A 3D printed ultra-short dental implant based on lattice structures and ZIRCONIA/Ca < sub > 2 < /sub > SiO < sub > 4 < /sub > combination
J Mech Behav Biomed Mater. 2024 Apr 21;155:106559. doi: 10.1016/j.jmbbm.2024.106559. Online ahead of print.ABSTRACTAdditive Manufacturing (AM) enables the generation of complex geometries and controlled internal cavities that are so interesting for the biomedical industry due to the benefits they provide in terms of osseointegration and bone growth. These technologies enable the manufacturing of the so-called lattice structures that are cells with different geometries and internal pores joint together for the formation of scaffold-type structures. In this context, the present paper analyses the feasibility of using diamond...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 24, 2024 Category: Materials Science Authors: Ahmed Binobaid Ahmet Guner Josette Camilleri Amaia Jim énez Khamis Essa Source Type: research
How do different intraoral scanners and milling machines affect the fit and fatigue behavior of lithium disilicate and resin composite endocrowns?
J Mech Behav Biomed Mater. 2024 Apr 18;155:106557. doi: 10.1016/j.jmbbm.2024.106557. Online ahead of print.ABSTRACTThe aim of this in vitro study was to evaluate the effect of the combinations of two different intraoral scanners (IOS), two milling machines, and two restorative materials on the marginal/internal fit and fatigue behavior of endocrowns produced by CAD-CAM. Eight groups (n= 10) were considered through the combination of TRIOS 3 (TR) or Primescan (PS) IOS; 4-axes (CR; CEREC MC XL) or 5-axes (PM; PrograMill PM7) milling machines; and lithium disilicate (LD; IPS e.max CAD) or resin composite (RC; Tetric CAD) rest...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 24, 2024 Category: Materials Science Authors: Rafaela Oliveira Pilecco Lucas Saldanha da Rosa Andrea Baldi Renan Vaz Machry Jo ão Paulo Mendes Tribst Luiz Felipe Valandro Cornelis Johannes Kleverlaan Nicola Scotti Gabriel Kalil Rocha Pereira Source Type: research
A Review of Current Achievements and Recent Challenges in Bacterial Medium-Chain-Length Polyhydroxyalkanoates: Production and Potential Applications
In conclusion, this review serves as a valuable resource to understand mcl-PHAs as sustainable alternatives to conventional plastics. However, further research is needed to optimize production methods, evaluate long-term ecological impacts, and assess the feasibility and viability in various industries.PMID:38656151 | DOI:10.1021/acs.biomac.4c00090 (Source: Biomacromolecules)
Source: Biomacromolecules - April 24, 2024 Category: Biochemistry Authors: Nahid Azizi Reza Eslami Shaghayegh Goudarzi Habibollah Younesi Hadis Zarrin Source Type: research
Fecal Microbiota Transplantation Improves Clinical Symptoms of Fibromyalgia: An open-label, Randomized, Nonplacebo-Controlled Study
This study was aimed to investigate the potential benefits of fecal microbiota transplantation (FMT) in patients with FM. A total of 45 patients completed this open-label randomized, nonplacebo-controlled clinical study. The Numerical Rating Scale (NRS) scores in the FMT group were slightly lower than the control group at 1 month (P> 0.05), and they decreased significantly at 2, 3, 6, and 12 months after treatment (P (Source: The Journal of Pain)
Source: The Journal of Pain - April 23, 2024 Category: Materials Science Authors: Hongwei Fang, Qianhao Hou, Wei Zhang, Zehua Su, Jinyuan Zhang, Jingze Li, Jiaqi Lin, Zetian Wang, Xiuqin Yu, Yu Yang, Qing Wang, Xin Li, Yuling Li, Lungui Hu, Shun Li, Xiangrui Wang, Lijun Liao Source Type: research
Interactions Between Endocannabinoid and Endogenous Opioid Systems Prospectively Influence Postoperative Opioid Use in Pregnant Patients Undergoing Cesarean Delivery
This study evaluated the interactive effects of preoperative beta-endorphin concentrations (a key analgesic endogenous opioid) in cerebrospinal fluid (CSF) and ECs (CSF and plasma 2-arachidonoylglycerol [2-AG] and plasma anandamide [AEA]) on postoperative opioid use and pain intensity in a prospective cohort of n = 112 pregnant patients undergoing scheduled cesarean delivery. (Source: The Journal of Pain)
Source: The Journal of Pain - April 23, 2024 Category: Materials Science Authors: Amanda L. Stone, Amelie Pham, Sarah S. Osmundson, Alex Pedowitz, Philip J. Kingsley, Larry J. Marnett, Sachin Patel, Nancy Wickersham, Laura L. Sorabella, Stephen Bruehl Source Type: research
Pain catastrophizing moderates the relationship between pain sensitivity and clinical pain in adolescents with functional abdominal pain
Pain catastrophizing has been linked to amplified pain sensitivity assessed using quantitative sensory testing (QST) in adults; pediatric data is limited, particularly in youth with functional abdominal pain (FAP). With increasing use of QST to evaluate somatosensory function and predict pain outcomes, we examined the associations between QST and clinical pain in adolescents with FAP and tested the moderating effects of pain catastrophizing. Seventy-seven adolescents (mean age 16.6 years, 85.7% female, 72.7% White, 90.8% non-Hispanic) who fulfilled diagnostic criteria for FAP completed QST assessment (pressure pain thresho...
Source: The Journal of Pain - April 22, 2024 Category: Materials Science Authors: See Wan Tham, Rui Li, Robert R. Edwards, Tonya M. Palermo Source Type: research
Beyond surface modification strategies to control infections associated with implanted biomaterials and devices - Addressing the opportunities offered by nanotechnology
Biomaterials. 2024 Apr 16;308:122576. doi: 10.1016/j.biomaterials.2024.122576. Online ahead of print.ABSTRACTBiomaterial-associated infection (BAI) is considered a unique infection due to the presence of a biomaterial yielding frustrated immune-cells, ineffective in clearing local micro-organisms. The involvement of surface-adherent/surface-adapted micro-organisms in BAI, logically points to biomaterial surface-modifications for BAI-control. Biomaterial surface-modification is most suitable for prevention before adhering bacteria have grown into a mature biofilm, while BAI-treatment is virtually impossible through surface-...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Da-Yuan Wang Linzhu Su Kees Poelstra David W Grainger Henny C van der Mei Linqi Shi Henk J Busscher Source Type: research
Implantable CAR T cell factories enhance solid tumor treatment
Biomaterials. 2024 Apr 15;308:122580. doi: 10.1016/j.biomaterials.2024.122580. Online ahead of print.ABSTRACTChimeric Antigen Receptor (CAR) T cell therapy has produced revolutionary success in hematological cancers such as leukemia and lymphoma. Nonetheless, its translation to solid tumors faces challenges due to manufacturing complexities, short-lived in vivo persistence, and transient therapeutic impact. We introduce 'Drydux' - an innovative macroporous biomaterial scaffold designed for rapid, efficient in-situ generation of tumor-specific CAR T cells. Drydux expedites CAR T cell preparation with a mere three-day turnar...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Sharda Pandit Pritha Agarwalla Feifei Song Anton Jansson Gianpietro Dotti Yevgeny Brudno Source Type: research
Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy
Biomaterials. 2024 Apr 15;308:122581. doi: 10.1016/j.biomaterials.2024.122581. Online ahead of print.ABSTRACTCancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by c...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Yiliang Yang Yiwei Peng Yitian Du Meng Lin Jiajia Li Datong Gao Zhenzhen Yang Wei Wang Yanxia Zhou Xinru Li Taiqiang Yan Xianrong Qi Source Type: research
3D-printed bioinspired spicules: Strengthening and toughening via stereolithography
In this study, structures inspired by spicules were designed and fabricated using the stereolithography (SLA) 3D printing technique. The mechanical properties of concentric cylindrical structures (CCSs) inspired by the spicule microstructure were evaluated, considering factors such as the wall thickness of the cylinders, the number of layers, and core diameter, all of which significantly affect the mechanical response. These results were compared with those obtained from solid rods used as solid samples. The findings indicated that CCSs with five layers or fewer exhibited a flexural strength close to or higher than that of...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 19, 2024 Category: Materials Science Authors: Fariborz Tavangarian Sorour Sadeghzade Niloofar Fani Dariush Khezrimotlagh Keivan Davami Source Type: research
SLA-3d printed building and characteristics of GelMA/HAP biomaterials with gradient porous structure
J Mech Behav Biomed Mater. 2024 Apr 12;155:106553. doi: 10.1016/j.jmbbm.2024.106553. Online ahead of print.ABSTRACTDeveloping a gradient porous scaffold similar to bone structure is gaining increasing attention in bone tissue engineering. The GelMA/HAP hydrogel has demonstrated potential in bone repair. Although 3D printing can build GelMA/HAP with porous structure, fabricating porous GelMA/HAP with gradient porosity and pore size in one step remains challenging. In this paper, a gradient porous structure with controllable pore size, based on gelatin methacryloyl (GelMA) and hydxroxyapatite (HAP), was engineered and printe...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 19, 2024 Category: Materials Science Authors: Qinghua Chen Bin Zou Xinfeng Wang Xingguo Zhou Gongxian Yang Qingguo Lai Yun Zhao Source Type: research
Beyond surface modification strategies to control infections associated with implanted biomaterials and devices - Addressing the opportunities offered by nanotechnology
Biomaterials. 2024 Apr 16;308:122576. doi: 10.1016/j.biomaterials.2024.122576. Online ahead of print.ABSTRACTBiomaterial-associated infection (BAI) is considered a unique infection due to the presence of a biomaterial yielding frustrated immune-cells, ineffective in clearing local micro-organisms. The involvement of surface-adherent/surface-adapted micro-organisms in BAI, logically points to biomaterial surface-modifications for BAI-control. Biomaterial surface-modification is most suitable for prevention before adhering bacteria have grown into a mature biofilm, while BAI-treatment is virtually impossible through surface-...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Da-Yuan Wang Linzhu Su Kees Poelstra David W Grainger Henny C van der Mei Linqi Shi Henk J Busscher Source Type: research
Implantable CAR T cell factories enhance solid tumor treatment
Biomaterials. 2024 Apr 15;308:122580. doi: 10.1016/j.biomaterials.2024.122580. Online ahead of print.ABSTRACTChimeric Antigen Receptor (CAR) T cell therapy has produced revolutionary success in hematological cancers such as leukemia and lymphoma. Nonetheless, its translation to solid tumors faces challenges due to manufacturing complexities, short-lived in vivo persistence, and transient therapeutic impact. We introduce 'Drydux' - an innovative macroporous biomaterial scaffold designed for rapid, efficient in-situ generation of tumor-specific CAR T cells. Drydux expedites CAR T cell preparation with a mere three-day turnar...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Sharda Pandit Pritha Agarwalla Feifei Song Anton Jansson Gianpietro Dotti Yevgeny Brudno Source Type: research
Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy
Biomaterials. 2024 Apr 15;308:122581. doi: 10.1016/j.biomaterials.2024.122581. Online ahead of print.ABSTRACTCancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by c...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Yiliang Yang Yiwei Peng Yitian Du Meng Lin Jiajia Li Datong Gao Zhenzhen Yang Wei Wang Yanxia Zhou Xinru Li Taiqiang Yan Xianrong Qi Source Type: research
SLA-3d printed building and characteristics of GelMA/HAP biomaterials with gradient porous structure
J Mech Behav Biomed Mater. 2024 Apr 12;155:106553. doi: 10.1016/j.jmbbm.2024.106553. Online ahead of print.ABSTRACTDeveloping a gradient porous scaffold similar to bone structure is gaining increasing attention in bone tissue engineering. The GelMA/HAP hydrogel has demonstrated potential in bone repair. Although 3D printing can build GelMA/HAP with porous structure, fabricating porous GelMA/HAP with gradient porosity and pore size in one step remains challenging. In this paper, a gradient porous structure with controllable pore size, based on gelatin methacryloyl (GelMA) and hydxroxyapatite (HAP), was engineered and printe...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 19, 2024 Category: Materials Science Authors: Qinghua Chen Bin Zou Xinfeng Wang Xingguo Zhou Gongxian Yang Qingguo Lai Yun Zhao Source Type: research
