Molecular mechanisms insulating proliferation from genotoxic stress in B lymphocytes
Trends Immunol. 2023 Aug 10:S1471-4906(23)00134-5. doi: 10.1016/j.it.2023.06.010. Online ahead of print.ABSTRACTIn mammals, B cells strictly segregate proliferation from somatic mutation as they develop within the bone marrow and then mature through germinal centers (GCs) in the periphery. Failure to do so risks autoimmunity and neoplastic transformation. Recent work has described how B cell progenitors transition between proliferation and mutation via cytokine signaling pathways, epigenetic chromatin regulation, and remodeling of 3D chromatin conformation. We propose a three-zone model of the GC that describes how prolife...
Source: Trends in Immunology - August 12, 2023 Category: Allergy & Immunology Authors: Nathaniel E Wright Malay Mandal Marcus R Clark Source Type: research
Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis
Trends Immunol. 2023 Aug 10:S1471-4906(23)00136-9. doi: 10.1016/j.it.2023.07.002. Online ahead of print.ABSTRACTThe natural history of advanced malignant melanoma demonstrates that, in most cases, widespread tumor dissemination is preceded by regional metastases involving tumor-draining lymph nodes [sentinel lymph nodes (SLNs)]. Under physiological conditions, LNs play a central role in immunosurveillance to non-self-antigens to which they are exposed via afferent lymph. The dysfunctional immunity in SLNs is mediated by tumor secretory factors that allow the survival of metastatic melanoma cells within the LN by creating a...
Source: Trends in Immunology - August 12, 2023 Category: Allergy & Immunology Authors: Shankar Suman Svetomir N Markovic Source Type: research
Molecular mechanisms insulating proliferation from genotoxic stress in B lymphocytes
Trends Immunol. 2023 Aug 10:S1471-4906(23)00134-5. doi: 10.1016/j.it.2023.06.010. Online ahead of print.ABSTRACTIn mammals, B cells strictly segregate proliferation from somatic mutation as they develop within the bone marrow and then mature through germinal centers (GCs) in the periphery. Failure to do so risks autoimmunity and neoplastic transformation. Recent work has described how B cell progenitors transition between proliferation and mutation via cytokine signaling pathways, epigenetic chromatin regulation, and remodeling of 3D chromatin conformation. We propose a three-zone model of the GC that describes how prolife...
Source: Trends in Immunology - August 12, 2023 Category: Allergy & Immunology Authors: Nathaniel E Wright Malay Mandal Marcus R Clark Source Type: research
Factors contributing to the potency of CD8 < sup > + < /sup > T cells
Trends Immunol. 2023 Aug 7:S1471-4906(23)00139-4. doi: 10.1016/j.it.2023.07.005. Online ahead of print.ABSTRACTCD8+ cytotoxic T lymphocytes (CTLs) play a crucial role in targeting virus-infected and cancer cells. Although other cytotoxic lymphocytes such as CD4+ T and natural killer (NK) cells, as well as chimeric antigen receptor (CAR)-T cells, can also identify and destroy aberrant cells, they seem to be significantly less potent based on available experimental data. Here, I contemplate the molecular mechanisms controlling the sensitivity and kinetics of granule-mediated CD8+ T cell cytolytic responses. I posit that the ...
Source: Trends in Immunology - August 9, 2023 Category: Allergy & Immunology Authors: Yuri Sykulev Source Type: research
Factors contributing to the potency of CD8 < sup > + < /sup > T cells
Trends Immunol. 2023 Aug 7:S1471-4906(23)00139-4. doi: 10.1016/j.it.2023.07.005. Online ahead of print.ABSTRACTCD8+ cytotoxic T lymphocytes (CTLs) play a crucial role in targeting virus-infected and cancer cells. Although other cytotoxic lymphocytes such as CD4+ T and natural killer (NK) cells, as well as chimeric antigen receptor (CAR)-T cells, can also identify and destroy aberrant cells, they seem to be significantly less potent based on available experimental data. Here, I contemplate the molecular mechanisms controlling the sensitivity and kinetics of granule-mediated CD8+ T cell cytolytic responses. I posit that the ...
Source: Trends in Immunology - August 9, 2023 Category: Allergy & Immunology Authors: Yuri Sykulev Source Type: research
