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Identification of significant marker-trait associations for Fusarium wilt resistance in a genetically diverse core collection of safflower using AFLP and SSR markers
J Appl Genet. 2022 May 6. doi: 10.1007/s13353-022-00694-z. Online ahead of print.ABSTRACTSafflower (Carthamus tinctorius L.), an oilseed crop, is severely affected by Fusarium oxysporum f. sp. carthami (Foc), a fungus causing Fusarium wilt (FW) resulting in up to 80% yield loss. In the present study, we used a panel of 84 diverse accessions from the composite core collection to perform association mapping for FW-resistance. Hydroponics-based screening resulted in categorization of 84 accessions as 31 immune, 19 highly resistant, 9 moderately resistant, 4 moderately susceptible, and 21 highly susceptible. Genotyping with a ...
Source: J Appl Genet - May 6, 2022 Category: Genetics & Stem Cells Authors: Krishna Nand Singh Sapna Rawat Kuldeep Kumar Surekha Katiyar Agarwal Shailendra Goel Arun Jagannath Manu Agarwal Source Type: research

Genetic analysis of novel resistance sources and genome-wide association mapping identified novel QTLs for resistance to Zymoseptoria tritici, the causal agent of septoria tritici blotch in wheat
In this study, a panel of bread wheat genotypes comprised 185 globally diverse genotypes were tested against 10 Z. tritici isolates at the seedling stage. Genome-wide association study (GWAS) using high-throughput DArTseq markers was performed and further gene expression analysis of significant markers trait association (MTAs) associated with resistance to STB was analyzed. Disease severity level showed significant differences among wheat genotypes for resistance to different Z. tritici isolates. We found novel landrace genotypes that showed highly resistance spectra to all tested isolates. GWAS analysis resulted in 19 qua...
Source: J Appl Genet - April 28, 2022 Category: Genetics & Stem Cells Authors: Mozghan Mahboubi Reza Talebi Rahim Mehrabi Amir Mohammad Naji Marco Maccaferri Gert H J Kema Source Type: research

An Update on Resistance Genes and Their Use in the Development of Leaf Rust Resistant Cultivars in Wheat
Wheat is one of the most important cereal crops in the world. The production and productivity of wheat is adversely affected by several diseases including leaf rust, which can cause yield losses, sometimes approaching >50%. In the present mini-review, we provide updated information on (i) all Lr genes including those derived from alien sources and 14 other novel resistance genes; (ii) a list of QTLs identified using interval mapping and MTAs identified using GWAS (particular those reported recently i.e., after 2018) and their association with known Lr genes; (iii) introgression/pyramiding of individual Lr genes in comme...
Source: Frontiers in Genetics - March 31, 2022 Category: Genetics & Stem Cells Source Type: research

Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy
Eur J Med Chem. 2022 Mar 20;235:114274. doi: 10.1016/j.ejmech.2022.114274. Online ahead of print.ABSTRACTAutophagy is a lysosome dependent cell survival mechanism and is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Targeting autophagy in cancer therapy attracted considerable attention in the past as stress-induced autophagy has been demonstrated to contribute to both drug resistance and malignant progression and recently interest in this area has re-emerged. Unlocking the therapeutic potential of autophagy modulation could be a valuable strategy for designing innov...
Source: European Journal of Medicinal Chemistry - March 28, 2022 Category: Chemistry Authors: Giuseppe Campiani Tuhina Khan Cristina Ulivieri Leopoldo Staiano Chiara Papulino Stefania Magnano Seema Nathwani Anna Ramunno Daniel Lucena-Agell Nicola Relitti Stefano Federico Luca Pozzetti Gabriele Carullo Alice Casagni Simone Brogi Francesca Vanni Pao Source Type: research

High-Density Genetic Variation Map Reveals Key Candidate Loci and Genes Associated With Important Agronomic Traits in Peanut
This study outlines the genetic basis of these peanut cultivars and provides 13,125 polymorphic SNP markers for further distinguishing and utility of these elite cultivars. In addition, the candidate loci and genes provide valuable information for further fine mapping of QTLs and improving the quality and yield of peanut using a genomic-assisted breeding method. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - March 25, 2022 Category: Genetics & Stem Cells Source Type: research

Clinical evaluation of Elecsys PIVKA-II for patients with advanced hepatocellular carcinoma
ConclusionThe Elecsys PIVKA-II was not only as useful as the Lumipulse PIVKA-II but also for stratifying the PFS of patients with advanced HCC. (Source: PLoS One)
Source: PLoS One - March 10, 2022 Category: Biomedical Science Authors: Shun Kaneko Source Type: research

Genotyping-by-sequencing and genome-wide association study reveal genetic diversity and loci controlling agronomic traits in triticale
Theor Appl Genet. 2022 Mar 4. doi: 10.1007/s00122-022-04064-5. Online ahead of print.ABSTRACTThe genetic diversity and loci underlying agronomic traits were analyzed by the reads coverage and genome-wide association study based genotyping-by-sequencing in a diverse population consisting of 199 accessions. Triticale (× Triticosecale Wittmack) is an economically important grain forage and energy crop planted worldwide for its high biomass. Little is known about the genetic diversity and loci underlying agronomic traits in triticale. We performed genotyping-by-sequencing of 199 cultivars and mapped reads to the A, B, D, and ...
Source: TAG. Theoretical and Applied Genetics - March 4, 2022 Category: Genetics & Stem Cells Authors: Dong Cao Dongxia Wang Shiming Li Yun Li Ming Hao Baolong Liu Source Type: research

Candidate Therapeutics by Screening for Multitargeting Ligands: Combining the CB2 Receptor With CB1, PPAR γ and 5-HT4 Receptors
In this study, we built activity models for CB2R and other targets for combinations that could be used for several indications. Those additional targets are the cannabinoid 1 receptor (CB1R), peroxisome proliferator-activated receptor gamma (PPARγ), and 5-Hydroxytryptamine receptor 4 (5-HT4R). All these models have high statistical parameters and are reliable. Many more CB2R/CBIR agonists were found than combined CB2R agonists with CB1R antagonist activity (by 200 fold). CB2R agonism combined with PPARγ or 5-HT4R agonist activity may be used for treating Inflammatory Bowel Disease (IBD). Combining CB2R agonism with 5-HT4...
Source: Frontiers in Pharmacology - February 28, 2022 Category: Drugs & Pharmacology Source Type: research

Massive Transfusion Activations in Non-Trauma Patients
CONCLUSIONS: Massive transfusion activations are frequently used in non-trauma patients. There was a low rate of adherence to 1:1:1 transfusion ratios as well as utilization of adjuncts and tools that could allow for targeted resuscitation. Understanding practice patterns relating to MTA may allow for an opportunity for improvement.PMID:35128953 | DOI:10.1177/00031348221075752 (Source: The American Surgeon)
Source: The American Surgeon - February 7, 2022 Category: Surgery Authors: Navpreet Dhillon Ihab Abumuhor Chelsea Hayes Shruthi Nammalwar Joshua Ghoulian Mona Asadi Eric J Ley Source Type: research