Differential contribution of 5-HT < sub > 4 < /sub > , 5-HT < sub > 5 < /sub > , and 5-HT < sub > 6 < /sub > receptors to acute pruriceptive processing induced by chloroquine and histamine in mice
Biol Pharm Bull. 2023 Sep 16. doi: 10.1248/bpb.b23-00445. Online ahead of print.ABSTRACTThe involvement of serotonin (5-HT) and/or noradrenaline in acute pruriceptive processing in the central nervous system (CNS) has been reported using antidepressants, such as milnacipran, a serotonin and noradrenaline reuptake inhibitor, and mirtazapine, a noradrenergic and specific serotonergic antidepressant; however, the roles of 5-HT receptor family in acute pruriceptive processing have not been fully elucidated in the CNS. In the present study, scratching behavior induced by chloroquine (CQ) was ameliorated by milnacipran or mirtaz...
Source: Biological and Pharmaceutical Bulletin - September 18, 2023 Category: Drugs & Pharmacology Authors: Yu Miyahara Hideki Funahashi Ayaka Haruta-Tsukamoto Yoichiro Kogoh Anna Kanemaru-Kawazoe Yoji Hirano Toshikazu Nishimori Yasushi Ishida Source Type: research
Usefulness of mirtazapine and SSRIs in late-life depression: post hoc analysis of the GUNDAM study
ConclusionThe potential usefulness of mirtazapine in elderly patients was demonstrated. The results also showed differences in the treatment response to SSRIs and mirtazapine between elderly and non-elderly patients. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - September 13, 2023 Category: Drugs & Pharmacology Source Type: research
Sedative drug-use in Denmark, 2000 to 2019: a nationwide drug utilization study
ConclusionIn Denmark different central regulations have influenced prescription practice toward more restrictive use of Z-drugs and benzodiazepines, except for hypnotic benzodiazepine prescriptions increased after the introduction of special palliative care. An increase in use of newer sedative drugs, however, indicates that the regulations do not remove the need for sedative drugs in the population. (Source: Social Psychiatry and Psychiatric Epidemiology)
Source: Social Psychiatry and Psychiatric Epidemiology - August 26, 2023 Category: Psychiatry Source Type: research
Environmentally relevant concentrations of antidepressant mirtazapine impair the neurodevelopment of zebrafish (Danio rerio)
Ecotoxicol Environ Saf. 2023 Aug 8;262:115335. doi: 10.1016/j.ecoenv.2023.115335. Online ahead of print.ABSTRACTMirtazapine is a commonly prescribed antidepressant and has been found widespread in aquatic environments. However, its toxicities to aquatic organisms has rarely been explored. Herein, we conducted a comprehensive study on the developmental effects of mirtazapine on early life stages of zebrafish at environmentally relevant concentrations (3.9 ng/L and 43.5 ng/L). Out of the endpoints measured, spontaneous contraction of embryos at 24 h post fertilization (hpf) and hatching rate and heart rate of embryos at 50 h...
Source: Ecotoxicology and Environmental Safety - August 11, 2023 Category: Environmental Health Authors: Jie Zhou Yanbin Zhao Jiayin Dai Kun Zhang Source Type: research
Simultaneous separation and determination of several chiral antidepressants and their enantiomers in wastewater by online heart-cutting two-dimensional liquid chromatography
Ecotoxicol Environ Saf. 2023 Jul 26;263:115302. doi: 10.1016/j.ecoenv.2023.115302. Online ahead of print.ABSTRACTA novel method for simultaneous separation and detection of the racemates and the enantiomers of common chiral antidepressants in wastewater matrix was developed by online heart-cutting two-dimensional liquid chromatography (2D-LC) coupled to solid-phase extraction (SPE). Screening of chiral stationary phases (CSPs) and chromatographic conditions was investigated for complete enantioseparation to be compatible with RP-HPLC in 1st D-LC. Using methanol-0.1 % (v/v) ammonia solution as mobile phase, a 2D-LC system w...
Source: Ecotoxicology and Environmental Safety - July 28, 2023 Category: Environmental Health Authors: Jinjian Zhong Xin Liu Linzhou Chen Kan Li Qingkun Hu Ke Wu Jidan Zhou Yuesen Shi Huajun Fan Source Type: research
Cancers, Vol. 15, Pages 3588: Mirtazapine versus Megestrol in the Treatment of Anorexia & ndash;Cachexia Syndrome in Patients with Advanced Cancer: A Randomized, Double-Blind, Controlled Phase II Clinical Trial
This study compared mirtazapine with megestrol in the management of cancer-related anorexia&ndash;cachexia syndrome in patients with advanced cancer. A randomized, double-blind, controlled clinical trial involving patients with advanced cancer and anorexia&ndash;cachexia syndrome was performed. Participants received mirtazapine 30 mg/day or megestrol 320 mg/day for eight weeks. The primary endpoint was the effect of mirtazapine on weight gain and the secondary endpoints were its effect on appetite, muscle strength, physical performance, body composition, adverse events, and medication adherence. Linear regr...
Source: Cancers - July 12, 2023 Category: Cancer & Oncology Authors: Olga Laura Sena Almeida Eduardo Ferriolli Roberta Cristina Cintra Taveira Meire Gallo Rosenburg Daniela Dalpubel Campanari Nat ália Maira da Cruz Alves Karina Pfrimer Liane Rapatoni Fernanda Maris Peria Nereida K. C. Lima Tags: Article Source Type: research
Mirtazapine attenuated cadmium-induced neuronal intoxication by regulating Nrf2 and NF- κB/TLR4 signals
. (Source: Toxicology Mechanisms and Methods)
Source: Toxicology Mechanisms and Methods - July 5, 2023 Category: Toxicology Authors: Saif A. Alharthy Torki A. Zughaibi Puneet Vij Shams Tabrez Majed N. Almashjary Sarah Alharthi Turki Alamri Badra S. Alghamdi Steve Harakeh Sheren A. Azhari Reem M. Farsi Hanan S. Althagafy Emad H. M. Hassanein Source Type: research
Novel pharmacotherapy targeting the positive symptoms of schizophrenia
Expert Opin Pharmacother. 2023 Jul 4. doi: 10.1080/14656566.2023.2231346. Online ahead of print.ABSTRACTINTRODUCTION: The severity of positive symptoms in schizophrenia is associated with poor prognosis. About one third of schizophrenia patients partially respond to treatment with available antipsychotics. Purpose of the present manuscript is to provide an updated overview of novel pharmacotherapy targeting positive symptoms in schizophrenia.AREAS COVERED: A comprehensive research on the main database sources (PubMed, PsychINFO, Isi Web of Knowledge, MEDLINE and EMBASE) was performed to obtain original articles published t...
Source: Expert Opinion on Pharmacotherapy - July 4, 2023 Category: Drugs & Pharmacology Authors: Enrico Capuzzi Alice Caldiroli Cecilia Quitadamo Francesco Butturini Teresa Surace Massimo Clerici Massimiliano Buoli Source Type: research
Novel pharmacotherapy targeting the positive symptoms of schizophrenia
Expert Opin Pharmacother. 2023 Jul 10:1-26. doi: 10.1080/14656566.2023.2231346. Online ahead of print.ABSTRACTINTRODUCTION: The severity of positive symptoms in schizophrenia is associated with poor prognosis. About one-third of schizophrenia patients partially respond to treatment with available antipsychotics. The purpose of the present manuscript is to provide an updated overview of novel pharmacotherapy targeting positive symptoms in schizophrenia.AREAS COVERED: A comprehensive research on the main database sources (PubMed, PsychINFO, Isi Web of Knowledge, MEDLINE, and EMBASE) was performed to obtain original articles ...
Source: Expert Opinion on Pharmacotherapy - July 4, 2023 Category: Drugs & Pharmacology Authors: Enrico Capuzzi Alice Caldiroli Cecilia Quitadamo Francesco Butturini Teresa Surace Massimo Clerici Massimiliano Buoli Source Type: research
A 9-year-old female with iron deficiency has severe periodic limb movements while taking mirtazapine for insomnia
Journal of Clinical Sleep Medicine,Volume 19, Issue 7, Page 1369-1373, July 2023. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - July 1, 2023 Category: Sleep Medicine Authors: Melody Hawkins
Inova Children ’s Sleep Center, Inova Hospital System, Fairfax, Virginia Source Type: research
