Immune-featured decidual stromal cells: pregnancy's multitasking superstars
Trends Immunol. 2023 Nov;44(11):862-864. doi: 10.1016/j.it.2023.09.009. Epub 2023 Oct 20.ABSTRACTPregnancy poses an immunological challenge, since the mother's immune system must adapt to tolerate the developing embryo until birth. The mechanisms governing this maternal-fetal dialogue have traditionally centered on the immune system. Yang et al. propose a new concept: immune-featured decidual stromal cells (DSCs), which emerge as pivotal players in mammalian maternal-fetal crosstalk.PMID:37867112 | DOI:10.1016/j.it.2023.09.009 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Nardhy Gomez-Lopez Source Type: research
Towards decoding the space-time continuum of pregnancy
Trends Immunol. 2023 Nov;44(11):859-861. doi: 10.1016/j.it.2023.09.011. Epub 2023 Oct 20.ABSTRACTPregnancy is likely nature's most elaborate model of dynamic adaptations occurring over a distinct period of time at specific sites of the maternal body. Spatially-resolved transcriptomic analyses now enable the comprehensive decoding of these dynamic adaptations during the early onset stages of mammalian pregnancies and throughout fetal development.PMID:37867113 | DOI:10.1016/j.it.2023.09.011 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Kristin Thiele Petra Clara Arck Source Type: research
Immune-featured decidual stromal cells: pregnancy's multitasking superstars
Trends Immunol. 2023 Nov;44(11):862-864. doi: 10.1016/j.it.2023.09.009. Epub 2023 Oct 20.ABSTRACTPregnancy poses an immunological challenge, since the mother's immune system must adapt to tolerate the developing embryo until birth. The mechanisms governing this maternal-fetal dialogue have traditionally centered on the immune system. Yang et al. propose a new concept: immune-featured decidual stromal cells (DSCs), which emerge as pivotal players in mammalian maternal-fetal crosstalk.PMID:37867112 | DOI:10.1016/j.it.2023.09.009 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Nardhy Gomez-Lopez Source Type: research
Towards decoding the space-time continuum of pregnancy
Trends Immunol. 2023 Nov;44(11):859-861. doi: 10.1016/j.it.2023.09.011. Epub 2023 Oct 20.ABSTRACTPregnancy is likely nature's most elaborate model of dynamic adaptations occurring over a distinct period of time at specific sites of the maternal body. Spatially-resolved transcriptomic analyses now enable the comprehensive decoding of these dynamic adaptations during the early onset stages of mammalian pregnancies and throughout fetal development.PMID:37867113 | DOI:10.1016/j.it.2023.09.011 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Kristin Thiele Petra Clara Arck Source Type: research
Immune-featured decidual stromal cells: pregnancy's multitasking superstars
Trends Immunol. 2023 Nov;44(11):862-864. doi: 10.1016/j.it.2023.09.009. Epub 2023 Oct 20.ABSTRACTPregnancy poses an immunological challenge, since the mother's immune system must adapt to tolerate the developing embryo until birth. The mechanisms governing this maternal-fetal dialogue have traditionally centered on the immune system. Yang et al. propose a new concept: immune-featured decidual stromal cells (DSCs), which emerge as pivotal players in mammalian maternal-fetal crosstalk.PMID:37867112 | DOI:10.1016/j.it.2023.09.009 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Nardhy Gomez-Lopez Source Type: research
Towards decoding the space-time continuum of pregnancy
Trends Immunol. 2023 Nov;44(11):859-861. doi: 10.1016/j.it.2023.09.011. Epub 2023 Oct 20.ABSTRACTPregnancy is likely nature's most elaborate model of dynamic adaptations occurring over a distinct period of time at specific sites of the maternal body. Spatially-resolved transcriptomic analyses now enable the comprehensive decoding of these dynamic adaptations during the early onset stages of mammalian pregnancies and throughout fetal development.PMID:37867113 | DOI:10.1016/j.it.2023.09.011 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Kristin Thiele Petra Clara Arck Source Type: research
Immune-featured decidual stromal cells: pregnancy's multitasking superstars
Trends Immunol. 2023 Oct 13:S1471-4906(23)00205-3. doi: 10.1016/j.it.2023.09.009. Online ahead of print.ABSTRACTPregnancy poses an immunological challenge, since the mother's immune system must adapt to tolerate the developing embryo until birth. The mechanisms governing this maternal-fetal dialogue have traditionally centered on the immune system. Yang et al. propose a new concept: immune-featured decidual stromal cells (DSCs), which emerge as pivotal players in mammalian maternal-fetal crosstalk.PMID:37867112 | DOI:10.1016/j.it.2023.09.009 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Nardhy Gomez-Lopez Source Type: research
Towards decoding the space-time continuum of pregnancy
Trends Immunol. 2023 Oct 12:S1471-4906(23)00207-7. doi: 10.1016/j.it.2023.09.011. Online ahead of print.ABSTRACTPregnancy is likely nature's most elaborate model of dynamic adaptations occurring over a distinct period of time at specific sites of the maternal body. Spatially-resolved transcriptomic analyses now enable the comprehensive decoding of these dynamic adaptations during the early onset stages of mammalian pregnancies and throughout fetal development.PMID:37867113 | DOI:10.1016/j.it.2023.09.011 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Kristin Thiele Petra Clara Arck Source Type: research
Immune-featured decidual stromal cells: pregnancy's multitasking superstars
Trends Immunol. 2023 Oct 13:S1471-4906(23)00205-3. doi: 10.1016/j.it.2023.09.009. Online ahead of print.ABSTRACTPregnancy poses an immunological challenge, since the mother's immune system must adapt to tolerate the developing embryo until birth. The mechanisms governing this maternal-fetal dialogue have traditionally centered on the immune system. Yang et al. propose a new concept: immune-featured decidual stromal cells (DSCs), which emerge as pivotal players in mammalian maternal-fetal crosstalk.PMID:37867112 | DOI:10.1016/j.it.2023.09.009 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Nardhy Gomez-Lopez Source Type: research
Towards decoding the space-time continuum of pregnancy
Trends Immunol. 2023 Oct 12:S1471-4906(23)00207-7. doi: 10.1016/j.it.2023.09.011. Online ahead of print.ABSTRACTPregnancy is likely nature's most elaborate model of dynamic adaptations occurring over a distinct period of time at specific sites of the maternal body. Spatially-resolved transcriptomic analyses now enable the comprehensive decoding of these dynamic adaptations during the early onset stages of mammalian pregnancies and throughout fetal development.PMID:37867113 | DOI:10.1016/j.it.2023.09.011 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Kristin Thiele Petra Clara Arck Source Type: research
Immune-featured decidual stromal cells: pregnancy's multitasking superstars
Trends Immunol. 2023 Oct 13:S1471-4906(23)00205-3. doi: 10.1016/j.it.2023.09.009. Online ahead of print.ABSTRACTPregnancy poses an immunological challenge, since the mother's immune system must adapt to tolerate the developing embryo until birth. The mechanisms governing this maternal-fetal dialogue have traditionally centered on the immune system. Yang et al. propose a new concept: immune-featured decidual stromal cells (DSCs), which emerge as pivotal players in mammalian maternal-fetal crosstalk.PMID:37867112 | DOI:10.1016/j.it.2023.09.009 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Nardhy Gomez-Lopez Source Type: research
Towards decoding the space-time continuum of pregnancy
Trends Immunol. 2023 Oct 12:S1471-4906(23)00207-7. doi: 10.1016/j.it.2023.09.011. Online ahead of print.ABSTRACTPregnancy is likely nature's most elaborate model of dynamic adaptations occurring over a distinct period of time at specific sites of the maternal body. Spatially-resolved transcriptomic analyses now enable the comprehensive decoding of these dynamic adaptations during the early onset stages of mammalian pregnancies and throughout fetal development.PMID:37867113 | DOI:10.1016/j.it.2023.09.011 (Source: Trends in Immunology)
Source: Trends in Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Kristin Thiele Petra Clara Arck Source Type: research
Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion
Trends Immunol. 2023 Oct 17:S1471-4906(23)00194-1. doi: 10.1016/j.it.2023.09.002. Online ahead of print.ABSTRACTFollowing stimulation, the T cell receptor (TCR) and its coreceptors integrate multiple intracellular signals to initiate T cell proliferation, migration, gene expression, and metabolism. Among these signaling molecules are the small GTPases RAS and RAP1, which induce MAPK pathways and cellular adhesion to activate downstream effector functions. Although many studies have helped to elucidate the signaling intermediates that mediate T cell activation, the molecules and pathways that keep naive T cells in check are...
Source: Trends in Immunology - October 20, 2023 Category: Allergy & Immunology Authors: Kristoffer H Johansen Dominic P Golec Klaus Okkenhaug Pamela L Schwartzberg Source Type: research
Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion
Trends Immunol. 2023 Oct 17:S1471-4906(23)00194-1. doi: 10.1016/j.it.2023.09.002. Online ahead of print.ABSTRACTFollowing stimulation, the T cell receptor (TCR) and its coreceptors integrate multiple intracellular signals to initiate T cell proliferation, migration, gene expression, and metabolism. Among these signaling molecules are the small GTPases RAS and RAP1, which induce MAPK pathways and cellular adhesion to activate downstream effector functions. Although many studies have helped to elucidate the signaling intermediates that mediate T cell activation, the molecules and pathways that keep naive T cells in check are...
Source: Trends in Immunology - October 20, 2023 Category: Allergy & Immunology Authors: Kristoffer H Johansen Dominic P Golec Klaus Okkenhaug Pamela L Schwartzberg Source Type: research
Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion
Trends Immunol. 2023 Oct 17:S1471-4906(23)00194-1. doi: 10.1016/j.it.2023.09.002. Online ahead of print.ABSTRACTFollowing stimulation, the T cell receptor (TCR) and its coreceptors integrate multiple intracellular signals to initiate T cell proliferation, migration, gene expression, and metabolism. Among these signaling molecules are the small GTPases RAS and RAP1, which induce MAPK pathways and cellular adhesion to activate downstream effector functions. Although many studies have helped to elucidate the signaling intermediates that mediate T cell activation, the molecules and pathways that keep naive T cells in check are...
Source: Trends in Immunology - October 20, 2023 Category: Allergy & Immunology Authors: Kristoffer H Johansen Dominic P Golec Klaus Okkenhaug Pamela L Schwartzberg Source Type: research
