CAR T cells ignite antitumor immunity
Trends Immunol. 2023 Aug 29:S1471-4906(23)00156-4. doi: 10.1016/j.it.2023.08.002. Online ahead of print.ABSTRACTBroadening immune responses through antigen spreading remains the 'Holy Grail' of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ.PMID:37652814 | DOI:10.1016/j.it.2023.08.002 (Source: Trends in Immunology)
Source: Trends in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Darya Alizadeh Christine E Brown Source Type: research
CAR T cells ignite antitumor immunity
Trends Immunol. 2023 Aug 29:S1471-4906(23)00156-4. doi: 10.1016/j.it.2023.08.002. Online ahead of print.ABSTRACTBroadening immune responses through antigen spreading remains the 'Holy Grail' of cancer immunotherapy. A study by Ma and colleagues reveals that vaccine boosting of chimeric antigen receptor (CAR)-T cells in mice promotes endogenous immunity and elicits antigen spread to eliminate antigenically heterogenous solid tumors through a mechanism crucially dependent on interferon (IFN)γ.PMID:37652814 | DOI:10.1016/j.it.2023.08.002 (Source: Trends in Immunology)
Source: Trends in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Darya Alizadeh Christine E Brown Source Type: research
DNA repair and antibody diversification: the 53BP1 paradigm
Trends Immunol. 2023 Aug 26:S1471-4906(23)00158-8. doi: 10.1016/j.it.2023.08.004. Online ahead of print.ABSTRACTThe DNA double-strand break (DSB) repair factor 53BP1 has long been implicated in V(D)J and class switch recombination (CSR) of mammalian lymphocyte receptors. However, the dissection of the underlying molecular activities is hampered by a paucity of studies [V(D)J] and plurality of phenotypes (CSR) associated with 53BP1 deficiency. Here, we revisit the currently accepted roles of 53BP1 in antibody diversification in view of the recent identification of its downstream effectors in DSB protection and latest advanc...
Source: Trends in Immunology - August 28, 2023 Category: Allergy & Immunology Authors: Eleni Kabrani Tannishtha Saha Michela Di Virgilio Source Type: research
DNA repair and antibody diversification: the 53BP1 paradigm
Trends Immunol. 2023 Aug 26:S1471-4906(23)00158-8. doi: 10.1016/j.it.2023.08.004. Online ahead of print.ABSTRACTThe DNA double-strand break (DSB) repair factor 53BP1 has long been implicated in V(D)J and class switch recombination (CSR) of mammalian lymphocyte receptors. However, the dissection of the underlying molecular activities is hampered by a paucity of studies [V(D)J] and plurality of phenotypes (CSR) associated with 53BP1 deficiency. Here, we revisit the currently accepted roles of 53BP1 in antibody diversification in view of the recent identification of its downstream effectors in DSB protection and latest advanc...
Source: Trends in Immunology - August 28, 2023 Category: Allergy & Immunology Authors: Eleni Kabrani Tannishtha Saha Michela Di Virgilio Source Type: research
DNA repair and antibody diversification: the 53BP1 paradigm
Trends Immunol. 2023 Aug 26:S1471-4906(23)00158-8. doi: 10.1016/j.it.2023.08.004. Online ahead of print.ABSTRACTThe DNA double-strand break (DSB) repair factor 53BP1 has long been implicated in V(D)J and class switch recombination (CSR) of mammalian lymphocyte receptors. However, the dissection of the underlying molecular activities is hampered by a paucity of studies [V(D)J] and plurality of phenotypes (CSR) associated with 53BP1 deficiency. Here, we revisit the currently accepted roles of 53BP1 in antibody diversification in view of the recent identification of its downstream effectors in DSB protection and latest advanc...
Source: Trends in Immunology - August 28, 2023 Category: Allergy & Immunology Authors: Eleni Kabrani Tannishtha Saha Michela Di Virgilio Source Type: research
RNA circuits and RNA-binding proteins in T cells
Trends Immunol. 2023 Aug 18:S1471-4906(23)00153-9. doi: 10.1016/j.it.2023.07.006. Online ahead of print.ABSTRACTRNA is integral to the regulatory circuits that control cell identity and behavior. Cis-regulatory elements in mRNAs interact with RNA-binding proteins (RBPs) that can alter RNA sequence, stability, and translation into protein. Similarly, long noncoding RNAs (lncRNAs) scaffold ribonucleoprotein complexes that mediate transcriptional and post-transcriptional regulation of gene expression. Indeed, cell programming is fundamental to multicellular life and, in this era of cellular therapies, it is of particular inte...
Source: Trends in Immunology - August 20, 2023 Category: Allergy & Immunology Authors: Wandi S Zhu Benjamin D Wheeler K Mark Ansel Source Type: research
RNA circuits and RNA-binding proteins in T cells
Trends Immunol. 2023 Aug 18:S1471-4906(23)00153-9. doi: 10.1016/j.it.2023.07.006. Online ahead of print.ABSTRACTRNA is integral to the regulatory circuits that control cell identity and behavior. Cis-regulatory elements in mRNAs interact with RNA-binding proteins (RBPs) that can alter RNA sequence, stability, and translation into protein. Similarly, long noncoding RNAs (lncRNAs) scaffold ribonucleoprotein complexes that mediate transcriptional and post-transcriptional regulation of gene expression. Indeed, cell programming is fundamental to multicellular life and, in this era of cellular therapies, it is of particular inte...
Source: Trends in Immunology - August 20, 2023 Category: Allergy & Immunology Authors: Wandi S Zhu Benjamin D Wheeler K Mark Ansel Source Type: research
RNA circuits and RNA-binding proteins in T cells
Trends Immunol. 2023 Aug 18:S1471-4906(23)00153-9. doi: 10.1016/j.it.2023.07.006. Online ahead of print.ABSTRACTRNA is integral to the regulatory circuits that control cell identity and behavior. Cis-regulatory elements in mRNAs interact with RNA-binding proteins (RBPs) that can alter RNA sequence, stability, and translation into protein. Similarly, long noncoding RNAs (lncRNAs) scaffold ribonucleoprotein complexes that mediate transcriptional and post-transcriptional regulation of gene expression. Indeed, cell programming is fundamental to multicellular life and, in this era of cellular therapies, it is of particular inte...
Source: Trends in Immunology - August 20, 2023 Category: Allergy & Immunology Authors: Wandi S Zhu Benjamin D Wheeler K Mark Ansel Source Type: research
RNA circuits and RNA-binding proteins in T cells
Trends Immunol. 2023 Aug 18:S1471-4906(23)00153-9. doi: 10.1016/j.it.2023.07.006. Online ahead of print.ABSTRACTRNA is integral to the regulatory circuits that control cell identity and behavior. Cis-regulatory elements in mRNAs interact with RNA-binding proteins (RBPs) that can alter RNA sequence, stability, and translation into protein. Similarly, long noncoding RNAs (lncRNAs) scaffold ribonucleoprotein complexes that mediate transcriptional and post-transcriptional regulation of gene expression. Indeed, cell programming is fundamental to multicellular life and, in this era of cellular therapies, it is of particular inte...
Source: Trends in Immunology - August 20, 2023 Category: Allergy & Immunology Authors: Wandi S Zhu Benjamin D Wheeler K Mark Ansel Source Type: research
RNA circuits and RNA-binding proteins in T cells
Trends Immunol. 2023 Aug 18:S1471-4906(23)00153-9. doi: 10.1016/j.it.2023.07.006. Online ahead of print.ABSTRACTRNA is integral to the regulatory circuits that control cell identity and behavior. Cis-regulatory elements in mRNAs interact with RNA-binding proteins (RBPs) that can alter RNA sequence, stability, and translation into protein. Similarly, long noncoding RNAs (lncRNAs) scaffold ribonucleoprotein complexes that mediate transcriptional and post-transcriptional regulation of gene expression. Indeed, cell programming is fundamental to multicellular life and, in this era of cellular therapies, it is of particular inte...
Source: Trends in Immunology - August 20, 2023 Category: Allergy & Immunology Authors: Wandi S Zhu Benjamin D Wheeler K Mark Ansel Source Type: research
RNA circuits and RNA-binding proteins in T cells
Trends Immunol. 2023 Aug 18:S1471-4906(23)00153-9. doi: 10.1016/j.it.2023.07.006. Online ahead of print.ABSTRACTRNA is integral to the regulatory circuits that control cell identity and behavior. Cis-regulatory elements in mRNAs interact with RNA-binding proteins (RBPs) that can alter RNA sequence, stability, and translation into protein. Similarly, long noncoding RNAs (lncRNAs) scaffold ribonucleoprotein complexes that mediate transcriptional and post-transcriptional regulation of gene expression. Indeed, cell programming is fundamental to multicellular life and, in this era of cellular therapies, it is of particular inte...
Source: Trends in Immunology - August 20, 2023 Category: Allergy & Immunology Authors: Wandi S Zhu Benjamin D Wheeler K Mark Ansel Source Type: research
RNA circuits and RNA-binding proteins in T cells
Trends Immunol. 2023 Aug 18:S1471-4906(23)00153-9. doi: 10.1016/j.it.2023.07.006. Online ahead of print.ABSTRACTRNA is integral to the regulatory circuits that control cell identity and behavior. Cis-regulatory elements in mRNAs interact with RNA-binding proteins (RBPs) that can alter RNA sequence, stability, and translation into protein. Similarly, long noncoding RNAs (lncRNAs) scaffold ribonucleoprotein complexes that mediate transcriptional and post-transcriptional regulation of gene expression. Indeed, cell programming is fundamental to multicellular life and, in this era of cellular therapies, it is of particular inte...
Source: Trends in Immunology - August 20, 2023 Category: Allergy & Immunology Authors: Wandi S Zhu Benjamin D Wheeler K Mark Ansel Source Type: research
T < sub > RM < /sub > cells: not born this way
Trends Immunol. 2023 Aug 15:S1471-4906(23)00155-2. doi: 10.1016/j.it.2023.08.001. Online ahead of print.ABSTRACTHuman tissue-resident memory T (TRM) cells seeded early in life undergo an age-associated functional maturation and residency acquisition throughout childhood.PMID:37591711 | DOI:10.1016/j.it.2023.08.001 (Source: Trends in Immunology)
Source: Trends in Immunology - August 17, 2023 Category: Allergy & Immunology Authors: Allison Clatch Susan N Christo Laura K Mackay Source Type: research
Immune defenses in the urinary tract
Trends Immunol. 2023 Aug 15:S1471-4906(23)00135-7. doi: 10.1016/j.it.2023.07.001. Online ahead of print.ABSTRACTRecent advances in preclinical modeling of urinary tract infections (UTIs) have enabled the identification of key facets of the host response that influence pathogen clearance and tissue damage. Here, we review new insights into the functions of neutrophils, macrophages, and antimicrobial peptides in innate control of uropathogens and in mammalian infection-related tissue injury and repair. We also discuss novel functions for renal epithelial cells in innate antimicrobial defense. In addition, epigenetic modifica...
Source: Trends in Immunology - August 17, 2023 Category: Allergy & Immunology Authors: Hunter W Kuhn Teri N Hreha David A Hunstad Source Type: research
Protists protecting food tolerance
Trends Immunol. 2023 Aug 15:S1471-4906(23)00157-6. doi: 10.1016/j.it.2023.08.003. Online ahead of print.ABSTRACTCeliac disease (CeD) is an immune disorder characterized by gluten intolerance that can be unleashed by enteric viral infections in mice. However, Sanchez-Medina et al. recently identified a murine commensal protist, Tritrichomonas arnold, that protects against reovirus-induced intolerance to dietary protein by counteracting virus-induced epithelial stress and proinflammatory dendritic cell (DC) activation.PMID:37591713 | DOI:10.1016/j.it.2023.08.003 (Source: Trends in Immunology)
Source: Trends in Immunology - August 17, 2023 Category: Allergy & Immunology Authors: Macy R Komnick Daria Esterh ázy Source Type: research
