Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis
Trends Immunol. 2023 Dec;44(12):1014-1030. doi: 10.1016/j.it.2023.10.003. Epub 2023 Nov 9.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease (ILD) that affects lung mechanical functions and gas exchange. IPF is caused by increased fibroblast activity and collagen deposition that compromise the alveolar-capillary barrier. Identifying an effective therapy for IPF remains a clinical challenge. Chemokines are key proteins in cell communication that have functions in immunity as well as in tissue homeostasis, damage, and repair. Chemokine receptor signaling induces the activation and prolif...
Source: Trends in Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Remo C Russo Valerie F J Quesniaux Bernhard Ryffel Source Type: research
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis
Trends Immunol. 2023 Nov 9:S1471-4906(23)00210-7. doi: 10.1016/j.it.2023.10.003. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease (ILD) that affects lung mechanical functions and gas exchange. IPF is caused by increased fibroblast activity and collagen deposition that compromise the alveolar-capillary barrier. Identifying an effective therapy for IPF remains a clinical challenge. Chemokines are key proteins in cell communication that have functions in immunity as well as in tissue homeostasis, damage, and repair. Chemokine receptor signaling induces the activati...
Source: Trends in Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Remo C Russo Valerie F J Quesniaux Bernhard Ryffel Source Type: research
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis
Trends Immunol. 2023 Nov 9:S1471-4906(23)00210-7. doi: 10.1016/j.it.2023.10.003. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease (ILD) that affects lung mechanical functions and gas exchange. IPF is caused by increased fibroblast activity and collagen deposition that compromise the alveolar-capillary barrier. Identifying an effective therapy for IPF remains a clinical challenge. Chemokines are key proteins in cell communication that have functions in immunity as well as in tissue homeostasis, damage, and repair. Chemokine receptor signaling induces the activati...
Source: Trends in Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Remo C Russo Valerie F J Quesniaux Bernhard Ryffel Source Type: research
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis
Trends Immunol. 2023 Nov 9:S1471-4906(23)00210-7. doi: 10.1016/j.it.2023.10.003. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease (ILD) that affects lung mechanical functions and gas exchange. IPF is caused by increased fibroblast activity and collagen deposition that compromise the alveolar-capillary barrier. Identifying an effective therapy for IPF remains a clinical challenge. Chemokines are key proteins in cell communication that have functions in immunity as well as in tissue homeostasis, damage, and repair. Chemokine receptor signaling induces the activati...
Source: Trends in Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Remo C Russo Valerie F J Quesniaux Bernhard Ryffel Source Type: research
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis
Trends Immunol. 2023 Nov 9:S1471-4906(23)00210-7. doi: 10.1016/j.it.2023.10.003. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease (ILD) that affects lung mechanical functions and gas exchange. IPF is caused by increased fibroblast activity and collagen deposition that compromise the alveolar-capillary barrier. Identifying an effective therapy for IPF remains a clinical challenge. Chemokines are key proteins in cell communication that have functions in immunity as well as in tissue homeostasis, damage, and repair. Chemokine receptor signaling induces the activati...
Source: Trends in Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Remo C Russo Valerie F J Quesniaux Bernhard Ryffel Source Type: research
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis
Trends Immunol. 2023 Nov 9:S1471-4906(23)00210-7. doi: 10.1016/j.it.2023.10.003. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease (ILD) that affects lung mechanical functions and gas exchange. IPF is caused by increased fibroblast activity and collagen deposition that compromise the alveolar-capillary barrier. Identifying an effective therapy for IPF remains a clinical challenge. Chemokines are key proteins in cell communication that have functions in immunity as well as in tissue homeostasis, damage, and repair. Chemokine receptor signaling induces the activati...
Source: Trends in Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Remo C Russo Valerie F J Quesniaux Bernhard Ryffel Source Type: research
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis
Trends Immunol. 2023 Nov 9:S1471-4906(23)00210-7. doi: 10.1016/j.it.2023.10.003. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease (ILD) that affects lung mechanical functions and gas exchange. IPF is caused by increased fibroblast activity and collagen deposition that compromise the alveolar-capillary barrier. Identifying an effective therapy for IPF remains a clinical challenge. Chemokines are key proteins in cell communication that have functions in immunity as well as in tissue homeostasis, damage, and repair. Chemokine receptor signaling induces the activati...
Source: Trends in Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Remo C Russo Valerie F J Quesniaux Bernhard Ryffel Source Type: research
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis
Trends Immunol. 2023 Nov 9:S1471-4906(23)00210-7. doi: 10.1016/j.it.2023.10.003. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease (ILD) that affects lung mechanical functions and gas exchange. IPF is caused by increased fibroblast activity and collagen deposition that compromise the alveolar-capillary barrier. Identifying an effective therapy for IPF remains a clinical challenge. Chemokines are key proteins in cell communication that have functions in immunity as well as in tissue homeostasis, damage, and repair. Chemokine receptor signaling induces the activati...
Source: Trends in Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Remo C Russo Valerie F J Quesniaux Bernhard Ryffel Source Type: research
