Discovery of novel secondary metabolites from the basidiomycete Lentinus cf. sajor-caju and their inhibitory effects on Staphylococcus aureus biofilms
Fitoterapia. 2024 Mar 18;175:105904. doi: 10.1016/j.fitote.2024.105904. Online ahead of print.ABSTRACTThree novel derivatives of microporenic acid, microporenic acids H-J, were identified from submerged cultures of a Lentinus species obtained from a basidiome collected during a field trip in the tropical rainforest in Western Kenya. Their structures were elucidated via HR-ESIMS spectra and 1D/2D NMR spectroscopic analyses, as well as by comparison with known derivatives. Applying biofilm assays based on crystal violet staining and confocal microscopy, two of these compounds, microporenic acids H and I, demonstrated the abi...
Source: Fitoterapia - March 20, 2024 Category: Biochemistry Authors: Haoxuan Zeng Marc Stadler Cony Decock Josphat Clement Matasyoh Hedda Schrey Mathias M üsken Source Type: research
Discovery of novel secondary metabolites from the basidiomycete Lentinus cf. sajor-caju and their inhibitory effects on Staphylococcus aureus biofilms
Fitoterapia. 2024 Mar 18;175:105904. doi: 10.1016/j.fitote.2024.105904. Online ahead of print.ABSTRACTThree novel derivatives of microporenic acid, microporenic acids H-J, were identified from submerged cultures of a Lentinus species obtained from a basidiome collected during a field trip in the tropical rainforest in Western Kenya. Their structures were elucidated via HR-ESIMS spectra and 1D/2D NMR spectroscopic analyses, as well as by comparison with known derivatives. Applying biofilm assays based on crystal violet staining and confocal microscopy, two of these compounds, microporenic acids H and I, demonstrated the abi...
Source: Fitoterapia - March 20, 2024 Category: Biochemistry Authors: Haoxuan Zeng Marc Stadler Cony Decock Josphat Clement Matasyoh Hedda Schrey Mathias M üsken Source Type: research
Are British soldiers adequately prepared to make safe sexual health decisions when deployed to areas with high HIV prevalence?
Conclusions
This study highlights that soldiers deploying on exercise in BATUK are inadequately prepared to make safe sexual health decisions. This raises the need for further research to understand soldiers’ understanding of high-risk sexual behaviours. This will inform the revised content of the sexual health brief required to improve the sexual health of soldiers and units deployed to BATUK, improve operational effectiveness, improve the reputation of the British Army and reduce the likelihood of sexually transmitted diseases being spread. Further research should also consider factors such as peer pressure and &ls...
Source: Journal of the Royal Army Medical Corps - March 20, 2024 Category: General Medicine Authors: Paveley, M. Tags: Original research Source Type: research
Factors associated with late diagnosis of cervical cancer at two national referral hospitals, Kenya 2017: A case control study
CONCLUSION: Cost of seeking care and the quality of the diagnostic process were important factors in this study. Decentralization of care, innovative health financing solutions and clear diagnostic and referral algorithms for women presenting with gynecological symptoms could reduce late-stage diagnosis in Kenya.PMID:38500641 | PMC:PMC10945120 | DOI:10.1016/j.gore.2024.101355 (Source: Cancer Control)
Source: Cancer Control - March 19, 2024 Category: Cancer & Oncology Authors: Valerian Mwenda Martin Mwangi Gladwell Gathecha Joseph Kibachio Robert Too Zeinab Gura Marleen Temmerman Source Type: research
Diabetes mellitus and associated risk factors among HIV infected patients on HAART
Understanding the impact of disease associations is becoming a priority in Kenya and other countries bearing the load of infectious diseases. With the increased incidences of non-communicable diseases and the ... (Source: BMC Public Health)
Source: BMC Public Health - March 19, 2024 Category: Consumer Health News Authors: Lucy Kanyara, Rency Lel, Sheila Kageha, Joyceline Kinyua, Sophie Matu, Asiko Ongaya, Mary Matilu, Paul Mwangi, Vincent Okoth, Joseph Mwangi and Dama Olungae Tags: Research Source Type: research
Women ’s autonomy and maternal health decision making in Kenya: implications for service delivery reform - a qualitative study
Maternal and neonatal outcomes in, Kakamega County is characterized by a maternal mortality rate of 316 per 100,000 live births and a neonatal mortality rate of 19 per 1,000 live births. In 2018, approximately... (Source: BMC Women's Health)
Source: BMC Women's Health - March 19, 2024 Category: OBGYN Authors: Easter Olwanda, Kennedy Opondo, Dorothy Oluoch, Kevin Croke, Justinah Maluni, Joyline Jepkosgei and Jacinta Nzinga Tags: Research Source Type: research
Comparison of different trapping methods to collect malaria vectors indoors and outdoors in western Kenya
Vector surveillance is among the World Health Organization global vector control response (2017 –2030) pillars. Human landing catches are a gold standard but difficult to implement and potentially expose collec... (Source: Malaria Journal)
Source: Malaria Journal - March 16, 2024 Category: Infectious Diseases Authors: Jackline Kosgei, John E. Gimnig, Vincent Moshi, Seline Omondi, Daniel P. McDermott, Martin J. Donnelly, Collins Ouma, Bernard Abong ’o and Eric Ochomo Tags: Research Source Type: research
Assessing the spatial distribution of elemental concentrations in surface sediments of Lake Victoria, Kenya: implications for ecological health and management
AbstractLacustrine sediment quality indicates the effects of both natural and anthropogenic activities on the ecosystem and communities. Despite its ecological importance, myriad complexities, and potential contaminant sources, the spatial distribution of surficial sediments in Lake Victoria ’s Winam Gulf has never been comprehensively documented. The purpose of this study was to assess the spatial distribution, pathways, and ecological risk of metal elements in the lake using a sediment matrix. Sediment samples were collected throughout the gulf in November 2022. The concentrations o f Al, As, Cd, Co, Cr, Cu, Fe, K, Mn,...
Source: Environmental Geochemistry and Health - March 14, 2024 Category: Environmental Health Source Type: research
Gendered Health Outcome Among Somali Refugee Youth in Displacement: A Role of Social Support and Religious Belief
This study examines the factors influencing physical health status, specifically focusing on the gender differences in risk and promotive factors affecting health outcomes among Somali refugee youth displaced in Nairobi, Kenya (n = 227). A survey was used to assess participants’ physical health along with psychosocial factors, somatic symptoms, and demographic characteristics. The study shows that religious belief and somatic symptoms among the total sample were significant predictors in influencing the outcome of phy sical health. A moderated mediation analysis and logistic regression analyses also revealed gender ...
Source: Journal of Immigrant and Minority Health - March 13, 2024 Category: International Medicine & Public Health Source Type: research
Is there an association between countries ’ culture and runners’ performance?
ConclusionRunners, coaches, and policymakers can better understand the drivers and barriers to performance and running practice across different countries. (Source: Sport Sciences for Health)
Source: Sport Sciences for Health - March 13, 2024 Category: Sports Medicine Source Type: research
Targeted Testing and Treatment To Reduce Human Malaria Transmission in High-Risk Populations: A Systematic Review
Am J Trop Med Hyg. 2024 Mar 12:tpmd230097. doi: 10.4269/ajtmh.23-0097. Online ahead of print.ABSTRACTAs countries approach elimination of malaria, groups with increased exposure to malaria vectors or poor access to health services may serve as important human reservoirs of infection that help maintain transmission in the community. Parasitological testing and treatment targeted to these groups may reduce malaria transmission overall. This systematic review assessed the effectiveness of targeted testing and treatment (TTaT) to reduce malaria transmission, the contextual factors, and the results of modeling studies that esti...
Source: The American Journal of Tropical Medicine and Hygiene - March 12, 2024 Category: Tropical Medicine Authors: Beena Bhamani Elisabet Mart í Coma-Cros Maria Tusell Vita Mithi Elisa Serra-Casas Nana Aba Williams Kim A Lindblade Koya C Allen Source Type: research
Short Report: Low Rate of Asymptomatic Dengue Infection Detected in Coastal Kenya Using Pooled Polymerase Chain Reaction Testing
Am J Trop Med Hyg. 2024 Mar 12:tpmd230650. doi: 10.4269/ajtmh.23-0650. Online ahead of print.ABSTRACTAsymptomatic dengue virus (DENV) infections have important public health implications but are challenging to identify. We performed a cross-sectional study of reverse transcription quantitative polymerase chain reaction on pooled sera of asymptomatic individuals from the south coast of Kenya at two time periods to identify cases of asymptomatic viremia. Among 2,460 samples tested in pools of 9 or 10, we found only one positive case (0.04% incidence). Although pooling of samples has the potential to be a cost-effective and t...
Source: The American Journal of Tropical Medicine and Hygiene - March 12, 2024 Category: Tropical Medicine Authors: Melanie Kiener Nader Shayegh Sindiso Victor Nyathi Bryson Alberto Ndenga Francis Maluki Mutuku Angelle Desiree LaBeaud Source Type: research
Targeted Testing and Treatment To Reduce Human Malaria Transmission in High-Risk Populations: A Systematic Review
Am J Trop Med Hyg. 2024 Mar 12:tpmd230097. doi: 10.4269/ajtmh.23-0097. Online ahead of print.ABSTRACTAs countries approach elimination of malaria, groups with increased exposure to malaria vectors or poor access to health services may serve as important human reservoirs of infection that help maintain transmission in the community. Parasitological testing and treatment targeted to these groups may reduce malaria transmission overall. This systematic review assessed the effectiveness of targeted testing and treatment (TTaT) to reduce malaria transmission, the contextual factors, and the results of modeling studies that esti...
Source: Am J Trop Med Hyg - March 12, 2024 Category: Infectious Diseases Authors: Beena Bhamani Elisabet Mart í Coma-Cros Maria Tusell Vita Mithi Elisa Serra-Casas Nana Aba Williams Kim A Lindblade Koya C Allen Source Type: research
Short Report: Low Rate of Asymptomatic Dengue Infection Detected in Coastal Kenya Using Pooled Polymerase Chain Reaction Testing
Am J Trop Med Hyg. 2024 Mar 12:tpmd230650. doi: 10.4269/ajtmh.23-0650. Online ahead of print.ABSTRACTAsymptomatic dengue virus (DENV) infections have important public health implications but are challenging to identify. We performed a cross-sectional study of reverse transcription quantitative polymerase chain reaction on pooled sera of asymptomatic individuals from the south coast of Kenya at two time periods to identify cases of asymptomatic viremia. Among 2,460 samples tested in pools of 9 or 10, we found only one positive case (0.04% incidence). Although pooling of samples has the potential to be a cost-effective and t...
Source: Am J Trop Med Hyg - March 12, 2024 Category: Infectious Diseases Authors: Melanie Kiener Nader Shayegh Sindiso Victor Nyathi Bryson Alberto Ndenga Francis Maluki Mutuku Angelle Desiree LaBeaud Source Type: research
Targeted Testing and Treatment To Reduce Human Malaria Transmission in High-Risk Populations: A Systematic Review
Am J Trop Med Hyg. 2024 Mar 12:tpmd230097. doi: 10.4269/ajtmh.23-0097. Online ahead of print.ABSTRACTAs countries approach elimination of malaria, groups with increased exposure to malaria vectors or poor access to health services may serve as important human reservoirs of infection that help maintain transmission in the community. Parasitological testing and treatment targeted to these groups may reduce malaria transmission overall. This systematic review assessed the effectiveness of targeted testing and treatment (TTaT) to reduce malaria transmission, the contextual factors, and the results of modeling studies that esti...
Source: The American Journal of Tropical Medicine and Hygiene - March 12, 2024 Category: Tropical Medicine Authors: Beena Bhamani Elisabet Mart í Coma-Cros Maria Tusell Vita Mithi Elisa Serra-Casas Nana Aba Williams Kim A Lindblade Koya C Allen Source Type: research
