Influence of additives and binder on the physical properties of dental silicate glass-ceramic feedstock for additive manufacturing
J Mech Behav Biomed Mater. 2024 Apr 25;155:106563. doi: 10.1016/j.jmbbm.2024.106563. Online ahead of print.ABSTRACTOBJECTIVES: The aim of the study was to investigate the impact of organic additives (binder, plasticizer, and the cross-linking ink) in the formulation of water-based feedstocks on the properties of a dental feldspathic glass-ceramic material developed for the slurry-based additive manufacturing technology "LSD-print."MATERIAL AND METHODS: Three water-based feldspathic feedstocks were produced to study the effects of polyvinyl alcohol (AC1) and poly (sodium 4-styrenesulfonate) (AC2) as binder systems. A feedst...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Moritz Hoffmann Bogna Stawarczyk Jens G ünster Andrea Zocca Source Type: research
Approach for contact medical device development via integrated testing, skeletal muscle modeling, and finite element analysis
J Mech Behav Biomed Mater. 2024 Apr 16;155:106541. doi: 10.1016/j.jmbbm.2024.106541. Online ahead of print.ABSTRACTDevelopment of novel medical devices for the treatment of musculoskeletal pain associated with neuro-muscular trigger points requires a model for relating the mechanical responses of in vivo biological tissues to applied palliative physical pressures and a method to design treatments for optimal effects. It is reasonable to hypothesize that the efficacy of therapeutic treatment is proportional to the maximum tensile strain at trigger point locations. This work presents modeling of the mechanical behavior of bi...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Conor Shanley Q Jane Wang Bruce Livingston Source Type: research
Trehalose enhanced cold atmospheric plasma-mediated cancer treatment
Biomaterials. 2024 Apr 18;309:122582. doi: 10.1016/j.biomaterials.2024.122582. Online ahead of print.ABSTRACTCold atmospheric plasma (CAP) is a unique form of physical plasma that has shown great potential for cancer therapy. CAP uses ionized gas to induce lethal oxidative stress on cancer cells; however, the efficacy of CAP therapy continues to be improved. Here, we report an injectable hydrogel-mediated approach to enhance the anti-tumor efficacy of CAP by regulating the phosphorylation of eIF2α. We discovered that reactive oxygen and nitrogen species (ROS/RNS), two main anti-tumor components in CAP, can lead to lethal ...
Source: Biomaterials - April 28, 2024 Category: Materials Science Authors: Xiaona Cao Tianxu Fang Mo Chen Tianqin Ning Jianyu Li Peter M Siegel Morag Park Zhitong Chen Guojun Chen Source Type: research
Influence of additives and binder on the physical properties of dental silicate glass-ceramic feedstock for additive manufacturing
J Mech Behav Biomed Mater. 2024 Apr 25;155:106563. doi: 10.1016/j.jmbbm.2024.106563. Online ahead of print.ABSTRACTOBJECTIVES: The aim of the study was to investigate the impact of organic additives (binder, plasticizer, and the cross-linking ink) in the formulation of water-based feedstocks on the properties of a dental feldspathic glass-ceramic material developed for the slurry-based additive manufacturing technology "LSD-print."MATERIAL AND METHODS: Three water-based feldspathic feedstocks were produced to study the effects of polyvinyl alcohol (AC1) and poly (sodium 4-styrenesulfonate) (AC2) as binder systems. A feedst...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Moritz Hoffmann Bogna Stawarczyk Jens G ünster Andrea Zocca Source Type: research
Subchondral bone fatigue injury in the parasagittal condylar grooves of the third metacarpal bone in thoroughbred racehorses elevates site-specific strain concentration
J Mech Behav Biomed Mater. 2024 Apr 24;155:106561. doi: 10.1016/j.jmbbm.2024.106561. Online ahead of print.ABSTRACTCondylar stress fracture of the distal end of the third metacarpal/metatarsal (MC3/MT3) bones is a major cause of Thoroughbred racehorse injury and euthanasia worldwide. Functional adaptation to exercise and fatigue damage lead to structural changes in the subchondral bone that include increased modeling (resulting in sclerotic bone tissue) and targeted remodeling repair (resulting in focal resorption spaces in the parasagittal groove). Whether these focal structural changes, as detectable by standing computed...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Soroush Irandoust R Christopher Whitton Peter Muir Corinne R Henak Source Type: research
Studying the nonlinear response of incompressible hyperelastic thin circular cylindrical shells with geometric imperfections
This study presents a comprehensive analysis of hyperelastic thin cylindrical shells exhibiting initial geometrical imperfections. The nonlinear equations of motion are derived using an improved formulation of Donnell's nonlinear shallow-shell theory and Lagrange's equations, incorporating the small strain hypothesis. Mooney-Rivlin constitutive model is employed to capture the hyperelastic behavior of the material. The coupled nonlinear equations of motion are analytically solved using Multiple-Scale method, which effectively accounts for the inherent nonlinearity of the system. To ensure the model's accuracy, the linear m...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Morteza Shayan Arani Mehrdad Bakhtiari Mohammad Toorani Aouni A Lakis Source Type: research
Approach for contact medical device development via integrated testing, skeletal muscle modeling, and finite element analysis
J Mech Behav Biomed Mater. 2024 Apr 16;155:106541. doi: 10.1016/j.jmbbm.2024.106541. Online ahead of print.ABSTRACTDevelopment of novel medical devices for the treatment of musculoskeletal pain associated with neuro-muscular trigger points requires a model for relating the mechanical responses of in vivo biological tissues to applied palliative physical pressures and a method to design treatments for optimal effects. It is reasonable to hypothesize that the efficacy of therapeutic treatment is proportional to the maximum tensile strain at trigger point locations. This work presents modeling of the mechanical behavior of bi...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Conor Shanley Q Jane Wang Bruce Livingston Source Type: research
Studying the nonlinear response of incompressible hyperelastic thin circular cylindrical shells with geometric imperfections
This study presents a comprehensive analysis of hyperelastic thin cylindrical shells exhibiting initial geometrical imperfections. The nonlinear equations of motion are derived using an improved formulation of Donnell's nonlinear shallow-shell theory and Lagrange's equations, incorporating the small strain hypothesis. Mooney-Rivlin constitutive model is employed to capture the hyperelastic behavior of the material. The coupled nonlinear equations of motion are analytically solved using Multiple-Scale method, which effectively accounts for the inherent nonlinearity of the system. To ensure the model's accuracy, the linear m...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Morteza Shayan Arani Mehrdad Bakhtiari Mohammad Toorani Aouni A Lakis Source Type: research
Subchondral bone fatigue injury in the parasagittal condylar grooves of the third metacarpal bone in thoroughbred racehorses elevates site-specific strain concentration
J Mech Behav Biomed Mater. 2024 Apr 24;155:106561. doi: 10.1016/j.jmbbm.2024.106561. Online ahead of print.ABSTRACTCondylar stress fracture of the distal end of the third metacarpal/metatarsal (MC3/MT3) bones is a major cause of Thoroughbred racehorse injury and euthanasia worldwide. Functional adaptation to exercise and fatigue damage lead to structural changes in the subchondral bone that include increased modeling (resulting in sclerotic bone tissue) and targeted remodeling repair (resulting in focal resorption spaces in the parasagittal groove). Whether these focal structural changes, as detectable by standing computed...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Soroush Irandoust R Christopher Whitton Peter Muir Corinne R Henak Source Type: research
Influence of additives and binder on the physical properties of dental silicate glass-ceramic feedstock for additive manufacturing
J Mech Behav Biomed Mater. 2024 Apr 25;155:106563. doi: 10.1016/j.jmbbm.2024.106563. Online ahead of print.ABSTRACTOBJECTIVES: The aim of the study was to investigate the impact of organic additives (binder, plasticizer, and the cross-linking ink) in the formulation of water-based feedstocks on the properties of a dental feldspathic glass-ceramic material developed for the slurry-based additive manufacturing technology "LSD-print."MATERIAL AND METHODS: Three water-based feldspathic feedstocks were produced to study the effects of polyvinyl alcohol (AC1) and poly (sodium 4-styrenesulfonate) (AC2) as binder systems. A feedst...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Moritz Hoffmann Bogna Stawarczyk Jens G ünster Andrea Zocca Source Type: research
Approach for contact medical device development via integrated testing, skeletal muscle modeling, and finite element analysis
J Mech Behav Biomed Mater. 2024 Apr 16;155:106541. doi: 10.1016/j.jmbbm.2024.106541. Online ahead of print.ABSTRACTDevelopment of novel medical devices for the treatment of musculoskeletal pain associated with neuro-muscular trigger points requires a model for relating the mechanical responses of in vivo biological tissues to applied palliative physical pressures and a method to design treatments for optimal effects. It is reasonable to hypothesize that the efficacy of therapeutic treatment is proportional to the maximum tensile strain at trigger point locations. This work presents modeling of the mechanical behavior of bi...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Conor Shanley Q Jane Wang Bruce Livingston Source Type: research
Trehalose enhanced cold atmospheric plasma-mediated cancer treatment
Biomaterials. 2024 Apr 18;309:122582. doi: 10.1016/j.biomaterials.2024.122582. Online ahead of print.ABSTRACTCold atmospheric plasma (CAP) is a unique form of physical plasma that has shown great potential for cancer therapy. CAP uses ionized gas to induce lethal oxidative stress on cancer cells; however, the efficacy of CAP therapy continues to be improved. Here, we report an injectable hydrogel-mediated approach to enhance the anti-tumor efficacy of CAP by regulating the phosphorylation of eIF2α. We discovered that reactive oxygen and nitrogen species (ROS/RNS), two main anti-tumor components in CAP, can lead to lethal ...
Source: Biomaterials - April 28, 2024 Category: Materials Science Authors: Xiaona Cao Tianxu Fang Mo Chen Tianqin Ning Jianyu Li Peter M Siegel Morag Park Zhitong Chen Guojun Chen Source Type: research
Biodegradable electrospun poly(L ‐lactide‐co‐ε‐caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering
In this study, we developed an electrospun composite scaffold for bone tissue engineering. The composite scaffold is made of a blend of poly(L-lactide-co- ε-caprolactone) (PLCL) and polyethylene glycol (PEG), with the incorporation of calcined and lyophilized silicate-chlorinated bioactive glass (BG) particles. Our investigation involved a comprehensive characterization of the scaffold's physical, chemical, and mechanical properties, alongside an eva luation of its biological efficacy employing alveolar bone-derived mesenchymal stem cells. The incorporation of PEG and BG resulted in elevated swelling ratios, consequently ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - April 28, 2024 Category: Materials Science Authors: Joyce R. de Souza,
Lais M. Cardoso,
Priscila T. A. de Toledo,
Maedeh Rahimnejad,
Let ícia T. Kito,
Gilmar P. Thim,
Tiago M. B. Campos,
Alexandre L. S. Borges,
Marco C. Bottino Tags: RESEARCH ARTICLE Source Type: research
Genetic risk factors for bortezomib-induced neuropathic pain in an Asian population: A genome-wide association study in South Korea
Bortezomib-induced neuropathic pain (BINP) poses a challenge in multiple myeloma (MM) treatment. Genetic factors play a key role in BINP susceptibility, but research has predominantly focused on Caucasian populations. This research explored novel genetic risk loci and pathways associated with BINP development in Korean MM patients, while evaluating reproducibility of variants from Caucasians. Clinical data and buffy coat samples from 185 MM patients on bortezomib were collected. The cohort was split into discovery and validation cohorts through random stratification of clinical risk factors for BINP. (Source: The Journal of Pain)
Source: The Journal of Pain - April 28, 2024 Category: Materials Science Authors: Young Gi Min, Sung-Yeoun Lee, Ehyun Lim, Mi-Young Park, Dong-ho Kim, Ja Min Byun, Youngil Koh, Junshik Hong, Dong-Yeop Shin, Sung-Soo Yoon, Jung-Joon Sung, Seog Bae Oh, Inho Kim Source Type: research
The crystallization properties of antifreeze GelMA hydrogel and its application in cryopreservation of tissue ‐engineered skin constructs
AbstractGelatin methacrylate (GelMA) hydrogels are expected to be ideal skin tissue engineering dressings for a wide range of clinical treatments. Herein, we report the preparation of GelMA or antifreeze GelMA hydrogel sheets with different GelMA concentrations, crosslinking times, and cryoprotectant (CPA) concentrations. The crystallization properties of GelMA or antifreeze GelMA hydrogel sheets were studied by cryomicroscopy and differential scanning calorimetry (DSC). It was found that the growth of ice crystals was slower when GelMA hydrogel concentration was more than 7%. The 10% DMSO-7% GelMA hydrogel sheets crosslin...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - April 27, 2024 Category: Materials Science Authors: Jia Tan,
Jiahui Li,
Xinli Zhou Tags: RESEARCH ARTICLE Source Type: research
