Prevalence and biopsychosocial factors associated with a current episode of low back pain amongst adults with previous history of low back pain: a cross-sectional study of market traders in an African population
Low back pain (LBP) is the leading cause of years lived with disability globally, with Nigeria having one of the greatest burdens. A current episode of LBP is important in Nigeria, but the associated factors are unknown. This cross-sectional study investigated the prevalence, biomechanical and psychosocial factors associated with a current episode of LBP amongst 700 adult market traders with previous LBP in an urban Nigerian population. Descriptive, bivariate, and multivariate analyses were conducted. (Source: The Journal of Pain)
Source: The Journal of Pain - April 8, 2024 Category: Materials Science Authors: Chinonso Nwamaka Igwesi-Chidobe, Confidence N Ifeanyichukwu, Joshua P Okorie, Muhammad Faisal, Benjamin C Ozumba Source Type: research
Body image measured via the Fremantle Awareness Questionnaire in individuals with and without pain: a systematic review and meta-analysis
Research suggests that pain negatively affects body image, and body image may also influence reported pain levels. This review aims to summarize the literature on differences in body image distortion between individuals with pain compared to pain-free individuals. The review was conducted according to the PRISMA 2020 statement and an a priori pre-registered protocol. The literature was searched using five electronic databases. Studies assessing body image with the Fremantle Awareness Questionnaire (FAQ) in individuals with and without pain were eligible for inclusion. (Source: The Journal of Pain)
Source: The Journal of Pain - April 8, 2024 Category: Materials Science Authors: Aleksandra Budzisz, Andres Jung, Waclaw M. Adamczyk, Tibor M. Szikszay, Gabriela F. Carvalho, Przemys ław Bąbel, Kerstin Luedtke Tags: Review Article Source Type: research
Perioperative Risk Factors for Persistent Postsurgical Pain after Inguinal Hernia Repair: Systematic Review and Meta-analysis
The objective of this study was to systematically review and meta-analyze risk factors that contribute to PPSP after IHR. The literature search resulted in 303 papers included in this review, 140 of which were used for meta-analyses. (Source: The Journal of Pain)
Source: The Journal of Pain - April 8, 2024 Category: Materials Science Authors: Harutyun Alaverdyan, Jooyoung Maeng, Peter K Park, Kavya Narayana Reddy, Michael P Gaume, Lauren Yaeger, Michael M. Awad, Simon Haroutounian Tags: Review Article Source Type: research
Optimization of lipid nanoparticles for gene editing of the liver via intraduodenal delivery
Biomaterials. 2024 Apr 4;308:122559. doi: 10.1016/j.biomaterials.2024.122559. Online ahead of print.ABSTRACTLipid nanoparticles (LNPs) have recently emerged as successful gene delivery platforms for a diverse array of disease treatments. Efforts to optimize their design for common administration methods such as intravenous injection, intramuscular injection, or inhalation, revolve primarily around the addition of targeting ligands or the choice of ionizable lipid. Here, we employed a multi-step screening method to optimize the type of helper lipid and component ratios in a plasmid DNA (pDNA) LNP library to efficiently deli...
Source: Biomaterials - April 7, 2024 Category: Materials Science Authors: Yining Zhu Shuting Sarah Cai Jingyao Ma Leonardo Cheng Christine Wei Ataes Aggarwal Wu Han Toh Charles Shin Ruochen Shen Jiayuan Kong Shuming Alan Mao Yeh-Hsing Lao Kam W Leong Hai-Quan Mao Source Type: research
Engineered extracellular vesicle-based gene therapy for the treatment of discogenic back pain
Biomaterials. 2024 Apr 1;308:122562. doi: 10.1016/j.biomaterials.2024.122562. Online ahead of print.ABSTRACTPainful musculoskeletal disorders such as intervertebral disc (IVD) degeneration associated with chronic low back pain (termed "Discogenic back pain", DBP), are a significant socio-economic burden worldwide and contribute to the growing opioid crisis. Yet there are very few if any successful interventions that can restore the tissue's structure and function while also addressing the symptomatic pain. Here we have developed a novel non-viral gene therapy, using engineered extracellular vesicles (eEVs) to deliver the d...
Source: Biomaterials - April 7, 2024 Category: Materials Science Authors: Shirley N Tang Ana I Salazar-Puerta Mary K Heimann Kyle Kuchynsky Mar ía A Rincon-Benavides Mia Kordowski Gilian Gunsch Lucy Bodine Khady Diop Connor Gantt Safdar Khan Anna Bratasz Olga Kokiko-Cochran Julie Fitzgerald Damien M Laudier Judith A Hoyland Be Source Type: research
