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miR-195 Potentiates the Efficacy of Microtubule-Targeting Agents in Non-Small Cell Lung Cancer
Microtubule-targeting agents (MTAs) are widely used for the treatment of non-small cell lung cancer (NSCLC). The response rate is only ∼25%, mainly attributable to drug resistance. To identify determinants of resistance in NSCLC, we performed a high-throughput screen using a library of miRNA mimics. Here we report that miR-195 synergizes with MTAs to inhibit the growth of NSCLC cells in vitro, that increased expression of miR-195 sensitizes NSCLC cells to MTAs and that repression of miR-195 confers resistance to MTAs. (Source: Cancer Letters)
Source: Cancer Letters - April 13, 2018 Category: Cancer & Oncology Authors: Xiaojie Yu, Yiqiang Zhang, Xiuye Ma, Alexander Pertsemlidis Tags: Original Articles Source Type: research

Meta-analysis of molecular targeted agents in the treatment of elderly patients with metastatic colorectal cancer: Does the age matter ?
Conclusions: The introduction of MTAs to therapies offered a survival benefit in elderly patients with mCRC. Further studies aimed at this specific patient population were still needed to watchfully monitor potential treatment-related toxicities to optimize the use of these drugs. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - March 26, 2018 Category: Cancer & Oncology Authors: Chuan Jie Zhao ShuLiang Li Qiang Liu Source Type: research

Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130Cas/Src inhibition by eribulin.
Authors: Dybdal-Hargreaves NF, Risinger AL, Mooberry SL Abstract Microtubule targeting agents (MTAs) are some of the most effective anticancer drugs used to treat a wide variety of adult and pediatric cancers. Building evidence suggests that these drugs inhibit interphase signaling events and that this contributes to their anticancer actions. The effects of diverse MTAs were evaluated following a 2 hour incubation with clinically relevant concentrations to test the hypothesis that these drugs rapidly and differentially disrupt epithelial-to-mesenchymal transition (EMT)-related signaling. The MTAs rapidly p...
Source: Oncotarget - February 23, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Genetic dissection of wheat panicle traits using linkage analysis and a genome-wide association study.
This study provides potentially valuable information on the dissection of yield-component traits and valuable genetic alleles for molecular-design breeding or functional gene exploration. PMID: 29470622 [PubMed - as supplied by publisher] (Source: TAG. Theoretical and Applied Genetics)
Source: TAG. Theoretical and Applied Genetics - February 22, 2018 Category: Genetics & Stem Cells Authors: Liu K, Sun X, Ning T, Duan X, Wang Q, Liu T, An Y, Guan X, Tian J, Chen J Tags: Theor Appl Genet Source Type: research

Current Status and Future Prospects of Next-Generation Data Management and Analytical Decision Support Tools for Enhancing Genetic Gains in Crops.
Abstract Agricultural disciplines are becoming data intensive and the agricultural research data generation technologies are becoming sophisticated and high throughput. On the one hand, high-throughput genotyping is generating petabytes of data; on the other hand, high-throughput phenotyping platforms are also generating data of similar magnitude. Under modern integrated crop breeding, scientists are working together by integrating genomic and phenomic data sets of huge data volumes on a routine basis. To manage such huge research data sets and use them appropriately in decision making, Data Management Ana...
Source: Advances in Biochemical Engineering Biotechnology - January 26, 2018 Category: Biotechnology Authors: Rathore A, Singh VK, Pandey SK, Rao CS, Thakur V, Pandey MK, Anil Kumar V, Das RR Tags: Adv Biochem Eng Biotechnol Source Type: research

Interactome Analysis of Microtubule-targeting Agents Reveals Cytotoxicity Bases in Normal Cells
Publication date: Available online 12 December 2017 Source:Genomics, Proteomics & Bioinformatics Author(s): Andrés Julián Gutiérrez-Escobar, Gina Méndez-Callejas Cancer causes millions of deaths annually and microtubule-targeting agents (MTAs) are the most commonly-used anti-cancer drugs. However, the high toxicity of MTAs on normal cells raises great concern. Due to the non-selectivity of MTA targets, we analyzed the interaction network in a non-cancerous human cell. Subnetworks of fourteen MTAs were reconstructed and the merged network was compared against a randomized network to evaluate the functional r...
Source: Genomics, Proteomics and Bioinformatics - December 16, 2017 Category: Bioinformatics Source Type: research

Revisiting the definition of dose-limiting toxicities in paediatric oncology phase I clinical trials: An analysis from the Innovative Therapies for Children with Cancer Consortium
Dose-escalation trials aim to identify the maximum tolerated dose and, importantly, the recommended phase II dose (RP2D) and rely on the occurrence of dose-limiting toxicities (DLTs) during the first treatment cycle. Molecularly targeted agents (MTAs) often follow continuous and prolonged administrations, displaying a distinct toxicity profile compared to conventional chemotherapeutics, and classical DLT criteria might not be appropriate to evaluate MTAs' toxicity. We investigated this issue in children. (Source: European Journal of Cancer)
Source: European Journal of Cancer - October 19, 2017 Category: Cancer & Oncology Authors: Francisco Bautista, Lucas Moreno, Lynley Marshall, Andrew D.J. Pearson, Birgit Geoerger, Xavier Paoletti Tags: Original Research Source Type: research

Genome-wide association mapping of vitamins B1 and B2 in common wheat
Publication date: Available online 4 October 2017 Source:The Crop Journal Author(s): Jieyun Li, Jindong Liu, Wei'e Wen, Pingzhi Zhang, Yingxiu Wan, Xianchun Xia, Yan Zhang, Zhonghu He Vitamin B is essential for maintaining normal life activities in humans and animals who have to intake the microelement from the outside, especially from cereal products. In the present study 166 Chinese and foreign wheat cultivars planted in two environments were characterized for variation in vitamin B1 and B2 contents. A genome-wide association study (GWAS) using the wheat 90K SNP assay identified 17 loci for vitamin B1 and 7 for...
Source: The Crop Journal - October 5, 2017 Category: Food Science Source Type: research

Enhancing monoterpene alcohols in sweet potato shochu using the diglycoside-specific β-primeverosidase
Publication date: Available online 12 September 2017 Source:Journal of Bioscience and Bioengineering Author(s): Yuichiro Sato, Jinshun Han, Hisashi Fukuda, Shigeaki Mikami Monoterpene alcohols (MTAs) are characteristic flavour-imparting compounds in sweet potato shochu (Japanese distilled spirit) that are liberated following hydrolysis by specific enzymes during fermentation. In the present study, we evaluated the effect of an exogenously added diglycoside-specific β-glycosidase (β-primeverosidase) on aroma formation during shochu brewing using various sweet potato species to address whether MTAs are predominantly ...
Source: Journal of Bioscience and Bioengineering - September 13, 2017 Category: Biomedical Science Source Type: research

MTA1 expression in human cancers – Clinical and pharmacological significance
Publication date: November 2017 Source:Biomedicine & Pharmacotherapy, Volume 95 Author(s): Vijaya Lakshmi Malisetty, Vasudevarao Penugurti, Prashanth Panta, Suresh Kumar Chitta, Bramanandam Manavathi Remarkably, majority of the cancer deaths are due to metastasis, not because of primary tumors. Metastasis is one of the important hallmarks of cancer. During metastasis invasion of primary tumor cells from the site of origin to a new organ occurs. Metastasis associated proteins (MTAs) are a small family of transcriptional coregulators that are closely associated with tumor metastasis. These proteins are integra...
Source: Biomedicine and Pharmacotherapy - September 12, 2017 Category: Drugs & Pharmacology Source Type: research

MTA1 expression in human cancers - Clinical and pharmacological significance.
Abstract Remarkably, majority of the cancer deaths are due to metastasis, not because of primary tumors. Metastasis is one of the important hallmarks of cancer. During metastasis invasion of primary tumor cells from the site of origin to a new organ occurs. Metastasis associated proteins (MTAs) are a small family of transcriptional coregulators that are closely associated with tumor metastasis. These proteins are integral components of nuclear remodeling and deacetylation complex (NuRD). By virtue of being integral components of NuRD, these proteins regulate the gene expression by altering the epigenetic c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 11, 2017 Category: Drugs & Pharmacology Authors: Malisetty VL, Penugurti V, Panta P, Chitta SK, Manavathi B Tags: Biomed Pharmacother Source Type: research

Molecularly targeted agents in oculoplastic surgery
Purpose of review:Significant advances have been made in oncology and rheumatology with the introduction of molecularly targeted agents (MTAs). MTAs consist of monoclonal antibodies and small molecule inhibitors. The purpose of this manuscript is to review the recent applications of MTAs to orbital, lacrimal, and eyelid disease. Recent findings:The use of monoclonal antibodies has been described in the treatment of orbital vascular lesions, lymphoma, and squamous cell carcinoma. Inflammatory conditions treated with monoclonal antibodies include thyroid eye disease, IgG4 disease, and granulomatosis with polyangiitis. Immun...
Source: Current Opinion in Ophthalmology - August 18, 2017 Category: Opthalmology Tags: OCULOPLASTIC AND ORBITAL SURGERY: Edited by Richard C. Allen Source Type: research

The novel microtubule targeting agent BAL101553 in combination with radiotherapy in treatment-refractory tumor models.
CONCLUSIONS: BAL101553 is a promising alternative in taxane- and epothilone-refractory tumors as part of a combined treatment modality with ionizing radiation. Its potent antitumor effect is not only tumor cell-directed but also targets the tumor microenvironment. PMID: 28797699 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 7, 2017 Category: Radiology Authors: Sharma A, Broggini-Tenzer A, Vuong V, Messikommer A, Nytko KJ, Guckenberger M, Bachmann F, Lane HA, Pruschy M Tags: Radiother Oncol Source Type: research

The novel microtubule targeting agent BAL101553 in combination with radiotherapy in treatment-refractory tumor models
Resistance to microtubule targeting agents (MTA) represents a major drawback in successful cancer therapy with MTAs. Here we investigated the combined treatment modality of the novel MTA BAL101553 in combination with radiotherapy in paclitaxel and epothilone-resistant tumor models. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - August 7, 2017 Category: Radiology Authors: Ashish Sharma, Angela Broggini-Tenzer, Van Vuong, Alessandra Messikommer, Katarzyna J. Nytko, Matthias Guckenberger, Felix Bachmann, Heidi A. Lane, Martin Pruschy Tags: Original article Source Type: research