Transformation of metallo-elastomer grafts in a carotid artery interposition model over a year
Biomaterials. 2024 Apr 26;309:122598. doi: 10.1016/j.biomaterials.2024.122598. Online ahead of print.ABSTRACTCurrent vascular grafts, primarily Gore-Tex® and Dacron®, don't integrate with the host and have low patency in small-diameter vessels (<6 mm). Biomaterials that possess appropriate viscoelasticity, compliance, and high biocompatibility are essential for their application in small blood vessels. We have developed metal ion crosslinked poly(propanediol-co-(hydroxyphenyl methylene)amino-propanediol sebacate) (M-PAS), a biodegradable elastomer with a wide range of mechanical properties. We call these materials met...
Source: Biomaterials - May 2, 2024 Category: Materials Science Authors: Ying Grace Chen Catia Dombaxe Anthony Richard D'Amato Simon Van Herck Halle Welch Qin Fu Sheng Zhang Yadong Wang Source Type: research
Dynamic injectable tissue adhesives with strong adhesion and rapid self-healing for regeneration of large muscle injury
Biomaterials. 2024 Apr 26;309:122597. doi: 10.1016/j.biomaterials.2024.122597. Online ahead of print.ABSTRACTWounds often necessitate the use of instructive biomaterials to facilitate effective healing. Yet, consistently filling the wound and retaining the material in place presents notable challenges. Here, we develop a new class of injectable tissue adhesives by leveraging the dynamic crosslinking chemistry of Schiff base reactions. These adhesives demonstrate outstanding mechanical properties, especially in regard to stretchability and self-healing capacity, and biodegradability. Furthermore, they also form robust adhes...
Source: Biomaterials - May 2, 2024 Category: Materials Science Authors: Sungmin Nam Junzhe Lou Sangmin Lee Jan-Marc Kartenbender David J Mooney Source Type: research
In vitro models for studying implant-associated biofilms - A review from the perspective of bioengineering 3D microenvironments
Biomaterials. 2024 Apr 20;309:122578. doi: 10.1016/j.biomaterials.2024.122578. Online ahead of print.ABSTRACTBiofilm research has grown exponentially over the last decades, arguably due to their contribution to hospital acquired infections when they form on foreign body surfaces such as catheters and implants. Yet, translation of the knowledge acquired in the laboratory to the clinic has been slow and/or often it is not attempted by research teams to walk the talk of what is defined as 'bench to bedside'. We therefore reviewed the biofilm literature to better understand this gap. Our search revealed substantial development...
Source: Biomaterials - May 1, 2024 Category: Materials Science Authors: Silvia Cometta Dietmar W Hutmacher Liraz Chai Source Type: research
Microenvironment-sensitive nanozymes for tissue regeneration
Biomaterials. 2024 Apr 27;309:122585. doi: 10.1016/j.biomaterials.2024.122585. Online ahead of print.ABSTRACTTissue defect is one of the significant challenges encountered in clinical practice. Nanomaterials, including nanoparticles, nanofibers, and metal-organic frameworks, have demonstrated an extensive potential in tissue regeneration, offering a promising avenue for future clinical applications. Nonetheless, the intricate landscape of the inflammatory tissue microenvironment has engendered challenges to the efficacy of nanomaterial-based therapies. This quandary has spurred researchers to pivot towards advanced nanotec...
Source: Biomaterials - May 1, 2024 Category: Materials Science Authors: Yuan Xiong Bobin Mi Guohui Liu Yanli Zhao Source Type: research
Photosensitive AIEgens sensitize bacteria to oxidative damage and modulate the inflammatory responses of macrophages to salvage the photodynamic therapy against MRSA
Biomaterials. 2024 Apr 26;309:122583. doi: 10.1016/j.biomaterials.2024.122583. Online ahead of print.ABSTRACTThe urgent need for antimicrobial agents to combat infections caused by multidrug-resistant bacteria facilitates the exploration of alternative strategies such as photosensitizer (PS)-mediated photoinactivation. However, increasing studies have discovered uncorrelated bactericidal activities among PSs possessing similar photodynamic and pathogen-targeted properties. To optimize the photodynamic therapy (PDT) against infections, we investigated three type-I PSs of D-π-A AIEgens TI, TBI, and TTI. The capacities of re...
Source: Biomaterials - May 1, 2024 Category: Materials Science Authors: Yifan Wu Jiangao Li Liwei Zhu Deliang Wang Jiayi Song Xiyong Yu Ying Li Ben Zhong Tang Source Type: research
Microenvironment-sensitive nanozymes for tissue regeneration
Biomaterials. 2024 Apr 27;309:122585. doi: 10.1016/j.biomaterials.2024.122585. Online ahead of print.ABSTRACTTissue defect is one of the significant challenges encountered in clinical practice. Nanomaterials, including nanoparticles, nanofibers, and metal-organic frameworks, have demonstrated an extensive potential in tissue regeneration, offering a promising avenue for future clinical applications. Nonetheless, the intricate landscape of the inflammatory tissue microenvironment has engendered challenges to the efficacy of nanomaterial-based therapies. This quandary has spurred researchers to pivot towards advanced nanotec...
Source: Biomaterials - May 1, 2024 Category: Materials Science Authors: Yuan Xiong Bobin Mi Guohui Liu Yanli Zhao Source Type: research
In vitro models for studying implant-associated biofilms - A review from the perspective of bioengineering 3D microenvironments
Biomaterials. 2024 Apr 20;309:122578. doi: 10.1016/j.biomaterials.2024.122578. Online ahead of print.ABSTRACTBiofilm research has grown exponentially over the last decades, arguably due to their contribution to hospital acquired infections when they form on foreign body surfaces such as catheters and implants. Yet, translation of the knowledge acquired in the laboratory to the clinic has been slow and/or often it is not attempted by research teams to walk the talk of what is defined as 'bench to bedside'. We therefore reviewed the biofilm literature to better understand this gap. Our search revealed substantial development...
Source: Biomaterials - May 1, 2024 Category: Materials Science Authors: Silvia Cometta Dietmar W Hutmacher Liraz Chai Source Type: research
Photosensitive AIEgens sensitize bacteria to oxidative damage and modulate the inflammatory responses of macrophages to salvage the photodynamic therapy against MRSA
Biomaterials. 2024 Apr 26;309:122583. doi: 10.1016/j.biomaterials.2024.122583. Online ahead of print.ABSTRACTThe urgent need for antimicrobial agents to combat infections caused by multidrug-resistant bacteria facilitates the exploration of alternative strategies such as photosensitizer (PS)-mediated photoinactivation. However, increasing studies have discovered uncorrelated bactericidal activities among PSs possessing similar photodynamic and pathogen-targeted properties. To optimize the photodynamic therapy (PDT) against infections, we investigated three type-I PSs of D-π-A AIEgens TI, TBI, and TTI. The capacities of re...
Source: Biomaterials - May 1, 2024 Category: Materials Science Authors: Yifan Wu Jiangao Li Liwei Zhu Deliang Wang Jiayi Song Xiyong Yu Ying Li Ben Zhong Tang Source Type: research
Thermal and photoinduced radical cascade annulation using aryl isonitriles: An approach to quinoline-derived benzophosphole oxides
Angew Chem Int Ed Engl. 2024 Apr 30:e202404275. doi: 10.1002/anie.202404275. Online ahead of print.ABSTRACTHerein, we present a radical cascade addition cyclization sequence to access quinoline-based benzophosphole oxides from ortho-alkynylated aromatic phosphine oxides using various aryl isonitriles as radical acceptors and inexpensive tert-butyl-hydroperoxide (TBHP) as a terminal oxidant in the presence of a catalytic amount of silver acetate. Alternatively, the same cascade can be realized through a sustainable photochemical approach utilizing 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN) as an organic pho...
Source: Angewandte Chemie - April 30, 2024 Category: Chemistry Authors: Shyam Kumar Banjare Lena Lezius Elena Sophia Horst Dirk Leifert Constantin Gabriel Daniliuc Fatmah Alasmary Armido Studer Source Type: research
Measurement of Pain Frequency Associated with Knee Osteoarthritis: Future Directions
We were appreciative to read the study by Chang et al, which examined the dual trajectories of intermittent and constant pain over a 4-year period in a large sample of middle-aged and older adults with or at risk of knee osteoarthritis (OA).4 Based on the Intermittent and Constant Osteoarthritis Pain (ICOAP) questionnaire,7 the investigators found 4 distinct groups based on intermittent and constant pain patterns, which on average remained relatively stable over the 4-year time period. Several factors were associated with less favorable group memberships, but few were uniquely predictive of a specific pain phenotype. (Sour...
Source: The Journal of Pain - April 29, 2024 Category: Materials Science Authors: Javier A. Tamargo, Alisa J. Johnson, Yenisel Cruz-Almeida, Kimberly T. Sibille Source Type: research
Documenting Race and Gender Biases in Pain Assessment and a Novel Intervention Designed to Reduce Biases
Disparities in pain care are well-documented such that women and people of color have their pain undertreated and underestimated compared to men and White people. One of the contributors of the undertreatment of pain for people of color and women may be the inaccurate assessment of pain. Understanding the pain assessment process is an important step in evaluating the magnitude of and intervening on pain disparities in care. In the current work, we focus on documenting intersectional race and gender biases in pain assessment and present results of a novel intervention for reducing these biases. (Source: The Journal of Pain)
Source: The Journal of Pain - April 29, 2024 Category: Materials Science Authors: Mollie A. Ruben, Morgan D. Stosic Tags: Original Reports Source Type: research
Adverse Childhood Experiences and Chronic Low Back Pain In Adulthood: The Role of Emotion Regulation
Chronic low back pain (cLBP) is characterized by biopsychosocial determinants that collectively result in substantial burden at the individual, community, and healthcare system levels. A growing body of literature suggests that childhood adversity is longitudinally associated with the development and maintenance of various chronic pain conditions in adulthood. Little research has investigated the psychological processes that might underlie the association between adverse childhood experiences (ACEs) and cLBP. (Source: The Journal of Pain)
Source: The Journal of Pain - April 29, 2024 Category: Materials Science Authors: Pavithra A. Thomas, Burel R. Goodin, Samantha M. Meints, Michael A. Owens, Asia M. Wiggins, Tammie Quinn, Leann Long, Edwin N. Aroke, Matthew C. Morris, Robert E. Sorge, Demario S. Overstreet Source Type: research
Approach for contact medical device development via integrated testing, skeletal muscle modeling, and finite element analysis
J Mech Behav Biomed Mater. 2024 Apr 16;155:106541. doi: 10.1016/j.jmbbm.2024.106541. Online ahead of print.ABSTRACTDevelopment of novel medical devices for the treatment of musculoskeletal pain associated with neuro-muscular trigger points requires a model for relating the mechanical responses of in vivo biological tissues to applied palliative physical pressures and a method to design treatments for optimal effects. It is reasonable to hypothesize that the efficacy of therapeutic treatment is proportional to the maximum tensile strain at trigger point locations. This work presents modeling of the mechanical behavior of bi...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Conor Shanley Q Jane Wang Bruce Livingston Source Type: research
Influence of additives and binder on the physical properties of dental silicate glass-ceramic feedstock for additive manufacturing
J Mech Behav Biomed Mater. 2024 Apr 25;155:106563. doi: 10.1016/j.jmbbm.2024.106563. Online ahead of print.ABSTRACTOBJECTIVES: The aim of the study was to investigate the impact of organic additives (binder, plasticizer, and the cross-linking ink) in the formulation of water-based feedstocks on the properties of a dental feldspathic glass-ceramic material developed for the slurry-based additive manufacturing technology "LSD-print."MATERIAL AND METHODS: Three water-based feldspathic feedstocks were produced to study the effects of polyvinyl alcohol (AC1) and poly (sodium 4-styrenesulfonate) (AC2) as binder systems. A feedst...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Moritz Hoffmann Bogna Stawarczyk Jens G ünster Andrea Zocca Source Type: research
Subchondral bone fatigue injury in the parasagittal condylar grooves of the third metacarpal bone in thoroughbred racehorses elevates site-specific strain concentration
J Mech Behav Biomed Mater. 2024 Apr 24;155:106561. doi: 10.1016/j.jmbbm.2024.106561. Online ahead of print.ABSTRACTCondylar stress fracture of the distal end of the third metacarpal/metatarsal (MC3/MT3) bones is a major cause of Thoroughbred racehorse injury and euthanasia worldwide. Functional adaptation to exercise and fatigue damage lead to structural changes in the subchondral bone that include increased modeling (resulting in sclerotic bone tissue) and targeted remodeling repair (resulting in focal resorption spaces in the parasagittal groove). Whether these focal structural changes, as detectable by standing computed...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Soroush Irandoust R Christopher Whitton Peter Muir Corinne R Henak Source Type: research
