Building Community Health Volunteers' Capacity to Support Parents With Young Children With SafeCare Kenya
Conditions: Child Maltreatment; Parenting Interventions: Behavioral: SafeCare Kenya; Other: Care as Usual by Community Health Volunteers Sponsors: Pacific University; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); Africa Mental Health Research and Training Foundation; Georgia State University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2024 Category: Research Source Type: clinical trials
The World Health Organization Antenatal CorTicosteroids for Improving Outcomes in preterm Newborns (ACTION-III) Trial: study protocol for a multi-country, multi-centre, double-blind, three-arm, placebo-controlled, individually randomized trial of antenatal corticosteroids for women at high probability of late preterm birth in hospitals in low- resource countries
DiscussionThis trial will evaluate the benefits and possible harms of ACS when used in women likely to have a late preterm birth. It will also evaluate a lower-dose ACS regimen based on literature from pharmacokinetic studies. The results of this trial will provide robust critical evidence on the safe and appropriate use of ACS in the late preterm period internationally.Trial registrationISRCTN11434567. Registered on 7 June 2021. (Source: Trials)
Source: Trials - April 12, 2024 Category: Research Source Type: clinical trials
Implementing and evaluating group interpersonal therapy for postnatal depression in Lebanon and Kenya —individually randomised superiority trial
This study seeks to gauge the potency of g-IPT for women with PND in two LMICs.MethodsThis multi-site randomised controlled trial is a continuation of two preceding phases —conceptual mapping and a feasibility study executed in Lebanon and Kenya. Insights gleaned from these phases underpin this comprehensive RCT, which contrasts the efficacy and cost-effectiveness of high-quality standard care (HQ-SC) augmented with g-IPT against HQ-SC in isolation. The trial, chara cterised as an individually randomised superiority assessment, targets women with postnatal depression in Beirut, Lebanon, and Nairobi, Kenya. It aims to det...
Source: Trials - March 26, 2024 Category: Research Source Type: clinical trials
Evaluation of a financial incentive intervention on malaria prevalence among the residents in Lake Victoria basin, Kenya: study protocol for a cluster-randomized controlled trial
This study will aim to develop a demand-side policy tool to encourage local residents ’ active malaria prevention and early treatment-seeking behaviors. We examine the causal impact of a financial incentive intervention complemented with malaria education to residents in malaria-prone areas. A cluster-randomized controlled trial is designed to assess the effect of the financial inc entive intervention on reducing malaria prevalence in residents of Suba South in Homa Bay County, Kenya. The intervention includes two components. The first component is the introduction of a financial incentive scheme tied to negative RDT res...
Source: Trials - March 4, 2024 Category: Research Source Type: clinical trials
Real World Evaluation of an Albendazole-Ivermectin Coformulation Safety and Effectiveness
Conditions: Soil-Transmitted Helminths Interventions: Drug: Pre-screening Phase; Drug: Screenig Phase; Drug: Randomization; Drug: Baseline Effectiveness Cohort; Drug: Day 0 Trial Intervention; Drug: Active Surveillance (study visit Day 1, Day 2 and Day 7); Drug: Passive Surveillance; Drug: Post-Treatment Effectiveness Evaluation Sponsors: Insud Pharma; Ghana Health Services; Kenya Medical Research Institute; Bridges to Development; Sanger Institute; Barcelona Institute for Global Health; European Union; Swiss Confederation; Mundo Sano Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 28, 2024 Category: Research Source Type: clinical trials
Impact Evaluation of a Targeted mHealth Intervention to Improve Uptake of Postpartum Contraception in Kenya
Conditions: Postpartum Family Planning Interventions: Behavioral: PROMPTS Enhanced Family Planning Counselling Sponsors: Jacaranda Health; Harvard School of Public Health (HSPH); Jhpiego; IPSOS Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 20, 2024 Category: Research Source Type: clinical trials
Pharmacokinetics of Intravaginal, Self-administered Artesunate Vaginal Pessaries Among Women in Kenya
Conditions: Cervix Cancer; Cervix Intraepithelial Neoplasia Grade 3; Cervix; Intraepithelial Neoplasia, Grade I; Cervix; Intraepithelial Neoplasia, Grade II Interventions: Drug: Artesunate pessary; Diagnostic Test: blood draws for pharmacokinetics of the study drug Sponsors: UNC Lineberger Comprehensive Cancer Center Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 16, 2024 Category: Research Source Type: clinical trials
Supporting CHWs as Vaccine Educators: Impact of a Digital Training and Chatbot Intervention on Vaccination in Kenya
Conditions: Vaccine Knowledge; Vaccine Hesitancy; Vaccine Refusal Interventions: Behavioral: Digital Vaccine Education Training& Patient-facing Chatbot Tool; Behavioral: Standard Training Sponsors: Stanford University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 1, 2024 Category: Research Source Type: clinical trials
Comparison of Self-collection Using Dry Compared to Wet Swabs for HPV Detection
Conditions: Human Papillomavirus Infection Interventions: Device: • COPAN Self-collection FLOQSwabs® (COPAN, Italy) Sponsors: Foundation for Innovative New Diagnostics, Switzerland; Kenya Medical Research Institute; Frere Hospital, East London, South Africa Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 19, 2024 Category: Research Source Type: clinical trials
Improving Perinatal Outcomes Among Kenyan Pregnant Women With an Integrated STI Testing Model
Conditions: Hiv; Sexually Transmitted Infections (Not HIV or Hepatitis) Interventions: Diagnostic Test: Xpert ® CT/NG and TV testing Sponsors: University of Washington; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 12, 2024 Category: Research Source Type: clinical trials
To adopt or adapt an existing neonatal core outcome set in Kenya: a study protocol
ConclusionsA COS for use in neonatal care in Kenya will help enhance outcome measurements and reporting not just in research but also in routine practice. This will enhance the comparability of interventions in trials and routine settings leading to reduced research wastage and likely improved quality of care. Additionally, the methodology used for this work can be adopted in other settings as a means of adopting or adapting an existing COS. (Source: Trials)
Source: Trials - December 15, 2023 Category: Research Source Type: clinical trials
Evaluation of a Group-based Parenting Intervention for Early Childhood Development
Conditions: Child Development Interventions: Behavioral: Parenting program Sponsors: Harvard School of Public Health (HSPH); ChildFund Kenya; Conrad N. Hilton Foundation; B&M Consult Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 11, 2023 Category: Research Source Type: clinical trials
Artesunate Pessaries (Vaginal Inserts) for Cervical Precancer in Kenya
Conditions: Cervix Cancer; Cervix Neoplasm; Precancerous Conditions; Cervical Precancer Interventions: Drug: Artesunate pessary; Procedure: Colposcopy Sponsors: UNC Lineberger Comprehensive Cancer Center; Gilead Sciences Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 11, 2023 Category: Research Source Type: clinical trials
Impact of a disability-targeted microentrepreneurship programme in Kenya: study protocol for a randomised controlled trial of the InBusiness programme
This study will provide evidence on the impact of a large-scale disability-targeted livelihood programme on household and individual financial security and well-being. Currently, there is a lack of evidence on the effectiveness of livelihood programmes amongst people with disabilities, and so this trial can help inform the design and delivery of InBusiness as well as other livelihood programmes targeted to people with disabilities.Trial registrationClinicalTrials.gov ISRCTN13693137. Registered on April 24, 2023. (Source: Trials)
Source: Trials - December 11, 2023 Category: Research Source Type: clinical trials
Master statistical analysis plan: attractive targeted sugar bait phase III trials in Kenya, Mali, and Zambia
AbstractThis manuscript is a master statistical analysis plan for each of three-cluster randomized controlled trials to evaluate the efficacy of attractive targeted sugar baits (ATSB) described in an already published protocol. The master SAP contains an overarching plan for all three trials, which can be adapted to trial-specific circumstances. The primary objective of the trials is to evaluate the efficacy of ATSB in the presence of universal vector control coverage with insecticide-treated nets (ITN) or indoor residual spraying (IRS) after two transmission seasons on clinical malaria incidence as compared with universal...
Source: Trials - November 29, 2023 Category: Research Source Type: clinical trials