Unleashing dendritic cell-mediated tumor clearance by targeting Bcl-2
Trends Immunol. 2023 Oct 7:S1471-4906(23)00203-X. doi: 10.1016/j.it.2023.09.007. Online ahead of print.ABSTRACTBcl-2 family proteins serve as key regulators of apoptosis and are frequently overexpressed in cancer. Consequently, small-molecule Bcl-2-antagonists (BH3 mimetics) have emerged as a new class of targeted therapeutics. A recent study by Zhao et al. has unexpectedly found that BH3 mimetics can also activate dendritic cells (DCs) to prime for T cell-mediated tumor clearance.PMID:37813733 | DOI:10.1016/j.it.2023.09.007 (Source: Trends in Immunology)
Source: Trends in Immunology - October 9, 2023 Category: Allergy & Immunology Authors: Seamus J Martin Source Type: research
Dietary fibers affecting gastrointestinal immunity
Trends Immunol. 2023 Oct 6:S1471-4906(23)00204-1. doi: 10.1016/j.it.2023.09.008. Online ahead of print.ABSTRACTDietary fibers, including chitin, have a major impact on gastrointestinal (GI) physiology and immunity. Two recent articles, by Parrish et al. and Kim et al., credit depletion of dietary fibers or supplementation with chitin, with negative and positive effects, respectively, on the immune system of the murine digestive tract. This has relevant implications for food allergies and systemic metabolism.PMID:37806931 | DOI:10.1016/j.it.2023.09.008 (Source: Trends in Immunology)
Source: Trends in Immunology - October 8, 2023 Category: Allergy & Immunology Authors: Laurence Zitvogel Guido Kroemer Source Type: research
Dietary fibers affecting gastrointestinal immunity
Trends Immunol. 2023 Oct 6:S1471-4906(23)00204-1. doi: 10.1016/j.it.2023.09.008. Online ahead of print.ABSTRACTDietary fibers, including chitin, have a major impact on gastrointestinal (GI) physiology and immunity. Two recent articles, by Parrish et al. and Kim et al., credit depletion of dietary fibers or supplementation with chitin, with negative and positive effects, respectively, on the immune system of the murine digestive tract. This has relevant implications for food allergies and systemic metabolism.PMID:37806931 | DOI:10.1016/j.it.2023.09.008 (Source: Trends in Immunology)
Source: Trends in Immunology - October 8, 2023 Category: Allergy & Immunology Authors: Laurence Zitvogel Guido Kroemer Source Type: research
Monoclonal antibodies lock down SARS-CoV-2 spike
Trends Immunol. 2023 Oct 5:S1471-4906(23)00202-8. doi: 10.1016/j.it.2023.09.006. Online ahead of print.ABSTRACTSARS-CoV-2 rapidly accumulated mutations in its immunodominant receptor-binding domain (RBD), rendering all clinically authorized monoclonal antibodies (mAbs) ineffective. Liu et al. unveil potent human mAbs that neutralize all tested SARS-CoV-2 variants by locking the Spike protein RBD in a downward conformation, thus inhibiting receptor engagement.PMID:37805348 | DOI:10.1016/j.it.2023.09.006 (Source: Trends in Immunology)
Source: Trends in Immunology - October 7, 2023 Category: Allergy & Immunology Authors: Hsiang-Chi Huang Davide Angeletti Source Type: research
Monoclonal antibodies lock down SARS-CoV-2 spike
Trends Immunol. 2023 Oct 5:S1471-4906(23)00202-8. doi: 10.1016/j.it.2023.09.006. Online ahead of print.ABSTRACTSARS-CoV-2 rapidly accumulated mutations in its immunodominant receptor-binding domain (RBD), rendering all clinically authorized monoclonal antibodies (mAbs) ineffective. Liu et al. unveil potent human mAbs that neutralize all tested SARS-CoV-2 variants by locking the Spike protein RBD in a downward conformation, thus inhibiting receptor engagement.PMID:37805348 | DOI:10.1016/j.it.2023.09.006 (Source: Trends in Immunology)
Source: Trends in Immunology - October 7, 2023 Category: Allergy & Immunology Authors: Hsiang-Chi Huang Davide Angeletti Source Type: research
Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?
Trends Immunol. 2023 Oct;44(10):757-759. doi: 10.1016/j.it.2023.08.010. Epub 2023 Sep 18.ABSTRACTHumans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.PMID:37730500 | DOI:10.1016/j.it.2023.08.010 (Source: Trends in Immunology)
Source: Trends in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Ildiko Van Rhijn Source Type: research
Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?
Trends Immunol. 2023 Oct;44(10):757-759. doi: 10.1016/j.it.2023.08.010. Epub 2023 Sep 18.ABSTRACTHumans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.PMID:37730500 | DOI:10.1016/j.it.2023.08.010 (Source: Trends in Immunology)
Source: Trends in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Ildiko Van Rhijn Source Type: research
Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?
Trends Immunol. 2023 Oct;44(10):757-759. doi: 10.1016/j.it.2023.08.010. Epub 2023 Sep 18.ABSTRACTHumans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.PMID:37730500 | DOI:10.1016/j.it.2023.08.010 (Source: Trends in Immunology)
Source: Trends in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Ildiko Van Rhijn Source Type: research
Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?
Trends Immunol. 2023 Oct;44(10):757-759. doi: 10.1016/j.it.2023.08.010. Epub 2023 Sep 18.ABSTRACTHumans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.PMID:37730500 | DOI:10.1016/j.it.2023.08.010 (Source: Trends in Immunology)
Source: Trends in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Ildiko Van Rhijn Source Type: research
Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?
Trends Immunol. 2023 Oct;44(10):757-759. doi: 10.1016/j.it.2023.08.010. Epub 2023 Sep 18.ABSTRACTHumans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.PMID:37730500 | DOI:10.1016/j.it.2023.08.010 (Source: Trends in Immunology)
Source: Trends in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Ildiko Van Rhijn Source Type: research
Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?
Trends Immunol. 2023 Oct;44(10):757-759. doi: 10.1016/j.it.2023.08.010. Epub 2023 Sep 18.ABSTRACTHumans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.PMID:37730500 | DOI:10.1016/j.it.2023.08.010 (Source: Trends in Immunology)
Source: Trends in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Ildiko Van Rhijn Source Type: research
Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?
Trends Immunol. 2023 Sep 9:S1471-4906(23)00178-3. doi: 10.1016/j.it.2023.08.010. Online ahead of print.ABSTRACTHumans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.PMID:37730500 | DOI:10.1016/j.it.2023.08.010 (Source: Trends in Immunology)
Source: Trends in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Ildiko Van Rhijn Source Type: research
Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?
Trends Immunol. 2023 Sep 9:S1471-4906(23)00178-3. doi: 10.1016/j.it.2023.08.010. Online ahead of print.ABSTRACTHumans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.PMID:37730500 | DOI:10.1016/j.it.2023.08.010 (Source: Trends in Immunology)
Source: Trends in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Ildiko Van Rhijn Source Type: research
Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?
Trends Immunol. 2023 Sep 9:S1471-4906(23)00178-3. doi: 10.1016/j.it.2023.08.010. Online ahead of print.ABSTRACTHumans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.PMID:37730500 | DOI:10.1016/j.it.2023.08.010 (Source: Trends in Immunology)
Source: Trends in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Ildiko Van Rhijn Source Type: research
Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?
Trends Immunol. 2023 Sep 9:S1471-4906(23)00178-3. doi: 10.1016/j.it.2023.08.010. Online ahead of print.ABSTRACTHumans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.PMID:37730500 | DOI:10.1016/j.it.2023.08.010 (Source: Trends in Immunology)
Source: Trends in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Ildiko Van Rhijn Source Type: research
