Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?
Trends Immunol. 2023 Sep 9:S1471-4906(23)00178-3. doi: 10.1016/j.it.2023.08.010. Online ahead of print.ABSTRACTHumans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.PMID:37730500 | DOI:10.1016/j.it.2023.08.010 (Source: Trends in Immunology)
Source: Trends in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Ildiko Van Rhijn Source Type: research
Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?
Trends Immunol. 2023 Sep 9:S1471-4906(23)00178-3. doi: 10.1016/j.it.2023.08.010. Online ahead of print.ABSTRACTHumans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.PMID:37730500 | DOI:10.1016/j.it.2023.08.010 (Source: Trends in Immunology)
Source: Trends in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Ildiko Van Rhijn Source Type: research
Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?
Trends Immunol. 2023 Sep 9:S1471-4906(23)00178-3. doi: 10.1016/j.it.2023.08.010. Online ahead of print.ABSTRACTHumans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.PMID:37730500 | DOI:10.1016/j.it.2023.08.010 (Source: Trends in Immunology)
Source: Trends in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Ildiko Van Rhijn Source Type: research
The diversity of cGLR receptors: shedding new light on innate immunity
Trends Immunol. 2023 Sep 12:S1471-4906(23)00181-3. doi: 10.1016/j.it.2023.09.001. Online ahead of print.ABSTRACTThe characterization of a new group of innate pattern recognition receptors detected in >500 species across the tree of life by Li et al. reveals surprising commonalities and peculiarities shared with other innate receptors. Receptor diversity within and among species opens the way to reconsidering the costs and benefits of innate immune recognition.PMID:37718173 | DOI:10.1016/j.it.2023.09.001 (Source: Trends in Immunology)
Source: Trends in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: C Jessica E Metcalf Alexander E Downie Source Type: research
cGAS-like receptors: back to the future
Trends Immunol. 2023 Sep 11:S1471-4906(23)00177-1. doi: 10.1016/j.it.2023.08.009. Online ahead of print.ABSTRACTRecent studies have characterized ancient forms of cyclic GMP-AMP (cGAMP) synthase (cGAS)-like receptors (cGLRs) in bacterial and Drosophila immunity. Using bioinformatics and biochemical screening, Li et al. recently constructed and characterized >3000 cGLRs to reveal conserved mechanisms of nucleic acid sensing across animal immunity.PMID:37718174 | DOI:10.1016/j.it.2023.08.009 (Source: Trends in Immunology)
Source: Trends in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Fiachra Humphries Source Type: research
The diversity of cGLR receptors: shedding new light on innate immunity
Trends Immunol. 2023 Sep 12:S1471-4906(23)00181-3. doi: 10.1016/j.it.2023.09.001. Online ahead of print.ABSTRACTThe characterization of a new group of innate pattern recognition receptors detected in >500 species across the tree of life by Li et al. reveals surprising commonalities and peculiarities shared with other innate receptors. Receptor diversity within and among species opens the way to reconsidering the costs and benefits of innate immune recognition.PMID:37718173 | DOI:10.1016/j.it.2023.09.001 (Source: Trends in Immunology)
Source: Trends in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: C Jessica E Metcalf Alexander E Downie Source Type: research
cGAS-like receptors: back to the future
Trends Immunol. 2023 Sep 11:S1471-4906(23)00177-1. doi: 10.1016/j.it.2023.08.009. Online ahead of print.ABSTRACTRecent studies have characterized ancient forms of cyclic GMP-AMP (cGAMP) synthase (cGAS)-like receptors (cGLRs) in bacterial and Drosophila immunity. Using bioinformatics and biochemical screening, Li et al. recently constructed and characterized >3000 cGLRs to reveal conserved mechanisms of nucleic acid sensing across animal immunity.PMID:37718174 | DOI:10.1016/j.it.2023.08.009 (Source: Trends in Immunology)
Source: Trends in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Fiachra Humphries Source Type: research
The diversity of cGLR receptors: shedding new light on innate immunity
Trends Immunol. 2023 Sep 12:S1471-4906(23)00181-3. doi: 10.1016/j.it.2023.09.001. Online ahead of print.ABSTRACTThe characterization of a new group of innate pattern recognition receptors detected in >500 species across the tree of life by Li et al. reveals surprising commonalities and peculiarities shared with other innate receptors. Receptor diversity within and among species opens the way to reconsidering the costs and benefits of innate immune recognition.PMID:37718173 | DOI:10.1016/j.it.2023.09.001 (Source: Trends in Immunology)
Source: Trends in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: C Jessica E Metcalf Alexander E Downie Source Type: research
cGAS-like receptors: back to the future
Trends Immunol. 2023 Sep 11:S1471-4906(23)00177-1. doi: 10.1016/j.it.2023.08.009. Online ahead of print.ABSTRACTRecent studies have characterized ancient forms of cyclic GMP-AMP (cGAMP) synthase (cGAS)-like receptors (cGLRs) in bacterial and Drosophila immunity. Using bioinformatics and biochemical screening, Li et al. recently constructed and characterized >3000 cGLRs to reveal conserved mechanisms of nucleic acid sensing across animal immunity.PMID:37718174 | DOI:10.1016/j.it.2023.08.009 (Source: Trends in Immunology)
Source: Trends in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Fiachra Humphries Source Type: research
pH sensing at the intersection of tissue homeostasis and inflammation
Trends Immunol. 2023 Sep 14:S1471-4906(23)00162-X. doi: 10.1016/j.it.2023.08.008. Online ahead of print.ABSTRACTpH is tightly maintained at cellular, tissue, and systemic levels, and altered pH - particularly in the acidic range - is associated with infection, injury, solid tumors, and physiological and pathological inflammation. However, how pH is sensed and regulated and how it influences immune responses remain poorly understood at the tissue level. Applying conceptual frameworks of homeostatic and inflammatory circuitries, we categorize cellular and tissue components engaged in pH regulation, drawing parallels from est...
Source: Trends in Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Stephanie Hajjar Xu Zhou Source Type: research
pH sensing at the intersection of tissue homeostasis and inflammation
Trends Immunol. 2023 Sep 14:S1471-4906(23)00162-X. doi: 10.1016/j.it.2023.08.008. Online ahead of print.ABSTRACTpH is tightly maintained at cellular, tissue, and systemic levels, and altered pH - particularly in the acidic range - is associated with infection, injury, solid tumors, and physiological and pathological inflammation. However, how pH is sensed and regulated and how it influences immune responses remain poorly understood at the tissue level. Applying conceptual frameworks of homeostatic and inflammatory circuitries, we categorize cellular and tissue components engaged in pH regulation, drawing parallels from est...
Source: Trends in Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Stephanie Hajjar Xu Zhou Source Type: research
Over but not gone: lingering epigenetic effects of COVID-19
Trends Immunol. 2023 Sep 11:S1471-4906(23)00180-1. doi: 10.1016/j.it.2023.08.012. Online ahead of print.ABSTRACT'Long COVID' affects nearly one in five adults who have had coronavirus disease 2019 (COVID-19), yet the mechanisms underlying this disorder remain poorly understood. In a new study, Cheong et al. show that the epigenetic and transcriptional state of myeloid immune cells and their progenitors are durably altered in patients following severe COVID-19.PMID:37704548 | DOI:10.1016/j.it.2023.08.012 (Source: Trends in Immunology)
Source: Trends in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Brandon T Tran Ruoqiong Cao Katherine Y King Source Type: research
Klebsiella pneumoniae: adaptive immune landscapes and vaccine horizons
Trends Immunol. 2023 Sep 11:S1471-4906(23)00159-X. doi: 10.1016/j.it.2023.08.005. Online ahead of print.ABSTRACTKlebsiella pneumoniae is among the most common antibiotic-resistant pathogens causing nosocomial infections. Additionally, it is a leading cause of neonatal sepsis and childhood mortality across the globe. Despite its clinical importance, we are only beginning to understand how the mammalian adaptive immune system responds to this pathogen. Further, many studies investigating potential K. pneumoniae vaccine candidates or alternative therapies have been launched in recent years. Here, we review the current state o...
Source: Trends in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Paeton L Wantuch David A Rosen Source Type: research
Over but not gone: lingering epigenetic effects of COVID-19
Trends Immunol. 2023 Sep 11:S1471-4906(23)00180-1. doi: 10.1016/j.it.2023.08.012. Online ahead of print.ABSTRACT'Long COVID' affects nearly one in five adults who have had coronavirus disease 2019 (COVID-19), yet the mechanisms underlying this disorder remain poorly understood. In a new study, Cheong et al. show that the epigenetic and transcriptional state of myeloid immune cells and their progenitors are durably altered in patients following severe COVID-19.PMID:37704548 | DOI:10.1016/j.it.2023.08.012 (Source: Trends in Immunology)
Source: Trends in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Brandon T Tran Ruoqiong Cao Katherine Y King Source Type: research
Klebsiella pneumoniae: adaptive immune landscapes and vaccine horizons
Trends Immunol. 2023 Sep 11:S1471-4906(23)00159-X. doi: 10.1016/j.it.2023.08.005. Online ahead of print.ABSTRACTKlebsiella pneumoniae is among the most common antibiotic-resistant pathogens causing nosocomial infections. Additionally, it is a leading cause of neonatal sepsis and childhood mortality across the globe. Despite its clinical importance, we are only beginning to understand how the mammalian adaptive immune system responds to this pathogen. Further, many studies investigating potential K. pneumoniae vaccine candidates or alternative therapies have been launched in recent years. Here, we review the current state o...
Source: Trends in Immunology - September 13, 2023 Category: Allergy & Immunology Authors: Paeton L Wantuch David A Rosen Source Type: research
