Chimeric antigen receptor T < sub > reg < /sub > therapy in transplantation
Trends Immunol. 2023 Dec 19:S1471-4906(23)00259-4. doi: 10.1016/j.it.2023.11.005. Online ahead of print.ABSTRACTIn the quest for more precise and effective organ transplantation therapies, chimeric antigen receptor (CAR) regulatory T cell (Treg) therapies represent a potential cutting-edge advance. This review comprehensively analyses CAR Tregs and how they may address important drawbacks of polyclonal Tregs and conventional immunosuppressants. We examine a growing body of preclinical findings of CAR Treg therapy in transplantation, discuss CAR Treg design specifics, and explore established and attractive new targets in tr...
Source: Trends in Immunology - December 20, 2023 Category: Allergy & Immunology Authors: Siawosh K Eskandari Andrea Daccache Jamil R Azzi Source Type: research
Targeting neuraminidase: the next frontier for broadly protective influenza vaccines
Trends Immunol. 2023 Dec 15:S1471-4906(23)00255-7. doi: 10.1016/j.it.2023.11.001. Online ahead of print.ABSTRACTCurrent seasonal influenza vaccines, which mainly target hemagglutinin (HA), require annual updates due to the continuous antigenic drift of the influenza virus. Developing an influenza vaccine with increased breadth of protection will have significant public health benefits. The recent discovery of broadly protective antibodies to neuraminidase (NA) has provided important insights into developing a universal influenza vaccine, either by improving seasonal influenza vaccines or designing novel immunogens. However...
Source: Trends in Immunology - December 16, 2023 Category: Allergy & Immunology Authors: Nicholas C Wu Ali H Ellebedy Source Type: research
Targeting neuraminidase: the next frontier for broadly protective influenza vaccines
Trends Immunol. 2023 Dec 15:S1471-4906(23)00255-7. doi: 10.1016/j.it.2023.11.001. Online ahead of print.ABSTRACTCurrent seasonal influenza vaccines, which mainly target hemagglutinin (HA), require annual updates due to the continuous antigenic drift of the influenza virus. Developing an influenza vaccine with increased breadth of protection will have significant public health benefits. The recent discovery of broadly protective antibodies to neuraminidase (NA) has provided important insights into developing a universal influenza vaccine, either by improving seasonal influenza vaccines or designing novel immunogens. However...
Source: Trends in Immunology - December 16, 2023 Category: Allergy & Immunology Authors: Nicholas C Wu Ali H Ellebedy Source Type: research
Targeting neuraminidase: the next frontier for broadly protective influenza vaccines
Trends Immunol. 2023 Dec 15:S1471-4906(23)00255-7. doi: 10.1016/j.it.2023.11.001. Online ahead of print.ABSTRACTCurrent seasonal influenza vaccines, which mainly target hemagglutinin (HA), require annual updates due to the continuous antigenic drift of the influenza virus. Developing an influenza vaccine with increased breadth of protection will have significant public health benefits. The recent discovery of broadly protective antibodies to neuraminidase (NA) has provided important insights into developing a universal influenza vaccine, either by improving seasonal influenza vaccines or designing novel immunogens. However...
Source: Trends in Immunology - December 16, 2023 Category: Allergy & Immunology Authors: Nicholas C Wu Ali H Ellebedy Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
Trends Immunol. 2023 Dec;44(12):971-985. doi: 10.1016/j.it.2023.10.007.ABSTRACTMacrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, pheno...
Source: Trends in Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Ibraheem Nasir Conor McGuinness Ashleigh R Poh Matthias Ernst Phillip K Darcy Kara L Britt Source Type: research
