ejphar.2023.176064. Online ahead of print.ABSTRACTWe previously reported that in different cell types antidepressant drugs activate lysophosphatidic acid (LPA) LPA1 receptor to induce proliferative and prosurvival responses. Here, we further characterize this unique action of antidepressants by examining their effects on two additional LPA receptor family members, LPA2 and LPA3. Human LPA1-3 receptors were stably expressed in HEK-293 cells (HEK-LPA1, -LPA2 and -LPA3 cells) and their functional activity was determined by Western blot and immunofluorescence. LPA effectively...
Source: European Journal of Pharmacology - September 27, 2023 Category: Drugs & Pharmacology Authors: Maria C Olianas Simona Dedoni Pierluigi Onali Source Type: research
Differential targeting of lysophosphatidic acid LPA < sub > 1 < /sub > , LPA < sub > 2 < /sub > , and LPA < sub > 3 < /sub > receptor signalling by tricyclic and tetracyclic antidepressants
Eur J Pharmacol. 2023 Sep 25:176064. doi: 10.1016/j.ejphar.2023.176064. Online ahead of print.ABSTRACTWe previously reported that in different cell types antidepressant drugs activate lysophosphatidic acid (LPA) LPA1 receptor to induce proliferative and prosurvival responses. Here, we further characterize this unique action of antidepressants by examining their effects on two additional LPA receptor family members, LPA2 and LPA3. Human LPA1-3 receptors were stably expressed in HEK-293 cells (HEK-LPA1, -LPA2 and -LPA3 cells) and their functional activity was determined by Western blot and immunofluorescence. LPA effectively...
Source: European Journal of Pharmacology - September 27, 2023 Category: Drugs & Pharmacology Authors: Maria C Olianas Simona Dedoni Pierluigi Onali Source Type: research
Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs
Conclusion: Clinicians should monitor the adverse events associated with the concomitant use of adaptogens and antidepressant drugs in patients with mental disorders. Aggregation of side effects and pharmacokinetic interactions (inhibition of CYP and p-glycoprotein) between those medicines may result in clinically significant adverse events. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 27, 2023 Category: Drugs & Pharmacology Source Type: research
