Beyond surface modification strategies to control infections associated with implanted biomaterials and devices - Addressing the opportunities offered by nanotechnology
Biomaterials. 2024 Apr 16;308:122576. doi: 10.1016/j.biomaterials.2024.122576. Online ahead of print.ABSTRACTBiomaterial-associated infection (BAI) is considered a unique infection due to the presence of a biomaterial yielding frustrated immune-cells, ineffective in clearing local micro-organisms. The involvement of surface-adherent/surface-adapted micro-organisms in BAI, logically points to biomaterial surface-modifications for BAI-control. Biomaterial surface-modification is most suitable for prevention before adhering bacteria have grown into a mature biofilm, while BAI-treatment is virtually impossible through surface-...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Da-Yuan Wang Linzhu Su Kees Poelstra David W Grainger Henny C van der Mei Linqi Shi Henk J Busscher Source Type: research
Implantable CAR T cell factories enhance solid tumor treatment
Biomaterials. 2024 Apr 15;308:122580. doi: 10.1016/j.biomaterials.2024.122580. Online ahead of print.ABSTRACTChimeric Antigen Receptor (CAR) T cell therapy has produced revolutionary success in hematological cancers such as leukemia and lymphoma. Nonetheless, its translation to solid tumors faces challenges due to manufacturing complexities, short-lived in vivo persistence, and transient therapeutic impact. We introduce 'Drydux' - an innovative macroporous biomaterial scaffold designed for rapid, efficient in-situ generation of tumor-specific CAR T cells. Drydux expedites CAR T cell preparation with a mere three-day turnar...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Sharda Pandit Pritha Agarwalla Feifei Song Anton Jansson Gianpietro Dotti Yevgeny Brudno Source Type: research
Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy
Biomaterials. 2024 Apr 15;308:122581. doi: 10.1016/j.biomaterials.2024.122581. Online ahead of print.ABSTRACTCancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by c...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Yiliang Yang Yiwei Peng Yitian Du Meng Lin Jiajia Li Datong Gao Zhenzhen Yang Wei Wang Yanxia Zhou Xinru Li Taiqiang Yan Xianrong Qi Source Type: research
3D-printed bioinspired spicules: Strengthening and toughening via stereolithography
In this study, structures inspired by spicules were designed and fabricated using the stereolithography (SLA) 3D printing technique. The mechanical properties of concentric cylindrical structures (CCSs) inspired by the spicule microstructure were evaluated, considering factors such as the wall thickness of the cylinders, the number of layers, and core diameter, all of which significantly affect the mechanical response. These results were compared with those obtained from solid rods used as solid samples. The findings indicated that CCSs with five layers or fewer exhibited a flexural strength close to or higher than that of...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 19, 2024 Category: Materials Science Authors: Fariborz Tavangarian Sorour Sadeghzade Niloofar Fani Dariush Khezrimotlagh Keivan Davami Source Type: research
SLA-3d printed building and characteristics of GelMA/HAP biomaterials with gradient porous structure
J Mech Behav Biomed Mater. 2024 Apr 12;155:106553. doi: 10.1016/j.jmbbm.2024.106553. Online ahead of print.ABSTRACTDeveloping a gradient porous scaffold similar to bone structure is gaining increasing attention in bone tissue engineering. The GelMA/HAP hydrogel has demonstrated potential in bone repair. Although 3D printing can build GelMA/HAP with porous structure, fabricating porous GelMA/HAP with gradient porosity and pore size in one step remains challenging. In this paper, a gradient porous structure with controllable pore size, based on gelatin methacryloyl (GelMA) and hydxroxyapatite (HAP), was engineered and printe...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 19, 2024 Category: Materials Science Authors: Qinghua Chen Bin Zou Xinfeng Wang Xingguo Zhou Gongxian Yang Qingguo Lai Yun Zhao Source Type: research
Beyond surface modification strategies to control infections associated with implanted biomaterials and devices - Addressing the opportunities offered by nanotechnology
Biomaterials. 2024 Apr 16;308:122576. doi: 10.1016/j.biomaterials.2024.122576. Online ahead of print.ABSTRACTBiomaterial-associated infection (BAI) is considered a unique infection due to the presence of a biomaterial yielding frustrated immune-cells, ineffective in clearing local micro-organisms. The involvement of surface-adherent/surface-adapted micro-organisms in BAI, logically points to biomaterial surface-modifications for BAI-control. Biomaterial surface-modification is most suitable for prevention before adhering bacteria have grown into a mature biofilm, while BAI-treatment is virtually impossible through surface-...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Da-Yuan Wang Linzhu Su Kees Poelstra David W Grainger Henny C van der Mei Linqi Shi Henk J Busscher Source Type: research
Implantable CAR T cell factories enhance solid tumor treatment
Biomaterials. 2024 Apr 15;308:122580. doi: 10.1016/j.biomaterials.2024.122580. Online ahead of print.ABSTRACTChimeric Antigen Receptor (CAR) T cell therapy has produced revolutionary success in hematological cancers such as leukemia and lymphoma. Nonetheless, its translation to solid tumors faces challenges due to manufacturing complexities, short-lived in vivo persistence, and transient therapeutic impact. We introduce 'Drydux' - an innovative macroporous biomaterial scaffold designed for rapid, efficient in-situ generation of tumor-specific CAR T cells. Drydux expedites CAR T cell preparation with a mere three-day turnar...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Sharda Pandit Pritha Agarwalla Feifei Song Anton Jansson Gianpietro Dotti Yevgeny Brudno Source Type: research
Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy
Biomaterials. 2024 Apr 15;308:122581. doi: 10.1016/j.biomaterials.2024.122581. Online ahead of print.ABSTRACTCancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by c...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Yiliang Yang Yiwei Peng Yitian Du Meng Lin Jiajia Li Datong Gao Zhenzhen Yang Wei Wang Yanxia Zhou Xinru Li Taiqiang Yan Xianrong Qi Source Type: research
SLA-3d printed building and characteristics of GelMA/HAP biomaterials with gradient porous structure
J Mech Behav Biomed Mater. 2024 Apr 12;155:106553. doi: 10.1016/j.jmbbm.2024.106553. Online ahead of print.ABSTRACTDeveloping a gradient porous scaffold similar to bone structure is gaining increasing attention in bone tissue engineering. The GelMA/HAP hydrogel has demonstrated potential in bone repair. Although 3D printing can build GelMA/HAP with porous structure, fabricating porous GelMA/HAP with gradient porosity and pore size in one step remains challenging. In this paper, a gradient porous structure with controllable pore size, based on gelatin methacryloyl (GelMA) and hydxroxyapatite (HAP), was engineered and printe...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 19, 2024 Category: Materials Science Authors: Qinghua Chen Bin Zou Xinfeng Wang Xingguo Zhou Gongxian Yang Qingguo Lai Yun Zhao Source Type: research
3D-printed bioinspired spicules: Strengthening and toughening via stereolithography
In this study, structures inspired by spicules were designed and fabricated using the stereolithography (SLA) 3D printing technique. The mechanical properties of concentric cylindrical structures (CCSs) inspired by the spicule microstructure were evaluated, considering factors such as the wall thickness of the cylinders, the number of layers, and core diameter, all of which significantly affect the mechanical response. These results were compared with those obtained from solid rods used as solid samples. The findings indicated that CCSs with five layers or fewer exhibited a flexural strength close to or higher than that of...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 19, 2024 Category: Materials Science Authors: Fariborz Tavangarian Sorour Sadeghzade Niloofar Fani Dariush Khezrimotlagh Keivan Davami Source Type: research
Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy
Biomaterials. 2024 Apr 15;308:122581. doi: 10.1016/j.biomaterials.2024.122581. Online ahead of print.ABSTRACTCancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by c...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Yiliang Yang Yiwei Peng Yitian Du Meng Lin Jiajia Li Datong Gao Zhenzhen Yang Wei Wang Yanxia Zhou Xinru Li Taiqiang Yan Xianrong Qi Source Type: research
Implantable CAR T cell factories enhance solid tumor treatment
Biomaterials. 2024 Apr 15;308:122580. doi: 10.1016/j.biomaterials.2024.122580. Online ahead of print.ABSTRACTChimeric Antigen Receptor (CAR) T cell therapy has produced revolutionary success in hematological cancers such as leukemia and lymphoma. Nonetheless, its translation to solid tumors faces challenges due to manufacturing complexities, short-lived in vivo persistence, and transient therapeutic impact. We introduce 'Drydux' - an innovative macroporous biomaterial scaffold designed for rapid, efficient in-situ generation of tumor-specific CAR T cells. Drydux expedites CAR T cell preparation with a mere three-day turnar...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Sharda Pandit Pritha Agarwalla Feifei Song Anton Jansson Gianpietro Dotti Yevgeny Brudno Source Type: research
Beyond surface modification strategies to control infections associated with implanted biomaterials and devices - Addressing the opportunities offered by nanotechnology
Biomaterials. 2024 Apr 16;308:122576. doi: 10.1016/j.biomaterials.2024.122576. Online ahead of print.ABSTRACTBiomaterial-associated infection (BAI) is considered a unique infection due to the presence of a biomaterial yielding frustrated immune-cells, ineffective in clearing local micro-organisms. The involvement of surface-adherent/surface-adapted micro-organisms in BAI, logically points to biomaterial surface-modifications for BAI-control. Biomaterial surface-modification is most suitable for prevention before adhering bacteria have grown into a mature biofilm, while BAI-treatment is virtually impossible through surface-...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Da-Yuan Wang Linzhu Su Kees Poelstra David W Grainger Henny C van der Mei Linqi Shi Henk J Busscher Source Type: research
Issue Information
(Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - April 19, 2024 Category: Materials Science Tags: ISSUE INFORMATION Source Type: research
Enhancing Scientific Research with FAIR Digital Objects in the National Science Data Fabric
This perspective article presents the vision of combining findable, accessible, interoperable, and reusable (FAIR) Digital Objects with the National Science Data Fabric (NSDF) to enhance data accessibility, scientific discovery, and education. Integrating FAIR Digital Objects into the NSDF overcomes data access barriers and facilitates the extraction of machine-actionable metadata in alignment with FAIR principles. The article discusses examples of climate simulations and materials science workflows and establishes the groundwork for a dataflow design that prioritizes inclusivity, web-centricity, and a network-first approa...
Source: Computing in Science and Engineering - April 18, 2024 Category: Information Technology Source Type: research
