Post-formation of fused pentagonal structure on fjord region of polyaromatic hydrocarbons under hydrothermal conditions
This study explores the synthesis of cyclopenta-fused polyaromatic hydrocarbons (CP-PAHs) via Pt-catalyzed cyclization in water, focusing on the formation of fused pentagonal rings within heavily fused PAH frameworks. Utilizing platinum catalysts at lower temperatures (200-260°C) in water, led to the successful synthesis of singly cyclized CP-PAHs. The reaction conditions facilitated the mono-cyclization of substrates such as dibenzo[g,p]chrysene and its isomers, yielding the desired products while suppressing the formation of bis-cyclized compounds. The use of Fe2O3 as an additive in conjunction with PtO2 was effective t...
Source: Chemistry - April 17, 2024 Category: Chemistry Authors: Naoto Hamaguchi Takumi Kubota Masaaki Yamada Hikaru Kimura Hayato Tsuji Source Type: research
Elastic parameter identification of three-dimensional soft tissue based on deep neural network
J Mech Behav Biomed Mater. 2024 Apr 12;155:106542. doi: 10.1016/j.jmbbm.2024.106542. Online ahead of print.ABSTRACTIn the field of virtual surgery and deformation simulation, the identification of elastic parameters of human soft tissues is a critical technology that directly affects the accuracy of deformation simulation. Current research on soft tissue deformation simulation predominantly assumes that the elasticity of tissues is fixed and already known, leading to the difficulty in populating with the elasticity measured or identified from specific tissues of real patients. Existing elasticity modeling efforts struggle ...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 17, 2024 Category: Materials Science Authors: Ziyang Hu Shenghui Liao Jianda Zhou Qiuyang Chen Renzhong Wu Source Type: research
Post-formation of fused pentagonal structure on fjord region of polyaromatic hydrocarbons under hydrothermal conditions
This study explores the synthesis of cyclopenta-fused polyaromatic hydrocarbons (CP-PAHs) via Pt-catalyzed cyclization in water, focusing on the formation of fused pentagonal rings within heavily fused PAH frameworks. Utilizing platinum catalysts at lower temperatures (200-260°C) in water, led to the successful synthesis of singly cyclized CP-PAHs. The reaction conditions facilitated the mono-cyclization of substrates such as dibenzo[g,p]chrysene and its isomers, yielding the desired products while suppressing the formation of bis-cyclized compounds. The use of Fe2O3 as an additive in conjunction with PtO2 was effective t...
Source: Chemistry - April 17, 2024 Category: Chemistry Authors: Naoto Hamaguchi Takumi Kubota Masaaki Yamada Hikaru Kimura Hayato Tsuji Source Type: research
Biological, physical and morphological factors for the programming of a novel microbial hygromorphic material
This study spans many fields including microbiology, materials science, design, fabrication and architectural technology, working at multiple scales from single cells to ‘bench-top’ prototype. Exploration of biological factors at cellular and ultracellular levels enabled optimisation of growth and sporulation conditions to biologically preprogramme optimum spore hygromorphic response and yield. Material explorations revealed physical factors influencing biomecha nics, preprogramming shape and response complexity through fabrication and inert substrate interactions, to produce a palette of HBCs. Morphological aggregatio...
Source: Bioinspiration and Biomimetics - April 17, 2024 Category: Science Authors: Emily Birch, Ben Bridgens, Meng Zhang and Martyn Dade-Robertson Source Type: research
Recent advances in the synthesis of single-stranded DNA in vitro
Biotechnol J. 2024 Apr;19(4):e2400026. doi: 10.1002/biot.202400026.ABSTRACTSingle-stranded DNA (ssDNA) is the foundation of modern biology, with wide applications in gene editing, sequencing, DNA information storage, and materials science. However, synthesizing ssDNA with high efficiency, high throughput, and low error rate in vitro remains a major challenge. Various methods have been developed for ssDNA synthesis, and some significant results have been achieved. In this review, six main methods were introduced, including solid-phase oligonucleotide synthesis, terminal deoxynucleotidyl transferase-based ssDNA synthesis, re...
Source: Biotechnology Journal - April 16, 2024 Category: Biotechnology Authors: Shuai Li Wei Tan Xuemei Jia Qing Miao Ying Liu Dayong Yang Source Type: research
The orientation of CpG conjugation on aluminum oxyhydroxide nanoparticles determines the immunostimulatory effects of combination adjuvants
Biomaterials. 2024 Apr 11;308:122569. doi: 10.1016/j.biomaterials.2024.122569. Online ahead of print.ABSTRACTIn subunit vaccines, aluminum salts (Alum) are commonly used as adjuvants, but with limited cellular immune responses. To overcome this limitation, CpG oligodeoxynucleotides (ODNs) have been used in combination with Alum. However, current combined usage of Alum and CpG is limited to linear mixtures, and the underlying interaction mechanism between CpG and Alum is not well understood. Thus, we propose to chemically conjugate Alum nanoparticles and CpG (with 5' or 3' end exposed) to design combination adjuvants. Our s...
Source: Biomaterials - April 16, 2024 Category: Materials Science Authors: Zhihui Liang Hang Bao Zhiying Yao Min Li Chen Chen Lei Zhang Huiyang Wang Yiyang Guo Yubin Ma Xuecheng Yang Ge Yu Jiancheng Zhang Changying Xue Bingbing Sun Chuanbin Mao Source Type: research
Recent advances in the synthesis of single-stranded DNA in vitro
Biotechnol J. 2024 Apr;19(4):e2400026. doi: 10.1002/biot.202400026.ABSTRACTSingle-stranded DNA (ssDNA) is the foundation of modern biology, with wide applications in gene editing, sequencing, DNA information storage, and materials science. However, synthesizing ssDNA with high efficiency, high throughput, and low error rate in vitro remains a major challenge. Various methods have been developed for ssDNA synthesis, and some significant results have been achieved. In this review, six main methods were introduced, including solid-phase oligonucleotide synthesis, terminal deoxynucleotidyl transferase-based ssDNA synthesis, re...
Source: Biotechnology Journal - April 16, 2024 Category: Biotechnology Authors: Shuai Li Wei Tan Xuemei Jia Qing Miao Ying Liu Dayong Yang Source Type: research
The orientation of CpG conjugation on aluminum oxyhydroxide nanoparticles determines the immunostimulatory effects of combination adjuvants
Biomaterials. 2024 Apr 11;308:122569. doi: 10.1016/j.biomaterials.2024.122569. Online ahead of print.ABSTRACTIn subunit vaccines, aluminum salts (Alum) are commonly used as adjuvants, but with limited cellular immune responses. To overcome this limitation, CpG oligodeoxynucleotides (ODNs) have been used in combination with Alum. However, current combined usage of Alum and CpG is limited to linear mixtures, and the underlying interaction mechanism between CpG and Alum is not well understood. Thus, we propose to chemically conjugate Alum nanoparticles and CpG (with 5' or 3' end exposed) to design combination adjuvants. Our s...
Source: Biomaterials - April 16, 2024 Category: Materials Science Authors: Zhihui Liang Hang Bao Zhiying Yao Min Li Chen Chen Lei Zhang Huiyang Wang Yiyang Guo Yubin Ma Xuecheng Yang Ge Yu Jiancheng Zhang Changying Xue Bingbing Sun Chuanbin Mao Source Type: research
Recent advances in the synthesis of single-stranded DNA in vitro
Biotechnol J. 2024 Apr;19(4):e2400026. doi: 10.1002/biot.202400026.ABSTRACTSingle-stranded DNA (ssDNA) is the foundation of modern biology, with wide applications in gene editing, sequencing, DNA information storage, and materials science. However, synthesizing ssDNA with high efficiency, high throughput, and low error rate in vitro remains a major challenge. Various methods have been developed for ssDNA synthesis, and some significant results have been achieved. In this review, six main methods were introduced, including solid-phase oligonucleotide synthesis, terminal deoxynucleotidyl transferase-based ssDNA synthesis, re...
Source: Biotechnology Journal - April 16, 2024 Category: Biotechnology Authors: Shuai Li Wei Tan Xuemei Jia Qing Miao Ying Liu Dayong Yang Source Type: research
Synthesis Strategies, Preparation Methods, and Applications of Chiral Metal-Organic Frameworks
Chemistry. 2024 Apr 16:e202401091. doi: 10.1002/chem.202401091. Online ahead of print.ABSTRACTChiral metal-organic framework (CMOFs) is a kind of material with great application value in recent years. Formed by the coordination of metal ions or metal clusters with organic ligands. It is widely used in chemistry, biology, medicine and materials science because of its ordered and adjustable pores, multi-dimensional network structure, large specific surface area and excellent adsorption properties. In this paper, the synthesis strategies and preparation methods of chiral metal-organic frameworks are reviewed. In addition, the...
Source: Chemistry - April 16, 2024 Category: Chemistry Authors: Hui Zhang Qingsong Cheng Hebing Pei Simin He Ruibin Guo Nijuan Liu Zunli Mo Source Type: research
Photoswitching Reagent for Super-resolution Fluorescence Microscopy
This study contributes to a broader understanding of the molecular photoswitching mechanism in SMLM imaging and provides a basis for designing improved photoswitching reagents with potential applications extending to materials science and chemistry.PMID:38622700 | DOI:10.1002/anie.202405246 (Source: Angewandte Chemie)
Source: Angewandte Chemie - April 15, 2024 Category: Chemistry Authors: Ga-Eun Go Uidon Jeong Hyunbum Park Seokran Go Doory Kim Source Type: research
Photoswitching Reagent for Super-resolution Fluorescence Microscopy
This study contributes to a broader understanding of the molecular photoswitching mechanism in SMLM imaging and provides a basis for designing improved photoswitching reagents with potential applications extending to materials science and chemistry.PMID:38622700 | DOI:10.1002/anie.202405246 (Source: Angewandte Chemie)
Source: Angewandte Chemie - April 15, 2024 Category: Chemistry Authors: Ga-Eun Go Uidon Jeong Hyunbum Park Seokran Go Doory Kim Source Type: research
Biodegradable polyvinyl alcohol/nano-hydroxyapatite composite membrane enhanced by MXene nanosheets for guided bone regeneration
J Mech Behav Biomed Mater. 2024 Apr 8;155:106540. doi: 10.1016/j.jmbbm.2024.106540. Online ahead of print.ABSTRACTMXene, as a new category of two-dimensional nanomaterials, exhibits a promising prospect in biomedical applications due to its ultrathin structure and morphology, as well as a range of remarkable properties such as biological, chemical, electronic, and optical properties. In this work, different concentrations of MXene (M) were added to polyvinyl alcohol (PVA, P)/nano-hydroxyapatite (n-HA, H) mixed solution, and series of PVA/n-HA/MXene (PHM) composite membranes were obtained by combining sol-gel and freeze-dry...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 14, 2024 Category: Materials Science Authors: Kefan Yang Siqi Lei Xiaoli Qin Xiaoxue Mai Weibo Xie Shengrong Yang Jinqing Wang Source Type: research
Optical controlled and nuclear targeted CECR2 competitor to downregulate CSF-1 for metastatic breast cancer immunotherapy
This study provides a promising therapeutic target and reliable strategy for metastatic breast cancer treatment by interrupting immunosuppressive crosstalk between tumor cells and macrophages.PMID:38615488 | DOI:10.1016/j.biomaterials.2024.122568 (Source: Biomaterials)
Source: Biomaterials - April 14, 2024 Category: Materials Science Authors: Yi Cen Ying Chen Xinxuan Li Xiayun Chen Baixue Yu Mengyi Yan Ni Yan Hong Cheng Shiying Li Source Type: research
Biodegradable polyvinyl alcohol/nano-hydroxyapatite composite membrane enhanced by MXene nanosheets for guided bone regeneration
J Mech Behav Biomed Mater. 2024 Apr 8;155:106540. doi: 10.1016/j.jmbbm.2024.106540. Online ahead of print.ABSTRACTMXene, as a new category of two-dimensional nanomaterials, exhibits a promising prospect in biomedical applications due to its ultrathin structure and morphology, as well as a range of remarkable properties such as biological, chemical, electronic, and optical properties. In this work, different concentrations of MXene (M) were added to polyvinyl alcohol (PVA, P)/nano-hydroxyapatite (n-HA, H) mixed solution, and series of PVA/n-HA/MXene (PHM) composite membranes were obtained by combining sol-gel and freeze-dry...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 14, 2024 Category: Materials Science Authors: Kefan Yang Siqi Lei Xiaoli Qin Xiaoxue Mai Weibo Xie Shengrong Yang Jinqing Wang Source Type: research
